date generated: “2019-06-11”

Background

Mitch performs multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##         rna_LGvHG rna_HGvHGV
## A1BG     0.971638  -0.731457
## A1CF     2.247960  -0.344901
## A2M      0.154344  -2.167180
## A2M-AS1  1.534120  -0.310504
## A4GALT   1.207370  59.565200
## AAAS     0.565670  -6.516140

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genes_in_profile 16368
duplicated_genes_present 0
num_profile_genes_in_sets 7556
num_profile_genes_not_in_sets 8812
profile_pearson_correl 0.00044
profile_spearman_correl -0.00536

Here is a scatterplot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all genes.

Here is the distribution of genes in the quadrants/sectors

Input genesets

Here are some metrics about the gene sets used: [1] “GMT file of genesets: ReactomePathways.gmt”

Gene sets metrics
Gene sets metrics
num_genesets 2231
num_genesets_excluded 966
num_genesets_included 1265
num_sets_significant 542

null device 1

Enrichment scatterplot with taucharts

All sets with p.adjustMANOVA<0.05. Try hovering over the points.

Enrichment scatterplot with taucharts

Top N sets irrespective of FDR. Try hovering over the points.

## Prioritisation done by significance

## A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top gene sets
set setSize pMANOVA p.adjustMANOVA s.dist confESp s.rna_LGvHG s.rna_HGvHGV p.rna_LGvHG p.rna_HGvHGV
Metabolism of RNA 676 2.86e-58 3.61e-55 0.367 NA -0.170 -0.32500 6.05e-14 7.01e-47
Translation 286 1.52e-36 8.99e-34 0.440 NA -0.273 -0.34500 2.13e-15 1.04e-23
Metabolism of proteins 1653 2.13e-36 8.99e-34 0.191 NA -0.160 -0.10400 7.67e-27 4.09e-12
Processing of Capped Intron-Containing Pre-mRNA 233 8.81e-27 2.79e-24 0.416 NA -0.170 -0.37900 8.27e-06 1.95e-23
rRNA processing in the nucleus and cytosol 186 4.71e-26 1.19e-23 0.458 NA -0.285 -0.35800 2.10e-11 3.65e-17
rRNA processing 218 8.66e-25 1.83e-22 0.413 NA -0.242 -0.33500 8.19e-10 1.79e-17
Major pathway of rRNA processing in the nucleolus and cytosol 176 5.91e-24 1.07e-21 0.451 NA -0.288 -0.34700 4.58e-11 2.19e-15
mRNA Splicing - Major Pathway 174 8.93e-24 1.41e-21 0.452 NA -0.203 -0.40400 4.10e-06 4.12e-20
mRNA Splicing 183 1.47e-23 2.06e-21 0.438 NA -0.198 -0.39100 3.89e-06 7.16e-20
SRP-dependent cotranslational protein targeting to membrane 108 5.71e-23 7.22e-21 0.562 NA -0.478 -0.29500 8.76e-18 1.19e-07
Cap-dependent Translation Initiation 116 4.08e-21 4.30e-19 0.519 NA -0.379 -0.35400 1.70e-12 4.32e-11
Eukaryotic Translation Initiation 116 4.08e-21 4.30e-19 0.519 NA -0.379 -0.35400 1.70e-12 4.32e-11
GTP hydrolysis and joining of the 60S ribosomal subunit 109 7.40e-21 7.20e-19 0.532 NA -0.397 -0.35400 7.93e-13 1.70e-10
L13a-mediated translational silencing of Ceruloplasmin expression 108 8.64e-21 7.80e-19 0.534 NA -0.401 -0.35200 6.24e-13 2.53e-10
Chromatin modifying enzymes 205 3.66e-19 2.77e-17 0.373 NA -0.209 -0.30900 2.72e-07 2.69e-14
Chromatin organization 205 3.66e-19 2.77e-17 0.373 NA -0.209 -0.30900 2.72e-07 2.69e-14
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 111 3.94e-19 2.77e-17 0.504 NA -0.375 -0.33700 8.36e-12 9.05e-10
Nonsense-Mediated Decay (NMD) 111 3.94e-19 2.77e-17 0.504 NA -0.375 -0.33700 8.36e-12 9.05e-10
Asparagine N-linked glycosylation 259 8.27e-19 5.51e-17 0.330 NA -0.330 -0.00156 7.17e-20 9.66e-01
Signal Transduction 1625 1.75e-18 1.11e-16 0.137 NA -0.109 0.08230 4.77e-13 4.79e-08
Formation of a pool of free 40S subunits 98 1.96e-18 1.18e-16 0.526 NA -0.403 -0.33800 5.34e-12 7.25e-09
Influenza Infection 151 9.24e-18 5.32e-16 0.417 NA -0.333 -0.25000 1.59e-12 1.20e-07
Influenza Life Cycle 140 2.09e-17 1.15e-15 0.428 NA -0.327 -0.27600 2.37e-11 1.81e-08
Eukaryotic Translation Elongation 90 3.35e-17 1.76e-15 0.530 NA -0.422 -0.32000 4.38e-12 1.61e-07
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 91 7.55e-17 3.82e-15 0.521 NA -0.416 -0.31400 7.06e-12 2.29e-07


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist confESp s.rna_LGvHG s.rna_HGvHGV p.rna_LGvHG p.rna_HGvHGV
Metabolism of RNA 676 2.86e-58 3.61e-55 0.3670 NA -0.170000 -0.325000 6.05e-14 7.01e-47
Translation 286 1.52e-36 8.99e-34 0.4400 NA -0.273000 -0.345000 2.13e-15 1.04e-23
Metabolism of proteins 1653 2.13e-36 8.99e-34 0.1910 NA -0.160000 -0.104000 7.67e-27 4.09e-12
Processing of Capped Intron-Containing Pre-mRNA 233 8.81e-27 2.79e-24 0.4160 NA -0.170000 -0.379000 8.27e-06 1.95e-23
rRNA processing in the nucleus and cytosol 186 4.71e-26 1.19e-23 0.4580 NA -0.285000 -0.358000 2.10e-11 3.65e-17
rRNA processing 218 8.66e-25 1.83e-22 0.4130 NA -0.242000 -0.335000 8.19e-10 1.79e-17
Major pathway of rRNA processing in the nucleolus and cytosol 176 5.91e-24 1.07e-21 0.4510 NA -0.288000 -0.347000 4.58e-11 2.19e-15
mRNA Splicing - Major Pathway 174 8.93e-24 1.41e-21 0.4520 NA -0.203000 -0.404000 4.10e-06 4.12e-20
mRNA Splicing 183 1.47e-23 2.06e-21 0.4380 NA -0.198000 -0.391000 3.89e-06 7.16e-20
SRP-dependent cotranslational protein targeting to membrane 108 5.71e-23 7.22e-21 0.5620 NA -0.478000 -0.295000 8.76e-18 1.19e-07
Cap-dependent Translation Initiation 116 4.08e-21 4.30e-19 0.5190 NA -0.379000 -0.354000 1.70e-12 4.32e-11
Eukaryotic Translation Initiation 116 4.08e-21 4.30e-19 0.5190 NA -0.379000 -0.354000 1.70e-12 4.32e-11
GTP hydrolysis and joining of the 60S ribosomal subunit 109 7.40e-21 7.20e-19 0.5320 NA -0.397000 -0.354000 7.93e-13 1.70e-10
L13a-mediated translational silencing of Ceruloplasmin expression 108 8.64e-21 7.80e-19 0.5340 NA -0.401000 -0.352000 6.24e-13 2.53e-10
Chromatin modifying enzymes 205 3.66e-19 2.77e-17 0.3730 NA -0.209000 -0.309000 2.72e-07 2.69e-14
Chromatin organization 205 3.66e-19 2.77e-17 0.3730 NA -0.209000 -0.309000 2.72e-07 2.69e-14
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 111 3.94e-19 2.77e-17 0.5040 NA -0.375000 -0.337000 8.36e-12 9.05e-10
Nonsense-Mediated Decay (NMD) 111 3.94e-19 2.77e-17 0.5040 NA -0.375000 -0.337000 8.36e-12 9.05e-10
Asparagine N-linked glycosylation 259 8.27e-19 5.51e-17 0.3300 NA -0.330000 -0.001560 7.17e-20 9.66e-01
Signal Transduction 1625 1.75e-18 1.11e-16 0.1370 NA -0.109000 0.082300 4.77e-13 4.79e-08
Formation of a pool of free 40S subunits 98 1.96e-18 1.18e-16 0.5260 NA -0.403000 -0.338000 5.34e-12 7.25e-09
Influenza Infection 151 9.24e-18 5.32e-16 0.4170 NA -0.333000 -0.250000 1.59e-12 1.20e-07
Influenza Life Cycle 140 2.09e-17 1.15e-15 0.4280 NA -0.327000 -0.276000 2.37e-11 1.81e-08
Eukaryotic Translation Elongation 90 3.35e-17 1.76e-15 0.5300 NA -0.422000 -0.320000 4.38e-12 1.61e-07
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 91 7.55e-17 3.82e-15 0.5210 NA -0.416000 -0.314000 7.06e-12 2.29e-07
Viral mRNA Translation 86 1.19e-16 5.80e-15 0.5330 NA -0.420000 -0.327000 1.58e-11 1.62e-07
Peptide chain elongation 86 1.25e-16 5.88e-15 0.5320 NA -0.418000 -0.329000 2.05e-11 1.31e-07
Selenoamino acid metabolism 112 1.89e-16 8.52e-15 0.4640 NA -0.324000 -0.332000 3.15e-09 1.27e-09
Developmental Biology 686 2.92e-16 1.28e-14 0.1910 NA -0.184000 0.049500 2.87e-16 2.81e-02
Selenocysteine synthesis 90 5.33e-16 2.25e-14 0.5100 NA -0.391000 -0.328000 1.47e-10 7.93e-08
Regulation of expression of SLITs and ROBOs 156 6.72e-16 2.74e-14 0.3870 NA -0.309000 -0.232000 2.65e-11 5.65e-07
Axon guidance 443 8.09e-16 3.20e-14 0.2320 NA -0.218000 0.080300 4.70e-15 3.90e-03
Post-translational protein modification 1153 1.32e-15 5.07e-14 0.1460 NA -0.130000 -0.064900 1.45e-13 2.33e-04
Gene expression (Transcription) 1265 1.88e-15 7.00e-14 0.1390 NA -0.030700 -0.135000 6.89e-02 1.05e-15
Eukaryotic Translation Termination 89 2.02e-15 7.29e-14 0.5030 NA -0.398000 -0.307000 8.27e-11 5.54e-07
Infectious disease 351 2.26e-15 7.94e-14 0.2550 NA -0.225000 -0.121000 5.26e-13 1.08e-04
Influenza Viral RNA Transcription and Replication 131 2.91e-15 9.93e-14 0.4130 NA -0.304000 -0.279000 1.81e-09 3.60e-08
Membrane Trafficking 543 5.55e-14 1.85e-12 0.1970 NA -0.178000 0.083700 1.36e-12 8.97e-04
Vesicle-mediated transport 568 2.10e-13 6.82e-12 0.1890 NA -0.173000 0.075200 2.21e-12 2.29e-03
Signaling by GPCR 384 2.94e-13 9.30e-12 0.2270 NA -0.051800 0.221000 8.25e-02 1.32e-13
Signaling by ROBO receptors 195 3.41e-13 1.05e-11 0.3140 NA -0.277000 -0.149000 2.73e-11 3.54e-04
Disease 885 1.64e-12 4.93e-11 0.1470 NA -0.139000 -0.045700 2.77e-12 2.20e-02
Immune System 1388 2.11e-12 6.21e-11 0.1190 NA -0.115000 0.031500 1.44e-12 5.21e-02
Ribosomal scanning and start codon recognition 57 4.01e-12 1.15e-10 0.5530 NA -0.412000 -0.369000 7.45e-08 1.45e-06
Translation initiation complex formation 57 1.18e-11 3.32e-10 0.5420 NA -0.406000 -0.359000 1.17e-07 2.81e-06
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 58 1.29e-11 3.55e-10 0.5360 NA -0.389000 -0.369000 3.10e-07 1.15e-06
Innate Immune System 740 1.32e-11 3.55e-10 0.1540 NA -0.140000 0.065000 1.28e-10 2.77e-03
HATs acetylate histones 88 2.44e-11 6.42e-10 0.4300 NA -0.190000 -0.386000 2.05e-03 3.93e-10
RNA Polymerase II Transcription 1138 2.72e-11 7.03e-10 0.1240 NA -0.026800 -0.121000 1.31e-01 1.04e-11
GPCR downstream signalling 353 3.69e-11 9.33e-10 0.2150 NA -0.056300 0.208000 6.98e-02 2.09e-11
Unfolded Protein Response (UPR) 87 4.60e-11 1.14e-09 0.4280 NA -0.426000 -0.043000 6.85e-12 4.88e-01
Signaling by Receptor Tyrosine Kinases 357 4.97e-11 1.21e-09 0.2130 NA -0.201000 0.069200 6.77e-11 2.52e-02
Transport of small molecules 540 7.91e-11 1.89e-09 0.1730 NA -0.157000 0.071600 5.03e-10 4.61e-03
Neuronal System 223 8.12e-11 1.90e-09 0.2650 NA 0.002920 0.265000 9.40e-01 9.37e-12
PIP3 activates AKT signaling 225 1.45e-10 3.33e-09 0.2600 NA -0.244000 -0.090600 3.00e-10 1.94e-02
Cholesterol biosynthesis 23 1.70e-10 3.84e-09 0.8080 NA 0.805000 -0.070100 2.30e-11 5.61e-01
Cellular responses to external stimuli 424 1.79e-10 3.97e-09 0.1900 NA -0.166000 -0.092000 5.02e-09 1.20e-03
Transport to the Golgi and subsequent modification 150 2.54e-10 5.54e-09 0.3150 NA -0.312000 0.040600 4.21e-11 3.91e-01
Formation of the ternary complex, and subsequently, the 43S complex 50 4.34e-10 9.30e-09 0.5350 NA -0.424000 -0.327000 2.15e-07 6.41e-05
Transport of Mature Transcript to Cytoplasm 80 4.59e-10 9.67e-09 0.4240 NA -0.116000 -0.407000 7.21e-02 3.05e-10
Regulation of Complement cascade 30 1.14e-09 2.37e-08 0.6780 NA 0.553000 -0.392000 1.54e-07 2.01e-04
IRE1alpha activates chaperones 49 1.42e-09 2.91e-08 0.5270 NA -0.526000 0.034100 1.87e-10 6.79e-01
ER to Golgi Anterograde Transport 126 1.57e-09 3.14e-08 0.3290 NA -0.324000 0.054300 3.26e-10 2.93e-01
Mitochondrial translation initiation 87 1.60e-09 3.17e-08 0.3940 NA -0.080800 -0.386000 1.93e-01 4.90e-10
Metabolism of amino acids and derivatives 315 1.77e-09 3.45e-08 0.2080 NA -0.090400 -0.187000 5.90e-03 1.17e-08
Transport of Mature mRNA derived from an Intron-Containing Transcript 71 1.81e-09 3.47e-08 0.4350 NA -0.119000 -0.418000 8.26e-02 1.11e-09
mRNA 3’-end processing 56 3.43e-09 6.47e-08 0.4820 NA -0.138000 -0.461000 7.41e-02 2.33e-09
Mitochondrial translation elongation 87 3.68e-09 6.84e-08 0.3860 NA -0.097500 -0.374000 1.16e-01 1.72e-09
rRNA modification in the nucleus and cytosol 58 3.82e-09 7.01e-08 0.4720 NA -0.234000 -0.410000 2.09e-03 6.87e-08
Mitochondrial translation termination 87 3.90e-09 7.05e-08 0.3850 NA -0.105000 -0.371000 9.09e-02 2.24e-09
Complement cascade 36 4.92e-09 8.76e-08 0.5970 NA 0.462000 -0.379000 1.65e-06 8.37e-05
Mitochondrial translation 93 6.57e-09 1.15e-07 0.3680 NA -0.105000 -0.353000 8.05e-02 4.24e-09
Intracellular signaling by second messengers 255 6.67e-09 1.16e-07 0.2230 NA -0.221000 -0.029500 1.22e-09 4.18e-01
DNA strand elongation 32 9.14e-09 1.56e-07 0.6200 NA 0.566000 0.254000 3.05e-08 1.29e-02
XBP1(S) activates chaperone genes 47 1.37e-08 2.31e-07 0.5070 NA -0.506000 0.032600 1.89e-09 6.99e-01
PTEN Regulation 136 1.58e-08 2.62e-07 0.2970 NA -0.239000 -0.176000 1.49e-06 3.91e-04
Cilium Assembly 177 2.06e-08 3.36e-07 0.2590 NA 0.166000 0.199000 1.45e-04 5.20e-06
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 2.07e-08 3.36e-07 0.5800 NA -0.575000 -0.080900 3.96e-09 4.08e-01
Neurotransmitter receptors and postsynaptic signal transmission 118 2.47e-08 3.95e-07 0.3150 NA 0.028900 0.314000 5.88e-01 3.83e-09
RNA Polymerase II Transcription Termination 65 3.10e-08 4.90e-07 0.4210 NA -0.129000 -0.401000 7.30e-02 2.27e-08
Deubiquitination 234 3.70e-08 5.78e-07 0.2220 NA -0.164000 -0.149000 1.53e-05 9.06e-05
Transmission across Chemical Synapses 161 3.82e-08 5.90e-07 0.2670 NA -0.007450 0.267000 8.71e-01 5.12e-09
Signaling by Interleukins 314 4.06e-08 6.19e-07 0.1920 NA -0.188000 -0.035700 1.02e-08 2.78e-01
Muscle contraction 120 5.05e-08 7.61e-07 0.3070 NA -0.021800 0.306000 6.80e-01 7.29e-09
Diseases of signal transduction 332 7.94e-08 1.18e-06 0.1830 NA -0.182000 0.015100 1.19e-08 6.38e-01
Calnexin/calreticulin cycle 26 9.81e-08 1.44e-06 0.6430 NA -0.640000 -0.067600 1.64e-08 5.51e-01
Cardiac conduction 77 2.53e-07 3.67e-06 0.3640 NA -0.087400 0.353000 1.85e-01 8.45e-08
Hemostasis 420 2.63e-07 3.79e-06 0.1570 NA -0.077800 0.137000 6.41e-03 1.62e-06
MAPK family signaling cascades 236 2.84e-07 4.04e-06 0.2080 NA -0.178000 0.108000 2.59e-06 4.23e-03
Generic Transcription Pathway 1019 3.51e-07 4.93e-06 0.1020 NA -0.011200 -0.101000 5.51e-01 6.09e-08
Biological oxidations 153 5.36e-07 7.45e-06 0.2530 NA 0.216000 -0.130000 3.96e-06 5.46e-03
Cellular responses to stress 341 6.83e-07 9.39e-06 0.1680 NA -0.117000 -0.120000 2.05e-04 1.44e-04
Neutrophil degranulation 354 7.66e-07 1.04e-05 0.1650 NA -0.130000 0.102000 2.81e-05 1.04e-03
Signaling by NTRK1 (TRKA) 68 8.03e-07 1.08e-05 0.3720 NA -0.356000 0.108000 3.85e-07 1.23e-01
G alpha (q) signalling events 98 8.22e-07 1.09e-05 0.3100 NA -0.123000 0.285000 3.60e-02 1.11e-06
Homologous DNA Pairing and Strand Exchange 40 1.04e-06 1.37e-05 0.4790 NA 0.463000 0.122000 4.02e-07 1.81e-01
EPH-Ephrin signaling 84 1.12e-06 1.45e-05 0.3310 NA -0.207000 0.259000 1.05e-03 4.13e-05
Insulin receptor recycling 23 1.32e-06 1.71e-05 0.6280 NA -0.515000 0.360000 1.90e-05 2.83e-03
SUMOylation 164 1.35e-06 1.73e-05 0.2350 NA -0.095600 -0.215000 3.48e-02 2.15e-06
COPI-mediated anterograde transport 77 1.42e-06 1.80e-05 0.3420 NA -0.341000 0.032600 2.37e-07 6.21e-01
Signaling by Insulin receptor 56 1.59e-06 1.98e-05 0.4000 NA -0.382000 0.119000 7.76e-07 1.24e-01
Ub-specific processing proteases 162 1.60e-06 1.98e-05 0.2350 NA -0.169000 -0.163000 2.03e-04 3.59e-04
RAF/MAP kinase cascade 194 1.70e-06 2.09e-05 0.2150 NA -0.185000 0.110000 9.04e-06 8.25e-03
MyD88 cascade initiated on plasma membrane 77 1.88e-06 2.24e-05 0.3390 NA -0.338000 0.028300 3.07e-07 6.68e-01
Toll Like Receptor 10 (TLR10) Cascade 77 1.88e-06 2.24e-05 0.3390 NA -0.338000 0.028300 3.07e-07 6.68e-01
Toll Like Receptor 5 (TLR5) Cascade 77 1.88e-06 2.24e-05 0.3390 NA -0.338000 0.028300 3.07e-07 6.68e-01
SUMO E3 ligases SUMOylate target proteins 158 2.44e-06 2.89e-05 0.2340 NA -0.092300 -0.215000 4.56e-02 3.11e-06
ROS and RNS production in phagocytes 26 3.19e-06 3.74e-05 0.5710 NA -0.395000 0.413000 4.89e-04 2.68e-04
Resolution of D-loop Structures through Holliday Junction Intermediates 30 3.67e-06 4.26e-05 0.5270 NA 0.525000 0.045700 6.30e-07 6.65e-01
trans-Golgi Network Vesicle Budding 69 3.85e-06 4.43e-05 0.3480 NA -0.330000 0.112000 2.17e-06 1.08e-01
MAPK1/MAPK3 signaling 199 4.22e-06 4.81e-05 0.2050 NA -0.176000 0.106000 1.97e-05 9.94e-03
COPII-mediated vesicle transport 63 4.53e-06 5.12e-05 0.3620 NA -0.350000 0.091500 1.54e-06 2.10e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 80 4.78e-06 5.35e-05 0.3200 NA -0.320000 0.014800 7.58e-07 8.19e-01
Macroautophagy 84 4.82e-06 5.35e-05 0.3120 NA -0.305000 -0.066800 1.38e-06 2.90e-01
ER Quality Control Compartment (ERQC) 21 4.99e-06 5.49e-05 0.6230 NA -0.623000 0.015800 7.81e-07 9.00e-01
Toll Like Receptor 9 (TLR9) Cascade 84 5.29e-06 5.77e-05 0.3110 NA -0.311000 0.018100 8.54e-07 7.75e-01
Toll Like Receptor 3 (TLR3) Cascade 87 5.62e-06 6.08e-05 0.3050 NA -0.303000 0.035800 1.03e-06 5.64e-01
Potassium Channels 35 6.74e-06 7.23e-05 0.4770 NA -0.073900 0.471000 4.49e-01 1.40e-06
Circadian Clock 67 7.80e-06 8.29e-05 0.3420 NA -0.278000 -0.199000 8.38e-05 4.87e-03
GPCR ligand binding 136 7.93e-06 8.36e-05 0.2410 NA 0.027900 0.239000 5.75e-01 1.50e-06
Transport of inorganic cations/anions and amino acids/oligopeptides 72 8.10e-06 8.40e-05 0.3310 NA -0.291000 0.158000 1.99e-05 2.07e-02
Presynaptic phase of homologous DNA pairing and strand exchange 37 8.10e-06 8.40e-05 0.4590 NA 0.436000 0.143000 4.36e-06 1.32e-01
Regulation of PTEN stability and activity 65 8.76e-06 9.01e-05 0.3450 NA -0.294000 -0.181000 4.14e-05 1.16e-02
tRNA processing 135 8.88e-06 9.05e-05 0.2410 NA 0.005900 -0.241000 9.06e-01 1.42e-06
G-protein mediated events 40 9.18e-06 9.29e-05 0.4410 NA -0.106000 0.428000 2.47e-01 2.85e-06
MyD88 dependent cascade initiated on endosome 81 9.47e-06 9.43e-05 0.3090 NA -0.309000 0.018800 1.57e-06 7.70e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 81 9.47e-06 9.43e-05 0.3090 NA -0.309000 0.018800 1.57e-06 7.70e-01
Signaling by WNT 236 1.00e-05 9.93e-05 0.1820 NA -0.182000 -0.003090 1.61e-06 9.35e-01
UCH proteinases 85 1.07e-05 1.05e-04 0.3000 NA -0.252000 -0.162000 5.82e-05 1.01e-02
Resolution of D-Loop Structures 31 1.13e-05 1.10e-04 0.4950 NA 0.492000 0.051500 2.09e-06 6.20e-01
Intraflagellar transport 37 1.14e-05 1.10e-04 0.4520 NA 0.281000 0.354000 3.11e-03 1.93e-04
PLC beta mediated events 39 1.28e-05 1.22e-04 0.4400 NA -0.123000 0.422000 1.84e-01 5.02e-06
Class I MHC mediated antigen processing & presentation 335 1.28e-05 1.22e-04 0.1510 NA -0.116000 -0.096200 2.68e-04 2.53e-03
Regulation of mRNA stability by proteins that bind AU-rich elements 86 1.29e-05 1.22e-04 0.2950 NA -0.223000 -0.194000 3.61e-04 1.88e-03
tRNA Aminoacylation 42 1.35e-05 1.26e-04 0.4220 NA -0.045400 -0.420000 6.11e-01 2.53e-06
Signaling by the B Cell Receptor (BCR) 100 1.41e-05 1.30e-04 0.2740 NA -0.273000 0.014000 2.34e-06 8.08e-01
MyD88-independent TLR4 cascade 90 1.42e-05 1.30e-04 0.2880 NA -0.287000 0.028700 2.56e-06 6.38e-01
TRIF(TICAM1)-mediated TLR4 signaling 90 1.42e-05 1.30e-04 0.2880 NA -0.287000 0.028700 2.56e-06 6.38e-01
Fc epsilon receptor (FCERI) signaling 115 1.51e-05 1.37e-04 0.2540 NA -0.254000 -0.006850 2.48e-06 8.99e-01
Opioid Signalling 64 1.55e-05 1.40e-04 0.3410 NA -0.143000 0.310000 4.87e-02 1.84e-05
Adaptive Immune System 565 1.61e-05 1.44e-04 0.1160 NA -0.113000 0.026000 4.55e-06 2.92e-01
HDR through Homologous Recombination (HRR) 63 1.73e-05 1.54e-04 0.3410 NA 0.330000 0.083800 5.82e-06 2.50e-01
Metabolism of water-soluble vitamins and cofactors 98 1.77e-05 1.56e-04 0.2740 NA 0.075400 -0.263000 1.97e-01 6.67e-06
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 25 1.81e-05 1.59e-04 0.5390 NA 0.528000 0.108000 4.80e-06 3.50e-01
Effects of PIP2 hydrolysis 21 1.84e-05 1.60e-04 0.5900 NA -0.251000 0.534000 4.65e-02 2.29e-05
Protein localization 150 1.92e-05 1.66e-04 0.2210 NA -0.028400 -0.219000 5.49e-01 3.86e-06
Peroxisomal protein import 58 2.24e-05 1.93e-04 0.3520 NA 0.202000 -0.289000 7.95e-03 1.43e-04
Ion channel transport 116 2.26e-05 1.93e-04 0.2490 NA -0.168000 0.184000 1.78e-03 6.10e-04
TCR signaling 92 2.47e-05 2.10e-04 0.2780 NA -0.275000 -0.036200 5.03e-06 5.49e-01
Unwinding of DNA 12 2.54e-05 2.14e-04 0.7660 NA 0.727000 0.241000 1.31e-05 1.48e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 45 2.65e-05 2.21e-04 0.3950 NA 0.146000 0.367000 9.05e-02 2.06e-05
SUMOylation of transcription cofactors 43 2.65e-05 2.21e-04 0.4040 NA -0.228000 -0.333000 9.57e-03 1.60e-04
TCF dependent signaling in response to WNT 163 2.72e-05 2.25e-04 0.2080 NA -0.179000 -0.106000 8.12e-05 2.02e-02
Antigen processing: Ubiquitination & Proteasome degradation 281 3.10e-05 2.55e-04 0.1580 NA -0.103000 -0.120000 3.08e-03 5.65e-04
Activation of ATR in response to replication stress 36 3.29e-05 2.69e-04 0.4370 NA 0.396000 0.184000 3.91e-05 5.65e-02
MAP kinase activation 61 3.44e-05 2.79e-04 0.3360 NA -0.334000 0.036000 6.47e-06 6.27e-01
Cytokine Signaling in Immune system 478 3.59e-05 2.89e-04 0.1210 NA -0.120000 -0.016500 7.51e-06 5.37e-01
Transcriptional regulation by RUNX1 170 3.63e-05 2.91e-04 0.2010 NA -0.129000 -0.154000 3.85e-03 5.39e-04
Signaling by NTRKs 84 3.66e-05 2.91e-04 0.2860 NA -0.276000 0.075100 1.26e-05 2.35e-01
Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD 53 3.75e-05 2.96e-04 0.3580 NA -0.332000 -0.133000 2.88e-05 9.39e-02
Cytosolic tRNA aminoacylation 24 3.77e-05 2.96e-04 0.5310 NA -0.283000 -0.449000 1.66e-02 1.38e-04
Clathrin-mediated endocytosis 117 3.82e-05 2.98e-04 0.2420 NA -0.187000 0.154000 4.83e-04 4.03e-03
Synthesis of bile acids and bile salts via 27-hydroxycholesterol 13 3.85e-05 2.99e-04 0.7210 NA -0.226000 -0.684000 1.57e-01 1.93e-05
Hh mutants abrogate ligand secretion 55 3.99e-05 3.07e-04 0.3500 NA -0.325000 -0.131000 3.08e-05 9.34e-02
Interleukin-17 signaling 65 4.04e-05 3.09e-04 0.3230 NA -0.322000 0.024200 7.21e-06 7.36e-01
Downstream TCR signaling 77 4.10e-05 3.12e-04 0.2960 NA -0.269000 -0.122000 4.44e-05 6.34e-02
Hedgehog ligand biogenesis 60 4.37e-05 3.31e-04 0.3340 NA -0.316000 -0.109000 2.34e-05 1.45e-01
O-linked glycosylation 68 4.54e-05 3.42e-04 0.3140 NA -0.008960 0.314000 8.98e-01 7.78e-06
Defective CFTR causes cystic fibrosis 56 4.79e-05 3.59e-04 0.3440 NA -0.319000 -0.129000 3.68e-05 9.51e-02
Activation of NF-kappaB in B cells 63 4.93e-05 3.67e-04 0.3240 NA -0.288000 -0.149000 7.93e-05 4.11e-02
Semaphorin interactions 57 5.02e-05 3.71e-04 0.3420 NA -0.174000 0.294000 2.30e-02 1.25e-04
Transferrin endocytosis and recycling 29 5.28e-05 3.88e-04 0.4770 NA -0.421000 0.225000 8.70e-05 3.63e-02
Intra-Golgi and retrograde Golgi-to-ER traffic 173 5.33e-05 3.90e-04 0.1960 NA -0.187000 0.058500 2.23e-05 1.85e-01
Phase II - Conjugation of compounds 74 5.83e-05 4.24e-04 0.2980 NA 0.258000 -0.149000 1.27e-04 2.68e-02
Diseases associated with O-glycosylation of proteins 40 6.24e-05 4.51e-04 0.4020 NA 0.069400 0.396000 4.48e-01 1.49e-05
L1CAM interactions 78 6.43e-05 4.62e-04 0.2890 NA -0.140000 0.252000 3.25e-02 1.18e-04
G alpha (i) signalling events 195 6.83e-05 4.88e-04 0.1820 NA 0.013600 0.182000 7.44e-01 1.27e-05
Negative regulation of MAPK pathway 39 7.08e-05 5.03e-04 0.4050 NA -0.388000 0.117000 2.76e-05 2.08e-01
Downstream signaling events of B Cell Receptor (BCR) 77 7.37e-05 5.21e-04 0.2870 NA -0.281000 -0.061400 2.07e-05 3.52e-01
Initial triggering of complement 13 7.58e-05 5.33e-04 0.7000 NA 0.517000 -0.471000 1.24e-03 3.30e-03
Neddylation 210 8.05e-05 5.63e-04 0.1740 NA -0.102000 -0.140000 1.06e-02 4.72e-04
ABC transporter disorders 68 8.33e-05 5.78e-04 0.3030 NA -0.243000 -0.181000 5.31e-04 9.75e-03
Degradation of beta-catenin by the destruction complex 81 8.36e-05 5.78e-04 0.2780 NA -0.250000 -0.122000 1.01e-04 5.84e-02
Interleukin-1 signaling 93 9.24e-05 6.35e-04 0.2580 NA -0.238000 -0.101000 7.59e-05 9.16e-02
Signaling by TGF-beta Receptor Complex 72 9.42e-05 6.44e-04 0.2930 NA -0.281000 -0.083100 3.74e-05 2.23e-01
Formation of Fibrin Clot (Clotting Cascade) 29 9.91e-05 6.74e-04 0.4620 NA 0.381000 -0.261000 3.87e-04 1.49e-02
Voltage gated Potassium channels 14 1.01e-04 6.83e-04 0.6630 NA -0.109000 0.654000 4.78e-01 2.29e-05
G alpha (s) signalling events 68 1.03e-04 6.96e-04 0.3010 NA -0.074400 0.292000 2.89e-01 3.23e-05
Degradation of AXIN 52 1.06e-04 7.11e-04 0.3420 NA -0.279000 -0.197000 4.92e-04 1.38e-02
Nuclear Receptor transcription pathway 42 1.08e-04 7.16e-04 0.3800 NA -0.317000 -0.209000 3.72e-04 1.89e-02
Platelet activation, signaling and aggregation 192 1.09e-04 7.23e-04 0.1790 NA -0.118000 0.136000 5.02e-03 1.22e-03
G alpha (z) signalling events 32 1.16e-04 7.64e-04 0.4350 NA -0.100000 0.424000 3.26e-01 3.36e-05
Class B/2 (Secretin family receptors) 47 1.18e-04 7.70e-04 0.3580 NA 0.025100 0.358000 7.66e-01 2.22e-05
Disorders of transmembrane transporters 136 1.18e-04 7.70e-04 0.2110 NA -0.154000 -0.144000 1.97e-03 3.73e-03
Cell Cycle 555 1.19e-04 7.70e-04 0.1060 NA 0.102000 -0.029000 4.21e-05 2.45e-01
Activation of gene expression by SREBF (SREBP) 42 1.23e-04 7.92e-04 0.3790 NA 0.312000 -0.216000 4.75e-04 1.52e-02
Interleukin-1 family signaling 111 1.40e-04 8.99e-04 0.2310 NA -0.204000 -0.109000 2.11e-04 4.75e-02
TGF-beta receptor signaling activates SMADs 32 1.41e-04 8.99e-04 0.4300 NA -0.417000 -0.101000 4.38e-05 3.21e-01
Signaling by VEGF 90 1.41e-04 8.99e-04 0.2570 NA -0.253000 0.043200 3.26e-05 4.79e-01
HIV Infection 215 1.43e-04 9.02e-04 0.1660 NA -0.127000 -0.107000 1.35e-03 6.74e-03
Homology Directed Repair 107 1.51e-04 9.47e-04 0.2350 NA 0.233000 0.026000 3.08e-05 6.42e-01
HDMs demethylate histones 22 1.64e-04 1.02e-03 0.5130 NA -0.406000 -0.314000 9.92e-04 1.08e-02
Interaction between L1 and Ankyrins 21 1.72e-04 1.07e-03 0.5250 NA 0.001030 0.525000 9.93e-01 3.13e-05
Transcriptional regulation by RUNX3 94 1.73e-04 1.07e-03 0.2480 NA -0.190000 -0.160000 1.50e-03 7.49e-03
Lagging Strand Synthesis 20 1.74e-04 1.07e-03 0.5360 NA 0.468000 0.261000 2.89e-04 4.30e-02
Extracellular matrix organization 190 1.74e-04 1.07e-03 0.1750 NA 0.053500 0.167000 2.04e-01 7.63e-05
Mitotic Prometaphase 177 1.85e-04 1.13e-03 0.1810 NA 0.179000 -0.027400 4.10e-05 5.31e-01
ESR-mediated signaling 152 1.86e-04 1.13e-03 0.1950 NA -0.188000 -0.052400 6.72e-05 2.66e-01
Fatty acid metabolism 134 1.93e-04 1.16e-03 0.2070 NA 0.207000 -0.006470 3.56e-05 8.97e-01
Mitochondrial protein import 58 1.93e-04 1.16e-03 0.3140 NA -0.096300 -0.298000 2.05e-01 8.52e-05
Cargo recognition for clathrin-mediated endocytosis 82 1.96e-04 1.17e-03 0.2650 NA -0.186000 0.188000 3.53e-03 3.26e-03
NCAM signaling for neurite out-growth 41 1.97e-04 1.18e-03 0.3730 NA 0.069400 0.366000 4.42e-01 5.02e-05
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 2.13e-04 1.26e-03 0.3950 NA -0.150000 -0.366000 1.19e-01 1.46e-04
tRNA modification in the nucleus and cytosol 41 2.17e-04 1.28e-03 0.3710 NA 0.046100 -0.368000 6.09e-01 4.54e-05
Lysosome Vesicle Biogenesis 32 2.21e-04 1.30e-03 0.4200 NA -0.408000 0.097600 6.46e-05 3.40e-01
Processive synthesis on the lagging strand 15 2.38e-04 1.39e-03 0.6080 NA 0.531000 0.297000 3.74e-04 4.67e-02
Golgi Associated Vesicle Biogenesis 55 2.46e-04 1.43e-03 0.3180 NA -0.300000 0.106000 1.18e-04 1.75e-01
Cargo concentration in the ER 29 2.56e-04 1.49e-03 0.4370 NA -0.426000 0.094600 7.04e-05 3.78e-01
Anchoring of the basal body to the plasma membrane 94 2.77e-04 1.60e-03 0.2410 NA 0.185000 0.155000 1.97e-03 9.59e-03
Degradation of DVL 52 2.93e-04 1.68e-03 0.3230 NA -0.244000 -0.211000 2.33e-03 8.54e-03
Host Interactions of HIV factors 120 2.93e-04 1.68e-03 0.2130 NA -0.168000 -0.131000 1.51e-03 1.34e-02
Removal of the Flap Intermediate 14 3.01e-04 1.72e-03 0.6200 NA 0.512000 0.349000 9.09e-04 2.36e-02
PI Metabolism 71 3.13e-04 1.77e-03 0.2760 NA -0.272000 0.049400 7.61e-05 4.72e-01
NCAM1 interactions 21 3.19e-04 1.80e-03 0.5050 NA 0.202000 0.463000 1.10e-01 2.41e-04
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 3.19e-04 1.80e-03 0.4940 NA -0.494000 0.027100 6.14e-05 8.26e-01
Deadenylation-dependent mRNA decay 56 3.42e-04 1.92e-03 0.3080 NA -0.092800 -0.294000 2.30e-01 1.43e-04
SUMOylation of RNA binding proteins 46 3.46e-04 1.93e-03 0.3400 NA -0.012000 -0.340000 8.88e-01 6.64e-05
C-type lectin receptors (CLRs) 117 3.50e-04 1.94e-03 0.2140 NA -0.214000 -0.005260 6.68e-05 9.22e-01
FCERI mediated NF-kB activation 73 3.57e-04 1.97e-03 0.2690 NA -0.229000 -0.141000 7.18e-04 3.69e-02
MAPK targets/ Nuclear events mediated by MAP kinases 29 3.64e-04 2.00e-03 0.4280 NA -0.362000 0.228000 7.31e-04 3.39e-02
Striated Muscle Contraction 22 3.64e-04 2.00e-03 0.4890 NA 0.296000 0.389000 1.62e-02 1.59e-03
Iron uptake and transport 55 3.74e-04 2.04e-03 0.3100 NA -0.295000 0.095500 1.53e-04 2.21e-01
Ion homeostasis 34 3.82e-04 2.07e-03 0.3940 NA -0.144000 0.367000 1.46e-01 2.16e-04
Activation of the pre-replicative complex 32 3.84e-04 2.07e-03 0.4040 NA 0.355000 0.193000 5.12e-04 5.83e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 86 3.94e-04 2.09e-03 0.2470 NA -0.245000 0.032900 8.59e-05 5.99e-01
Toll Like Receptor 2 (TLR2) Cascade 86 3.94e-04 2.09e-03 0.2470 NA -0.245000 0.032900 8.59e-05 5.99e-01
Toll Like Receptor TLR1:TLR2 Cascade 86 3.94e-04 2.09e-03 0.2470 NA -0.245000 0.032900 8.59e-05 5.99e-01
Toll Like Receptor TLR6:TLR2 Cascade 86 3.94e-04 2.09e-03 0.2470 NA -0.245000 0.032900 8.59e-05 5.99e-01
Regulation of insulin secretion 53 4.02e-04 2.13e-03 0.3140 NA -0.066800 0.307000 4.00e-01 1.10e-04
HDR through Single Strand Annealing (SSA) 35 4.05e-04 2.13e-03 0.3860 NA 0.372000 0.101000 1.39e-04 3.02e-01
GABA receptor activation 26 4.35e-04 2.28e-03 0.4460 NA 0.052000 0.442000 6.47e-01 9.41e-05
CLEC7A (Dectin-1) signaling 91 4.47e-04 2.34e-03 0.2380 NA -0.223000 -0.082700 2.37e-04 1.73e-01
Regulation of TP53 Activity through Acetylation 30 4.51e-04 2.34e-03 0.4130 NA -0.383000 -0.156000 2.85e-04 1.39e-01
Metabolism of vitamins and cofactors 157 4.51e-04 2.34e-03 0.1820 NA 0.061600 -0.171000 1.83e-01 2.16e-04
Interactions of Rev with host cellular proteins 36 4.96e-04 2.56e-03 0.3750 NA -0.079200 -0.367000 4.11e-01 1.40e-04
Leading Strand Synthesis 14 5.09e-04 2.60e-03 0.6000 NA 0.512000 0.313000 9.14e-04 4.29e-02
Polymerase switching 14 5.09e-04 2.60e-03 0.6000 NA 0.512000 0.313000 9.14e-04 4.29e-02
Polymerase switching on the C-strand of the telomere 14 5.09e-04 2.60e-03 0.6000 NA 0.512000 0.313000 9.14e-04 4.29e-02
Fcgamma receptor (FCGR) dependent phagocytosis 69 5.25e-04 2.67e-03 0.2710 NA -0.230000 0.144000 9.50e-04 3.92e-02
Cellular response to heat stress 94 5.39e-04 2.73e-03 0.2310 NA -0.168000 -0.159000 4.95e-03 7.83e-03
Ephrin signaling 18 5.63e-04 2.84e-03 0.5280 NA -0.208000 0.485000 1.27e-01 3.67e-04
Diseases associated with N-glycosylation of proteins 17 5.93e-04 2.96e-03 0.5390 NA -0.267000 -0.468000 5.67e-02 8.37e-04
Dectin-1 mediated noncanonical NF-kB signaling 57 5.94e-04 2.96e-03 0.2950 NA -0.262000 -0.135000 6.32e-04 7.78e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 52 5.94e-04 2.96e-03 0.3080 NA -0.245000 -0.187000 2.27e-03 1.95e-02
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 35 5.97e-04 2.96e-03 0.3770 NA 0.250000 -0.283000 1.05e-02 3.79e-03
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 30 6.00e-04 2.96e-03 0.4050 NA -0.289000 -0.285000 6.23e-03 7.00e-03
Cellular response to hypoxia 70 6.04e-04 2.97e-03 0.2660 NA -0.210000 -0.163000 2.41e-03 1.86e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 101 6.07e-04 2.97e-03 0.2220 NA 0.221000 0.020800 1.28e-04 7.19e-01
Metabolism 1715 6.29e-04 3.07e-03 0.0566 NA 0.002030 -0.056500 8.91e-01 1.24e-04
Regulation of TLR by endogenous ligand 13 6.35e-04 3.09e-03 0.6150 NA 0.608000 -0.095300 1.48e-04 5.52e-01
Transport of Mature mRNA Derived from an Intronless Transcript 41 6.40e-04 3.09e-03 0.3460 NA -0.047300 -0.343000 6.01e-01 1.47e-04
Transcriptional Regulation by TP53 345 6.41e-04 3.09e-03 0.1200 NA -0.093400 -0.075600 2.94e-03 1.62e-02
VEGFA-VEGFR2 Pathway 86 6.46e-04 3.10e-03 0.2390 NA -0.236000 0.040800 1.57e-04 5.14e-01
Collagen chain trimerization 18 6.47e-04 3.10e-03 0.5210 NA 0.500000 0.146000 2.40e-04 2.82e-01
O-linked glycosylation of mucins 39 6.68e-04 3.19e-03 0.3540 NA -0.080300 0.345000 3.86e-01 1.93e-04
RAB geranylgeranylation 54 6.83e-04 3.25e-03 0.3010 NA -0.187000 0.236000 1.75e-02 2.70e-03
Regulation of RUNX3 expression and activity 54 7.06e-04 3.34e-03 0.2990 NA -0.263000 -0.143000 8.49e-04 6.87e-02
Nuclear import of Rev protein 33 7.10e-04 3.35e-03 0.3830 NA -0.096500 -0.370000 3.38e-01 2.33e-04
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 51 7.35e-04 3.46e-03 0.3070 NA -0.246000 -0.183000 2.39e-03 2.35e-02
Autodegradation of the E3 ubiquitin ligase COP1 49 7.48e-04 3.51e-03 0.3130 NA -0.242000 -0.197000 3.33e-03 1.70e-02
Adenylate cyclase inhibitory pathway 11 7.98e-04 3.72e-03 0.6580 NA -0.020000 0.657000 9.08e-01 1.59e-04
ABC-family proteins mediated transport 92 8.04e-04 3.74e-03 0.2280 NA -0.224000 -0.041600 2.09e-04 4.91e-01
DNA Double-Strand Break Repair 132 8.13e-04 3.75e-03 0.1900 NA 0.189000 -0.023200 1.79e-04 6.46e-01
Toll Like Receptor 4 (TLR4) Cascade 110 8.13e-04 3.75e-03 0.2090 NA -0.202000 0.051100 2.50e-04 3.55e-01
NIK–>noncanonical NF-kB signaling 56 8.20e-04 3.77e-03 0.2910 NA -0.259000 -0.131000 7.86e-04 9.00e-02
Integration of energy metabolism 81 8.33e-04 3.82e-03 0.2420 NA -0.037700 0.239000 5.57e-01 1.97e-04
Non-genomic estrogen signaling 57 8.73e-04 3.98e-03 0.2880 NA -0.273000 0.092800 3.73e-04 2.26e-01
DAG and IP3 signaling 31 8.87e-04 4.03e-03 0.3890 NA -0.042600 0.387000 6.82e-01 1.92e-04
Carboxyterminal post-translational modifications of tubulin 28 9.12e-04 4.10e-03 0.4070 NA 0.249000 0.322000 2.25e-02 3.15e-03
Activation of GABAB receptors 22 9.13e-04 4.10e-03 0.4610 NA -0.007260 0.461000 9.53e-01 1.83e-04
GABA B receptor activation 22 9.13e-04 4.10e-03 0.4610 NA -0.007260 0.461000 9.53e-01 1.83e-04
Cell-Cell communication 84 9.14e-04 4.10e-03 0.2370 NA -0.093900 0.217000 1.37e-01 5.81e-04
Chromosome Maintenance 76 9.38e-04 4.19e-03 0.2480 NA 0.241000 0.056300 2.81e-04 3.97e-01
Rho GTPase cycle 118 9.65e-04 4.30e-03 0.1990 NA -0.073000 0.185000 1.71e-01 5.14e-04
Cell Cycle, Mitotic 461 9.95e-04 4.42e-03 0.1020 NA 0.091700 -0.043700 7.70e-04 1.09e-01
Signaling by NOTCH 177 1.00e-03 4.44e-03 0.1620 NA -0.160000 -0.025800 2.47e-04 5.54e-01
Signaling by TGF-beta family members 89 1.01e-03 4.46e-03 0.2280 NA -0.224000 -0.041900 2.66e-04 4.94e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 47 1.02e-03 4.50e-03 0.3120 NA -0.256000 -0.178000 2.36e-03 3.49e-02
Ubiquitin-dependent degradation of Cyclin D 49 1.08e-03 4.73e-03 0.3050 NA -0.264000 -0.152000 1.39e-03 6.64e-02
Downregulation of TGF-beta receptor signaling 26 1.11e-03 4.82e-03 0.4180 NA -0.409000 -0.086500 3.11e-04 4.45e-01
SUMOylation of DNA damage response and repair proteins 75 1.11e-03 4.83e-03 0.2460 NA 0.005230 -0.246000 9.38e-01 2.26e-04
Phase 0 - rapid depolarisation 25 1.19e-03 5.15e-03 0.4240 NA 0.096800 0.412000 4.02e-01 3.59e-04
EPH-ephrin mediated repulsion of cells 41 1.20e-03 5.19e-03 0.3320 NA -0.107000 0.314000 2.36e-01 5.09e-04
TBC/RABGAPs 43 1.21e-03 5.19e-03 0.3240 NA -0.293000 0.137000 8.79e-04 1.19e-01
Signalling to ERKs 29 1.22e-03 5.22e-03 0.3940 NA -0.379000 0.108000 4.19e-04 3.14e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 42 1.23e-03 5.24e-03 0.3260 NA -0.066600 -0.319000 4.55e-01 3.43e-04
Defective B3GAT3 causes JDSSDHD 19 1.23e-03 5.25e-03 0.4840 NA 0.201000 0.440000 1.29e-01 8.91e-04
PI3K/AKT Signaling in Cancer 69 1.25e-03 5.31e-03 0.2550 NA -0.249000 0.056700 3.58e-04 4.16e-01
Toll-like Receptor Cascades 127 1.29e-03 5.45e-03 0.1880 NA -0.184000 0.035800 3.38e-04 4.86e-01
Degradation of GLI1 by the proteasome 56 1.29e-03 5.45e-03 0.2810 NA -0.254000 -0.120000 9.91e-04 1.21e-01
SLC-mediated transmembrane transport 176 1.35e-03 5.67e-03 0.1590 NA -0.134000 0.086500 2.21e-03 4.80e-02
The role of GTSE1 in G2/M progression after G2 checkpoint 57 1.36e-03 5.71e-03 0.2780 NA -0.201000 -0.191000 8.60e-03 1.26e-02
Mitochondrial biogenesis 71 1.41e-03 5.89e-03 0.2480 NA -0.134000 -0.209000 5.14e-02 2.33e-03
Degradation of GLI2 by the proteasome 55 1.43e-03 5.95e-03 0.2820 NA -0.248000 -0.134000 1.49e-03 8.65e-02
GLI3 is processed to GLI3R by the proteasome 55 1.43e-03 5.95e-03 0.2820 NA -0.248000 -0.134000 1.49e-03 8.65e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 61 1.45e-03 5.99e-03 0.2670 NA -0.215000 -0.158000 3.70e-03 3.24e-02
Metabolism of non-coding RNA 52 1.59e-03 6.53e-03 0.2880 NA 0.026900 -0.287000 7.37e-01 3.49e-04
snRNP Assembly 52 1.59e-03 6.53e-03 0.2880 NA 0.026900 -0.287000 7.37e-01 3.49e-04
Signaling by Nuclear Receptors 184 1.60e-03 6.53e-03 0.1530 NA -0.146000 -0.047700 6.62e-04 2.65e-01
SCF-beta-TrCP mediated degradation of Emi1 52 1.60e-03 6.53e-03 0.2870 NA -0.225000 -0.179000 5.08e-03 2.60e-02
Mitochondrial tRNA aminoacylation 21 1.66e-03 6.75e-03 0.4520 NA 0.184000 -0.413000 1.45e-01 1.06e-03
Uptake and actions of bacterial toxins 24 1.68e-03 6.82e-03 0.4220 NA -0.359000 0.223000 2.34e-03 5.87e-02
Respiratory electron transport 101 1.81e-03 7.31e-03 0.2040 NA -0.058800 -0.196000 3.08e-01 6.77e-04
Negative regulation of the PI3K/AKT network 74 1.82e-03 7.32e-03 0.2390 NA -0.234000 0.050300 5.07e-04 4.54e-01
RET signaling 33 1.85e-03 7.43e-03 0.3580 NA -0.328000 0.143000 1.12e-03 1.56e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 21 1.86e-03 7.46e-03 0.4460 NA -0.101000 -0.435000 4.23e-01 5.62e-04
Activated NOTCH1 Transmits Signal to the Nucleus 28 1.92e-03 7.68e-03 0.3870 NA -0.279000 0.268000 1.06e-02 1.40e-02
Defective B4GALT7 causes EDS, progeroid type 19 2.11e-03 8.39e-03 0.4640 NA 0.247000 0.393000 6.20e-02 3.05e-03
Signaling by MET 62 2.13e-03 8.46e-03 0.2580 NA -0.244000 0.082900 8.79e-04 2.59e-01
DAP12 signaling 19 2.17e-03 8.58e-03 0.4650 NA -0.356000 0.300000 7.25e-03 2.37e-02
Defects in vitamin and cofactor metabolism 20 2.20e-03 8.65e-03 0.4520 NA 0.011000 -0.452000 9.32e-01 4.68e-04
DNA Repair 286 2.23e-03 8.76e-03 0.1210 NA 0.102000 -0.063900 2.97e-03 6.34e-02
mTOR signalling 39 2.29e-03 8.98e-03 0.3220 NA -0.233000 -0.222000 1.18e-02 1.65e-02
Rev-mediated nuclear export of HIV RNA 34 2.32e-03 9.06e-03 0.3450 NA -0.047400 -0.342000 6.33e-01 5.65e-04
Rab regulation of trafficking 115 2.38e-03 9.26e-03 0.1880 NA -0.163000 0.094900 2.62e-03 7.90e-02
Regulation of actin dynamics for phagocytic cup formation 50 2.39e-03 9.26e-03 0.2850 NA -0.275000 0.073600 7.76e-04 3.68e-01
Signaling by EGFR 42 2.41e-03 9.33e-03 0.3100 NA -0.301000 0.073200 7.31e-04 4.12e-01
Chondroitin sulfate/dermatan sulfate metabolism 47 2.43e-03 9.39e-03 0.2930 NA -0.016000 0.292000 8.49e-01 5.30e-04
Interleukin-12 signaling 37 2.45e-03 9.41e-03 0.3290 NA -0.288000 -0.159000 2.45e-03 9.46e-02
M Phase 322 2.54e-03 9.75e-03 0.1130 NA 0.058600 -0.096100 7.12e-02 3.10e-03
Deadenylation of mRNA 25 2.55e-03 9.76e-03 0.3980 NA -0.192000 -0.349000 9.67e-02 2.52e-03
SUMOylation of ubiquitinylation proteins 38 2.63e-03 1.00e-02 0.3230 NA -0.092900 -0.309000 3.22e-01 9.82e-04
Vif-mediated degradation of APOBEC3G 49 2.73e-03 1.04e-02 0.2830 NA -0.221000 -0.176000 7.35e-03 3.28e-02
FCERI mediated Ca+2 mobilization 21 2.74e-03 1.04e-02 0.4340 NA -0.293000 0.320000 2.01e-02 1.11e-02
PERK regulates gene expression 29 2.79e-03 1.05e-02 0.3670 NA -0.283000 -0.234000 8.41e-03 2.92e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 2.79e-03 1.05e-02 0.4940 NA -0.457000 -0.187000 1.54e-03 1.95e-01
Amino acid transport across the plasma membrane 28 2.82e-03 1.05e-02 0.3740 NA -0.370000 -0.055400 7.09e-04 6.12e-01
Common Pathway of Fibrin Clot Formation 16 2.83e-03 1.05e-02 0.4960 NA 0.345000 -0.356000 1.68e-02 1.37e-02
Negative regulation of NOTCH4 signaling 53 2.83e-03 1.05e-02 0.2710 NA -0.213000 -0.169000 7.47e-03 3.36e-02
Regulation of signaling by CBL 13 2.83e-03 1.05e-02 0.5500 NA -0.496000 0.238000 1.96e-03 1.38e-01
Generation of second messenger molecules 15 2.93e-03 1.09e-02 0.5110 NA -0.272000 0.432000 6.87e-02 3.74e-03
Inactivation of APC/C via direct inhibition of the APC/C complex 20 2.97e-03 1.09e-02 0.4420 NA 0.323000 -0.302000 1.25e-02 1.94e-02
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 20 2.97e-03 1.09e-02 0.4420 NA 0.323000 -0.302000 1.25e-02 1.94e-02
Estrogen-dependent gene expression 98 2.97e-03 1.09e-02 0.1990 NA -0.154000 -0.126000 8.36e-03 3.16e-02
Diseases associated with glycosaminoglycan metabolism 34 2.97e-03 1.09e-02 0.3370 NA 0.125000 0.313000 2.06e-01 1.57e-03
Regulation of RAS by GAPs 63 2.98e-03 1.09e-02 0.2480 NA -0.225000 -0.104000 2.02e-03 1.52e-01
Glutathione conjugation 28 3.07e-03 1.12e-02 0.3720 NA 0.343000 -0.145000 1.69e-03 1.85e-01
Telomere C-strand (Lagging Strand) Synthesis 24 3.08e-03 1.12e-02 0.4000 NA 0.359000 0.176000 2.32e-03 1.35e-01
Stabilization of p53 54 3.12e-03 1.13e-02 0.2670 NA -0.197000 -0.180000 1.23e-02 2.24e-02
Folding of actin by CCT/TriC 10 3.16e-03 1.14e-02 0.6180 NA -0.564000 -0.254000 2.01e-03 1.65e-01
A tetrasaccharide linker sequence is required for GAG synthesis 24 3.20e-03 1.15e-02 0.3990 NA 0.150000 0.370000 2.02e-01 1.73e-03
TP53 Regulates Metabolic Genes 84 3.20e-03 1.15e-02 0.2140 NA -0.188000 -0.101000 2.90e-03 1.09e-01
HIV Life Cycle 141 3.24e-03 1.16e-02 0.1650 NA -0.074600 -0.147000 1.26e-01 2.58e-03
O-glycosylation of TSR domain-containing proteins 22 3.34e-03 1.19e-02 0.4150 NA 0.165000 0.381000 1.79e-01 1.99e-03
Late Phase of HIV Life Cycle 129 3.38e-03 1.20e-02 0.1720 NA -0.095800 -0.143000 6.06e-02 5.22e-03
AKT phosphorylates targets in the cytosol 14 3.48e-03 1.24e-02 0.5190 NA -0.509000 -0.102000 9.83e-04 5.07e-01
Post-translational protein phosphorylation 88 3.55e-03 1.26e-02 0.2070 NA -0.061100 -0.198000 3.22e-01 1.35e-03
Nuclear Pore Complex (NPC) Disassembly 35 3.60e-03 1.27e-02 0.3280 NA 0.056300 -0.323000 5.65e-01 9.40e-04
Gamma carboxylation, hypusine formation and arylsulfatase activation 34 3.62e-03 1.28e-02 0.3320 NA 0.009360 -0.332000 9.25e-01 8.02e-04
Diseases of metabolism 77 3.67e-03 1.29e-02 0.2210 NA 0.029800 -0.219000 6.51e-01 8.97e-04
RAF-independent MAPK1/3 activation 21 3.67e-03 1.29e-02 0.4230 NA -0.312000 0.286000 1.33e-02 2.32e-02
Defective B3GALTL causes Peters-plus syndrome (PpS) 21 3.69e-03 1.29e-02 0.4210 NA 0.177000 0.382000 1.61e-01 2.43e-03
Regulation of RUNX2 expression and activity 66 3.70e-03 1.29e-02 0.2380 NA -0.232000 -0.051100 1.10e-03 4.73e-01
Regulation of Apoptosis 50 3.73e-03 1.30e-02 0.2730 NA -0.223000 -0.158000 6.48e-03 5.41e-02
DAP12 interactions 22 3.76e-03 1.30e-02 0.4130 NA -0.253000 0.326000 4.01e-02 8.11e-03
Cell Cycle Checkpoints 254 3.80e-03 1.31e-02 0.1220 NA 0.116000 -0.037100 1.45e-03 3.09e-01
Hedgehog ‘on’ state 75 4.03e-03 1.39e-02 0.2220 NA -0.217000 -0.042900 1.13e-03 5.21e-01
Beta-catenin independent WNT signaling 123 4.06e-03 1.39e-02 0.1740 NA -0.171000 0.030300 1.07e-03 5.62e-01
MAPK6/MAPK4 signaling 84 4.08e-03 1.39e-02 0.2090 NA -0.206000 -0.036800 1.11e-03 5.60e-01
Signaling by FGFR3 31 4.08e-03 1.39e-02 0.3450 NA -0.326000 0.111000 1.66e-03 2.84e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 67 4.09e-03 1.39e-02 0.2350 NA -0.218000 0.087300 2.04e-03 2.17e-01
Nuclear Envelope Breakdown 52 4.09e-03 1.39e-02 0.2660 NA 0.024600 -0.265000 7.59e-01 9.54e-04
Nuclear Events (kinase and transcription factor activation) 24 4.11e-03 1.39e-02 0.3920 NA -0.354000 0.167000 2.66e-03 1.56e-01
Diseases of glycosylation 108 4.11e-03 1.39e-02 0.1850 NA 0.017600 0.184000 7.52e-01 9.74e-04
Constitutive Signaling by NOTCH1 HD Domain Mutants 15 4.17e-03 1.40e-02 0.4950 NA -0.297000 0.396000 4.62e-02 7.96e-03
Signaling by NOTCH1 HD Domain Mutants in Cancer 15 4.17e-03 1.40e-02 0.4950 NA -0.297000 0.396000 4.62e-02 7.96e-03
SUMOylation of chromatin organization proteins 56 4.53e-03 1.52e-02 0.2540 NA -0.009080 -0.254000 9.07e-01 1.03e-03
Regulation of HSF1-mediated heat shock response 76 4.58e-03 1.53e-02 0.2170 NA -0.164000 -0.143000 1.37e-02 3.12e-02
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 14 4.62e-03 1.53e-02 0.5050 NA 0.283000 0.418000 6.67e-02 6.75e-03
Defective EXT2 causes exostoses 2 14 4.62e-03 1.53e-02 0.5050 NA 0.283000 0.418000 6.67e-02 6.75e-03
Signaling by FGFR1 36 4.62e-03 1.53e-02 0.3170 NA -0.290000 0.128000 2.63e-03 1.86e-01
Ca-dependent events 26 4.63e-03 1.53e-02 0.3720 NA -0.027800 0.371000 8.06e-01 1.07e-03
Regulation of ornithine decarboxylase (ODC) 48 4.67e-03 1.54e-02 0.2730 NA -0.230000 -0.147000 5.88e-03 7.86e-02
Mitotic Spindle Checkpoint 105 4.74e-03 1.56e-02 0.1850 NA 0.171000 -0.072200 2.53e-03 2.02e-01
Signaling by Hedgehog 122 4.83e-03 1.59e-02 0.1720 NA -0.165000 0.048200 1.70e-03 3.58e-01
Long-term potentiation 18 4.92e-03 1.61e-02 0.4430 NA 0.224000 0.382000 1.00e-01 5.00e-03
FCERI mediated MAPK activation 24 4.96e-03 1.62e-02 0.3850 NA -0.345000 0.171000 3.45e-03 1.47e-01
Miscellaneous transport and binding events 22 5.01e-03 1.63e-02 0.4020 NA -0.307000 0.260000 1.27e-02 3.51e-02
AURKA Activation by TPX2 71 5.06e-03 1.64e-02 0.2230 NA 0.211000 0.070700 2.08e-03 3.03e-01
Regulation of PTEN gene transcription 59 5.07e-03 1.64e-02 0.2440 NA -0.222000 -0.103000 3.23e-03 1.73e-01
CaM pathway 25 5.11e-03 1.65e-02 0.3750 NA -0.000443 0.375000 9.97e-01 1.16e-03
Calmodulin induced events 25 5.11e-03 1.65e-02 0.3750 NA -0.000443 0.375000 9.97e-01 1.16e-03
Assembly of collagen fibrils and other multimeric structures 36 5.17e-03 1.66e-02 0.3120 NA 0.221000 0.220000 2.19e-02 2.24e-02
NEP/NS2 Interacts with the Cellular Export Machinery 31 5.25e-03 1.68e-02 0.3360 NA -0.058300 -0.331000 5.74e-01 1.43e-03
ERK/MAPK targets 21 5.26e-03 1.68e-02 0.4090 NA -0.332000 0.239000 8.40e-03 5.78e-02
Netrin-1 signaling 38 5.26e-03 1.68e-02 0.3040 NA -0.124000 0.278000 1.86e-01 3.03e-03
Regulation of APC/C activators between G1/S and early anaphase 76 5.27e-03 1.68e-02 0.2150 NA -0.041700 -0.211000 5.30e-01 1.50e-03
Signaling by FGFR4 31 5.32e-03 1.69e-02 0.3360 NA -0.330000 0.063700 1.47e-03 5.40e-01
Extension of Telomeres 30 5.35e-03 1.69e-02 0.3410 NA 0.321000 0.115000 2.37e-03 2.75e-01
Glycosaminoglycan metabolism 96 5.38e-03 1.70e-02 0.1910 NA -0.023900 0.190000 6.86e-01 1.33e-03
Interleukin-12 family signaling 45 5.39e-03 1.70e-02 0.2780 NA -0.239000 -0.143000 5.64e-03 9.81e-02
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 24 5.43e-03 1.71e-02 0.3820 NA -0.243000 0.295000 3.94e-02 1.25e-02
MET activates RAS signaling 10 5.47e-03 1.72e-02 0.5910 NA -0.532000 0.257000 3.61e-03 1.59e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 96 5.57e-03 1.74e-02 0.1900 NA -0.022400 -0.189000 7.05e-01 1.39e-03
Phosphorylation of the APC/C 19 5.65e-03 1.76e-02 0.4280 NA 0.276000 -0.327000 3.75e-02 1.37e-02
Complex I biogenesis 55 5.69e-03 1.77e-02 0.2510 NA -0.029900 -0.249000 7.01e-01 1.42e-03
Retrograde transport at the Trans-Golgi-Network 48 5.77e-03 1.79e-02 0.2680 NA -0.267000 -0.014400 1.35e-03 8.63e-01
Transport of Ribonucleoproteins into the Host Nucleus 31 5.80e-03 1.80e-02 0.3330 NA -0.080900 -0.323000 4.36e-01 1.88e-03
Class A/1 (Rhodopsin-like receptors) 83 5.83e-03 1.80e-02 0.2040 NA -0.003900 0.204000 9.51e-01 1.34e-03
Defective B3GALT6 causes EDSP2 and SEMDJL1 19 5.94e-03 1.83e-02 0.4230 NA 0.188000 0.380000 1.57e-01 4.19e-03
RMTs methylate histone arginines 36 6.00e-03 1.85e-02 0.3080 NA -0.000170 -0.308000 9.99e-01 1.38e-03
Autodegradation of Cdh1 by Cdh1:APC/C 62 6.03e-03 1.85e-02 0.2340 NA -0.108000 -0.208000 1.42e-01 4.62e-03
Vpu mediated degradation of CD4 49 6.07e-03 1.86e-02 0.2630 NA -0.212000 -0.157000 1.04e-02 5.80e-02
WNT ligand biogenesis and trafficking 15 6.22e-03 1.90e-02 0.4760 NA -0.175000 0.443000 2.41e-01 2.97e-03
Transport of the SLBP independent Mature mRNA 34 6.66e-03 2.03e-02 0.3140 NA -0.049400 -0.310000 6.18e-01 1.79e-03
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 6.69e-03 2.03e-02 0.4870 NA 0.441000 0.208000 4.28e-03 1.78e-01
SUMOylation of DNA replication proteins 45 6.95e-03 2.11e-02 0.2720 NA 0.070300 -0.263000 4.15e-01 2.29e-03
Nicotinate metabolism 19 7.01e-03 2.12e-02 0.4180 NA 0.189000 -0.373000 1.53e-01 4.89e-03
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 26 7.03e-03 2.12e-02 0.3560 NA -0.085000 -0.346000 4.53e-01 2.26e-03
RNA Polymerase III Abortive And Retractive Initiation 41 7.07e-03 2.12e-02 0.2830 NA -0.202000 -0.199000 2.54e-02 2.76e-02
RNA Polymerase III Transcription 41 7.07e-03 2.12e-02 0.2830 NA -0.202000 -0.199000 2.54e-02 2.76e-02
RHO GTPases Activate ROCKs 19 7.13e-03 2.13e-02 0.4180 NA -0.228000 0.350000 8.58e-02 8.22e-03
PKA activation 14 7.14e-03 2.13e-02 0.4850 NA 0.016500 0.485000 9.15e-01 1.68e-03
Signaling by EGFR in Cancer 21 7.15e-03 2.13e-02 0.3970 NA -0.380000 0.113000 2.55e-03 3.70e-01
Cell-extracellular matrix interactions 13 7.47e-03 2.22e-02 0.5020 NA -0.442000 0.239000 5.79e-03 1.36e-01
Phase I - Functionalization of compounds 72 7.49e-03 2.23e-02 0.2140 NA 0.172000 -0.127000 1.18e-02 6.16e-02
Nucleobase biosynthesis 15 7.74e-03 2.29e-02 0.4660 NA 0.249000 -0.394000 9.54e-02 8.20e-03
Organelle biogenesis and maintenance 248 7.91e-03 2.34e-02 0.1150 NA 0.080100 0.082000 3.02e-02 2.65e-02
Loss of Nlp from mitotic centrosomes 68 8.14e-03 2.39e-02 0.2170 NA 0.198000 0.088300 4.68e-03 2.08e-01
Loss of proteins required for interphase microtubule organization from the centrosome 68 8.14e-03 2.39e-02 0.2170 NA 0.198000 0.088300 4.68e-03 2.08e-01
RORA activates gene expression 18 8.19e-03 2.40e-02 0.4210 NA -0.252000 -0.337000 6.42e-02 1.33e-02
Formation of TC-NER Pre-Incision Complex 53 8.25e-03 2.41e-02 0.2450 NA -0.182000 -0.165000 2.20e-02 3.82e-02
Ion transport by P-type ATPases 37 8.38e-03 2.45e-02 0.2940 NA -0.079600 0.283000 4.02e-01 2.87e-03
Insulin receptor signalling cascade 34 8.41e-03 2.45e-02 0.3060 NA -0.301000 -0.057400 2.42e-03 5.63e-01
Negative regulation of MET activity 18 8.49e-03 2.47e-02 0.4210 NA -0.370000 0.202000 6.63e-03 1.37e-01
mRNA Splicing - Minor Pathway 51 8.53e-03 2.48e-02 0.2490 NA -0.129000 -0.213000 1.10e-01 8.48e-03
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 116 8.72e-03 2.51e-02 0.1650 NA -0.061800 -0.153000 2.51e-01 4.35e-03
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 8.72e-03 2.51e-02 0.4200 NA -0.410000 0.089200 2.59e-03 5.13e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 8.72e-03 2.51e-02 0.4200 NA -0.410000 0.089200 2.59e-03 5.13e-01
Signaling by Rho GTPases 346 8.74e-03 2.51e-02 0.0968 NA -0.033700 0.090700 2.82e-01 3.84e-03
Uptake and function of anthrax toxins 11 8.91e-03 2.56e-02 0.5350 NA -0.532000 0.055800 2.23e-03 7.49e-01
APC/C:Cdc20 mediated degradation of Securin 64 8.99e-03 2.56e-02 0.2210 NA -0.094400 -0.200000 1.92e-01 5.58e-03
TRAF6 mediated NF-kB activation 20 9.01e-03 2.56e-02 0.3960 NA -0.371000 -0.137000 4.05e-03 2.89e-01
Apoptosis 157 9.01e-03 2.56e-02 0.1420 NA -0.123000 -0.070200 7.82e-03 1.29e-01
Intra-Golgi traffic 40 9.01e-03 2.56e-02 0.2810 NA -0.268000 0.083200 3.33e-03 3.63e-01
Host Interactions with Influenza Factors 42 9.03e-03 2.56e-02 0.2730 NA -0.166000 -0.217000 6.27e-02 1.51e-02
RHO GTPases activate PAKs 21 9.05e-03 2.56e-02 0.3880 NA -0.248000 0.298000 4.91e-02 1.81e-02
SUMOylation of SUMOylation proteins 34 9.07e-03 2.56e-02 0.3040 NA -0.040800 -0.301000 6.80e-01 2.39e-03
Transcriptional activation of mitochondrial biogenesis 50 9.09e-03 2.56e-02 0.2500 NA -0.113000 -0.223000 1.69e-01 6.29e-03
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 9.13e-03 2.57e-02 0.3680 NA -0.295000 -0.220000 1.42e-02 6.80e-02
Nephrin family interactions 21 9.20e-03 2.57e-02 0.3870 NA -0.277000 0.270000 2.78e-02 3.22e-02
Vpr-mediated nuclear import of PICs 33 9.22e-03 2.57e-02 0.3080 NA -0.035300 -0.306000 7.26e-01 2.37e-03
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 68 9.22e-03 2.57e-02 0.2150 NA -0.045600 -0.210000 5.16e-01 2.81e-03
ATF6 (ATF6-alpha) activates chaperones 12 9.34e-03 2.60e-02 0.5090 NA -0.433000 -0.266000 9.38e-03 1.10e-01
Mitotic Prophase 95 9.34e-03 2.60e-02 0.1810 NA -0.043500 -0.176000 4.64e-01 3.03e-03
PCP/CE pathway 83 9.63e-03 2.67e-02 0.1940 NA -0.193000 0.010700 2.34e-03 8.66e-01
Metabolism of folate and pterines 15 9.78e-03 2.71e-02 0.4530 NA -0.130000 -0.434000 3.82e-01 3.62e-03
Cyclin E associated events during G1/S transition 80 1.00e-02 2.76e-02 0.1960 NA -0.150000 -0.126000 2.06e-02 5.13e-02
CD28 co-stimulation 27 1.01e-02 2.77e-02 0.3380 NA -0.331000 0.067400 2.93e-03 5.45e-01
Resolution of Sister Chromatid Cohesion 101 1.02e-02 2.79e-02 0.1750 NA 0.159000 -0.073600 5.89e-03 2.01e-01
PPARA activates gene expression 114 1.02e-02 2.79e-02 0.1640 NA -0.059400 -0.153000 2.73e-01 4.83e-03
RUNX1 regulates transcription of genes involved in differentiation of HSCs 77 1.04e-02 2.85e-02 0.1990 NA -0.175000 -0.093600 7.81e-03 1.56e-01
Resolution of Abasic Sites (AP sites) 38 1.04e-02 2.85e-02 0.2830 NA 0.280000 -0.040900 2.78e-03 6.63e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 54 1.04e-02 2.85e-02 0.2380 NA 0.089400 -0.221000 2.56e-01 5.03e-03
Signaling by FGFR 68 1.07e-02 2.91e-02 0.2120 NA -0.210000 0.022200 2.72e-03 7.52e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 108 1.09e-02 2.95e-02 0.1670 NA -0.044300 -0.161000 4.27e-01 3.78e-03
Mitophagy 25 1.10e-02 2.99e-02 0.3460 NA -0.300000 -0.173000 9.43e-03 1.35e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 30 1.12e-02 3.02e-02 0.3160 NA 0.009760 -0.316000 9.26e-01 2.74e-03
Regulation of Glucokinase by Glucokinase Regulatory Protein 30 1.12e-02 3.02e-02 0.3160 NA 0.009760 -0.316000 9.26e-01 2.74e-03
Transcriptional regulation by RUNX2 102 1.13e-02 3.03e-02 0.1720 NA -0.172000 0.002570 2.74e-03 9.64e-01
Antimicrobial peptides 16 1.14e-02 3.06e-02 0.4310 NA 0.337000 0.268000 1.95e-02 6.35e-02
Transport of the SLBP Dependant Mature mRNA 35 1.14e-02 3.06e-02 0.2920 NA -0.072600 -0.283000 4.58e-01 3.82e-03
p75 NTR receptor-mediated signalling 83 1.15e-02 3.07e-02 0.1900 NA -0.188000 0.025100 3.03e-03 6.93e-01
Mitotic Metaphase and Anaphase 174 1.15e-02 3.08e-02 0.1320 NA 0.042100 -0.125000 3.39e-01 4.58e-03
Cytosolic sensors of pathogen-associated DNA 57 1.16e-02 3.08e-02 0.2280 NA -0.198000 -0.114000 9.87e-03 1.36e-01
Transcriptional regulation of white adipocyte differentiation 76 1.18e-02 3.12e-02 0.1970 NA -0.148000 -0.130000 2.55e-02 4.99e-02
Mitotic Anaphase 173 1.18e-02 3.12e-02 0.1320 NA 0.045100 -0.124000 3.07e-01 5.03e-03
Interferon gamma signaling 65 1.19e-02 3.16e-02 0.2130 NA 0.124000 0.173000 8.46e-02 1.57e-02
Export of Viral Ribonucleoproteins from Nucleus 32 1.21e-02 3.20e-02 0.3030 NA -0.030500 -0.302000 7.66e-01 3.13e-03
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 72 1.21e-02 3.20e-02 0.2020 NA -0.016500 -0.202000 8.09e-01 3.08e-03
Association of TriC/CCT with target proteins during biosynthesis 38 1.25e-02 3.29e-02 0.2770 NA -0.133000 -0.243000 1.56e-01 9.57e-03
NS1 Mediated Effects on Host Pathways 40 1.26e-02 3.30e-02 0.2700 NA -0.136000 -0.233000 1.36e-01 1.09e-02
tRNA processing in the nucleus 57 1.29e-02 3.37e-02 0.2260 NA -0.073100 -0.213000 3.40e-01 5.33e-03
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 28 1.29e-02 3.37e-02 0.3230 NA -0.114000 0.302000 2.97e-01 5.70e-03
Recruitment of NuMA to mitotic centrosomes 79 1.30e-02 3.39e-02 0.1920 NA 0.187000 0.040000 3.98e-03 5.39e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 1.32e-02 3.44e-02 0.4530 NA 0.437000 0.122000 4.67e-03 4.29e-01
Vitamin B5 (pantothenate) metabolism 16 1.32e-02 3.44e-02 0.4260 NA 0.212000 -0.369000 1.42e-01 1.06e-02
ATF6 (ATF6-alpha) activates chaperone genes 10 1.34e-02 3.47e-02 0.5350 NA -0.478000 -0.240000 8.80e-03 1.89e-01
Cell surface interactions at the vascular wall 84 1.34e-02 3.47e-02 0.1860 NA -0.115000 0.146000 6.89e-02 2.06e-02
NF-kB is activated and signals survival 12 1.34e-02 3.47e-02 0.4880 NA -0.431000 -0.230000 9.80e-03 1.67e-01
Assembly and cell surface presentation of NMDA receptors 22 1.35e-02 3.48e-02 0.3610 NA 0.186000 0.309000 1.31e-01 1.22e-02
Golgi-to-ER retrograde transport 108 1.35e-02 3.48e-02 0.1640 NA -0.138000 0.087700 1.30e-02 1.16e-01
Biotin transport and metabolism 11 1.36e-02 3.50e-02 0.5090 NA -0.243000 -0.447000 1.62e-01 1.02e-02
Death Receptor Signalling 123 1.38e-02 3.54e-02 0.1530 NA -0.147000 -0.042500 5.00e-03 4.16e-01
Negative regulation of FGFR4 signaling 21 1.39e-02 3.54e-02 0.3690 NA -0.367000 0.036900 3.59e-03 7.70e-01
RIP-mediated NFkB activation via ZBP1 15 1.40e-02 3.58e-02 0.4350 NA -0.414000 -0.132000 5.47e-03 3.75e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 17 1.41e-02 3.59e-02 0.4080 NA -0.331000 -0.238000 1.81e-02 8.90e-02
Negative regulation of FGFR1 signaling 21 1.43e-02 3.61e-02 0.3680 NA -0.358000 0.087300 4.57e-03 4.89e-01
The role of Nef in HIV-1 replication and disease pathogenesis 23 1.43e-02 3.61e-02 0.3520 NA -0.159000 0.314000 1.88e-01 9.09e-03
Mismatch Repair 15 1.43e-02 3.62e-02 0.4340 NA 0.407000 0.150000 6.34e-03 3.14e-01
RUNX3 regulates p14-ARF 10 1.44e-02 3.63e-02 0.5330 NA -0.494000 0.199000 6.81e-03 2.75e-01
Post-chaperonin tubulin folding pathway 20 1.48e-02 3.72e-02 0.3740 NA 0.313000 0.205000 1.55e-02 1.12e-01
DNA Damage Recognition in GG-NER 38 1.49e-02 3.75e-02 0.2710 NA -0.090500 -0.256000 3.34e-01 6.34e-03
HDACs deacetylate histones 43 1.49e-02 3.75e-02 0.2550 NA -0.243000 -0.079100 5.91e-03 3.70e-01
HS-GAG degradation 20 1.50e-02 3.75e-02 0.3740 NA 0.230000 0.295000 7.54e-02 2.26e-02
Synthesis of PIPs at the plasma membrane 44 1.52e-02 3.79e-02 0.2520 NA -0.251000 -0.024300 3.98e-03 7.80e-01
Interactions of Vpr with host cellular proteins 36 1.52e-02 3.80e-02 0.2780 NA -0.075300 -0.268000 4.34e-01 5.42e-03
EGFR downregulation 25 1.54e-02 3.84e-02 0.3340 NA -0.330000 0.053500 4.32e-03 6.44e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 69 1.56e-02 3.87e-02 0.2010 NA -0.035700 -0.198000 6.08e-01 4.56e-03
Signaling by NOTCH1 68 1.56e-02 3.87e-02 0.2030 NA -0.190000 0.071500 6.86e-03 3.08e-01
Phospholipid metabolism 167 1.56e-02 3.87e-02 0.1300 NA -0.112000 0.065800 1.27e-02 1.43e-01
Metabolism of polyamines 77 1.57e-02 3.89e-02 0.1900 NA -0.157000 -0.106000 1.72e-02 1.08e-01
SUMOylation of intracellular receptors 27 1.64e-02 4.03e-02 0.3180 NA -0.262000 -0.181000 1.86e-02 1.04e-01
Programmed Cell Death 160 1.66e-02 4.07e-02 0.1310 NA -0.114000 -0.063800 1.26e-02 1.64e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 69 1.66e-02 4.08e-02 0.1990 NA -0.054300 -0.192000 4.36e-01 5.95e-03
Signaling by NOTCH4 79 1.67e-02 4.09e-02 0.1860 NA -0.157000 -0.099000 1.58e-02 1.28e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 49 1.68e-02 4.09e-02 0.2360 NA -0.183000 -0.148000 2.64e-02 7.35e-02
p53-Independent DNA Damage Response 49 1.68e-02 4.09e-02 0.2360 NA -0.183000 -0.148000 2.64e-02 7.35e-02
p53-Independent G1/S DNA damage checkpoint 49 1.68e-02 4.09e-02 0.2360 NA -0.183000 -0.148000 2.64e-02 7.35e-02
Sphingolipid metabolism 75 1.68e-02 4.09e-02 0.1910 NA -0.176000 0.075100 8.45e-03 2.61e-01
p53-Dependent G1 DNA Damage Response 62 1.70e-02 4.11e-02 0.2090 NA -0.175000 -0.115000 1.74e-02 1.17e-01
p53-Dependent G1/S DNA damage checkpoint 62 1.70e-02 4.11e-02 0.2090 NA -0.175000 -0.115000 1.74e-02 1.17e-01
CD28 dependent PI3K/Akt signaling 18 1.73e-02 4.19e-02 0.3880 NA -0.386000 -0.032600 4.56e-03 8.11e-01
TNFR2 non-canonical NF-kB pathway 76 1.74e-02 4.21e-02 0.1890 NA -0.173000 -0.074700 9.11e-03 2.61e-01
Recycling pathway of L1 22 1.77e-02 4.26e-02 0.3510 NA -0.249000 0.247000 4.34e-02 4.46e-02
Activation of NMDA receptors and postsynaptic events 61 1.80e-02 4.32e-02 0.2100 NA 0.034700 0.207000 6.39e-01 5.21e-03
SCF(Skp2)-mediated degradation of p27/p21 57 1.82e-02 4.36e-02 0.2160 NA -0.183000 -0.115000 1.68e-02 1.33e-01
Signalling to RAS 18 1.82e-02 4.37e-02 0.3860 NA -0.373000 0.098800 6.16e-03 4.68e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 31 1.84e-02 4.39e-02 0.2940 NA -0.276000 0.101000 7.78e-03 3.32e-01
Kinesins 38 1.84e-02 4.40e-02 0.2640 NA 0.165000 0.207000 7.92e-02 2.74e-02
APC/C:Cdc20 mediated degradation of mitotic proteins 71 1.86e-02 4.42e-02 0.1940 NA -0.025100 -0.192000 7.14e-01 5.14e-03
Costimulation by the CD28 family 45 1.87e-02 4.44e-02 0.2440 NA -0.219000 0.106000 1.09e-02 2.19e-01
Processive synthesis on the C-strand of the telomere 11 1.90e-02 4.50e-02 0.4890 NA 0.421000 0.249000 1.56e-02 1.53e-01
mTORC1-mediated signalling 23 1.90e-02 4.50e-02 0.3380 NA -0.296000 -0.164000 1.40e-02 1.74e-01
Constitutive Signaling by EGFRvIII 14 1.92e-02 4.54e-02 0.4350 NA -0.412000 0.139000 7.65e-03 3.66e-01
Signaling by EGFRvIII in Cancer 14 1.92e-02 4.54e-02 0.4350 NA -0.412000 0.139000 7.65e-03 3.66e-01
Cross-presentation of soluble exogenous antigens (endosomes) 44 1.93e-02 4.55e-02 0.2440 NA -0.203000 -0.136000 2.00e-02 1.18e-01
Unblocking of NMDA receptors, glutamate binding and activation 15 1.96e-02 4.61e-02 0.4170 NA 0.185000 0.374000 2.15e-01 1.21e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 2.00e-02 4.70e-02 0.4880 NA -0.406000 0.271000 1.97e-02 1.20e-01
Factors involved in megakaryocyte development and platelet production 106 2.04e-02 4.78e-02 0.1570 NA -0.030500 0.154000 5.88e-01 6.15e-03
Regulation of TP53 Activity through Methylation 18 2.06e-02 4.83e-02 0.3790 NA -0.152000 -0.347000 2.64e-01 1.09e-02
Methylation 11 2.09e-02 4.87e-02 0.4860 NA 0.269000 -0.404000 1.22e-01 2.03e-02
LDL clearance 19 2.16e-02 5.03e-02 0.3680 NA -0.318000 0.184000 1.63e-02 1.65e-01
Advanced glycosylation endproduct receptor signaling 10 2.16e-02 5.03e-02 0.5050 NA -0.448000 -0.231000 1.41e-02 2.05e-01
Cyclin A:Cdk2-associated events at S phase entry 82 2.19e-02 5.08e-02 0.1760 NA -0.136000 -0.112000 3.28e-02 8.11e-02
Integrin cell surface interactions 42 2.20e-02 5.10e-02 0.2460 NA 0.220000 0.110000 1.38e-02 2.16e-01
Constitutive Signaling by Aberrant PI3K in Cancer 42 2.21e-02 5.11e-02 0.2470 NA -0.211000 0.128000 1.79e-02 1.51e-01
Tie2 Signaling 13 2.23e-02 5.15e-02 0.4420 NA -0.426000 0.120000 7.87e-03 4.54e-01
Phase 2 - plateau phase 11 2.26e-02 5.22e-02 0.4790 NA 0.044300 0.477000 7.99e-01 6.16e-03
Elastic fibre formation 29 2.27e-02 5.22e-02 0.2940 NA 0.147000 0.255000 1.71e-01 1.74e-02
Negative regulation of FGFR3 signaling 20 2.28e-02 5.22e-02 0.3560 NA -0.346000 0.081600 7.36e-03 5.27e-01
Polo-like kinase mediated events 16 2.28e-02 5.22e-02 0.3980 NA 0.248000 -0.311000 8.57e-02 3.11e-02
Adrenaline,noradrenaline inhibits insulin secretion 19 2.31e-02 5.27e-02 0.3650 NA -0.141000 0.336000 2.87e-01 1.12e-02
Separation of Sister Chromatids 162 2.31e-02 5.28e-02 0.1250 NA 0.051100 -0.114000 2.62e-01 1.20e-02
APC-Cdc20 mediated degradation of Nek2A 25 2.32e-02 5.29e-02 0.3180 NA 0.219000 -0.231000 5.84e-02 4.59e-02
MHC class II antigen presentation 84 2.33e-02 5.29e-02 0.1740 NA -0.113000 0.132000 7.36e-02 3.68e-02
COPI-dependent Golgi-to-ER retrograde traffic 77 2.34e-02 5.32e-02 0.1810 NA -0.136000 0.120000 3.91e-02 6.97e-02
Defects in cobalamin (B12) metabolism 12 2.35e-02 5.32e-02 0.4580 NA 0.269000 -0.370000 1.06e-01 2.63e-02
Removal of the Flap Intermediate from the C-strand 10 2.35e-02 5.32e-02 0.4990 NA 0.384000 0.318000 3.54e-02 8.15e-02
Heparan sulfate/heparin (HS-GAG) metabolism 43 2.37e-02 5.36e-02 0.2410 NA 0.105000 0.216000 2.32e-01 1.41e-02
Peroxisomal lipid metabolism 25 2.39e-02 5.37e-02 0.3170 NA 0.254000 -0.189000 2.79e-02 1.02e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 18 2.39e-02 5.37e-02 0.3710 NA 0.170000 0.330000 2.11e-01 1.54e-02
Cell junction organization 55 2.40e-02 5.39e-02 0.2130 NA -0.084600 0.196000 2.78e-01 1.20e-02
Other semaphorin interactions 12 2.41e-02 5.41e-02 0.4560 NA -0.116000 0.441000 4.87e-01 8.22e-03
Centrosome maturation 80 2.42e-02 5.42e-02 0.1760 NA 0.170000 0.046600 8.62e-03 4.72e-01
Recruitment of mitotic centrosome proteins and complexes 80 2.42e-02 5.42e-02 0.1760 NA 0.170000 0.046600 8.62e-03 4.72e-01
Glyoxylate metabolism and glycine degradation 27 2.45e-02 5.47e-02 0.3030 NA 0.293000 -0.077700 8.39e-03 4.85e-01
Positive epigenetic regulation of rRNA expression 61 2.46e-02 5.47e-02 0.2010 NA -0.122000 -0.160000 9.95e-02 3.09e-02
EPHB-mediated forward signaling 34 2.46e-02 5.47e-02 0.2700 NA -0.226000 0.148000 2.25e-02 1.35e-01
PKA-mediated phosphorylation of CREB 15 2.47e-02 5.47e-02 0.4060 NA 0.022500 0.405000 8.80e-01 6.60e-03
Metabolism of steroids 122 2.48e-02 5.49e-02 0.1430 NA 0.072800 -0.123000 1.66e-01 1.90e-02
Acyl chain remodelling of PE 16 2.48e-02 5.49e-02 0.3920 NA 0.290000 0.263000 4.47e-02 6.84e-02
Regulation of PTEN mRNA translation 12 2.50e-02 5.52e-02 0.4520 NA -0.131000 -0.433000 4.32e-01 9.43e-03
ZBP1(DAI) mediated induction of type I IFNs 18 2.55e-02 5.63e-02 0.3690 NA -0.368000 -0.012600 6.81e-03 9.26e-01
CDT1 association with the CDC6:ORC:origin complex 56 2.63e-02 5.79e-02 0.2080 NA -0.187000 -0.090700 1.54e-02 2.40e-01
PKMTs methylate histone lysines 37 2.64e-02 5.79e-02 0.2550 NA -0.182000 -0.179000 5.55e-02 5.92e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity 24 2.64e-02 5.79e-02 0.3180 NA 0.038700 0.315000 7.43e-01 7.50e-03
Trafficking of AMPA receptors 24 2.64e-02 5.79e-02 0.3180 NA 0.038700 0.315000 7.43e-01 7.50e-03
FOXO-mediated transcription 56 2.71e-02 5.93e-02 0.2080 NA -0.207000 0.009770 7.28e-03 8.99e-01
SHC-mediated cascade:FGFR1 10 2.74e-02 5.97e-02 0.4910 NA -0.371000 0.322000 4.20e-02 7.83e-02
CDK-mediated phosphorylation and removal of Cdc6 68 2.74e-02 5.97e-02 0.1880 NA -0.105000 -0.156000 1.36e-01 2.64e-02
Caspase activation via Death Receptors in the presence of ligand 13 2.77e-02 6.02e-02 0.4290 NA -0.003120 -0.429000 9.84e-01 7.41e-03
CRMPs in Sema3A signaling 16 2.78e-02 6.03e-02 0.3860 NA 0.027600 0.385000 8.48e-01 7.60e-03
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 43 2.85e-02 6.18e-02 0.2350 NA -0.194000 -0.132000 2.81e-02 1.33e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 31 2.89e-02 6.24e-02 0.2770 NA -0.240000 0.139000 2.10e-02 1.81e-01
ERKs are inactivated 13 2.95e-02 6.36e-02 0.4260 NA -0.406000 0.129000 1.13e-02 4.19e-01
Intrinsic Pathway of Fibrin Clot Formation 18 2.95e-02 6.36e-02 0.3620 NA 0.243000 -0.268000 7.39e-02 4.86e-02
Antigen processing-Cross presentation 89 2.97e-02 6.39e-02 0.1620 NA -0.155000 -0.047800 1.14e-02 4.36e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 19 3.04e-02 6.53e-02 0.3510 NA -0.142000 0.321000 2.84e-01 1.54e-02
Chondroitin sulfate biosynthesis 19 3.05e-02 6.53e-02 0.3510 NA -0.090600 0.339000 4.94e-01 1.06e-02
Mitotic Telophase/Cytokinesis 13 3.08e-02 6.60e-02 0.4230 NA -0.000964 -0.423000 9.95e-01 8.35e-03
p75NTR signals via NF-kB 15 3.11e-02 6.64e-02 0.3920 NA -0.357000 -0.163000 1.67e-02 2.76e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 67 3.14e-02 6.69e-02 0.1860 NA -0.181000 -0.040500 1.03e-02 5.67e-01
Neurexins and neuroligins 39 3.23e-02 6.87e-02 0.2420 NA 0.073200 0.231000 4.29e-01 1.26e-02
Constitutive Signaling by AKT1 E17K in Cancer 26 3.26e-02 6.92e-02 0.2960 NA -0.291000 -0.055700 1.02e-02 6.23e-01
Processing of SMDT1 15 3.26e-02 6.93e-02 0.3900 NA -0.091400 -0.379000 5.40e-01 1.11e-02
APC/C-mediated degradation of cell cycle proteins 82 3.30e-02 6.95e-02 0.1670 NA 0.000978 -0.167000 9.88e-01 8.99e-03
Regulation of mitotic cell cycle 82 3.30e-02 6.95e-02 0.1670 NA 0.000978 -0.167000 9.88e-01 8.99e-03
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 89 3.30e-02 6.95e-02 0.1600 NA 0.158000 -0.027500 9.99e-03 6.54e-01
Amplification of signal from the kinetochores 89 3.30e-02 6.95e-02 0.1600 NA 0.158000 -0.027500 9.99e-03 6.54e-01
IRS-mediated signalling 29 3.33e-02 7.01e-02 0.2800 NA -0.272000 -0.063300 1.12e-02 5.55e-01
IGF1R signaling cascade 32 3.34e-02 7.01e-02 0.2660 NA -0.258000 -0.064300 1.15e-02 5.29e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 32 3.34e-02 7.01e-02 0.2660 NA -0.258000 -0.064300 1.15e-02 5.29e-01
Signaling by NOTCH3 44 3.35e-02 7.02e-02 0.2280 NA -0.126000 0.190000 1.49e-01 2.95e-02
Assembly Of The HIV Virion 16 3.40e-02 7.10e-02 0.3750 NA -0.283000 -0.245000 4.97e-02 8.98e-02
Nucleotide Excision Repair 110 3.40e-02 7.10e-02 0.1440 NA 0.016000 -0.143000 7.72e-01 9.72e-03
APC/C:Cdc20 mediated degradation of Cyclin B 23 3.43e-02 7.14e-02 0.3140 NA 0.162000 -0.268000 1.78e-01 2.58e-02
Ras activation upon Ca2+ influx through NMDA receptor 19 3.50e-02 7.28e-02 0.3430 NA 0.065000 0.337000 6.24e-01 1.11e-02
ABC transporters in lipid homeostasis 15 3.51e-02 7.29e-02 0.3850 NA 0.192000 0.334000 1.97e-01 2.53e-02
Global Genome Nucleotide Excision Repair (GG-NER) 84 3.56e-02 7.38e-02 0.1630 NA 0.075500 -0.145000 2.32e-01 2.17e-02
WNT5A-dependent internalization of FZD4 14 3.57e-02 7.39e-02 0.4000 NA -0.243000 0.318000 1.16e-01 3.97e-02
ATF4 activates genes in response to endoplasmic reticulum stress 24 3.61e-02 7.46e-02 0.3030 NA -0.183000 -0.241000 1.20e-01 4.07e-02
RNA Polymerase I Transcription Initiation 47 3.62e-02 7.46e-02 0.2170 NA -0.022500 -0.216000 7.90e-01 1.04e-02
SHC-mediated cascade:FGFR2 10 3.65e-02 7.52e-02 0.4710 NA -0.190000 0.431000 2.98e-01 1.83e-02
Synthesis of bile acids and bile salts via 24-hydroxycholesterol 12 3.66e-02 7.52e-02 0.4280 NA -0.224000 -0.365000 1.79e-01 2.88e-02
Transcriptional regulation of pluripotent stem cells 23 3.66e-02 7.52e-02 0.3100 NA -0.024800 0.309000 8.37e-01 1.03e-02
G1/S DNA Damage Checkpoints 64 3.72e-02 7.62e-02 0.1850 NA -0.146000 -0.113000 4.31e-02 1.17e-01
Signaling by FGFR2 58 3.72e-02 7.62e-02 0.1950 NA -0.194000 0.021500 1.07e-02 7.77e-01
Inositol phosphate metabolism 40 3.81e-02 7.78e-02 0.2340 NA -0.169000 0.163000 6.52e-02 7.50e-02
Erythropoietin activates RAS 13 3.82e-02 7.78e-02 0.4100 NA -0.340000 0.230000 3.40e-02 1.50e-01
Base Excision Repair 59 3.82e-02 7.78e-02 0.1920 NA 0.192000 -0.011400 1.07e-02 8.79e-01
Synthesis of IP3 and IP4 in the cytosol 21 3.83e-02 7.79e-02 0.3230 NA -0.226000 0.231000 7.33e-02 6.72e-02
Ovarian tumor domain proteases 35 3.90e-02 7.91e-02 0.2490 NA -0.245000 -0.043700 1.22e-02 6.54e-01
Epigenetic regulation of gene expression 102 3.90e-02 7.91e-02 0.1460 NA -0.089700 -0.115000 1.18e-01 4.54e-02
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 10 3.99e-02 8.07e-02 0.4630 NA -0.062000 -0.459000 7.34e-01 1.19e-02
CLEC7A (Dectin-1) induces NFAT activation 11 4.01e-02 8.09e-02 0.4430 NA -0.198000 0.396000 2.55e-01 2.30e-02
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 19 4.03e-02 8.12e-02 0.3370 NA 0.240000 -0.236000 7.01e-02 7.46e-02
Sema4D in semaphorin signaling 24 4.07e-02 8.21e-02 0.2990 NA -0.196000 0.226000 9.59e-02 5.57e-02
Scavenging by Class A Receptors 11 4.08e-02 8.21e-02 0.4400 NA -0.415000 -0.144000 1.71e-02 4.08e-01
CASP8 activity is inhibited 10 4.16e-02 8.31e-02 0.4600 NA -0.043600 -0.458000 8.11e-01 1.21e-02
Dimerization of procaspase-8 10 4.16e-02 8.31e-02 0.4600 NA -0.043600 -0.458000 8.11e-01 1.21e-02
Regulation by c-FLIP 10 4.16e-02 8.31e-02 0.4600 NA -0.043600 -0.458000 8.11e-01 1.21e-02
Nonhomologous End-Joining (NHEJ) 42 4.16e-02 8.31e-02 0.2250 NA 0.046300 -0.220000 6.04e-01 1.35e-02
Synthesis of substrates in N-glycan biosythesis 52 4.19e-02 8.35e-02 0.2020 NA -0.185000 0.081900 2.10e-02 3.07e-01
ER-Phagosome pathway 79 4.23e-02 8.42e-02 0.1630 NA -0.153000 -0.057800 1.88e-02 3.75e-01
Cyclin A/B1/B2 associated events during G2/M transition 24 4.25e-02 8.45e-02 0.2970 NA 0.274000 -0.114000 2.00e-02 3.34e-01
G2/M DNA damage checkpoint 67 4.27e-02 8.48e-02 0.1770 NA 0.175000 0.026400 1.31e-02 7.08e-01
Telomere Maintenance 50 4.28e-02 8.48e-02 0.2050 NA 0.188000 0.080700 2.13e-02 3.24e-01
Spry regulation of FGF signaling 16 4.28e-02 8.48e-02 0.3630 NA -0.362000 0.010300 1.21e-02 9.43e-01
PI3K Cascade 25 4.31e-02 8.52e-02 0.2890 NA -0.274000 -0.093100 1.78e-02 4.21e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 4.33e-02 8.55e-02 0.2730 NA -0.247000 -0.117000 2.38e-02 2.86e-01
Norepinephrine Neurotransmitter Release Cycle 13 4.35e-02 8.56e-02 0.4020 NA -0.131000 0.380000 4.12e-01 1.78e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 4.45e-02 8.75e-02 0.3600 NA -0.360000 0.007920 1.26e-02 9.56e-01
G-protein activation 16 4.51e-02 8.85e-02 0.3600 NA -0.149000 0.328000 3.03e-01 2.31e-02
Cristae formation 13 4.52e-02 8.86e-02 0.3980 NA -0.233000 -0.322000 1.45e-01 4.44e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 4.59e-02 8.99e-02 0.3840 NA -0.063100 0.378000 6.83e-01 1.43e-02
The activation of arylsulfatases 10 4.61e-02 9.02e-02 0.4530 NA -0.059000 -0.449000 7.47e-01 1.40e-02
Gene Silencing by RNA 83 4.70e-02 9.17e-02 0.1570 NA -0.071600 -0.139000 2.60e-01 2.82e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 4.72e-02 9.19e-02 0.3450 NA -0.218000 -0.268000 1.20e-01 5.56e-02
Synthesis of very long-chain fatty acyl-CoAs 18 4.78e-02 9.31e-02 0.3350 NA 0.218000 0.254000 1.10e-01 6.17e-02
RNA Polymerase III Transcription Termination 23 4.83e-02 9.38e-02 0.2960 NA -0.252000 -0.155000 3.66e-02 1.97e-01
RAF activation 30 4.84e-02 9.38e-02 0.2600 NA -0.258000 0.026300 1.43e-02 8.03e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 25 4.85e-02 9.39e-02 0.2840 NA -0.268000 -0.094100 2.05e-02 4.15e-01
MECP2 regulates neuronal receptors and channels 13 4.87e-02 9.42e-02 0.3950 NA -0.283000 0.275000 7.69e-02 8.60e-02
Platelet calcium homeostasis 19 4.97e-02 9.60e-02 0.3250 NA -0.132000 0.298000 3.21e-01 2.48e-02
Glutamate Neurotransmitter Release Cycle 17 5.02e-02 9.67e-02 0.3430 NA -0.099400 0.329000 4.78e-01 1.90e-02
SHC-mediated cascade:FGFR4 10 5.07e-02 9.76e-02 0.4470 NA -0.391000 0.216000 3.21e-02 2.37e-01
Fanconi Anemia Pathway 34 5.11e-02 9.83e-02 0.2410 NA 0.214000 0.112000 3.11e-02 2.59e-01
Pausing and recovery of Tat-mediated HIV elongation 27 5.15e-02 9.86e-02 0.2710 NA -0.265000 -0.055200 1.72e-02 6.20e-01
Tat-mediated HIV elongation arrest and recovery 27 5.15e-02 9.86e-02 0.2710 NA -0.265000 -0.055200 1.72e-02 6.20e-01
IRS-related events triggered by IGF1R 31 5.27e-02 1.01e-01 0.2510 NA -0.235000 -0.089000 2.35e-02 3.91e-01
Synthesis of bile acids and bile salts 28 5.33e-02 1.02e-01 0.2640 NA -0.164000 -0.207000 1.33e-01 5.86e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 5.35e-02 1.02e-01 0.2640 NA -0.208000 -0.162000 5.69e-02 1.38e-01
N-Glycan antennae elongation 11 5.41e-02 1.03e-01 0.4190 NA -0.303000 -0.290000 8.18e-02 9.59e-02
The citric acid (TCA) cycle and respiratory electron transport 152 5.42e-02 1.03e-01 0.1140 NA -0.018000 -0.112000 7.02e-01 1.72e-02
GPVI-mediated activation cascade 21 5.42e-02 1.03e-01 0.3050 NA -0.280000 0.122000 2.66e-02 3.33e-01
Negative regulation of FGFR2 signaling 21 5.44e-02 1.03e-01 0.3050 NA -0.271000 0.139000 3.15e-02 2.69e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25 5.47e-02 1.03e-01 0.2780 NA -0.273000 -0.053800 1.81e-02 6.42e-01
Processing of Intronless Pre-mRNAs 19 5.48e-02 1.04e-01 0.3190 NA -0.018600 -0.319000 8.89e-01 1.62e-02
Post NMDA receptor activation events 51 5.49e-02 1.04e-01 0.1950 NA 0.011700 0.195000 8.85e-01 1.62e-02
Synthesis of PIPs at the early endosome membrane 15 5.55e-02 1.05e-01 0.3590 NA -0.313000 0.177000 3.59e-02 2.36e-01
Cell-cell junction organization 35 5.59e-02 1.05e-01 0.2340 NA 0.111000 0.206000 2.58e-01 3.47e-02
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 5.65e-02 1.06e-01 0.4190 NA -0.294000 0.298000 9.09e-02 8.76e-02
DARPP-32 events 22 5.69e-02 1.07e-01 0.2960 NA -0.236000 0.178000 5.52e-02 1.49e-01
Formation of RNA Pol II elongation complex 54 5.70e-02 1.07e-01 0.1880 NA -0.177000 -0.064700 2.49e-02 4.11e-01
RNA Polymerase II Transcription Elongation 54 5.70e-02 1.07e-01 0.1880 NA -0.177000 -0.064700 2.49e-02 4.11e-01
Regulation of necroptotic cell death 13 5.81e-02 1.08e-01 0.3820 NA -0.032400 -0.381000 8.40e-01 1.75e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 5.83e-02 1.09e-01 0.3330 NA -0.240000 -0.231000 8.68e-02 9.91e-02
Attenuation phase 23 5.87e-02 1.09e-01 0.2860 NA -0.269000 -0.098200 2.56e-02 4.15e-01
Metabolism of nucleotides 87 5.89e-02 1.09e-01 0.1480 NA 0.111000 -0.097600 7.26e-02 1.16e-01
Downstream signaling of activated FGFR1 19 5.90e-02 1.09e-01 0.3160 NA -0.210000 0.236000 1.13e-01 7.48e-02
Aquaporin-mediated transport 31 5.90e-02 1.09e-01 0.2470 NA -0.028000 0.246000 7.88e-01 1.80e-02
Protein-protein interactions at synapses 55 5.92e-02 1.10e-01 0.1850 NA 0.088900 0.162000 2.54e-01 3.75e-02
Dectin-2 family 13 5.93e-02 1.10e-01 0.3810 NA -0.138000 0.355000 3.88e-01 2.65e-02
DNA Replication 122 5.97e-02 1.10e-01 0.1250 NA 0.125000 -0.000644 1.76e-02 9.90e-01
TP53 Regulates Transcription of Cell Death Genes 40 6.00e-02 1.11e-01 0.2160 NA -0.132000 -0.172000 1.50e-01 6.06e-02
Transcriptional regulation by small RNAs 61 6.03e-02 1.11e-01 0.1750 NA -0.064800 -0.163000 3.81e-01 2.80e-02
Role of LAT2/NTAL/LAB on calcium mobilization 11 6.08e-02 1.12e-01 0.4130 NA -0.386000 0.148000 2.68e-02 3.97e-01
Role of phospholipids in phagocytosis 15 6.11e-02 1.12e-01 0.3530 NA -0.139000 0.325000 3.52e-01 2.94e-02
Interferon alpha/beta signaling 52 6.14e-02 1.12e-01 0.1890 NA 0.127000 0.140000 1.13e-01 8.09e-02
Downstream signaling of activated FGFR4 17 6.16e-02 1.12e-01 0.3310 NA -0.300000 0.140000 3.20e-02 3.18e-01
AMER1 mutants destabilize the destruction complex 14 6.20e-02 1.12e-01 0.3640 NA -0.357000 -0.069600 2.08e-02 6.52e-01
APC truncation mutants have impaired AXIN binding 14 6.20e-02 1.12e-01 0.3640 NA -0.357000 -0.069600 2.08e-02 6.52e-01
AXIN missense mutants destabilize the destruction complex 14 6.20e-02 1.12e-01 0.3640 NA -0.357000 -0.069600 2.08e-02 6.52e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 14 6.20e-02 1.12e-01 0.3640 NA -0.357000 -0.069600 2.08e-02 6.52e-01
Truncations of AMER1 destabilize the destruction complex 14 6.20e-02 1.12e-01 0.3640 NA -0.357000 -0.069600 2.08e-02 6.52e-01
truncated APC mutants destabilize the destruction complex 14 6.20e-02 1.12e-01 0.3640 NA -0.357000 -0.069600 2.08e-02 6.52e-01
Interleukin receptor SHC signaling 18 6.24e-02 1.13e-01 0.3210 NA -0.315000 0.060200 2.06e-02 6.58e-01
CD209 (DC-SIGN) signaling 19 6.27e-02 1.13e-01 0.3130 NA -0.260000 0.174000 4.99e-02 1.89e-01
PKA activation in glucagon signalling 14 6.31e-02 1.14e-01 0.3630 NA 0.028200 0.362000 8.55e-01 1.91e-02
SHC1 events in EGFR signaling 10 6.34e-02 1.14e-01 0.4300 NA -0.388000 0.185000 3.36e-02 3.11e-01
Bile acid and bile salt metabolism 31 6.34e-02 1.14e-01 0.2430 NA -0.125000 -0.209000 2.28e-01 4.45e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus 24 6.35e-02 1.14e-01 0.2780 NA -0.195000 0.198000 9.90e-02 9.30e-02
Degradation of cysteine and homocysteine 12 6.38e-02 1.15e-01 0.3910 NA 0.391000 0.013900 1.91e-02 9.33e-01
InlB-mediated entry of Listeria monocytogenes into host cell 13 6.45e-02 1.16e-01 0.3760 NA -0.331000 0.178000 3.87e-02 2.66e-01
Keratinization 28 6.55e-02 1.17e-01 0.2540 NA -0.199000 -0.158000 6.79e-02 1.48e-01
Platelet homeostasis 52 6.59e-02 1.18e-01 0.1870 NA -0.048300 0.181000 5.47e-01 2.41e-02
Downstream signaling of activated FGFR3 16 6.61e-02 1.18e-01 0.3380 NA -0.270000 0.202000 6.14e-02 1.61e-01
Activation of HOX genes during differentiation 70 6.61e-02 1.18e-01 0.1610 NA -0.159000 -0.023900 2.13e-02 7.30e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 70 6.61e-02 1.18e-01 0.1610 NA -0.159000 -0.023900 2.13e-02 7.30e-01
CTLA4 inhibitory signaling 18 6.64e-02 1.18e-01 0.3180 NA -0.289000 0.131000 3.36e-02 3.35e-01
Signaling by ERBB2 44 6.66e-02 1.18e-01 0.2030 NA -0.193000 0.062200 2.65e-02 4.75e-01
HIV elongation arrest and recovery 29 6.68e-02 1.18e-01 0.2490 NA -0.239000 -0.071200 2.60e-02 5.07e-01
Pausing and recovery of HIV elongation 29 6.68e-02 1.18e-01 0.2490 NA -0.239000 -0.071200 2.60e-02 5.07e-01
FOXO-mediated transcription of cell cycle genes 15 6.68e-02 1.18e-01 0.3470 NA -0.334000 0.097300 2.53e-02 5.14e-01
E2F mediated regulation of DNA replication 22 6.71e-02 1.19e-01 0.2860 NA 0.267000 0.103000 3.05e-02 4.03e-01
Signaling by ERBB4 36 6.73e-02 1.19e-01 0.2240 NA -0.218000 -0.047500 2.33e-02 6.22e-01
Basigin interactions 23 6.84e-02 1.20e-01 0.2800 NA -0.203000 0.192000 9.17e-02 1.10e-01
Inactivation, recovery and regulation of the phototransduction cascade 20 6.84e-02 1.20e-01 0.3000 NA -0.110000 0.279000 3.94e-01 3.09e-02
Deposition of new CENPA-containing nucleosomes at the centromere 41 6.93e-02 1.22e-01 0.2080 NA 0.205000 0.038500 2.33e-02 6.69e-01
Nucleosome assembly 41 6.93e-02 1.22e-01 0.2080 NA 0.205000 0.038500 2.33e-02 6.69e-01
Formation of the cornified envelope 20 6.98e-02 1.22e-01 0.2980 NA -0.113000 -0.275000 3.82e-01 3.31e-02
Mitochondrial calcium ion transport 22 7.02e-02 1.23e-01 0.2830 NA -0.114000 -0.259000 3.53e-01 3.54e-02
Activation of SMO 13 7.05e-02 1.23e-01 0.3700 NA -0.130000 0.346000 4.16e-01 3.09e-02
Receptor Mediated Mitophagy 10 7.07e-02 1.23e-01 0.4190 NA -0.343000 -0.241000 6.05e-02 1.86e-01
Signaling by SCF-KIT 37 7.11e-02 1.24e-01 0.2190 NA -0.104000 0.193000 2.73e-01 4.27e-02
Downstream signaling of activated FGFR2 17 7.14e-02 1.24e-01 0.3230 NA -0.182000 0.267000 1.94e-01 5.71e-02
Fatty acyl-CoA biosynthesis 30 7.17e-02 1.25e-01 0.2420 NA 0.205000 0.127000 5.15e-02 2.28e-01
Acyl chain remodelling of PC 18 7.19e-02 1.25e-01 0.3120 NA 0.231000 0.209000 8.96e-02 1.25e-01
FOXO-mediated transcription of cell death genes 15 7.23e-02 1.25e-01 0.3410 NA -0.309000 -0.145000 3.85e-02 3.30e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 59 7.24e-02 1.25e-01 0.1720 NA -0.167000 -0.043100 2.67e-02 5.67e-01
Asymmetric localization of PCP proteins 59 7.27e-02 1.26e-01 0.1720 NA -0.155000 -0.074100 3.92e-02 3.25e-01
Visual phototransduction 72 7.27e-02 1.26e-01 0.1560 NA 0.065200 0.142000 3.39e-01 3.80e-02
ISG15 antiviral mechanism 72 7.56e-02 1.30e-01 0.1550 NA -0.087900 -0.127000 1.98e-01 6.21e-02
Vasopressin regulates renal water homeostasis via Aquaporins 27 7.75e-02 1.33e-01 0.2520 NA -0.023400 0.251000 8.33e-01 2.43e-02
Gap junction trafficking 15 7.96e-02 1.37e-01 0.3350 NA 0.055500 0.331000 7.10e-01 2.66e-02
Acyl chain remodelling of PS 12 8.06e-02 1.38e-01 0.3730 NA 0.221000 0.301000 1.85e-01 7.14e-02
Myogenesis 21 8.08e-02 1.38e-01 0.2840 NA -0.203000 0.198000 1.07e-01 1.16e-01
CDC6 association with the ORC:origin complex 11 8.13e-02 1.39e-01 0.3890 NA 0.249000 0.299000 1.52e-01 8.63e-02
FRS-mediated FGFR1 signaling 12 8.17e-02 1.40e-01 0.3740 NA -0.267000 0.262000 1.09e-01 1.17e-01
EPHA-mediated growth cone collapse 15 8.23e-02 1.40e-01 0.3340 NA -0.165000 0.291000 2.69e-01 5.14e-02
Regulation of TP53 Degradation 35 8.35e-02 1.42e-01 0.2170 NA -0.143000 -0.163000 1.43e-01 9.49e-02
Regulation of TP53 Expression and Degradation 35 8.35e-02 1.42e-01 0.2170 NA -0.143000 -0.163000 1.43e-01 9.49e-02
Formation of Incision Complex in GG-NER 43 8.35e-02 1.42e-01 0.1970 NA 0.137000 -0.142000 1.21e-01 1.08e-01
FRS-mediated FGFR2 signaling 12 8.42e-02 1.43e-01 0.3710 NA -0.116000 0.353000 4.85e-01 3.44e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 25 8.47e-02 1.44e-01 0.2560 NA 0.242000 0.083900 3.61e-02 4.68e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 13 8.49e-02 1.44e-01 0.3570 NA 0.180000 -0.308000 2.60e-01 5.49e-02
Glucagon signaling in metabolic regulation 23 8.50e-02 1.44e-01 0.2670 NA 0.038900 0.264000 7.47e-01 2.82e-02
RHO GTPases Activate WASPs and WAVEs 33 8.75e-02 1.48e-01 0.2220 NA -0.206000 0.084200 4.07e-02 4.03e-01
Regulation of KIT signaling 15 8.78e-02 1.48e-01 0.3300 NA -0.154000 0.291000 3.01e-01 5.08e-02
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 10 8.89e-02 1.50e-01 0.4010 NA 0.381000 0.125000 3.69e-02 4.94e-01
SHC1 events in ERBB4 signaling 11 8.91e-02 1.50e-01 0.3840 NA -0.189000 0.334000 2.77e-01 5.52e-02
RNA polymerase II transcribes snRNA genes 72 8.93e-02 1.50e-01 0.1500 NA -0.140000 -0.052400 3.98e-02 4.43e-01
Incretin synthesis, secretion, and inactivation 13 8.94e-02 1.50e-01 0.3520 NA -0.344000 0.076500 3.17e-02 6.33e-01
TRP channels 10 9.01e-02 1.51e-01 0.4000 NA 0.084900 0.391000 6.42e-01 3.22e-02
Condensation of Prometaphase Chromosomes 11 9.05e-02 1.51e-01 0.3830 NA 0.222000 -0.312000 2.03e-01 7.32e-02
G1/S-Specific Transcription 28 9.07e-02 1.51e-01 0.2390 NA 0.195000 0.138000 7.41e-02 2.08e-01
Loss of function of MECP2 in Rett syndrome 11 9.11e-02 1.52e-01 0.3820 NA -0.374000 0.077700 3.19e-02 6.55e-01
Pervasive developmental disorders 11 9.11e-02 1.52e-01 0.3820 NA -0.374000 0.077700 3.19e-02 6.55e-01
Signaling by Erythropoietin 22 9.19e-02 1.53e-01 0.2700 NA -0.249000 0.104000 4.35e-02 3.98e-01
RAB GEFs exchange GTP for GDP on RABs 83 9.31e-02 1.55e-01 0.1390 NA -0.118000 0.073600 6.41e-02 2.47e-01
Sphingolipid de novo biosynthesis 38 9.33e-02 1.55e-01 0.2050 NA -0.175000 0.106000 6.17e-02 2.59e-01
Misspliced GSK3beta mutants stabilize beta-catenin 15 9.43e-02 1.55e-01 0.3240 NA -0.311000 -0.089700 3.71e-02 5.47e-01
S33 mutants of beta-catenin aren’t phosphorylated 15 9.43e-02 1.55e-01 0.3240 NA -0.311000 -0.089700 3.71e-02 5.47e-01
S37 mutants of beta-catenin aren’t phosphorylated 15 9.43e-02 1.55e-01 0.3240 NA -0.311000 -0.089700 3.71e-02 5.47e-01
S45 mutants of beta-catenin aren’t phosphorylated 15 9.43e-02 1.55e-01 0.3240 NA -0.311000 -0.089700 3.71e-02 5.47e-01
T41 mutants of beta-catenin aren’t phosphorylated 15 9.43e-02 1.55e-01 0.3240 NA -0.311000 -0.089700 3.71e-02 5.47e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 15 9.43e-02 1.55e-01 0.3240 NA -0.311000 -0.089700 3.71e-02 5.47e-01
Synthesis of PA 25 9.46e-02 1.56e-01 0.2510 NA 0.247000 0.040600 3.23e-02 7.25e-01
Processing of DNA double-strand break ends 69 9.52e-02 1.56e-01 0.1510 NA 0.149000 0.024700 3.26e-02 7.23e-01
HSF1-dependent transactivation 33 9.54e-02 1.56e-01 0.2180 NA -0.203000 -0.077600 4.32e-02 4.41e-01
Cargo trafficking to the periciliary membrane 48 9.60e-02 1.57e-01 0.1810 NA 0.000417 0.181000 9.96e-01 3.04e-02
Acetylcholine Neurotransmitter Release Cycle 10 9.69e-02 1.59e-01 0.3950 NA -0.009070 0.395000 9.60e-01 3.07e-02
RNA Polymerase III Transcription Initiation 36 9.87e-02 1.61e-01 0.2070 NA -0.155000 -0.137000 1.07e-01 1.56e-01
RIPK1-mediated regulated necrosis 15 9.91e-02 1.61e-01 0.3210 NA 0.002100 -0.321000 9.89e-01 3.15e-02
Regulated Necrosis 15 9.91e-02 1.61e-01 0.3210 NA 0.002100 -0.321000 9.89e-01 3.15e-02
Pink/Parkin Mediated Mitophagy 18 1.02e-01 1.66e-01 0.2910 NA -0.287000 -0.044900 3.48e-02 7.42e-01
MET promotes cell motility 26 1.03e-01 1.67e-01 0.2420 NA -0.238000 0.044800 3.59e-02 6.92e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 21 1.04e-01 1.69e-01 0.2690 NA -0.103000 0.248000 4.16e-01 4.89e-02
Collagen biosynthesis and modifying enzymes 34 1.04e-01 1.69e-01 0.2110 NA 0.207000 0.039500 3.69e-02 6.91e-01
Sema4D induced cell migration and growth-cone collapse 20 1.05e-01 1.71e-01 0.2750 NA -0.127000 0.244000 3.27e-01 5.92e-02
Hedgehog ‘off’ state 92 1.06e-01 1.72e-01 0.1280 NA -0.123000 0.035600 4.17e-02 5.56e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 1.06e-01 1.72e-01 0.2350 NA -0.186000 -0.144000 9.50e-02 1.96e-01
Activation of RAC1 11 1.08e-01 1.74e-01 0.3680 NA -0.361000 0.070800 3.82e-02 6.84e-01
Viral Messenger RNA Synthesis 43 1.08e-01 1.74e-01 0.1860 NA -0.058600 -0.176000 5.07e-01 4.55e-02
Gastrin-CREB signalling pathway via PKC and MAPK 16 1.09e-01 1.75e-01 0.3050 NA -0.289000 0.097300 4.56e-02 5.01e-01
N-glycan antennae elongation in the medial/trans-Golgi 19 1.10e-01 1.77e-01 0.2780 NA -0.247000 -0.127000 6.23e-02 3.38e-01
The canonical retinoid cycle in rods (twilight vision) 15 1.10e-01 1.77e-01 0.3120 NA 0.194000 0.245000 1.93e-01 1.01e-01
Post-translational modification: synthesis of GPI-anchored proteins 44 1.11e-01 1.78e-01 0.1820 NA 0.146000 0.110000 9.48e-02 2.08e-01
Regulation of PLK1 Activity at G2/M Transition 86 1.12e-01 1.79e-01 0.1300 NA 0.127000 0.029300 4.17e-02 6.38e-01
Adherens junctions interactions 14 1.13e-01 1.80e-01 0.3220 NA 0.252000 0.200000 1.02e-01 1.95e-01
Beta-catenin phosphorylation cascade 17 1.15e-01 1.84e-01 0.2910 NA -0.278000 -0.084800 4.70e-02 5.45e-01
Processing of Capped Intronless Pre-mRNA 28 1.16e-01 1.84e-01 0.2270 NA -0.035000 -0.224000 7.49e-01 4.03e-02
SUMOylation of immune response proteins 11 1.16e-01 1.85e-01 0.3600 NA -0.288000 -0.216000 9.79e-02 2.15e-01
MicroRNA (miRNA) biogenesis 24 1.17e-01 1.87e-01 0.2430 NA -0.174000 -0.171000 1.41e-01 1.48e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 20 1.20e-01 1.90e-01 0.2660 NA -0.260000 -0.057200 4.44e-02 6.58e-01
ECM proteoglycans 35 1.21e-01 1.91e-01 0.2010 NA 0.054000 0.193000 5.80e-01 4.79e-02
FRS-mediated FGFR3 signaling 11 1.22e-01 1.93e-01 0.3580 NA -0.239000 0.267000 1.70e-01 1.25e-01
Serotonin Neurotransmitter Release Cycle 12 1.22e-01 1.94e-01 0.3420 NA 0.016900 0.341000 9.19e-01 4.07e-02
RNA Polymerase I Promoter Clearance 65 1.23e-01 1.94e-01 0.1470 NA -0.028400 -0.144000 6.92e-01 4.47e-02
KSRP (KHSRP) binds and destabilizes mRNA 17 1.24e-01 1.95e-01 0.2860 NA -0.127000 -0.256000 3.66e-01 6.75e-02
Physiological factors 11 1.24e-01 1.95e-01 0.3570 NA -0.282000 0.218000 1.05e-01 2.11e-01
Glycogen storage diseases 14 1.24e-01 1.95e-01 0.3160 NA 0.135000 -0.286000 3.83e-01 6.41e-02
Synthesis of DNA 115 1.24e-01 1.95e-01 0.1100 NA 0.107000 -0.026200 4.70e-02 6.28e-01
Initiation of Nuclear Envelope Reformation 13 1.24e-01 1.95e-01 0.3260 NA -0.139000 -0.296000 3.87e-01 6.50e-02
Nuclear Envelope Reassembly 13 1.24e-01 1.95e-01 0.3260 NA -0.139000 -0.296000 3.87e-01 6.50e-02
RNA Polymerase II Pre-transcription Events 75 1.24e-01 1.95e-01 0.1360 NA -0.134000 -0.022300 4.42e-02 7.39e-01
PI-3K cascade:FGFR1 10 1.26e-01 1.97e-01 0.3730 NA -0.335000 0.164000 6.69e-02 3.70e-01
Signal transduction by L1 20 1.26e-01 1.98e-01 0.2630 NA -0.245000 0.095300 5.76e-02 4.61e-01
Activation of BAD and translocation to mitochondria 15 1.30e-01 2.03e-01 0.3010 NA -0.298000 0.043000 4.54e-02 7.73e-01
Purine ribonucleoside monophosphate biosynthesis 12 1.30e-01 2.03e-01 0.3370 NA 0.124000 -0.313000 4.55e-01 6.02e-02
Trafficking of GluR2-containing AMPA receptors 13 1.31e-01 2.04e-01 0.3240 NA -0.123000 0.299000 4.41e-01 6.16e-02
Sema3A PAK dependent Axon repulsion 16 1.32e-01 2.05e-01 0.2910 NA -0.121000 0.265000 4.01e-01 6.68e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) 34 1.33e-01 2.06e-01 0.1990 NA -0.198000 0.021000 4.57e-02 8.32e-01
CS/DS degradation 13 1.33e-01 2.06e-01 0.3220 NA -0.109000 0.303000 4.98e-01 5.82e-02
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 26 1.33e-01 2.06e-01 0.2270 NA 0.013800 0.227000 9.03e-01 4.51e-02
Cellular Senescence 139 1.37e-01 2.12e-01 0.0979 NA -0.038800 -0.089900 4.31e-01 6.75e-02
FRS-mediated FGFR4 signaling 12 1.37e-01 2.12e-01 0.3330 NA -0.284000 0.174000 8.83e-02 2.98e-01
SHC1 events in ERBB2 signaling 18 1.38e-01 2.13e-01 0.2720 NA -0.212000 0.170000 1.20e-01 2.11e-01
RHO GTPases activate CIT 19 1.38e-01 2.13e-01 0.2640 NA -0.027000 0.262000 8.39e-01 4.78e-02
Synthesis, secretion, and deacylation of Ghrelin 10 1.39e-01 2.14e-01 0.3630 NA -0.349000 0.102000 5.63e-02 5.76e-01
Prolonged ERK activation events 10 1.40e-01 2.16e-01 0.3620 NA -0.350000 0.095700 5.56e-02 6.00e-01
RUNX2 regulates osteoblast differentiation 18 1.41e-01 2.17e-01 0.2690 NA 0.074800 0.258000 5.83e-01 5.77e-02
Budding and maturation of HIV virion 28 1.42e-01 2.18e-01 0.2150 NA -0.142000 -0.162000 1.94e-01 1.38e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 28 1.42e-01 2.18e-01 0.2150 NA -0.212000 -0.038600 5.23e-02 7.24e-01
PI-3K cascade:FGFR4 10 1.45e-01 2.21e-01 0.3590 NA -0.355000 0.058100 5.21e-02 7.51e-01
Nicotinamide salvaging 10 1.45e-01 2.21e-01 0.3600 NA 0.245000 -0.264000 1.81e-01 1.48e-01
Plasma lipoprotein clearance 31 1.46e-01 2.22e-01 0.2040 NA -0.203000 0.013300 5.01e-02 8.98e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 56 1.46e-01 2.22e-01 0.1520 NA -0.147000 0.036400 5.67e-02 6.38e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 56 1.46e-01 2.22e-01 0.1520 NA -0.147000 0.036400 5.67e-02 6.38e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 56 1.46e-01 2.22e-01 0.1520 NA -0.147000 0.036400 5.67e-02 6.38e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 56 1.46e-01 2.22e-01 0.1520 NA -0.147000 0.036400 5.67e-02 6.38e-01
Signaling by NOTCH1 in Cancer 56 1.46e-01 2.22e-01 0.1520 NA -0.147000 0.036400 5.67e-02 6.38e-01
NOTCH1 Intracellular Domain Regulates Transcription 45 1.47e-01 2.23e-01 0.1690 NA -0.162000 -0.046300 6.00e-02 5.91e-01
Regulation of gene expression in beta cells 14 1.47e-01 2.23e-01 0.3030 NA 0.199000 -0.228000 1.97e-01 1.39e-01
Rap1 signalling 14 1.49e-01 2.25e-01 0.3020 NA -0.127000 0.274000 4.10e-01 7.59e-02
Antiviral mechanism by IFN-stimulated genes 80 1.53e-01 2.32e-01 0.1250 NA -0.106000 -0.066700 1.02e-01 3.03e-01
HS-GAG biosynthesis 23 1.54e-01 2.33e-01 0.2320 NA 0.153000 0.175000 2.04e-01 1.47e-01
Elevation of cytosolic Ca2+ levels 10 1.55e-01 2.33e-01 0.3540 NA -0.217000 0.279000 2.35e-01 1.26e-01
Neurotransmitter release cycle 35 1.55e-01 2.34e-01 0.1890 NA -0.116000 0.149000 2.36e-01 1.26e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 1.56e-01 2.34e-01 0.3520 NA -0.002350 0.352000 9.90e-01 5.38e-02
Sulfur amino acid metabolism 25 1.56e-01 2.35e-01 0.2230 NA 0.219000 -0.040900 5.79e-02 7.23e-01
Protein methylation 15 1.57e-01 2.35e-01 0.2870 NA -0.003430 -0.287000 9.82e-01 5.43e-02
Signaling by RAS mutants 51 1.57e-01 2.36e-01 0.1560 NA -0.142000 0.065800 8.06e-02 4.16e-01
Arachidonic acid metabolism 35 1.57e-01 2.36e-01 0.1870 NA 0.153000 0.108000 1.17e-01 2.69e-01
Retrograde neurotrophin signalling 10 1.58e-01 2.36e-01 0.3520 NA -0.204000 0.287000 2.65e-01 1.16e-01
Signaling by FGFR3 in disease 13 1.59e-01 2.37e-01 0.3080 NA -0.263000 0.159000 1.00e-01 3.20e-01
Signaling by FGFR3 point mutants in cancer 13 1.59e-01 2.37e-01 0.3080 NA -0.263000 0.159000 1.00e-01 3.20e-01
Glycosphingolipid metabolism 37 1.63e-01 2.43e-01 0.1810 NA -0.176000 0.043200 6.41e-02 6.50e-01
G alpha (12/13) signalling events 60 1.64e-01 2.44e-01 0.1420 NA -0.121000 0.074900 1.05e-01 3.16e-01
mRNA decay by 3’ to 5’ exoribonuclease 16 1.67e-01 2.48e-01 0.2740 NA 0.069300 -0.265000 6.31e-01 6.67e-02
The phototransduction cascade 21 1.67e-01 2.48e-01 0.2390 NA -0.074600 0.227000 5.54e-01 7.19e-02
Formation of the beta-catenin:TCF transactivating complex 45 1.69e-01 2.50e-01 0.1630 NA -0.162000 -0.007060 5.95e-02 9.35e-01
Signaling by FGFR2 in disease 30 1.69e-01 2.51e-01 0.1990 NA -0.114000 0.163000 2.79e-01 1.21e-01
S Phase 155 1.70e-01 2.52e-01 0.0879 NA 0.067000 -0.056900 1.50e-01 2.22e-01
Endogenous sterols 19 1.71e-01 2.53e-01 0.2500 NA 0.158000 -0.194000 2.34e-01 1.44e-01
Membrane binding and targetting of GAG proteins 14 1.71e-01 2.53e-01 0.2890 NA -0.232000 -0.172000 1.32e-01 2.65e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 1.71e-01 2.53e-01 0.2890 NA -0.232000 -0.172000 1.32e-01 2.65e-01
Cell death signalling via NRAGE, NRIF and NADE 65 1.72e-01 2.54e-01 0.1350 NA -0.130000 0.034700 6.96e-02 6.29e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 31 1.73e-01 2.54e-01 0.1940 NA -0.087500 -0.173000 3.99e-01 9.52e-02
Glycolysis 65 1.73e-01 2.55e-01 0.1340 NA -0.130000 -0.035000 7.11e-02 6.26e-01
Endosomal/Vacuolar pathway 12 1.74e-01 2.55e-01 0.3110 NA 0.162000 0.266000 3.31e-01 1.11e-01
TNFR1-induced NFkappaB signaling pathway 24 1.75e-01 2.56e-01 0.2200 NA -0.040600 -0.216000 7.31e-01 6.67e-02
rRNA processing in the mitochondrion 32 1.75e-01 2.57e-01 0.1910 NA 0.013800 -0.190000 8.93e-01 6.26e-02
Dopamine Neurotransmitter Release Cycle 17 1.76e-01 2.57e-01 0.2610 NA 0.027600 0.260000 8.44e-01 6.38e-02
Insulin processing 20 1.76e-01 2.57e-01 0.2410 NA -0.174000 0.167000 1.77e-01 1.96e-01
Keratan sulfate/keratin metabolism 23 1.77e-01 2.59e-01 0.2250 NA -0.172000 0.145000 1.54e-01 2.28e-01
RNA Polymerase I Transcription 66 1.78e-01 2.60e-01 0.1320 NA -0.034500 -0.127000 6.28e-01 7.35e-02
tRNA processing in the mitochondrion 35 1.80e-01 2.63e-01 0.1810 NA 0.102000 -0.150000 2.96e-01 1.25e-01
Glucagon-type ligand receptors 15 1.81e-01 2.63e-01 0.2750 NA 0.103000 0.255000 4.90e-01 8.68e-02
Oncogenic MAPK signaling 72 1.82e-01 2.65e-01 0.1260 NA -0.107000 0.067100 1.17e-01 3.25e-01
PIWI-interacting RNA (piRNA) biogenesis 21 1.83e-01 2.65e-01 0.2330 NA -0.114000 0.203000 3.65e-01 1.07e-01
Activation of kainate receptors upon glutamate binding 17 1.83e-01 2.65e-01 0.2580 NA 0.022500 0.257000 8.73e-01 6.63e-02
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 1.83e-01 2.65e-01 0.2950 NA -0.295000 0.017100 6.58e-02 9.15e-01
Switching of origins to a post-replicative state 86 1.85e-01 2.67e-01 0.1150 NA -0.002350 -0.115000 9.70e-01 6.61e-02
Signal amplification 18 1.88e-01 2.71e-01 0.2500 NA -0.182000 0.171000 1.81e-01 2.10e-01
Blood group systems biosynthesis 12 1.88e-01 2.72e-01 0.3050 NA 0.028400 -0.303000 8.65e-01 6.88e-02
Collagen formation 52 1.91e-01 2.76e-01 0.1450 NA 0.100000 0.105000 2.11e-01 1.89e-01
Purine catabolism 15 1.93e-01 2.78e-01 0.2710 NA 0.078600 -0.259000 5.98e-01 8.23e-02
p38MAPK events 13 1.94e-01 2.79e-01 0.2910 NA -0.264000 0.122000 9.95e-02 4.47e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 12 1.95e-01 2.80e-01 0.3020 NA -0.297000 0.052000 7.47e-02 7.55e-01
Meiotic recombination 36 1.96e-01 2.81e-01 0.1740 NA 0.166000 0.051800 8.51e-02 5.91e-01
G2/M Checkpoints 137 1.97e-01 2.82e-01 0.0894 NA 0.087700 -0.017200 7.65e-02 7.28e-01
Mitochondrial Fatty Acid Beta-Oxidation 31 2.01e-01 2.87e-01 0.1860 NA 0.183000 -0.033200 7.77e-02 7.49e-01
PCNA-Dependent Long Patch Base Excision Repair 21 2.01e-01 2.87e-01 0.2250 NA 0.198000 0.108000 1.16e-01 3.93e-01
Signaling by FGFR3 fusions in cancer 10 2.04e-01 2.91e-01 0.3260 NA -0.325000 0.019200 7.49e-02 9.16e-01
p75NTR recruits signalling complexes 12 2.06e-01 2.95e-01 0.2960 NA -0.296000 -0.011500 7.60e-02 9.45e-01
FGFR2 alternative splicing 26 2.10e-01 2.99e-01 0.2000 NA -0.149000 -0.133000 1.87e-01 2.42e-01
Inwardly rectifying K+ channels 13 2.10e-01 2.99e-01 0.2830 NA -0.005150 0.283000 9.74e-01 7.73e-02
SLC transporter disorders 68 2.12e-01 3.01e-01 0.1230 NA -0.063300 -0.106000 3.67e-01 1.32e-01
B-WICH complex positively regulates rRNA expression 46 2.13e-01 3.03e-01 0.1500 NA -0.121000 -0.087900 1.56e-01 3.02e-01
Peptide hormone metabolism 50 2.14e-01 3.03e-01 0.1440 NA -0.126000 0.069900 1.24e-01 3.92e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 2.14e-01 3.03e-01 0.2120 NA -0.211000 0.019000 8.02e-02 8.75e-01
Establishment of Sister Chromatid Cohesion 10 2.15e-01 3.04e-01 0.3210 NA 0.098800 -0.305000 5.88e-01 9.48e-02
MAP2K and MAPK activation 35 2.18e-01 3.08e-01 0.1710 NA -0.154000 0.074100 1.15e-01 4.48e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 2.22e-01 3.13e-01 0.1800 NA -0.141000 -0.111000 1.73e-01 2.86e-01
NOTCH3 Intracellular Domain Regulates Transcription 21 2.24e-01 3.15e-01 0.2180 NA -0.006090 0.218000 9.61e-01 8.35e-02
Binding and Uptake of Ligands by Scavenger Receptors 28 2.25e-01 3.18e-01 0.1880 NA -0.116000 -0.148000 2.87e-01 1.76e-01
Oxidative Stress Induced Senescence 77 2.27e-01 3.19e-01 0.1140 NA -0.112000 -0.018800 8.96e-02 7.76e-01
Metabolism of carbohydrates 242 2.27e-01 3.19e-01 0.0644 NA -0.011400 0.063400 7.60e-01 8.99e-02
Reversible hydration of carbon dioxide 10 2.28e-01 3.20e-01 0.3140 NA 0.083700 0.302000 6.47e-01 9.80e-02
ADP signalling through P2Y purinoceptor 12 12 2.29e-01 3.21e-01 0.2870 NA -0.165000 0.235000 3.22e-01 1.59e-01
NRAGE signals death through JNK 49 2.29e-01 3.21e-01 0.1420 NA -0.125000 0.067700 1.31e-01 4.12e-01
PI-3K cascade:FGFR2 10 2.31e-01 3.24e-01 0.3130 NA -0.153000 0.273000 4.01e-01 1.35e-01
Glutathione synthesis and recycling 12 2.33e-01 3.25e-01 0.2850 NA 0.277000 -0.068400 9.72e-02 6.82e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 13 2.33e-01 3.25e-01 0.2730 NA 0.254000 0.098500 1.12e-01 5.39e-01
alpha-linolenic acid (ALA) metabolism 13 2.33e-01 3.25e-01 0.2730 NA 0.254000 0.098500 1.12e-01 5.39e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 50 2.34e-01 3.26e-01 0.1400 NA -0.112000 0.083700 1.71e-01 3.06e-01
Downstream signal transduction 28 2.37e-01 3.30e-01 0.1850 NA -0.185000 -0.006660 9.00e-02 9.51e-01
RHO GTPases activate KTN1 11 2.38e-01 3.30e-01 0.2960 NA -0.273000 0.113000 1.17e-01 5.16e-01
Signaling by FGFR4 in disease 11 2.39e-01 3.31e-01 0.2950 NA -0.295000 -0.006960 9.06e-02 9.68e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 10 2.39e-01 3.31e-01 0.3090 NA -0.297000 0.088300 1.04e-01 6.29e-01
Termination of O-glycan biosynthesis 14 2.40e-01 3.33e-01 0.2610 NA -0.237000 0.111000 1.25e-01 4.73e-01
Biosynthesis of specialized proresolving mediators (SPMs) 11 2.40e-01 3.33e-01 0.2940 NA 0.076600 0.284000 6.60e-01 1.03e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 2.41e-01 3.33e-01 0.2510 NA -0.099900 -0.231000 5.03e-01 1.22e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 2.42e-01 3.35e-01 0.2690 NA 0.247000 0.107000 1.23e-01 5.04e-01
Metabolism of cofactors 18 2.43e-01 3.35e-01 0.2300 NA 0.064800 -0.220000 6.34e-01 1.06e-01
Other interleukin signaling 18 2.45e-01 3.38e-01 0.2290 NA -0.027800 0.227000 8.38e-01 9.58e-02
Termination of translesion DNA synthesis 31 2.50e-01 3.45e-01 0.1720 NA 0.121000 0.123000 2.45e-01 2.36e-01
Reproduction 72 2.54e-01 3.49e-01 0.1130 NA 0.085400 0.073500 2.11e-01 2.81e-01
Gap junction trafficking and regulation 17 2.54e-01 3.49e-01 0.2320 NA 0.038600 0.229000 7.83e-01 1.03e-01
Interleukin-10 signaling 18 2.56e-01 3.51e-01 0.2240 NA 0.139000 0.176000 3.08e-01 1.95e-01
IRAK1 recruits IKK complex 10 2.57e-01 3.51e-01 0.3020 NA -0.235000 0.189000 1.97e-01 3.00e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 2.57e-01 3.51e-01 0.3020 NA -0.235000 0.189000 1.97e-01 3.00e-01
SUMOylation of DNA methylation proteins 16 2.61e-01 3.57e-01 0.2370 NA 0.077400 -0.224000 5.92e-01 1.21e-01
Metabolic disorders of biological oxidation enzymes 24 2.65e-01 3.62e-01 0.1930 NA 0.143000 -0.130000 2.26e-01 2.72e-01
Interleukin-2 family signaling 29 2.65e-01 3.62e-01 0.1750 NA -0.139000 0.107000 1.96e-01 3.17e-01
MET activates PTK2 signaling 15 2.67e-01 3.64e-01 0.2430 NA -0.236000 0.055200 1.13e-01 7.12e-01
Regulation of TP53 Activity 150 2.68e-01 3.64e-01 0.0767 NA -0.051000 -0.057300 2.82e-01 2.26e-01
TICAM1, RIP1-mediated IKK complex recruitment 18 2.68e-01 3.65e-01 0.2210 NA -0.217000 -0.039300 1.11e-01 7.73e-01
Base-Excision Repair, AP Site Formation 31 2.69e-01 3.65e-01 0.1690 NA 0.158000 -0.060100 1.29e-01 5.62e-01
Non-integrin membrane-ECM interactions 37 2.69e-01 3.65e-01 0.1540 NA -0.118000 0.099700 2.15e-01 2.94e-01
Pre-NOTCH Processing in Golgi 18 2.71e-01 3.67e-01 0.2210 NA -0.096100 0.199000 4.80e-01 1.45e-01
FGFR2 mutant receptor activation 20 2.72e-01 3.69e-01 0.2090 NA -0.029100 0.207000 8.22e-01 1.10e-01
Repression of WNT target genes 14 2.73e-01 3.70e-01 0.2490 NA -0.235000 0.082400 1.28e-01 5.94e-01
Regulation of FZD by ubiquitination 15 2.74e-01 3.71e-01 0.2390 NA -0.106000 -0.215000 4.77e-01 1.50e-01
TP53 Regulates Transcription of DNA Repair Genes 58 2.75e-01 3.71e-01 0.1220 NA -0.064500 -0.103000 3.96e-01 1.74e-01
Regulation of beta-cell development 30 2.76e-01 3.72e-01 0.1700 NA 0.079600 -0.150000 4.51e-01 1.55e-01
Regulation of TNFR1 signaling 30 2.76e-01 3.72e-01 0.1690 NA -0.155000 -0.068000 1.43e-01 5.19e-01
TICAM1-dependent activation of IRF3/IRF7 11 2.76e-01 3.72e-01 0.2800 NA -0.267000 0.082800 1.25e-01 6.34e-01
Signaling by Non-Receptor Tyrosine Kinases 46 2.78e-01 3.73e-01 0.1370 NA -0.136000 0.009730 1.10e-01 9.09e-01
Signaling by PTK6 46 2.78e-01 3.73e-01 0.1370 NA -0.136000 0.009730 1.10e-01 9.09e-01
BBSome-mediated cargo-targeting to cilium 23 2.79e-01 3.74e-01 0.1930 NA -0.013500 0.192000 9.11e-01 1.11e-01
Early Phase of HIV Life Cycle 13 2.80e-01 3.75e-01 0.2560 NA 0.114000 -0.229000 4.75e-01 1.52e-01
Hyaluronan metabolism 13 2.80e-01 3.75e-01 0.2560 NA -0.084700 0.242000 5.97e-01 1.31e-01
Diseases of carbohydrate metabolism 30 2.82e-01 3.77e-01 0.1680 NA -0.014500 -0.167000 8.91e-01 1.13e-01
Orc1 removal from chromatin 67 2.83e-01 3.78e-01 0.1120 NA -0.061500 -0.093600 3.84e-01 1.85e-01
RA biosynthesis pathway 15 2.85e-01 3.80e-01 0.2370 NA 0.151000 -0.182000 3.10e-01 2.21e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 39 2.87e-01 3.81e-01 0.1460 NA -0.131000 -0.064000 1.56e-01 4.89e-01
HIV Transcription Elongation 39 2.87e-01 3.81e-01 0.1460 NA -0.131000 -0.064000 1.56e-01 4.89e-01
Tat-mediated elongation of the HIV-1 transcript 39 2.87e-01 3.81e-01 0.1460 NA -0.131000 -0.064000 1.56e-01 4.89e-01
Signaling by Leptin 10 2.87e-01 3.81e-01 0.2890 NA 0.152000 -0.246000 4.04e-01 1.78e-01
Signaling by high-kinase activity BRAF mutants 31 2.87e-01 3.81e-01 0.1640 NA -0.162000 0.029000 1.19e-01 7.80e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 13 2.88e-01 3.82e-01 0.2520 NA -0.075600 -0.241000 6.37e-01 1.33e-01
HSF1 activation 26 2.89e-01 3.82e-01 0.1780 NA -0.165000 -0.066900 1.45e-01 5.55e-01
Biosynthesis of DHA-derived SPMs 10 2.90e-01 3.84e-01 0.2870 NA 0.166000 0.234000 3.64e-01 2.00e-01
Cellular hexose transport 16 2.93e-01 3.87e-01 0.2270 NA -0.067800 0.216000 6.39e-01 1.34e-01
Formation of HIV elongation complex in the absence of HIV Tat 41 2.94e-01 3.88e-01 0.1410 NA -0.119000 -0.074900 1.86e-01 4.07e-01
RHO GTPase Effectors 237 2.94e-01 3.88e-01 0.0592 NA -0.022000 0.055000 5.60e-01 1.46e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 2.94e-01 3.88e-01 0.1810 NA 0.176000 0.039600 1.27e-01 7.32e-01
Lysine catabolism 12 2.98e-01 3.92e-01 0.2590 NA 0.258000 0.021500 1.21e-01 8.97e-01
Transport of bile salts and organic acids, metal ions and amine compounds 58 2.98e-01 3.92e-01 0.1180 NA -0.118000 -0.011400 1.22e-01 8.81e-01
Regulation of TP53 Activity through Phosphorylation 86 3.01e-01 3.95e-01 0.0968 NA 0.096700 -0.001060 1.21e-01 9.86e-01
Acyl chain remodelling of PG 11 3.02e-01 3.96e-01 0.2690 NA 0.253000 0.091000 1.46e-01 6.01e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 3.02e-01 3.96e-01 0.1010 NA -0.038500 -0.093600 5.57e-01 1.53e-01
Synthesis of PIPs at the Golgi membrane 15 3.04e-01 3.98e-01 0.2310 NA -0.176000 0.149000 2.38e-01 3.18e-01
Intrinsic Pathway for Apoptosis 49 3.08e-01 4.03e-01 0.1270 NA -0.122000 0.034400 1.39e-01 6.77e-01
Activation of BH3-only proteins 29 3.09e-01 4.04e-01 0.1650 NA -0.161000 0.036100 1.35e-01 7.36e-01
Hyaluronan uptake and degradation 11 3.11e-01 4.07e-01 0.2660 NA -0.078600 0.255000 6.52e-01 1.44e-01
VEGFR2 mediated vascular permeability 26 3.14e-01 4.09e-01 0.1720 NA -0.171000 -0.022900 1.31e-01 8.40e-01
Import of palmitoyl-CoA into the mitochondrial matrix 11 3.15e-01 4.10e-01 0.2650 NA 0.188000 -0.188000 2.81e-01 2.81e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 3.15e-01 4.10e-01 0.2640 NA -0.139000 -0.224000 4.23e-01 1.98e-01
RHO GTPases activate PKNs 45 3.17e-01 4.12e-01 0.1310 NA -0.106000 0.076800 2.18e-01 3.73e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 13 3.17e-01 4.12e-01 0.2420 NA 0.139000 0.199000 3.86e-01 2.15e-01
Activation of G protein gated Potassium channels 11 3.18e-01 4.12e-01 0.2640 NA 0.005520 0.263000 9.75e-01 1.30e-01
G protein gated Potassium channels 11 3.18e-01 4.12e-01 0.2640 NA 0.005520 0.263000 9.75e-01 1.30e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 11 3.18e-01 4.12e-01 0.2640 NA 0.005520 0.263000 9.75e-01 1.30e-01
Syndecan interactions 18 3.18e-01 4.12e-01 0.2070 NA -0.166000 0.123000 2.24e-01 3.64e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 31 3.25e-01 4.20e-01 0.1550 NA -0.101000 -0.118000 3.31e-01 2.56e-01
Cytosolic sulfonation of small molecules 20 3.25e-01 4.20e-01 0.1940 NA 0.193000 0.012800 1.35e-01 9.21e-01
Degradation of the extracellular matrix 68 3.27e-01 4.22e-01 0.1050 NA -0.049400 0.092800 4.81e-01 1.86e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 11 3.29e-01 4.24e-01 0.2590 NA -0.239000 -0.099600 1.70e-01 5.67e-01
RHO GTPases Activate Formins 115 3.30e-01 4.24e-01 0.0804 NA 0.078600 0.017000 1.46e-01 7.54e-01
G-protein beta:gamma signalling 18 3.31e-01 4.26e-01 0.2030 NA -0.192000 0.065000 1.59e-01 6.33e-01
Mitotic G2-G2/M phases 179 3.39e-01 4.35e-01 0.0639 NA 0.032100 -0.055300 4.59e-01 2.03e-01
Tight junction interactions 20 3.39e-01 4.35e-01 0.1900 NA 0.022500 0.188000 8.62e-01 1.45e-01
G2/M Transition 177 3.41e-01 4.37e-01 0.0642 NA 0.026900 -0.058200 5.37e-01 1.82e-01
TNF signaling 40 3.45e-01 4.42e-01 0.1330 NA -0.077300 -0.108000 3.98e-01 2.37e-01
Interleukin-4 and Interleukin-13 signaling 65 3.46e-01 4.43e-01 0.1040 NA -0.099000 -0.033100 1.68e-01 6.45e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 40 3.50e-01 4.46e-01 0.1330 NA -0.129000 0.032400 1.59e-01 7.23e-01
Signaling by moderate kinase activity BRAF mutants 40 3.50e-01 4.46e-01 0.1330 NA -0.129000 0.032400 1.59e-01 7.23e-01
Plasma lipoprotein remodeling 27 3.51e-01 4.47e-01 0.1610 NA 0.094400 -0.131000 3.96e-01 2.39e-01
Thrombin signalling through proteinase activated receptors (PARs) 20 3.52e-01 4.48e-01 0.1870 NA -0.165000 0.088500 2.02e-01 4.93e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 3.52e-01 4.49e-01 0.1230 NA -0.034100 -0.118000 6.89e-01 1.66e-01
Interleukin-7 signaling 17 3.53e-01 4.49e-01 0.2030 NA 0.144000 -0.143000 3.06e-01 3.07e-01
Processing and activation of SUMO 10 3.55e-01 4.51e-01 0.2630 NA -0.013600 -0.262000 9.41e-01 1.51e-01
Stimuli-sensing channels 58 3.56e-01 4.52e-01 0.1090 NA -0.094800 0.054600 2.12e-01 4.72e-01
Assembly of active LPL and LIPC lipase complexes 15 3.57e-01 4.53e-01 0.2140 NA 0.193000 -0.094000 1.96e-01 5.28e-01
VEGFR2 mediated cell proliferation 18 3.61e-01 4.57e-01 0.1950 NA -0.170000 0.095400 2.12e-01 4.83e-01
Interleukin-37 signaling 16 3.62e-01 4.57e-01 0.2060 NA -0.031000 -0.203000 8.30e-01 1.59e-01
Deactivation of the beta-catenin transactivating complex 40 3.62e-01 4.58e-01 0.1300 NA -0.127000 -0.029600 1.66e-01 7.46e-01
Lewis blood group biosynthesis 11 3.64e-01 4.59e-01 0.2470 NA -0.047400 -0.243000 7.86e-01 1.63e-01
Dual Incision in GG-NER 41 3.66e-01 4.61e-01 0.1280 NA 0.127000 -0.019200 1.61e-01 8.32e-01
Synthesis of PC 25 3.67e-01 4.62e-01 0.1630 NA -0.161000 -0.030100 1.64e-01 7.95e-01
HDL remodeling 10 3.72e-01 4.68e-01 0.2570 NA 0.249000 -0.064200 1.73e-01 7.25e-01
Peptide ligand-binding receptors 47 3.73e-01 4.69e-01 0.1190 NA -0.044200 0.110000 6.00e-01 1.92e-01
Signaling by BRAF and RAF fusions 58 3.75e-01 4.71e-01 0.1070 NA -0.073800 0.077100 3.31e-01 3.10e-01
IRAK2 mediated activation of TAK1 complex 10 3.78e-01 4.74e-01 0.2540 NA -0.138000 -0.214000 4.51e-01 2.42e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 3.79e-01 4.75e-01 0.2230 NA -0.115000 -0.190000 4.71e-01 2.35e-01
Sialic acid metabolism 22 3.80e-01 4.76e-01 0.1720 NA -0.151000 0.082500 2.21e-01 5.03e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 51 3.81e-01 4.76e-01 0.1120 NA -0.104000 -0.043500 2.01e-01 5.91e-01
COPI-independent Golgi-to-ER retrograde traffic 31 3.86e-01 4.82e-01 0.1430 NA -0.143000 0.007900 1.68e-01 9.39e-01
Retinoid metabolism and transport 38 3.86e-01 4.82e-01 0.1290 NA 0.108000 0.070300 2.48e-01 4.53e-01
Purine salvage 12 3.87e-01 4.82e-01 0.2300 NA 0.072100 0.218000 6.66e-01 1.91e-01
Signaling by FGFR1 in disease 30 3.87e-01 4.82e-01 0.1460 NA -0.143000 0.026800 1.75e-01 8.00e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 10 3.90e-01 4.86e-01 0.2500 NA -0.073500 -0.239000 6.87e-01 1.90e-01
Glycogen synthesis 14 3.92e-01 4.87e-01 0.2110 NA -0.101000 -0.185000 5.15e-01 2.30e-01
Metabolism of porphyrins 14 3.92e-01 4.87e-01 0.2110 NA 0.005700 0.211000 9.71e-01 1.71e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 14 3.94e-01 4.89e-01 0.2100 NA -0.089700 -0.190000 5.61e-01 2.18e-01
Cytochrome P450 - arranged by substrate type 41 3.94e-01 4.89e-01 0.1230 NA 0.090100 -0.084500 3.18e-01 3.50e-01
Signaling by NOTCH2 29 3.97e-01 4.92e-01 0.1460 NA -0.013700 0.145000 8.99e-01 1.76e-01
Cleavage of the damaged pyrimidine 29 3.98e-01 4.92e-01 0.1460 NA 0.143000 -0.028300 1.83e-01 7.92e-01
Depyrimidination 29 3.98e-01 4.92e-01 0.1460 NA 0.143000 -0.028300 1.83e-01 7.92e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 29 3.98e-01 4.92e-01 0.1460 NA 0.143000 -0.028300 1.83e-01 7.92e-01
Signaling by WNT in cancer 31 4.00e-01 4.94e-01 0.1400 NA -0.139000 -0.021900 1.82e-01 8.33e-01
IKK complex recruitment mediated by RIP1 21 4.01e-01 4.94e-01 0.1700 NA -0.166000 -0.039100 1.89e-01 7.57e-01
Synthesis of PIPs at the late endosome membrane 11 4.01e-01 4.94e-01 0.2360 NA -0.218000 0.090200 2.11e-01 6.05e-01
activated TAK1 mediates p38 MAPK activation 19 4.01e-01 4.94e-01 0.1790 NA -0.178000 0.021800 1.80e-01 8.69e-01
Branched-chain amino acid catabolism 21 4.03e-01 4.95e-01 0.1700 NA 0.163000 -0.047500 1.95e-01 7.07e-01
Signaling by FGFR2 IIIa TM 18 4.03e-01 4.95e-01 0.1830 NA -0.004720 0.183000 9.72e-01 1.78e-01
DNA Double Strand Break Response 47 4.04e-01 4.95e-01 0.1130 NA -0.047700 -0.103000 5.72e-01 2.23e-01
Organic cation/anion/zwitterion transport 10 4.04e-01 4.95e-01 0.2460 NA -0.241000 -0.049000 1.87e-01 7.88e-01
Signaling by NTRK2 (TRKB) 21 4.06e-01 4.97e-01 0.1700 NA -0.095700 0.140000 4.48e-01 2.66e-01
Smooth Muscle Contraction 27 4.11e-01 5.02e-01 0.1490 NA -0.061800 0.135000 5.79e-01 2.24e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 17 4.12e-01 5.03e-01 0.1860 NA -0.133000 -0.130000 3.41e-01 3.54e-01
Regulation of gene expression by Hypoxia-inducible Factor 11 4.13e-01 5.04e-01 0.2310 NA -0.226000 -0.047500 1.93e-01 7.85e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 10 4.14e-01 5.05e-01 0.2430 NA 0.241000 -0.030200 1.87e-01 8.69e-01
Signaling by FGFR in disease 50 4.14e-01 5.05e-01 0.1090 NA -0.101000 0.040600 2.17e-01 6.20e-01
Protein ubiquitination 70 4.16e-01 5.07e-01 0.0913 NA -0.077700 -0.048100 2.61e-01 4.87e-01
RHO GTPases Activate NADPH Oxidases 16 4.23e-01 5.14e-01 0.1900 NA -0.103000 0.160000 4.75e-01 2.69e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 26 4.24e-01 5.15e-01 0.1480 NA -0.104000 -0.105000 3.57e-01 3.54e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 29 4.26e-01 5.17e-01 0.1400 NA -0.129000 -0.054900 2.30e-01 6.09e-01
Glycerophospholipid biosynthesis 97 4.26e-01 5.17e-01 0.0768 NA -0.002250 0.076800 9.69e-01 1.92e-01
Regulated proteolysis of p75NTR 11 4.26e-01 5.17e-01 0.2270 NA -0.198000 -0.110000 2.55e-01 5.28e-01
Mucopolysaccharidoses 11 4.28e-01 5.18e-01 0.2260 NA -0.197000 -0.111000 2.57e-01 5.25e-01
Regulation of IFNA signaling 12 4.29e-01 5.19e-01 0.2170 NA 0.211000 0.049400 2.06e-01 7.67e-01
Chylomicron assembly 10 4.30e-01 5.20e-01 0.2370 NA 0.030500 -0.235000 8.67e-01 1.97e-01
SUMOylation of transcription factors 16 4.35e-01 5.25e-01 0.1860 NA -0.091700 -0.162000 5.25e-01 2.63e-01
GABA synthesis, release, reuptake and degradation 13 4.37e-01 5.27e-01 0.2070 NA -0.141000 0.151000 3.77e-01 3.47e-01
Thromboxane signalling through TP receptor 13 4.38e-01 5.28e-01 0.2060 NA -0.175000 0.109000 2.75e-01 4.95e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 4.38e-01 5.28e-01 0.1750 NA 0.032200 -0.172000 8.13e-01 2.06e-01
MET activates RAP1 and RAC1 10 4.40e-01 5.29e-01 0.2340 NA -0.232000 0.030700 2.04e-01 8.66e-01
RNA Polymerase III Chain Elongation 18 4.43e-01 5.32e-01 0.1740 NA -0.173000 -0.018900 2.05e-01 8.90e-01
Nucleotide salvage 20 4.49e-01 5.39e-01 0.1630 NA 0.103000 0.126000 4.25e-01 3.28e-01
Mitochondrial iron-sulfur cluster biogenesis 12 4.54e-01 5.44e-01 0.2090 NA 0.206000 0.035100 2.16e-01 8.33e-01
G0 and Early G1 26 4.58e-01 5.49e-01 0.1410 NA 0.130000 0.055500 2.51e-01 6.25e-01
RUNX2 regulates bone development 24 4.59e-01 5.50e-01 0.1470 NA 0.022500 0.145000 8.49e-01 2.18e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 15 4.60e-01 5.50e-01 0.1860 NA -0.177000 0.056800 2.34e-01 7.04e-01
Assembly of the pre-replicative complex 65 4.60e-01 5.50e-01 0.0891 NA -0.063900 -0.062200 3.73e-01 3.86e-01
Plasma lipoprotein assembly, remodeling, and clearance 63 4.64e-01 5.54e-01 0.0903 NA -0.089800 -0.009210 2.18e-01 8.99e-01
Signaling by Activin 11 4.66e-01 5.56e-01 0.2150 NA -0.215000 0.006250 2.17e-01 9.71e-01
Pre-NOTCH Expression and Processing 64 4.68e-01 5.57e-01 0.0890 NA -0.088500 -0.009870 2.21e-01 8.91e-01
Signaling by cytosolic FGFR1 fusion mutants 18 4.69e-01 5.57e-01 0.1670 NA -0.164000 -0.034800 2.29e-01 7.98e-01
G beta:gamma signalling through PLC beta 11 4.69e-01 5.57e-01 0.2150 NA -0.144000 0.159000 4.07e-01 3.61e-01
Presynaptic function of Kainate receptors 11 4.69e-01 5.57e-01 0.2150 NA -0.144000 0.159000 4.07e-01 3.61e-01
Platelet sensitization by LDL 14 4.71e-01 5.59e-01 0.1900 NA -0.152000 0.113000 3.23e-01 4.62e-01
Transcriptional Regulation by MECP2 46 4.76e-01 5.64e-01 0.1040 NA -0.103000 0.015500 2.28e-01 8.56e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 21 4.78e-01 5.66e-01 0.1530 NA -0.089200 -0.124000 4.79e-01 3.25e-01
Transcription of the HIV genome 64 4.80e-01 5.68e-01 0.0875 NA -0.086900 -0.010300 2.29e-01 8.87e-01
Keratan sulfate biosynthesis 18 4.83e-01 5.71e-01 0.1650 NA -0.125000 0.107000 3.58e-01 4.32e-01
Meiosis 63 4.84e-01 5.72e-01 0.0878 NA 0.087600 0.005510 2.29e-01 9.40e-01
Dissolution of Fibrin Clot 12 4.99e-01 5.89e-01 0.1970 NA 0.196000 -0.006050 2.39e-01 9.71e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 5.01e-01 5.91e-01 0.1100 NA 0.047400 0.099300 6.13e-01 2.90e-01
Prolactin receptor signaling 11 5.02e-01 5.91e-01 0.2040 NA -0.040300 -0.200000 8.17e-01 2.50e-01
Ca2+ pathway 47 5.03e-01 5.91e-01 0.0991 NA -0.045900 0.087900 5.86e-01 2.97e-01
Molecules associated with elastic fibres 19 5.04e-01 5.92e-01 0.1550 NA 0.053700 0.145000 6.85e-01 2.73e-01
Synaptic adhesion-like molecules 15 5.05e-01 5.94e-01 0.1740 NA 0.145000 0.095400 3.30e-01 5.22e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 5.11e-01 5.99e-01 0.1860 NA 0.182000 0.037200 2.57e-01 8.16e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 5.14e-01 6.02e-01 0.0834 NA -0.009990 -0.082800 8.90e-01 2.52e-01
RHO GTPases activate IQGAPs 11 5.14e-01 6.02e-01 0.2010 NA -0.101000 0.174000 5.61e-01 3.18e-01
FGFR1 mutant receptor activation 23 5.17e-01 6.05e-01 0.1390 NA -0.135000 0.031100 2.62e-01 7.96e-01
Triglyceride catabolism 12 5.17e-01 6.05e-01 0.1920 NA -0.143000 0.128000 3.91e-01 4.42e-01
GAB1 signalosome 13 5.19e-01 6.06e-01 0.1840 NA -0.180000 0.037600 2.62e-01 8.15e-01
Listeria monocytogenes entry into host cells 18 5.22e-01 6.09e-01 0.1560 NA -0.131000 0.084400 3.37e-01 5.35e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 13 5.29e-01 6.16e-01 0.1810 NA 0.102000 -0.150000 5.23e-01 3.50e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 5.30e-01 6.16e-01 0.1420 NA -0.130000 -0.057100 3.03e-01 6.51e-01
Neurodegenerative Diseases 21 5.30e-01 6.16e-01 0.1420 NA -0.130000 -0.057100 3.03e-01 6.51e-01
Apoptotic cleavage of cellular proteins 32 5.30e-01 6.16e-01 0.1150 NA -0.114000 -0.014800 2.64e-01 8.85e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 5.31e-01 6.17e-01 0.1630 NA 0.155000 -0.050000 2.84e-01 7.29e-01
Signaling by NTRK3 (TRKC) 14 5.38e-01 6.23e-01 0.1720 NA -0.163000 -0.053500 2.91e-01 7.29e-01
Amyloid fiber formation 53 5.38e-01 6.23e-01 0.0884 NA 0.012600 0.087500 8.74e-01 2.71e-01
Oncogene Induced Senescence 34 5.38e-01 6.23e-01 0.1100 NA -0.042500 -0.102000 6.68e-01 3.05e-01
Glycogen metabolism 25 5.38e-01 6.23e-01 0.1280 NA -0.078200 -0.102000 4.99e-01 3.79e-01
Regulation of localization of FOXO transcription factors 12 5.39e-01 6.23e-01 0.1860 NA -0.083800 0.166000 6.15e-01 3.20e-01
DCC mediated attractive signaling 13 5.42e-01 6.26e-01 0.1780 NA -0.052700 0.170000 7.42e-01 2.90e-01
E3 ubiquitin ligases ubiquitinate target proteins 51 5.46e-01 6.30e-01 0.0889 NA -0.058500 -0.066900 4.70e-01 4.08e-01
Plasma lipoprotein assembly 17 5.49e-01 6.33e-01 0.1530 NA -0.005610 -0.153000 9.68e-01 2.74e-01
DNA methylation 19 5.51e-01 6.35e-01 0.1440 NA 0.078200 0.121000 5.55e-01 3.60e-01
Transport of vitamins, nucleosides, and related molecules 33 5.53e-01 6.36e-01 0.1090 NA 0.106000 0.028800 2.94e-01 7.75e-01
NRIF signals cell death from the nucleus 15 5.53e-01 6.36e-01 0.1630 NA -0.155000 0.049600 2.99e-01 7.39e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 5.57e-01 6.40e-01 0.1610 NA -0.001460 0.161000 9.92e-01 2.79e-01
Apoptotic factor-mediated response 16 5.66e-01 6.49e-01 0.1540 NA -0.054700 0.144000 7.05e-01 3.17e-01
PECAM1 interactions 10 5.69e-01 6.53e-01 0.1940 NA -0.015900 0.193000 9.31e-01 2.90e-01
Regulation of RUNX1 Expression and Activity 18 5.70e-01 6.53e-01 0.1440 NA -0.108000 -0.095200 4.27e-01 4.85e-01
Activation of Matrix Metalloproteinases 16 5.72e-01 6.55e-01 0.1520 NA 0.066900 0.137000 6.43e-01 3.44e-01
Formation of the Early Elongation Complex 33 5.79e-01 6.62e-01 0.1050 NA -0.103000 -0.019500 3.05e-01 8.46e-01
Formation of the HIV-1 Early Elongation Complex 33 5.79e-01 6.62e-01 0.1050 NA -0.103000 -0.019500 3.05e-01 8.46e-01
VLDLR internalisation and degradation 12 5.80e-01 6.62e-01 0.1740 NA -0.166000 0.051800 3.18e-01 7.56e-01
G beta:gamma signalling through CDC42 11 5.82e-01 6.64e-01 0.1810 NA -0.045900 0.176000 7.92e-01 3.13e-01
Response to elevated platelet cytosolic Ca2+ 107 5.90e-01 6.72e-01 0.0576 NA -0.007750 0.057100 8.90e-01 3.08e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 47 5.90e-01 6.72e-01 0.0868 NA -0.079200 0.035400 3.48e-01 6.75e-01
RNA Polymerase I Promoter Escape 46 5.91e-01 6.73e-01 0.0873 NA -0.012300 -0.086500 8.85e-01 3.11e-01
Vitamin D (calciferol) metabolism 10 5.93e-01 6.73e-01 0.1870 NA -0.040000 0.183000 8.27e-01 3.17e-01
Interleukin-6 family signaling 19 5.94e-01 6.74e-01 0.1350 NA -0.116000 -0.069200 3.82e-01 6.01e-01
TRAF6 mediated IRF7 activation 14 5.96e-01 6.76e-01 0.1570 NA -0.141000 -0.068200 3.60e-01 6.59e-01
Zinc transporters 14 5.99e-01 6.79e-01 0.1570 NA -0.152000 0.038800 3.26e-01 8.01e-01
TNFR1-induced proapoptotic signaling 12 6.01e-01 6.80e-01 0.1680 NA -0.003530 -0.168000 9.83e-01 3.13e-01
Growth hormone receptor signaling 20 6.06e-01 6.86e-01 0.1300 NA 0.098800 -0.084000 4.44e-01 5.16e-01
Translesion synthesis by POLK 17 6.09e-01 6.89e-01 0.1390 NA 0.057300 0.127000 6.83e-01 3.65e-01
G beta:gamma signalling through PI3Kgamma 14 6.13e-01 6.92e-01 0.1530 NA -0.143000 -0.053000 3.54e-01 7.32e-01
RNA Polymerase I Transcription Termination 31 6.14e-01 6.93e-01 0.1030 NA 0.011000 -0.102000 9.16e-01 3.26e-01
MASTL Facilitates Mitotic Progression 10 6.18e-01 6.96e-01 0.1790 NA -0.053400 -0.171000 7.70e-01 3.50e-01
Translesion synthesis by POLI 17 6.20e-01 6.98e-01 0.1370 NA 0.071700 0.116000 6.09e-01 4.07e-01
Interconversion of nucleotide di- and triphosphates 26 6.21e-01 6.98e-01 0.1110 NA 0.032100 -0.106000 7.77e-01 3.49e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 6.25e-01 7.02e-01 0.1770 NA -0.016500 -0.176000 9.28e-01 3.34e-01
Detoxification of Reactive Oxygen Species 27 6.25e-01 7.02e-01 0.1080 NA -0.066200 -0.084900 5.52e-01 4.45e-01
Olfactory Signaling Pathway 11 6.34e-01 7.12e-01 0.1660 NA 0.092400 0.138000 5.96e-01 4.29e-01
Translesion Synthesis by POLH 19 6.40e-01 7.18e-01 0.1250 NA 0.075200 0.099700 5.71e-01 4.52e-01
Signaling by Hippo 20 6.42e-01 7.18e-01 0.1220 NA -0.118000 -0.027800 3.60e-01 8.30e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 6.42e-01 7.18e-01 0.1030 NA -0.091200 -0.047000 4.04e-01 6.67e-01
Negative regulators of DDX58/IFIH1 signaling 33 6.42e-01 7.18e-01 0.0949 NA -0.044700 0.083700 6.57e-01 4.05e-01
Negative epigenetic regulation of rRNA expression 64 6.43e-01 7.18e-01 0.0679 NA -0.067300 -0.008870 3.52e-01 9.02e-01
Surfactant metabolism 12 6.43e-01 7.18e-01 0.1570 NA -0.101000 0.120000 5.44e-01 4.71e-01
Apoptotic execution phase 43 6.48e-01 7.23e-01 0.0819 NA -0.065600 -0.049000 4.57e-01 5.79e-01
NoRC negatively regulates rRNA expression 61 6.52e-01 7.27e-01 0.0686 NA -0.064400 0.023600 3.84e-01 7.50e-01
Dual incision in TC-NER 65 6.54e-01 7.29e-01 0.0660 NA -0.019000 -0.063200 7.92e-01 3.78e-01
Transcriptional Regulation by E2F6 34 6.56e-01 7.29e-01 0.0912 NA 0.011300 -0.090500 9.09e-01 3.62e-01
NOD1/2 Signaling Pathway 31 6.56e-01 7.29e-01 0.0952 NA -0.088700 -0.034400 3.93e-01 7.40e-01
Metabolism of fat-soluble vitamins 42 6.57e-01 7.29e-01 0.0816 NA 0.044400 0.068500 6.19e-01 4.43e-01
Golgi Cisternae Pericentriolar Stack Reorganization 14 6.58e-01 7.30e-01 0.1410 NA -0.057000 -0.129000 7.12e-01 4.04e-01
GRB2 events in ERBB2 signaling 12 6.60e-01 7.32e-01 0.1520 NA -0.100000 0.115000 5.48e-01 4.90e-01
VxPx cargo-targeting to cilium 18 6.61e-01 7.32e-01 0.1240 NA -0.091600 0.084000 5.01e-01 5.37e-01
Pyruvate metabolism 25 6.62e-01 7.33e-01 0.1050 NA 0.058500 0.086800 6.13e-01 4.53e-01
SIRT1 negatively regulates rRNA expression 23 6.65e-01 7.35e-01 0.1090 NA -0.025500 -0.106000 8.32e-01 3.80e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 11 6.72e-01 7.43e-01 0.1550 NA -0.053800 0.146000 7.57e-01 4.02e-01
Inflammasomes 17 6.73e-01 7.43e-01 0.1250 NA -0.002260 0.125000 9.87e-01 3.73e-01
Senescence-Associated Secretory Phenotype (SASP) 62 6.76e-01 7.46e-01 0.0649 NA -0.010700 -0.064100 8.84e-01 3.83e-01
Apoptosis induced DNA fragmentation 10 6.80e-01 7.50e-01 0.1610 NA 0.141000 -0.076500 4.39e-01 6.76e-01
Signaling by NODAL 14 6.85e-01 7.54e-01 0.1340 NA -0.092500 -0.097000 5.49e-01 5.30e-01
Regulation of FOXO transcriptional activity by acetylation 10 6.87e-01 7.56e-01 0.1580 NA -0.122000 -0.100000 5.06e-01 5.82e-01
Caspase activation via extrinsic apoptotic signalling pathway 22 6.94e-01 7.62e-01 0.1050 NA -0.043500 -0.095700 7.24e-01 4.37e-01
Gluconeogenesis 30 6.94e-01 7.62e-01 0.0900 NA 0.017400 0.088300 8.69e-01 4.02e-01
Interleukin-20 family signaling 15 7.02e-01 7.71e-01 0.1250 NA 0.125000 0.002050 4.01e-01 9.89e-01
Integrin alphaIIb beta3 signaling 24 7.04e-01 7.71e-01 0.0989 NA -0.097900 0.013800 4.06e-01 9.07e-01
Integrin signaling 24 7.04e-01 7.71e-01 0.0989 NA -0.097900 0.013800 4.06e-01 9.07e-01
Caspase-mediated cleavage of cytoskeletal proteins 11 7.08e-01 7.75e-01 0.1450 NA 0.013800 0.144000 9.37e-01 4.09e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 10 7.11e-01 7.78e-01 0.1510 NA 0.147000 0.031800 4.20e-01 8.62e-01
Collagen degradation 23 7.13e-01 7.79e-01 0.0990 NA -0.011200 -0.098300 9.26e-01 4.14e-01
Triglyceride metabolism 23 7.20e-01 7.86e-01 0.0978 NA -0.028200 0.093600 8.15e-01 4.37e-01
Cytochrome c-mediated apoptotic response 13 7.20e-01 7.86e-01 0.1300 NA -0.099000 0.084400 5.37e-01 5.98e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 11 7.21e-01 7.86e-01 0.1410 NA 0.049900 0.131000 7.74e-01 4.50e-01
Interferon Signaling 156 7.23e-01 7.87e-01 0.0374 NA 0.035800 0.010800 4.41e-01 8.16e-01
Metalloprotease DUBs 22 7.28e-01 7.91e-01 0.0982 NA 0.021000 -0.096000 8.65e-01 4.36e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 15 7.29e-01 7.91e-01 0.1190 NA 0.031100 -0.115000 8.35e-01 4.43e-01
TRAF3-dependent IRF activation pathway 12 7.30e-01 7.91e-01 0.1320 NA -0.124000 0.047100 4.58e-01 7.77e-01
Interleukin-35 Signalling 11 7.31e-01 7.91e-01 0.1380 NA -0.078600 0.114000 6.52e-01 5.13e-01
Cyclin D associated events in G1 42 7.31e-01 7.91e-01 0.0708 NA -0.032000 0.063200 7.19e-01 4.79e-01
G1 Phase 42 7.31e-01 7.91e-01 0.0708 NA -0.032000 0.063200 7.19e-01 4.79e-01
Chaperonin-mediated protein folding 81 7.31e-01 7.91e-01 0.0509 NA -0.050900 0.003000 4.29e-01 9.63e-01
Regulation of MECP2 expression and activity 29 7.33e-01 7.93e-01 0.0843 NA -0.060200 -0.059000 5.75e-01 5.82e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 14 7.35e-01 7.94e-01 0.1210 NA -0.078000 -0.092300 6.13e-01 5.50e-01
Metabolism of steroid hormones 22 7.36e-01 7.94e-01 0.0962 NA 0.082700 0.049200 5.02e-01 6.90e-01
Downregulation of ERBB2 signaling 24 7.37e-01 7.95e-01 0.0919 NA -0.086100 -0.032400 4.66e-01 7.84e-01
Metal ion SLC transporters 22 7.38e-01 7.95e-01 0.0963 NA -0.084200 0.046800 4.94e-01 7.04e-01
p130Cas linkage to MAPK signaling for integrins 13 7.42e-01 7.99e-01 0.1240 NA 0.019700 -0.122000 9.02e-01 4.45e-01
Josephin domain DUBs 11 7.50e-01 8.07e-01 0.1320 NA -0.017300 -0.131000 9.21e-01 4.53e-01
Laminin interactions 21 7.59e-01 8.15e-01 0.0937 NA 0.000923 0.093700 9.94e-01 4.57e-01
Interleukin-15 signaling 14 7.59e-01 8.15e-01 0.1150 NA -0.071600 0.090000 6.43e-01 5.60e-01
DNA Damage Bypass 47 7.61e-01 8.17e-01 0.0623 NA 0.006200 0.061900 9.41e-01 4.63e-01
eNOS activation 11 7.64e-01 8.19e-01 0.1280 NA 0.071000 -0.107000 6.84e-01 5.40e-01
Translesion synthesis by REV1 16 7.67e-01 8.21e-01 0.1050 NA 0.029300 0.101000 8.39e-01 4.85e-01
RUNX3 regulates NOTCH signaling 14 7.69e-01 8.23e-01 0.1120 NA -0.111000 0.012100 4.71e-01 9.38e-01
Citric acid cycle (TCA cycle) 21 7.71e-01 8.25e-01 0.0908 NA -0.029900 -0.085700 8.12e-01 4.97e-01
Platelet degranulation 102 7.73e-01 8.26e-01 0.0412 NA -0.013400 0.038900 8.15e-01 4.97e-01
DNA Damage/Telomere Stress Induced Senescence 43 7.79e-01 8.31e-01 0.0624 NA 0.007490 -0.061900 9.32e-01 4.82e-01
Heme biosynthesis 10 7.79e-01 8.31e-01 0.1290 NA 0.045200 0.121000 8.05e-01 5.09e-01
Formation of tubulin folding intermediates by CCT/TriC 23 7.81e-01 8.32e-01 0.0847 NA 0.005680 0.084500 9.62e-01 4.83e-01
Platelet Aggregation (Plug Formation) 28 7.84e-01 8.35e-01 0.0759 NA -0.060100 -0.046400 5.82e-01 6.71e-01
Xenobiotics 15 7.85e-01 8.36e-01 0.1030 NA 0.067900 0.078000 6.49e-01 6.01e-01
STING mediated induction of host immune responses 12 7.88e-01 8.37e-01 0.1150 NA -0.028800 -0.111000 8.63e-01 5.04e-01
Interleukin-6 signaling 10 7.91e-01 8.41e-01 0.1250 NA -0.125000 0.006050 4.94e-01 9.74e-01
G1/S Transition 127 7.94e-01 8.42e-01 0.0350 NA 0.012800 -0.032600 8.04e-01 5.26e-01
Prefoldin mediated transfer of substrate to CCT/TriC 27 7.97e-01 8.45e-01 0.0750 NA -0.071100 0.023800 5.22e-01 8.31e-01
Condensation of Prophase Chromosomes 27 8.00e-01 8.47e-01 0.0743 NA -0.003350 -0.074200 9.76e-01 5.04e-01
Regulation of IFNG signaling 13 8.01e-01 8.48e-01 0.1070 NA 0.092200 -0.054500 5.65e-01 7.34e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 8.05e-01 8.52e-01 0.1050 NA 0.080900 0.067200 6.13e-01 6.75e-01
Triglyceride biosynthesis 11 8.13e-01 8.59e-01 0.1120 NA 0.097000 0.055900 5.77e-01 7.48e-01
IL-6-type cytokine receptor ligand interactions 13 8.13e-01 8.59e-01 0.1030 NA -0.092100 -0.045600 5.65e-01 7.76e-01
Synthesis of PE 11 8.15e-01 8.60e-01 0.1110 NA -0.100000 -0.047900 5.65e-01 7.83e-01
Diseases associated with glycosylation precursor biosynthesis 18 8.22e-01 8.64e-01 0.0854 NA -0.036700 0.077200 7.88e-01 5.71e-01
Formation of apoptosome 11 8.24e-01 8.64e-01 0.1080 NA -0.104000 0.031500 5.51e-01 8.56e-01
Regulation of the apoptosome activity 11 8.24e-01 8.64e-01 0.1080 NA -0.104000 0.031500 5.51e-01 8.56e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 19 8.25e-01 8.64e-01 0.0822 NA -0.077800 -0.026500 5.57e-01 8.41e-01
SLBP independent Processing of Histone Pre-mRNAs 10 8.27e-01 8.64e-01 0.1130 NA 0.082300 -0.077100 6.52e-01 6.73e-01
HIV Transcription Initiation 45 8.28e-01 8.64e-01 0.0530 NA -0.020400 0.049000 8.13e-01 5.70e-01
RNA Polymerase II HIV Promoter Escape 45 8.28e-01 8.64e-01 0.0530 NA -0.020400 0.049000 8.13e-01 5.70e-01
RNA Polymerase II Promoter Escape 45 8.28e-01 8.64e-01 0.0530 NA -0.020400 0.049000 8.13e-01 5.70e-01
RNA Polymerase II Transcription Initiation 45 8.28e-01 8.64e-01 0.0530 NA -0.020400 0.049000 8.13e-01 5.70e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 8.28e-01 8.64e-01 0.0530 NA -0.020400 0.049000 8.13e-01 5.70e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 8.28e-01 8.64e-01 0.0530 NA -0.020400 0.049000 8.13e-01 5.70e-01
Cleavage of the damaged purine 24 8.28e-01 8.64e-01 0.0724 NA 0.072200 -0.005490 5.41e-01 9.63e-01
Depurination 24 8.28e-01 8.64e-01 0.0724 NA 0.072200 -0.005490 5.41e-01 9.63e-01
Recognition and association of DNA glycosylase with site containing an affected purine 24 8.28e-01 8.64e-01 0.0724 NA 0.072200 -0.005490 5.41e-01 9.63e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 8.34e-01 8.69e-01 0.0845 NA 0.084200 -0.006660 5.48e-01 9.62e-01
YAP1- and WWTR1 (TAZ)-stimulated gene expression 14 8.36e-01 8.70e-01 0.0923 NA -0.030700 -0.087000 8.42e-01 5.73e-01
Signaling by Retinoic Acid 32 8.45e-01 8.79e-01 0.0594 NA 0.053900 -0.024800 5.98e-01 8.08e-01
Mitotic G1-G1/S phases 144 8.47e-01 8.81e-01 0.0278 NA 0.027600 -0.003730 5.68e-01 9.38e-01
Protein folding 87 8.57e-01 8.90e-01 0.0344 NA -0.033800 -0.006590 5.86e-01 9.15e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 8.64e-01 8.96e-01 0.0602 NA -0.049100 0.034900 6.59e-01 7.53e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 8.64e-01 8.96e-01 0.0602 NA -0.049100 0.034900 6.59e-01 7.53e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 11 8.65e-01 8.96e-01 0.0940 NA -0.033200 0.088000 8.49e-01 6.13e-01
Signaling by BMP 18 8.69e-01 9.00e-01 0.0723 NA 0.018200 -0.069900 8.94e-01 6.07e-01
PRC2 methylates histones and DNA 28 8.76e-01 9.07e-01 0.0561 NA -0.006450 0.055800 9.53e-01 6.10e-01
Regulation of TP53 Activity through Association with Co-factors 12 8.78e-01 9.07e-01 0.0854 NA -0.066000 0.054100 6.92e-01 7.46e-01
Recognition of DNA damage by PCNA-containing replication complex 30 8.87e-01 9.16e-01 0.0515 NA 0.035000 0.037800 7.40e-01 7.20e-01
The NLRP3 inflammasome 13 8.87e-01 9.16e-01 0.0781 NA 0.055700 0.054700 7.28e-01 7.33e-01
Pre-NOTCH Transcription and Translation 48 8.90e-01 9.18e-01 0.0402 NA -0.040200 -0.001450 6.30e-01 9.86e-01
PI3K events in ERBB2 signaling 12 8.92e-01 9.18e-01 0.0797 NA -0.053100 -0.059400 7.50e-01 7.22e-01
Notch-HLH transcription pathway 27 8.93e-01 9.18e-01 0.0530 NA 0.000537 -0.053000 9.96e-01 6.33e-01
Nuclear signaling by ERBB4 19 8.93e-01 9.18e-01 0.0629 NA -0.041400 -0.047300 7.55e-01 7.21e-01
Glucose metabolism 84 8.95e-01 9.20e-01 0.0297 NA -0.029700 -0.000616 6.38e-01 9.92e-01
Metabolism of lipids 595 8.98e-01 9.22e-01 0.0112 NA -0.011000 -0.001930 6.48e-01 9.36e-01
Pentose phosphate pathway 13 9.01e-01 9.24e-01 0.0731 NA 0.069500 0.022400 6.64e-01 8.89e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 48 9.02e-01 9.24e-01 0.0380 NA 0.037100 -0.008150 6.56e-01 9.22e-01
Downregulation of ERBB2:ERBB3 signaling 13 9.03e-01 9.25e-01 0.0723 NA -0.045100 -0.056500 7.78e-01 7.24e-01
AKT phosphorylates targets in the nucleus 10 9.06e-01 9.27e-01 0.0815 NA -0.045400 0.067700 8.04e-01 7.11e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 9.09e-01 9.30e-01 0.0364 NA 0.007630 -0.035600 9.27e-01 6.69e-01
ERBB2 Regulates Cell Motility 11 9.11e-01 9.31e-01 0.0749 NA -0.074200 -0.010200 6.70e-01 9.53e-01
Class I peroxisomal membrane protein import 18 9.17e-01 9.37e-01 0.0566 NA 0.009000 -0.055800 9.47e-01 6.82e-01
mRNA Capping 29 9.22e-01 9.41e-01 0.0433 NA -0.025300 0.035100 8.14e-01 7.43e-01
Metabolism of nitric oxide: eNOS activation and regulation 15 9.31e-01 9.49e-01 0.0563 NA -0.055500 0.009550 7.10e-01 9.49e-01
DNA Replication Pre-Initiation 81 9.35e-01 9.52e-01 0.0236 NA 0.023100 -0.004890 7.19e-01 9.39e-01
TNFs bind their physiological receptors 11 9.40e-01 9.57e-01 0.0611 NA 0.059100 -0.015600 7.34e-01 9.29e-01
IRF3-mediated induction of type I IFN 10 9.42e-01 9.58e-01 0.0628 NA -0.062000 -0.010400 7.34e-01 9.55e-01
Transcription of E2F targets under negative control by DREAM complex 19 9.50e-01 9.65e-01 0.0424 NA 0.042400 0.000454 7.49e-01 9.97e-01
Depolymerisation of the Nuclear Lamina 15 9.52e-01 9.67e-01 0.0464 NA -0.028200 -0.036900 8.50e-01 8.05e-01
Amino acid synthesis and interconversion (transamination) 27 9.56e-01 9.69e-01 0.0336 NA -0.031800 0.010900 7.75e-01 9.22e-01
NOTCH4 Intracellular Domain Regulates Transcription 18 9.58e-01 9.71e-01 0.0397 NA 0.034700 0.019300 7.99e-01 8.87e-01
ADP signalling through P2Y purinoceptor 1 13 9.63e-01 9.75e-01 0.0443 NA -0.032400 0.030200 8.39e-01 8.50e-01
RNA Polymerase I Promoter Opening 18 9.64e-01 9.76e-01 0.0370 NA -0.030500 0.021000 8.23e-01 8.77e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 23 9.66e-01 9.77e-01 0.0319 NA 0.024600 -0.020300 8.39e-01 8.66e-01
Signaling by PDGF 44 9.69e-01 9.79e-01 0.0220 NA 0.012200 -0.018300 8.89e-01 8.34e-01
Packaging Of Telomere Ends 20 9.72e-01 9.81e-01 0.0309 NA -0.010700 0.029000 9.34e-01 8.23e-01
Meiotic synapsis 42 9.75e-01 9.84e-01 0.0201 NA -0.018200 0.008390 8.38e-01 9.25e-01
Diseases associated with the TLR signaling cascade 19 9.79e-01 9.86e-01 0.0275 NA 0.024200 -0.013100 8.55e-01 9.21e-01
Diseases of Immune System 19 9.79e-01 9.86e-01 0.0275 NA 0.024200 -0.013100 8.55e-01 9.21e-01
Prostacyclin signalling through prostacyclin receptor 10 9.83e-01 9.89e-01 0.0343 NA -0.032100 0.012100 8.61e-01 9.47e-01
Cytosolic iron-sulfur cluster assembly 11 9.83e-01 9.89e-01 0.0322 NA 0.025200 -0.020000 8.85e-01 9.09e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 30 9.85e-01 9.89e-01 0.0187 NA -0.013300 0.013100 9.00e-01 9.01e-01
Interleukin-27 signaling 10 9.86e-01 9.90e-01 0.0302 NA -0.026500 0.014500 8.85e-01 9.37e-01
Regulation of innate immune responses to cytosolic DNA 13 9.88e-01 9.91e-01 0.0251 NA -0.015000 0.020100 9.26e-01 9.00e-01
Nucleobase catabolism 29 9.90e-01 9.92e-01 0.0155 NA 0.009960 -0.011800 9.26e-01 9.12e-01
Aflatoxin activation and detoxification 16 9.96e-01 9.97e-01 0.0131 NA -0.010100 0.008420 9.44e-01 9.53e-01
Glycogen breakdown (glycogenolysis) 15 9.97e-01 9.97e-01 0.0113 NA -0.010500 0.004190 9.44e-01 9.78e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 9.97e-01 9.97e-01 0.0127 NA -0.003180 -0.012300 9.85e-01 9.44e-01


Detailed Gene set reports

Metabolism of RNA

metric value
setSize 676
pMANOVA 2.86e-58
p.adjustMANOVA 3.61e-55
s.dist 0.367
confESp NA
s.rna_LGvHG -0.17
s.rna_HGvHGV -0.325
p.rna_LGvHG 6.05e-14
p.rna_HGvHGV 7.01e-47




Gene rna_LGvHG rna_HGvHGV
SRSF4 -7312 -7491
XPOT -6856 -7442
ALYREF -7253 -6934
DDX5 -7024 -6523
POM121 -6619 -6903
EIF4B -6017 -7498
EXOSC6 -6618 -6747
HNRNPA2B1 -6801 -6562
CASC3 -6360 -6976
SRRT -6638 -6682
SRRM2 -6278 -7049
RAN -6562 -6672
EIF4G1 -6162 -7098
SNRPA -7008 -6083
UTP14A -5810 -7129
TNPO1 -6654 -6157
HNRNPM -7192 -5669
UPF3A -6321 -6411
CSNK1D -6047 -6638
CNOT3 -6808 -5862

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
A1CF 6969.0 -1650.0
AAAS 3304.0 -6791.0
ACTB -5090.0 3901.0
ADAR -3837.0 -5775.0
ADARB1 1296.0 5027.0
ADAT1 740.0 2220.0
ADAT2 7233.0 -5422.0
ADAT3 -7426.0 1329.0
AKT1 -3317.0 -4920.0
ALKBH8 5447.0 430.0
ALYREF -7253.0 -6934.0
ANP32A 8635.0 -7480.0
APOBEC3B 1373.0 3981.5
APOBEC3C 8448.0 -6770.0
AQR -2579.0 -543.0
BCAS2 -775.0 -72.0
BMS1 -4822.0 -1690.0
BOP1 -2079.0 -2856.0
BUD31 -5689.0 4899.0
BYSL -2390.0 -4949.0
C1D 1937.0 2500.0
C2orf49 -3113.0 5185.0
CASC3 -6360.0 -6976.0
CCAR1 2999.0 -6944.0
CCNH 6007.0 1132.0
CD2BP2 -4151.0 758.0
CDC40 -2272.0 2503.0
CDC5L -2427.0 -5167.0
CDK7 -2197.0 -3227.0
CDKAL1 819.0 -5747.0
CHERP -3874.0 -6191.0
CHTOP 3488.0 -6995.0
CLNS1A 7453.0 -4467.0
CLP1 -5836.0 4588.0
CNOT1 -2159.0 -3454.0
CNOT10 -7459.0 -1214.0
CNOT11 4059.0 -4543.0
CNOT2 370.0 -7396.0
CNOT3 -6808.0 -5862.0
CNOT4 -5112.0 -1912.0
CNOT6 948.0 -2190.0
CNOT6L 6895.0 -880.0
CNOT7 -2754.0 -4126.0
CNOT8 -6365.0 6614.0
CPSF1 -4005.0 -5362.0
CPSF2 7234.0 -6822.0
CPSF3 6896.0 -1472.0
CPSF4 1809.0 2639.0
CPSF7 -2118.0 -7659.0
CRNKL1 -2541.0 -2203.0
CSNK1D -6047.0 -6638.0
CSNK1E 3315.0 2456.0
CSTF1 1636.0 -2884.0
CSTF2 1495.0 -2237.0
CSTF2T 8100.0 -702.0
CSTF3 2463.0 3081.0
CTNNBL1 3259.0 4702.0
CTU1 -5159.0 -5345.0
CTU2 -2434.0 -563.0
CWC15 -926.0 -5339.0
CWC22 -4074.0 -4930.0
CWC25 -3670.0 -2008.0
CWC27 -4440.0 -2358.0
DCAF13 4844.0 -1935.0
DCP1A 54.0 -5358.0
DCP1B 3384.0 -5189.0
DCP2 -5310.0 2260.0
DCPS 6341.0 -7636.0
DDX1 -4382.0 -4724.0
DDX20 -4798.0 -2254.0
DDX21 -111.0 -4414.0
DDX23 -3685.0 -4351.0
DDX39A -7343.0 -3925.0
DDX39B 2645.0 -6290.0
DDX42 6345.0 -5712.0
DDX46 -918.0 -3282.0
DDX47 3960.0 -3582.0
DDX49 -7270.0 1638.0
DDX5 -7024.0 -6523.0
DDX52 -4886.0 -1242.0
DDX6 -896.0 -7561.0
DHX15 -1512.0 -4636.0
DHX16 -3597.0 3278.0
DHX37 -5482.0 -7023.0
DHX38 -6640.0 -1536.0
DHX9 -4126.0 -6141.0
DIEXF -3206.0 -5671.0
DIMT1 2158.0 -4456.0
DIS3 -1501.0 2302.0
DKC1 -1036.0 -7546.0
DNAJC8 1875.0 2177.0
DUS2 4539.0 -2048.0
EBNA1BP2 -3618.0 917.0
EDC3 -3324.0 -189.0
EDC4 -5106.0 1954.0
EFTUD2 -2755.0 -2246.0
EIF4A1 241.0 -4341.0
EIF4A2 5877.0 -5660.0
EIF4A3 1298.0 3126.0
EIF4B -6017.0 -7498.0
EIF4E 2829.0 494.0
EIF4G1 -6162.0 -7098.0
ELAC2 -5422.0 -5441.0
ELAVL1 -3143.0 -412.0
EMG1 7798.0 -6511.0
ENPP2 8519.0 7183.0
EPRS 579.0 -5103.0
ERCC2 4.0 2846.0
ERCC3 -1681.0 1000.0
ERI1 -2096.0 5585.0
ETF1 -7375.0 1850.0
EXOSC1 3614.0 -3532.0
EXOSC10 -142.0 -6920.0
EXOSC2 3961.0 313.0
EXOSC3 -2961.0 1286.0
EXOSC4 2801.0 -4513.0
EXOSC5 -4907.0 -6416.0
EXOSC6 -6618.0 -6747.0
EXOSC7 5542.0 -5377.0
EXOSC8 412.0 -7068.0
EXOSC9 3277.0 1337.0
FAM98B 6678.0 -3450.0
FAU -5465.0 -1439.0
FBL -1464.0 -869.0
FCF1 -2147.0 -2175.0
FIP1L1 -6400.0 -4052.0
FTSJ1 -6170.0 -503.0
FTSJ3 2188.0 -5738.0
FUS 8631.0 -5688.0
FYTTD1 -6194.0 5437.0
GAR1 -2893.0 -6214.0
GCFC2 2497.0 -4268.0
GEMIN2 7639.0 3441.0
GEMIN4 4238.0 -6277.0
GEMIN5 -1847.0 -2699.0
GEMIN6 6608.0 2985.0
GEMIN7 5352.0 -906.0
GEMIN8 797.0 -2233.0
GLE1 2414.0 -5346.0
GNL3 -5645.0 -4043.0
GPKOW 3818.0 -3895.0
GPRC5A -7233.0 -1770.0
GSPT1 -7249.0 3458.0
GTF2F1 -3019.0 -1117.0
GTF2F2 4860.0 1441.0
GTF2H1 -5952.0 -2289.0
GTF2H2 4526.0 2082.0
GTF2H3 6865.0 -3842.0
GTF2H4 4580.0 466.0
GTF2H5 5038.5 -5279.0
GTPBP3 3543.0 4218.0
H19 8155.0 -621.0
HBS1L 2004.0 1216.0
HEATR1 -1439.0 -4988.0
HNRNPA0 5689.0 -5592.0
HNRNPA1 808.0 -5324.0
HNRNPA2B1 -6801.0 -6562.0
HNRNPA3 -1817.0 -6492.0
HNRNPC 778.0 -4822.0
HNRNPD 3122.0 -7219.0
HNRNPF -7059.0 -4014.0
HNRNPH1 1765.0 -6192.0
HNRNPH2 2916.0 -3602.0
HNRNPK -2841.0 -6969.0
HNRNPL -3565.0 -7077.0
HNRNPM -7192.0 -5669.0
HNRNPR 1761.0 -6740.0
HNRNPU -3829.0 -6230.0
HNRNPUL1 -984.0 -7329.0
HSD17B10 -4774.0 5391.0
HSPA1A 7380.0 5234.0
HSPA8 -4920.0 -6728.0
HSPB1 -3333.0 4757.0
IGF2 8755.0 -5186.0
IGF2BP1 -4722.0 -7794.0
IGF2BP2 -2108.0 -7355.0
IGF2BP3 -1283.0 -6440.0
IMP3 -4746.0 2697.0
IMP4 -5115.0 -5006.5
ISG20L2 -3740.0 6098.0
ISY1 -4820.0 -2333.0
KHSRP -932.0 -5350.0
KIAA0391 -4444.0 -2733.0
KRR1 1404.0 -3257.0
LAGE3 3069.0 -5237.0
LAS1L 8194.0 -3709.0
LCMT2 4799.0 -3723.0
LSM1 -4195.0 -1462.0
LSM10 -1677.0 1816.0
LSM11 6459.0 -4844.0
LSM2 1512.0 -4000.0
LSM3 5371.0 -817.0
LSM4 8090.0 3333.0
LSM5 5741.0 -1754.0
LSM6 5582.0 -4311.0
LSM7 -3871.0 -6159.0
LTV1 -5754.0 -3627.0
MAGOH -1096.0 -1098.0
MAGOHB 6510.0 -6663.0
MAPK11 882.0 8360.0
MAPK14 2288.0 2138.0
MAPKAPK2 -6924.0 5257.0
METTL1 2231.0 -6745.0
METTL14 4920.0 378.0
METTL3 4153.0 -4335.0
MNAT1 420.0 1550.0
MPHOSPH10 -7389.0 -3593.0
MPHOSPH6 6361.0 876.0
MRM1 4828.0 -6418.0
MT-ATP6 6587.0 -3233.0
MT-ATP8 7439.0 -3191.0
MT-CO1 7382.0 -2264.0
MT-CO2 1065.0 -1198.0
MT-CO3 8645.0 -1168.0
MT-CYB 8161.0 -3327.0
MT-ND1 -4982.0 -2594.0
MT-ND2 -1328.0 -3781.0
MT-ND3 3754.0 -209.0
MT-ND4 3208.0 -2413.0
MT-ND4L 1757.0 -1711.0
MT-ND5 3683.0 -3785.0
MT-ND6 5338.0 -4641.0
MTO1 -5494.0 -6301.0
MT-RNR1 711.0 1933.0
MT-RNR2 8019.0 3799.0
MT-TC 8399.0 2975.0
MT-TD -7360.0 -139.0
MT-TE 6172.0 -1736.0
MT-TF -7368.0 2105.0
MT-TG 3547.0 -819.0
MT-TH 1319.0 -2462.0
MT-TI -7541.0 -1150.0
MT-TL1 -7531.0 -2842.0
MT-TL2 1538.0 -374.0
MT-TM -7383.0 2817.0
MT-TP 4494.0 216.0
MT-TT 3440.0 429.0
MT-TV -7131.0 -358.0
MT-TW 2032.0 -731.0
MT-TY 8564.0 2983.0
MYC 2009.0 -5587.0
NAT10 3697.0 -6536.0
NCBP1 -1858.0 1533.0
NCBP2 7854.0 -262.0
NCL -1691.0 -6949.0
NDC1 -1208.0 -2073.0
NHP2 -2850.0 -2568.0
NIP7 -1876.0 -4614.0
NOB1 -3671.0 -6762.0
NOC4L -1762.0 -416.0
NOL11 4442.0 -4884.0
NOL12 -3884.0 -5985.0
NOL6 2264.0 535.0
NOL9 -5107.0 -4710.0
NOP10 -5228.0 1281.0
NOP14 -5380.0 -6917.0
NOP2 -3929.0 -5946.0
NOP56 -1126.0 -5490.0
NOP58 6235.0 -4117.0
NSUN2 -5970.0 -1465.0
NSUN4 4169.0 -6385.0
NSUN6 2607.0 3909.0
NT5C3B -3902.0 -1313.0
NUDT21 2349.0 -2007.0
NUP107 6965.0 -4327.0
NUP133 1406.0 1305.0
NUP153 2805.0 1278.0
NUP155 5259.0 -95.0
NUP160 -271.0 -1749.0
NUP188 -5044.0 -3795.0
NUP205 -5514.0 -2051.0
NUP210 7824.0 -4030.0
NUP214 -1509.0 -4585.0
NUP35 6880.0 -2911.0
NUP37 8176.0 -4271.0
NUP43 2778.0 1270.0
NUP50 -4694.0 -4478.0
NUP54 3508.0 -1767.0
NUP62 -73.0 -4951.0
NUP85 4624.0 1161.0
NUP88 -4829.0 -5548.0
NUP93 6534.0 2994.0
NUP98 -3617.0 2992.0
NUPL2 -3453.0 1853.0
NXF1 -6740.0 -5380.5
NXT1 -1912.0 4157.0
OSGEP 37.0 -3975.0
PABPC1 -3531.0 -2220.0
PABPN1 176.0 -7478.0
PAIP1 -1353.0 -5943.0
PAN2 8409.0 -6887.0
PAN3 -807.0 -3477.0
PAPOLA -2921.0 467.0
PARN -4954.0 -4136.0
PATL1 -7156.0 3908.0
PCBP1 -3840.0 -7004.0
PCBP2 2617.0 -6175.0
PCF11 -5164.0 -3300.0
PDCD11 3374.0 -5557.0
PDCD7 -1056.0 -6407.0
PELP1 -2911.0 -4848.0
PES1 -3448.0 -6032.0
PHAX -6084.0 -4325.0
PHF5A -396.0 -4188.0
PLRG1 -1479.0 3658.0
PNO1 -6059.0 -1025.0
PNRC2 3816.0 3638.0
POLDIP3 1423.0 -7246.0
POLR2A 2948.0 -6306.0
POLR2B -3795.0 2880.0
POLR2C -3177.0 1582.0
POLR2D 1696.0 -2523.0
POLR2E -4282.5 3215.0
POLR2F -5560.0 4701.0
POLR2G 2153.0 1453.0
POLR2H -4010.0 -1665.0
POLR2I 4612.0 -3659.0
POLR2J -246.0 4188.0
POLR2K 6791.0 5504.0
POLR2L -5741.0 6784.0
POM121 -6619.0 -6903.0
POM121C -5801.0 -6560.0
POP1 -3175.0 3347.0
POP4 -170.0 -1742.0
POP5 2669.0 3200.0
POP7 -1587.0 4042.0
PPIE 1706.0 -4763.0
PPIH 761.0 -4017.0
PPIL1 -4515.0 -5090.0
PPIL3 5458.0 1009.0
PPIL4 2337.0 -1236.0
PPP2CA -4705.0 -1300.0
PPP2R1A -4930.0 -6343.0
PPP2R2A 6243.0 3520.0
PPWD1 3814.0 -3467.0
PQBP1 -4479.0 -5797.0
PRCC -6588.0 -3285.0
PRKCA 2635.0 4268.0
PRKCD -5969.0 5212.0
PRMT5 -1496.0 -4582.0
PRPF19 2853.0 343.0
PRPF3 -6121.0 -3150.0
PRPF31 2550.0 -5300.0
PRPF38A -1605.0 -4838.0
PRPF4 2294.0 2962.0
PRPF40A -4008.0 -2286.0
PRPF6 3930.0 -5023.0
PRPF8 -5026.0 -5652.0
PSMA1 -3927.0 -2398.0
PSMA2 15.0 1100.0
PSMA3 -2496.0 1979.0
PSMA4 -4169.0 -2695.0
PSMA5 -2402.0 558.0
PSMA6 1150.0 -3215.0
PSMA7 -849.0 -1558.0
PSMB1 1173.0 -728.0
PSMB10 -2296.0 -7082.0
PSMB2 1929.0 1160.0
PSMB3 -1875.0 -1567.0
PSMB4 -1015.0 -171.0
PSMB5 -499.0 -6359.0
PSMB6 -5085.0 -6160.0
PSMB7 -3738.0 -1108.0
PSMB8 5998.0 -6450.0
PSMB9 8274.0 7642.0
PSMC1 -2073.0 -2143.0
PSMC2 -2382.0 1413.0
PSMC3 -1326.0 -4739.5
PSMC4 -5097.0 -3313.0
PSMC5 -3886.0 -5049.0
PSMC6 -4958.0 -3262.0
PSMD1 -5546.0 4652.0
PSMD10 5116.0 -309.0
PSMD11 -258.0 -3176.0
PSMD12 4562.0 -101.0
PSMD13 -2467.0 5077.0
PSMD14 6651.0 -459.0
PSMD2 -6864.0 3474.0
PSMD3 -5826.0 236.0
PSMD4 4967.0 -4640.0
PSMD5 5607.0 -4170.0
PSMD6 -6300.0 2254.0
PSMD7 5850.0 -3019.0
PSMD8 -2768.0 537.0
PSMD9 -3221.0 368.0
PSME1 -2066.0 -2429.0
PSME2 -5564.0 1864.0
PSME3 -3725.0 -3020.5
PSME4 -6847.0 1983.0
PSMF1 -7076.0 -2659.0
PTBP1 -6440.0 -4372.0
PUF60 -3692.0 -7312.0
PUS1 4019.0 -7117.0
PUS3 4490.0 2580.0
PUS7 2372.0 -7094.0
PWP2 1329.0 397.0
QTRT1 5715.0 -7305.0
RAE1 4684.0 -5543.0
RAN -6562.0 -6672.0
RANBP2 471.0 501.0
RBM17 -2766.0 -1173.0
RBM22 -3968.0 -5137.0
RBM28 283.0 -3818.0
RBM5 6173.0 -7369.0
RBM8A 956.0 -5273.0
RBMX -5407.0 -7349.0
RCL1 -1093.0 -1771.0
RIOK1 2469.0 530.0
RIOK2 -4274.0 -1347.0
RIOK3 -6729.0 5636.0
RNGTT -4575.0 6319.0
RNMT 4752.0 -858.0
RNPC3 4829.0 -3201.0
RNPS1 -7272.0 -555.0
RNU12 -6661.0 -276.0
RPL10 -5543.0 -4999.0
RPL10A -2566.0 -3948.0
RPL11 -5172.0 -2748.0
RPL12 -1507.0 -3084.0
RPL13 -471.0 -3317.0
RPL13A -2745.0 -2677.0
RPL14 -5527.0 -2682.0
RPL15 1849.0 -2009.0
RPL17 126.0 -3940.0
RPL18 -4183.0 -1071.0
RPL18A -5301.0 -585.0
RPL19 -5609.0 -3966.0
RPL21 -4209.0 -4036.5
RPL22 5249.0 -3942.0
RPL22L1 -160.0 -6353.5
RPL23 -1370.0 -2849.0
RPL23A -3454.0 -1887.0
RPL24 -1812.0 -3491.0
RPL26 -1365.0 -146.0
RPL26L1 -3945.0 1440.0
RPL27 -2005.0 -919.0
RPL27A -4506.0 -4250.0
RPL28 -3621.0 -752.0
RPL29 -4075.0 -3272.0
RPL3 -1503.0 -3206.0
RPL30 -4142.0 -2917.0
RPL31 981.0 -1139.0
RPL32 -3393.0 -1261.0
RPL34 -2770.0 -2030.0
RPL35 -2891.0 -1554.0
RPL35A -4369.0 -1415.0
RPL36 -3549.0 -3202.0
RPL36A 5630.0 -2965.0
RPL36AL -7445.0 -2641.0
RPL37 -3457.0 -2235.0
RPL37A -2415.0 -2945.0
RPL38 -1678.0 -1496.0
RPL39 -1636.0 842.0
RPL3L -4857.0 -260.0
RPL4 -2513.0 -3939.0
RPL41 1461.0 -3751.0
RPL5 -554.0 -2231.0
RPL6 -5151.0 -4811.0
RPL7 -1319.0 -3168.0
RPL7A -2609.0 -2165.0
RPL8 -3548.0 -2560.0
RPL9 -3114.0 -4301.0
RPLP0 -4427.0 -1121.0
RPLP1 -4373.0 -3370.0
RPLP2 -2777.0 -1899.0
RPP14 107.0 -2044.0
RPP21 1993.0 -3121.0
RPP25 5023.0 7108.0
RPP30 1743.0 3043.0
RPP38 633.0 -2188.0
RPP40 2305.0 -6456.0
RPPH1 1526.0 1744.0
RPS10 112.0 -1083.0
RPS11 -5078.0 -2933.0
RPS12 -4503.0 -2114.0
RPS13 -2629.0 -2290.0
RPS14 -3593.0 -2671.0
RPS15 -4564.0 -1911.0
RPS15A -3125.0 -197.0
RPS16 -3362.0 -2103.0
RPS18 -2870.0 -2001.0
RPS19 -4961.0 -2582.0
RPS2 -3922.0 -2651.0
RPS20 -1741.0 -1314.0
RPS21 -2922.0 -743.0
RPS23 -1789.0 -1850.0
RPS24 -2865.0 -1728.0
RPS25 -124.0 -980.0
RPS26 239.0 -3326.0
RPS27 -3410.0 -2769.0
RPS27A -2775.0 -2092.0
RPS27L -3395.0 -5791.0
RPS28 -3558.0 -1760.0
RPS29 -3554.0 19.0
RPS3 -2626.0 -1940.0
RPS3A 1310.0 -2352.0
RPS4X -3384.0 -3144.0
RPS4Y1 -2083.0 -2421.0
RPS5 -5073.0 439.0
RPS6 -2847.0 -2731.0
RPS7 -5915.0 -2189.0
RPS8 -1202.0 -2865.0
RPS9 -4220.0 -3027.0
RPSA -2539.0 -2294.0
RQCD1 1021.0 -4340.0
RRP1 -5330.0 -3896.0
RRP36 -6725.0 707.0
RRP7A 1747.0 -2435.0
RRP9 -2392.0 -3624.0
RTCB -5755.0 -4588.0
SARNP -2268.0 4054.0
SART1 -4976.0 -4440.0
SEC13 -7232.0 872.0
SEH1L -4786.0 -5035.0
SENP3 440.0 1030.0
SET 1866.0 -7378.0
SF1 -4537.0 -6386.0
SF3A1 -4276.0 -5926.0
SF3A2 -3288.0 -5060.0
SF3A3 -2906.0 4938.0
SF3B1 -217.0 -1958.0
SF3B2 -1534.0 -4075.0
SF3B3 -3791.0 -6401.0
SF3B4 -2944.0 -5113.0
SF3B5 -4446.0 4623.0
SKIV2L 6496.0 2653.0
SLBP -6437.0 5526.0
SLU7 130.0 -1437.0
SMG1 -2569.0 -131.0
SMG5 -557.0 -7060.0
SMG6 -1160.0 -5907.0
SMG7 -2472.0 -2619.0
SMG8 -3654.0 -5893.0
SMG9 3963.0 -7282.0
SMN1 2507.0 311.0
SMNDC1 -969.0 -5327.0
SNORD3A -335.0 819.0
SNRNP200 -1652.0 -3577.0
SNRNP25 372.0 -1540.0
SNRNP27 1234.0 1808.0
SNRNP35 8393.0 -4400.0
SNRNP40 -5278.0 -3214.0
SNRNP48 -6731.0 6341.0
SNRNP70 -3481.0 -5255.0
SNRPA -7008.0 -6083.0
SNRPA1 -7218.0 812.0
SNRPB -1673.0 -3808.0
SNRPB2 907.0 -3411.0
SNRPC 824.0 -4410.0
SNRPD1 6304.0 -3405.0
SNRPD2 -3359.0 2762.0
SNRPD3 -6109.0 2670.0
SNRPE 4103.0 -3791.0
SNRPF 2390.0 -4080.0
SNRPG 864.0 2918.0
SNRPN 4924.0 1207.0
SNUPN -1622.0 -6331.0
SNW1 -5749.0 -4537.0
SRRM1 236.0 -5520.0
SRRM2 -6278.0 -7049.0
SRRT -6638.0 -6682.0
SRSF1 -5869.0 -6395.0
SRSF10 -4936.0 -3062.0
SRSF11 -1542.0 -4010.0
SRSF2 623.0 -6578.0
SRSF3 -5573.0 -6803.0
SRSF4 -7312.0 -7491.0
SRSF5 7060.0 -7002.0
SRSF6 7330.0 -7363.0
SRSF7 2956.0 -6232.0
SRSF9 -4937.0 -4160.0
SUGP1 1519.0 -833.0
SUPT5H -6169.0 146.0
SYF2 -6533.0 -3945.0
SYMPK -34.0 -6687.0
TBL3 3281.0 -3098.0
TEX10 -4066.0 2308.0
TFB1M 665.0 1451.0
TFIP11 -619.0 -2596.0
TGS1 2077.0 -3010.0
THADA 2864.0 -3898.0
THG1L 2949.0 -6588.0
THOC1 435.0 -3212.0
THOC2 -1647.0 -1550.0
THOC3 3837.0 2313.0
THOC5 -3642.0 -6444.0
THOC6 3007.0 -7502.0
THOC7 1634.0 -5703.0
THUMPD1 1549.0 -890.0
TNFSF13 2033.0 -3513.0
TNKS1BP1 2064.0 5378.0
TNPO1 -6654.0 -6157.0
TP53RK -590.0 2450.0
TPR 610.0 -1079.0
TPRKB 2279.0 3158.0
TRA2B -1076.0 -4606.0
TRDMT1 6647.0 3611.0
TRIT1 148.0 -1072.0
TRMT1 -167.0 -6983.0
TRMT10A -290.0 -3159.0
TRMT10C 5497.0 1534.0
TRMT11 6158.0 -4682.0
TRMT112 -3724.0 -4119.0
TRMT12 3365.0 5633.0
TRMT13 2858.0 -1097.0
TRMT44 -4116.0 -720.0
TRMT5 7951.0 -3576.0
TRMT6 -2666.0 -2309.0
TRMT61A -504.0 -6489.0
TRMT61B 3572.0 182.0
TRMU -6056.5 -4500.0
TRNT1 3990.0 -3270.0
TSEN15 7391.0 -2130.0
TSEN2 3589.0 -2944.0
TSEN34 -4117.0 3208.0
TSEN54 543.0 4167.0
TSR1 -1745.0 -7045.0
TSR3 -649.0 -4935.0
TTC37 3352.0 3517.0
TXNL4A -2889.0 2889.0
TYW1 -5720.0 -1227.0
TYW3 275.0 -6808.0
TYW5 129.0 -2749.0
U2AF1 -6942.0 -4162.0
U2AF1L4 724.0 -5888.0
U2AF2 -928.0 -7743.0
U2SURP 2729.0 -3480.0
UBA52 -5323.0 1252.0
UBB -3737.0 1627.0
UBC 931.0 -2324.0
UPF1 -4750.0 -5252.0
UPF2 -3727.0 -3988.0
UPF3A -6321.0 -6411.0
UPF3B 2835.0 -2132.0
URM1 1185.0 -5663.0
USP39 -6054.0 4201.0
UTP14A -5810.0 -7129.0
UTP14C -6428.0 3119.0
UTP15 -3037.0 -1583.0
UTP18 -4480.0 -5004.0
UTP20 -2864.0 -7232.0
UTP3 4557.0 2878.0
UTP6 -1775.0 -3426.0
WBP11 -1814.0 -4776.0
WBP4 -1620.0 -1580.0
WBSCR22 -4690.0 -2603.0
WDR12 3926.0 -5704.0
WDR18 2475.0 -7484.0
WDR3 6367.0 -1606.0
WDR33 -3532.0 -4687.0
WDR36 6307.0 -4522.0
WDR4 -1329.0 -6617.0
WDR43 -4228.0 -6314.0
WDR46 1073.0 -1929.0
WDR61 443.0 557.0
WDR75 3713.0 -4133.0
WDR77 1078.0 -4517.0
WTAP -1796.0 -6044.0
XAB2 4322.0 2004.0
XPO1 -1381.0 -2685.0
XPOT -6856.0 -7442.0
XRN1 -3416.0 1960.0
XRN2 -3195.0 -5934.0
YBX1 -5901.0 -5024.0
YWHAB 2124.0 1177.0
YWHAZ -2.0 10.0
ZBTB8OS -2575.0 5252.0
ZC3H11A -716.0 -5756.0
ZCCHC11 -440.0 257.0
ZCCHC6 -4792.0 4161.0
ZCRB1 4997.0 4002.0
ZFP36 -6976.0 2711.0
ZFP36L1 -7214.0 -3676.0
ZMAT5 -2716.0 1921.0
ZNF473 2183.0 4805.0
ZRSR2 -4101.0 -4088.0



Translation

metric value
setSize 286
pMANOVA 1.52e-36
p.adjustMANOVA 8.99e-34
s.dist 0.44
confESp NA
s.rna_LGvHG -0.273
s.rna_HGvHGV -0.345
p.rna_LGvHG 2.13e-15
p.rna_HGvHGV 1.04e-23




Gene rna_LGvHG rna_HGvHGV
WARS -7558 -6553
VARS2 -6479 -7449
EIF4B -6017 -7498
EIF5 -6424 -6989
EIF4G1 -6162 -7098
MRPS15 -5686 -6583
EIF3A -7417 -4849
MRPL3 -5334 -6731
TARS -5974 -5754
MRPL23 -5016 -6836
SRP68 -6776 -5056
VARS -4865 -7001
SRP72 -5764 -5825
MRPL45 -4258 -7050
SRP14 -6238 -4757
MRPS18B -3942 -7376
EIF3B -5113 -5476
EIF3J -4525 -6126
RPL10 -5543 -4999
EIF2B5 -4978 -5455

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
AARS -3732 3728.0
AARS2 6670 1211.0
AIMP1 1834 -6654.0
AIMP2 -5 -5858.0
APEH 5088 5964.0
AURKAIP1 -5309 -235.0
CARS -5461 651.0
CARS2 2338 706.0
CHCHD1 827 -4007.0
DAP3 926 3512.0
DARS -2304 -7107.0
DARS2 2460 -5095.0
DDOST -6834 -3695.0
EARS2 1534 -6899.0
EEF1A1 -5269 -4120.0
EEF1A1P5 -4003 -2970.0
EEF1A2 585 8438.0
EEF1B2 -5288 -4607.0
EEF1D -5572 -3143.0
EEF1E1 -982 -512.0
EEF2 -5440 -3559.0
EIF1AX 1986 3709.0
EIF2B1 100 -487.0
EIF2B2 -5024 3183.0
EIF2B3 5865 1208.0
EIF2B4 475 -6680.0
EIF2B5 -4978 -5455.0
EIF2S1 -5366 2409.0
EIF2S2 -4423 -5981.0
EIF2S3 -3280 -1720.0
EIF3A -7417 -4849.0
EIF3B -5113 -5476.0
EIF3C 1948 -5119.0
EIF3D -3836 -5783.0
EIF3E 3525 -2684.0
EIF3F -612 -5160.0
EIF3G -4897 -4671.0
EIF3H 1030 -953.0
EIF3I -5628 -499.0
EIF3J -4525 -6126.0
EIF3K -2175 -767.0
EIF3L -2260 -3369.0
EIF3M -4437 -1125.0
EIF4A1 241 -4341.0
EIF4A2 5877 -5660.0
EIF4B -6017 -7498.0
EIF4E 2829 494.0
EIF4EBP1 5449 -7559.0
EIF4G1 -6162 -7098.0
EIF4H -4861 -4850.0
EIF5 -6424 -6989.0
EIF5B 3470 673.0
EPRS 579 -5103.0
ERAL1 2576 -6347.0
ETF1 -7375 1850.0
FARS2 1380 -2280.0
FARSA -3148 -4070.0
FARSB 3450 4365.0
FAU -5465 -1439.0
GADD45GIP1 -3901 -6100.0
GARS -3788 -6991.0
GFM1 -2568 3086.0
GFM2 -2790 6400.0
GSPT1 -7249 3458.0
HARS -7058 1209.0
HARS2 5628 -5081.0
IARS -1866 -6131.0
IARS2 -1493 -2194.0
KARS -2618 -3719.0
LARS 7698 -6475.0
LARS2 6732 -7357.0
MARS -1561 -6190.0
MARS2 1940 5157.0
MRPL1 6524 -6713.0
MRPL10 3834 -3291.0
MRPL11 4345 -4727.0
MRPL12 3753 -6609.0
MRPL13 700 5002.0
MRPL14 -5105 793.0
MRPL15 1474 -7380.0
MRPL16 6532 -5733.0
MRPL17 6748 1810.0
MRPL18 -696 2505.0
MRPL19 698 -4541.0
MRPL2 7246 -4146.0
MRPL20 564 -5368.0
MRPL21 2531 -3196.0
MRPL22 -1806 -1902.0
MRPL23 -5016 -6836.0
MRPL24 8211 -4354.0
MRPL27 2922 -5927.0
MRPL28 1266 1476.0
MRPL3 -5334 -6731.0
MRPL32 -4354 -4512.0
MRPL33 -4327 1553.0
MRPL34 -4919 -2521.0
MRPL35 -3572 -4584.0
MRPL36 -2848 -3983.0
MRPL37 -2890 -5360.0
MRPL38 -959 -3615.0
MRPL39 -2207 -1813.0
MRPL4 -1410 -3584.0
MRPL40 -848 473.0
MRPL41 -4828 4494.0
MRPL42 3344 1001.0
MRPL43 943 849.0
MRPL44 -4262 -5073.0
MRPL45 -4258 -7050.0
MRPL46 -2826 -5390.0
MRPL47 -4977 -760.0
MRPL48 -3176 -5352.0
MRPL49 4248 -5644.0
MRPL50 -243 -5437.0
MRPL51 -4523 -5647.0
MRPL52 1822 -1572.0
MRPL53 -325 1513.0
MRPL54 -2988 -7523.0
MRPL55 6565 1734.0
MRPL9 -1042 -7090.0
MRPS10 -189 -3064.0
MRPS11 -2381 4014.0
MRPS12 -5674 1237.0
MRPS14 1039 -344.0
MRPS15 -5686 -6583.0
MRPS16 6429 -5861.0
MRPS17 2431 894.0
MRPS18A -765 -5069.0
MRPS18B -3942 -7376.0
MRPS18C -3728 -3104.0
MRPS2 -5011 -4617.0
MRPS21 5202 -1608.0
MRPS22 -3455 -1460.0
MRPS23 -2979 3129.0
MRPS25 8141 -3416.0
MRPS26 3568 -6970.0
MRPS27 2417 -7118.0
MRPS28 -1440 -4628.0
MRPS30 -1324 -5676.0
MRPS31 6859 2397.0
MRPS33 5350 -244.0
MRPS34 -2667 -5277.0
MRPS35 -1156 -6268.0
MRPS36 -3733 -4794.0
MRPS5 739 -6255.0
MRPS6 -5886 2522.0
MRPS7 1553 -6430.0
MRPS9 -962 -4300.0
MRRF -3313 -5794.0
MTFMT 3529 1747.0
MTIF2 553 -6227.0
MTIF3 1029 -983.0
MTRF1L -5892 4596.0
MT-RNR1 711 1933.0
MT-RNR2 8019 3799.0
MT-TV -7131 -358.0
N6AMT1 8424 -5795.0
NARS -1013 -2531.0
NARS2 2236 4951.0
OXA1L 2411 -3518.0
PABPC1 -3531 -2220.0
PARS2 8446 75.0
PPA1 -1176 2410.0
PPA2 2586 -4444.0
PTCD3 1768 -1141.0
QARS -164 -3433.0
RARS 2867 2819.0
RARS2 5552 -1337.0
RPL10 -5543 -4999.0
RPL10A -2566 -3948.0
RPL11 -5172 -2748.0
RPL12 -1507 -3084.0
RPL13 -471 -3317.0
RPL13A -2745 -2677.0
RPL14 -5527 -2682.0
RPL15 1849 -2009.0
RPL17 126 -3940.0
RPL18 -4183 -1071.0
RPL18A -5301 -585.0
RPL19 -5609 -3966.0
RPL21 -4209 -4036.5
RPL22 5249 -3942.0
RPL22L1 -160 -6353.5
RPL23 -1370 -2849.0
RPL23A -3454 -1887.0
RPL24 -1812 -3491.0
RPL26 -1365 -146.0
RPL26L1 -3945 1440.0
RPL27 -2005 -919.0
RPL27A -4506 -4250.0
RPL28 -3621 -752.0
RPL29 -4075 -3272.0
RPL3 -1503 -3206.0
RPL30 -4142 -2917.0
RPL31 981 -1139.0
RPL32 -3393 -1261.0
RPL34 -2770 -2030.0
RPL35 -2891 -1554.0
RPL35A -4369 -1415.0
RPL36 -3549 -3202.0
RPL36A 5630 -2965.0
RPL36AL -7445 -2641.0
RPL37 -3457 -2235.0
RPL37A -2415 -2945.0
RPL38 -1678 -1496.0
RPL39 -1636 842.0
RPL3L -4857 -260.0
RPL4 -2513 -3939.0
RPL41 1461 -3751.0
RPL5 -554 -2231.0
RPL6 -5151 -4811.0
RPL7 -1319 -3168.0
RPL7A -2609 -2165.0
RPL8 -3548 -2560.0
RPL9 -3114 -4301.0
RPLP0 -4427 -1121.0
RPLP1 -4373 -3370.0
RPLP2 -2777 -1899.0
RPN1 -7473 -3567.0
RPN2 -6500 -2540.0
RPS10 112 -1083.0
RPS11 -5078 -2933.0
RPS12 -4503 -2114.0
RPS13 -2629 -2290.0
RPS14 -3593 -2671.0
RPS15 -4564 -1911.0
RPS15A -3125 -197.0
RPS16 -3362 -2103.0
RPS18 -2870 -2001.0
RPS19 -4961 -2582.0
RPS2 -3922 -2651.0
RPS20 -1741 -1314.0
RPS21 -2922 -743.0
RPS23 -1789 -1850.0
RPS24 -2865 -1728.0
RPS25 -124 -980.0
RPS26 239 -3326.0
RPS27 -3410 -2769.0
RPS27A -2775 -2092.0
RPS27L -3395 -5791.0
RPS28 -3558 -1760.0
RPS29 -3554 19.0
RPS3 -2626 -1940.0
RPS3A 1310 -2352.0
RPS4X -3384 -3144.0
RPS4Y1 -2083 -2421.0
RPS5 -5073 439.0
RPS6 -2847 -2731.0
RPS7 -5915 -2189.0
RPS8 -1202 -2865.0
RPS9 -4220 -3027.0
RPSA -2539 -2294.0
SARS -5625 -4637.0
SARS2 3996 -6809.0
SEC11A -2987 -1061.0
SEC11C -7434 -226.0
SEC61A1 -7486 -3284.0
SEC61A2 -228 7423.0
SEC61B -7405 -1370.0
SEC61G -4313 1345.0
SPCS1 2445 -153.0
SPCS2 -5875 -4003.0
SPCS3 -7033 985.0
SRP14 -6238 -4757.0
SRP19 -5678 1314.0
SRP54 -1869 5323.0
SRP68 -6776 -5056.0
SRP72 -5764 -5825.0
SRP9 6418 -949.0
SRPRB -7298 -2276.0
SSR1 -7335 -1989.0
SSR2 -7198 536.0
SSR3 -7349 -873.0
SSR4 -7460 -2082.0
TARS -5974 -5754.0
TARS2 3016 1978.0
TRAM1 -7465 -2243.0
TRMT112 -3724 -4119.0
TSFM -767 1189.0
TUFM -3389 -961.0
UBA52 -5323 1252.0
VARS -4865 -7001.0
VARS2 -6479 -7449.0
WARS -7558 -6553.0
WARS2 4148 -7589.0
YARS 980 -6774.0
YARS2 -375 -7405.0



Metabolism of proteins

metric value
setSize 1653
pMANOVA 2.13e-36
p.adjustMANOVA 8.99e-34
s.dist 0.191
confESp NA
s.rna_LGvHG -0.16
s.rna_HGvHGV -0.104
p.rna_LGvHG 7.67e-27
p.rna_HGvHGV 4.09e-12




Gene rna_LGvHG rna_HGvHGV
ARSB -7377 -7680
KLHL21 -7528 -7258
HDGF -7168 -7586
KEAP1 -6907 -7641
SPON2 -6855 -7542
NFKBIA -6857 -7408
NR1H4 -6340 -7816
WARS -7558 -6553
HCFC1 -6304 -7822
VARS2 -6479 -7449
APOA2 -6685 -7208
BMP4 -7307 -6558
FURIN -7130 -6700
FUCA2 -6781 -7012
SERPINC1 -6946 -6726
IKBKG -6257 -7466
CCT5 -6770 -6881
MBD6 -7184 -6384
DDX5 -7024 -6523
POM121 -6619 -6903

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
AAAS 3304.0 -6791.0
AARS -3732.0 3728.0
AARS2 6670.0 1211.0
ABCA3 3268.0 7652.0
ACADVL 4364.0 -4989.0
ACE2 4618.0 852.0
ACHE -1750.0 8479.0
ACTB -5090.0 3901.0
ACTL6A -863.0 -1364.0
ACTR10 5929.0 3416.0
ACTR1A -5316.0 2228.0
ACTR5 4097.0 970.0
ACTR8 -2989.0 -6437.0
ADAM10 -2895.0 1951.0
ADAMTS1 -977.0 5916.0
ADAMTS10 8586.0 6959.0
ADAMTS13 7338.0 5143.0
ADAMTS16 5595.0 6628.0
ADAMTS17 -3330.0 7382.0
ADAMTS2 8580.0 -182.0
ADAMTS4 -2077.0 6802.0
ADAMTS6 8152.0 6251.0
ADAMTS7 4819.0 8146.0
ADAMTS9 8167.0 -1389.0
ADAMTSL2 -3561.0 1318.0
ADAMTSL4 8341.0 3582.0
ADAMTSL5 -747.0 6905.0
ADD1 -6342.0 -4626.0
ADORA2A -5369.0 489.0
ADORA2B 6155.0 6015.0
ADRA2C -6899.0 -5884.0
ADRM1 -3607.0 185.0
AFP -4342.0 1611.0
AGBL2 7189.0 1540.0
AGBL3 3104.0 -528.0
AGBL5 3103.0 803.0
AGT 8382.0 -5389.0
AGTPBP1 6403.0 5207.0
AHSG 263.0 -2039.0
AIMP1 1834.0 -6654.0
AIMP2 -5.0 -5858.0
ALB 3538.0 -1484.0
ALG1 -5009.0 -5823.0
ALG10 2923.0 -1386.0
ALG10B 2823.0 -781.0
ALG11 -6016.0 291.0
ALG12 -6210.0 -4252.0
ALG13 1926.0 -5990.0
ALG14 -3538.0 -7525.0
ALG2 -6917.0 2798.0
ALG3 -7029.0 -6014.0
ALG5 -6875.0 -4101.0
ALG6 5729.0 -763.0
ALG8 1178.0 -6180.0
ALG9 5076.0 -3459.0
AMDHD2 2811.0 2011.0
AMFR -4049.0 -1070.0
ANK1 -6391.0 2812.0
ANK2 -7224.0 51.0
ANKRD28 4357.0 -2177.0
ANKRD9 6829.0 5926.0
ANO8 -172.0 5122.0
ANPEP 5109.0 -7080.0
AP3M1 3817.0 -2589.0
APC -1560.0 -768.0
APEH 5088.0 5964.0
APH1A 947.0 -3600.0
APH1B 7683.0 7233.0
APLP2 -3283.0 4028.0
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APP -6870.0 -216.0
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ARF4 -6167.0 3039.0
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ARL2 5772.0 -295.0
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ARSB -7377.0 -7680.0
ARSD -4943.0 -7620.0
ARSE -6909.0 -3960.0
ARSG 8074.0 -2273.0
ARSI 6960.0 -6445.0
ARSK -1347.0 4056.0
ART4 7775.0 -7348.0
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ASB13 7356.0 2070.0
ASB14 -1720.0 2261.0
ASB16 7358.0 4180.0
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ASB4 -5173.0 1811.0
ASB6 -5099.0 4730.0
ASB7 -3463.0 -3571.0
ASB8 -996.0 -861.0
ASB9 6340.0 3477.0
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ASNS 7070.0 3094.0
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ASXL2 -6180.0 -2942.0
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ATF4 -5958.0 -6121.0
ATF6 -7401.0 3673.0
ATP6AP2 -1106.0 6261.0
ATP6V0D1 -7372.0 7138.0
ATXN3 4274.0 410.0
ATXN7 -4962.0 -4471.0
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AURKB 8013.0 2208.0
AXIN1 -4408.0 -5939.0
AXIN2 -5592.0 -6378.0
B2M -2711.0 6053.0
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B3GNT2 -2428.0 6065.0
B3GNT3 5282.0 5328.0
B3GNT4 -6749.0 6785.0
B3GNT7 2995.0 7771.0
B3GNT8 5636.0 2210.0
B3GNT9 -5562.0 4221.0
B3GNTL1 -14.0 -6696.0
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B4GALT2 -2599.0 -7179.0
B4GALT3 -5032.0 -3029.0
B4GALT4 2121.0 -914.0
B4GALT5 7803.0 1732.0
B4GALT6 3733.0 3714.0
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BACE1 5800.0 6445.0
BAP1 -2636.0 -2742.0
BARD1 7395.0 5081.0
BCL10 -5193.0 4260.0
BECN1 -4109.0 -1316.0
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BET1L 4582.0 -4015.0
BIRC2 -327.0 -2178.0
BIRC3 5158.0 5808.0
BIRC5 6069.0 -1684.0
BLM 7677.0 4716.0
BMI1 -4122.0 -5850.0
BMP4 -7307.0 -6558.0
BPIFB2 -5255.0 -5200.0
BRCA1 6943.0 5795.0
BRCC3 2443.0 -6185.0
BRE 4763.0 -3870.0
BST1 3429.0 -2524.0
BTBD1 134.0 -1662.0
BTRC 1585.0 -4432.0
C19orf10 -7446.0 -2987.0
C1GALT1 929.0 3894.0
C1GALT1C1 -2720.0 1827.0
C3 8728.0 -6117.0
C4A 8681.0 -6810.0
CALM1 -753.0 8197.0
CALR -7600.0 3622.0
CALU -4673.0 5031.0
CAMKMT 897.0 4135.0
CAND1 -1529.0 -754.0
CANX -7544.0 -4761.0
CAPZA1 -4971.0 -2164.0
CAPZA2 -1816.0 -945.0
CAPZB -1014.0 1559.0
CARS -5461.0 651.0
CARS2 2338.0 706.0
CASP8AP2 6490.0 2800.0
CBX2 8031.0 1352.0
CBX4 -4232.5 -4187.0
CBX5 8543.0 5.0
CBX8 -4432.0 336.0
CCDC22 -1480.0 -5588.0
CCDC59 -4770.0 -5680.0
CCNA2 7539.0 -5983.0
CCNE1 2957.0 7818.0
CCNE2 -855.0 2938.0
CCNF 1639.0 4245.0
CCP110 7131.0 6973.0
CCT2 -6103.0 -3420.0
CCT3 -2761.0 -4112.0
CCT4 -1363.0 -4503.0
CCT5 -6770.0 -6881.0
CCT6A -6111.0 -71.0
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CCT7 -1288.0 -486.0
CCT8 -5885.0 -1394.0
CD109 -5467.0 359.0
CD55 -6972.0 1417.0
CD59 -3108.0 2472.0
CDC20 6337.0 -3782.0
CDC25A 6817.0 -149.0
CDC34 -5959.0 2290.0
CDC73 -4811.0 -532.0
CDCA8 7748.0 -3346.0
CDH2 -2223.0 -2420.0
CDK1 8557.0 4062.0
CDKN2A 4111.0 1842.0
CDX2 1992.0 6917.0
CES1 8177.0 3511.0
CETN2 6554.0 6794.0
CHCHD1 827.0 -4007.0
CHD3 -1154.0 -128.0
CHGB 2522.0 3225.0
CHM -61.0 746.0
CHML 2148.0 -42.0
CHST10 8077.0 -6278.0
CISH 7140.0 -7623.0
CKAP4 -4106.0 -6339.0
CLSPN 8191.0 5812.0
CMAS 6332.0 4477.0
CNIH1 -1930.0 -4529.0
CNIH2 1000.0 8087.0
CNIH3 -2322.0 -719.0
COG1 4646.0 -5650.0
COG2 -4190.0 2566.0
COG3 -6158.0 -3633.0
COG4 2405.0 -4428.0
COG5 -3955.0 2267.0
COG6 3676.0 4580.0
COG7 5531.0 -3351.0
COG8 4941.0 -6563.0
COL7A1 5570.0 1184.0
COMMD1 7017.0 4134.0
COMMD10 250.0 -6213.0
COMMD2 477.0 2803.0
COMMD3 3923.0 581.0
COMMD4 -433.0 -3798.0
COMMD5 -4587.0 -1511.0
COMMD6 6244.0 3211.0
COMMD7 5700.0 -6342.0
COMMD8 865.0 2724.0
COMMD9 -3218.0 -3741.0
COPA -3832.0 2432.0
COPB1 -4161.0 2152.0
COPB2 -6846.0 5256.0
COPE -6517.0 308.0
COPG1 -5353.0 -1531.0
COPG2 5720.0 -6498.0
COPS2 -5420.0 -5251.0
COPS3 -4823.0 -1293.0
COPS4 51.0 2075.0
COPS5 -3278.0 -5052.0
COPS6 -3252.0 -4909.0
COPS7A 6419.0 -270.0
COPS7B -427.0 839.0
COPS8 -4548.0 4313.0
COPZ1 983.0 -5195.0
COPZ2 685.0 5529.0
CP 8642.0 -7104.0
CPB2 4713.0 -5233.0
CPE -5367.0 1035.0
CPM -6223.0 7091.0
CREB3 -3666.0 6988.0
CREB3L1 -5496.0 7758.0
CREB3L2 -7200.0 6769.0
CREB3L3 6853.0 5161.0
CREB3L4 6822.0 -7286.0
CREBBP -3983.0 -7682.0
CREBRF -6355.0 -3908.0
CSF1 -7146.0 5792.0
CSNK1D -6047.0 -6638.0
CSNK2A1 -4165.0 -4925.0
CSNK2A2 -4677.0 -4027.0
CSNK2B -2785.0 -4104.0
CST3 4157.0 1485.0
CTBP1 136.0 -7454.0
CTDSP2 -4688.0 -7088.0
CTNNB1 3313.0 -2713.0
CTR9 -3900.0 5063.0
CTSA -6425.0 -520.0
CTSC -4835.0 -2345.0
CTSD 3616.0 -1973.0
CTSH 6323.0 -2315.0
CTSZ -4455.0 3214.0
CUL1 -4043.0 -7818.0
CUL2 507.0 1249.0
CUL3 -3083.0 -3669.0
CUL4A -2052.0 -6671.0
CUL4B -5075.0 2407.0
CUL5 -879.0 -5374.0
CUL7 4806.0 -7078.0
CUL9 7969.0 -77.0
CXXC1 -6375.0 2699.0
CYLD -6439.0 6890.0
CYR61 -2548.0 2249.0
DAD1 -6631.0 5875.0
DAG1 -1973.0 835.0
DAP3 926.0 3512.0
DARS -2304.0 -7107.0
DARS2 2460.0 -5095.0
DAXX -6691.0 1222.0
DCAF10 -5693.0 -4688.0
DCAF11 -6371.0 417.0
DCAF13 4844.0 -1935.0
DCAF16 5871.0 2332.0
DCAF17 3997.0 -2592.0
DCAF4 5919.0 -1599.0
DCAF5 -4595.0 -6166.0
DCAF6 -2320.0 -330.0
DCAF7 5808.0 -1042.0
DCAF8 5093.0 -6947.0
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DCTN1 -1103.0 -1008.0
DCTN2 -4024.0 -2440.0
DCTN3 1539.0 6556.0
DCTN4 -1760.0 -5497.0
DCTN5 -6284.0 -840.0
DCTN6 -916.0 -6365.0
DCUN1D1 1332.0 -1859.0
DCUN1D2 -4975.0 2951.0
DCUN1D3 -5916.0 1358.0
DCUN1D4 -222.0 4907.0
DCUN1D5 -1626.0 -368.0
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DDB1 -5919.0 -2642.0
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DDIT3 -7467.0 -2059.0
DDOST -6834.0 -3695.0
DDX11 5201.0 -3641.0
DDX17 -3005.0 -7490.0
DDX5 -7024.0 -6523.0
DDX58 -200.0 284.0
DERL1 -6455.0 4785.0
DERL2 -7492.0 -5988.0
DHDDS 2834.0 523.0
DHPS 3317.0 -1571.0
DIS3 -1501.0 2302.0
DNAJB11 -7599.0 7153.0
DNAJB9 -7587.0 -3653.0
DNAJC24 2054.0 2573.0
DNAJC3 -7590.0 -1959.0
DNMT1 2424.0 5434.0
DNMT3A 4273.0 -7775.0
DNMT3B 8203.0 7913.0
DOHH -4391.0 -4791.0
DOLK 103.0 845.0
DOLPP1 -5154.0 -6400.0
DPAGT1 -6349.0 582.0
DPH1 -5394.0 -4480.0
DPH2 -5973.0 -6291.0
DPH3 -5314.0 6531.0
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DPH7 -2087.0 -3520.0
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DPM2 -2097.0 4820.0
DPM3 3712.0 -1275.0
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DTL 5403.0 6180.0
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DYNC1LI1 -2027.0 -4249.0
DYNC1LI2 -4501.0 -188.0
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EDEM2 -5920.0 3449.0
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EEF1E1 -982.0 -512.0
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EID3 -4569.0 231.0
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EIF2AK3 -7454.0 1525.0
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EIF2B3 5865.0 1208.0
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EIF3K -2175.0 -767.0
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EIF5A2 -5241.0 7237.0
EIF5B 3470.0 673.0
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EP300 -6798.0 -5744.0
EPAS1 -5121.0 5176.0
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ERCC8 -2853.0 -3290.0
ERN1 -7328.0 4497.0
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ETFB -3.0 -6309.0
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EXOSC9 3277.0 1337.0
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F10 5941.0 877.0
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F5 992.0 -4065.0
F7 7349.5 -7773.0
F8 2119.0 3053.0
FAM175A 3774.0 1096.0
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FAM20A 8692.0 -7815.0
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FAU -5465.0 -1439.0
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FBXL12 -985.0 2039.0
FBXL13 -689.0 33.0
FBXL14 -2664.0 1812.0
FBXL15 2312.0 4082.0
FBXL16 8650.0 8272.0
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FBXL19 -1884.0 -5603.0
FBXL20 -6272.0 2217.0
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FBXO21 5296.0 245.0
FBXO22 5218.0 -4491.0
FBXO27 6848.0 6719.0
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FBXO44 -4998.0 -394.0
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FBXW8 4521.0 -3820.0
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FEM1A -2387.0 -4232.0
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FEM1C -4883.0 -482.0
FGA 8712.0 -6806.0
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FKBP14 -7316.0 7039.0
FKBP8 7161.0 -1838.0
FKBP9 8049.0 -4769.0
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FN3K 1341.0 -5906.0
FN3KRP 7057.0 3930.0
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FOXO4 -2011.0 6287.0
FPGT 7182.0 4727.0
FSTL3 -5743.0 6270.0
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FURIN -7130.0 -6700.0
FUT3 -7507.0 6151.0
FUT8 -4951.0 7570.0
GADD45GIP1 -3901.0 -6100.0
GALNT1 -814.0 4811.0
GALNT10 -4621.0 7530.0
GALNT11 8128.0 637.0
GALNT13 -893.0 1947.0
GALNT16 5302.0 8466.0
GALNT18 -1911.0 7975.0
GALNT2 7110.0 1489.0
GALNT3 -4889.0 5329.0
GALNT4 -1943.0 -1438.0
GALNT6 7265.0 7374.0
GALNT7 -4934.0 8239.0
GAN -3662.0 2703.0
GANAB 2891.0 -5477.0
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GAS6 5601.0 7739.0
GATA4 -6831.0 3353.0
GATA6 3378.0 5912.0
GBA -6672.0 5535.0
GBF1 -5240.0 5965.0
GCNT1 1420.5 8275.0
GCNT3 -7517.0 7618.0
GCNT4 5431.5 254.0
GFM1 -2568.0 3086.0
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GFPT1 -7494.0 -2011.0
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GGA1 3068.0 1467.0
GGA2 -6459.0 757.0
GGA3 4516.0 -5364.0
GGCX -4048.0 7368.0
GHRL 1133.0 -5118.0
GLB1 1661.0 -2070.0
GMDS -3504.0 -2597.0
GMPPA -6805.0 5075.0
GMPPB -4727.0 1381.0
GNAI1 -3147.0 7957.0
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GNAI3 -4547.0 2520.0
GNAO1 6529.0 8371.0
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GNB1 -2877.0 -1486.0
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GNB5 888.0 5876.0
GNE 6823.0 1276.0
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GNG3 -5739.0 -774.0
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GNG7 4509.0 7629.0
GNPNAT1 2281.0 -3877.0
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GOLGB1 -3507.0 -85.0
GOLM1 -3967.0 6023.0
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GPAA1 -2318.0 5572.0
GPC3 4501.0 -1909.0
GPLD1 -5338.0 -5673.0
GPR119 -3762.0 4108.0
GPS1 -3508.0 -676.0
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GSN 1542.0 -2655.0
GSPT1 -7249.0 3458.0
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H2AFZ -68.0 1841.0
H3F3A 534.0 -2193.0
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HCFC1 -6304.0 -7822.0
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HERPUD1 -7595.0 2297.0
HGS -4381.0 943.0
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HIST1H2BJ 3107.0 -2505.0
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HIST1H2BL 2052.0 3360.0
HIST1H2BN 6987.0 948.0
HIST1H2BO 2159.0 -847.0
HIST2H2AC -983.0 346.0
HIST2H2BE -6945.0 4840.0
HLA-A 1602.0 -229.0
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HLTF 7845.0 6443.0
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HRC 6639.0 2403.0
HSP90B1 -7588.0 -1691.0
HSPA5 -7602.0 -2698.0
HSPA8 -4920.0 -6728.0
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HYOU1 -7598.0 -2610.0
IARS -1866.0 -6131.0
IARS2 -1493.0 -2194.0
ICMT 3207.0 1121.0
IDE -4167.0 -4511.0
IFIH1 7684.0 4654.0
IGF2 8755.0 -5186.0
IGFALS 7543.0 -7439.0
IGFBP1 -4221.0 -4406.0
IGFBP2 7456.0 7453.0
IGFBP3 6832.0 8151.0
IGFBP4 5594.0 7600.0
IGFBP6 -3537.0 4638.0
IGFBP7 5351.0 -3637.0
IKBKE -899.0 5558.0
IKBKG -6257.0 -7466.0
IL8 4813.0 -1323.0
INCENP 5826.0 2009.0
ING2 -777.0 6171.0
INHA -326.0 -6482.0
INHBB -3000.0 4171.0
INHBC 4398.0 -5840.0
INHBE -4723.0 -3434.0
INO80 -3205.0 -6906.0
INO80B 3309.0 6908.0
INO80C 647.0 -2800.0
INO80D -3452.0 -7053.0
INO80E 5404.0 -4665.0
ITIH2 1807.0 -6772.0
ITM2B 4009.0 1164.0
JOSD1 -6451.0 5428.0
JOSD2 4903.0 2353.0
KARS -2618.0 -3719.0
KAT2A 5270.0 -7676.0
KAT2B -5350.0 6867.0
KBTBD6 7836.0 -3849.0
KBTBD7 7901.0 -5188.0
KBTBD8 4022.0 6815.0
KCTD6 86.0 5678.0
KCTD7 -3787.0 5005.0
KDELR1 -5247.0 -3829.0
KDELR2 -6140.0 2257.0
KDELR3 1081.0 6871.0
KDM1B -4979.0 7408.0
KEAP1 -6907.0 -7641.0
KHSRP -932.0 -5350.0
KIF13A -5038.0 -7346.0
KIF5A -7093.0 4787.0
KIF5B -5653.0 -1811.0
KIF5C 2421.0 8494.0
KIFC3 -6664.0 1949.0
KIN 4135.0 243.0
KLF4 -7576.0 6199.0
KLHDC3 -3931.0 827.0
KLHL11 -935.0 -3694.0
KLHL13 6129.0 6623.0
KLHL2 -2787.0 4375.0
KLHL20 3404.0 1635.0
KLHL21 -7528.0 -7258.0
KLHL22 5656.0 -27.0
KLHL25 -401.0 4455.0
KLHL3 2844.0 6984.0
KLHL42 -4881.0 -6516.0
KLHL5 -594.0 -4424.0
KLHL9 3910.0 -1727.0
KNG1 8754.0 -4742.0
KTN1 -3210.0 -2057.0
L3MBTL2 1402.0 -6413.0
LAMB1 3829.0 -5043.0
LAMB2 680.0 -4322.0
LAMC1 -942.0 -396.0
LARS 7698.0 -6475.0
LARS2 6732.0 -7357.0
LEO1 -3047.0 -4611.0
LGALS1 -7120.0 8300.0
LMAN1 -3493.0 -2265.0
LMAN2 -7000.0 -1431.0
LMAN2L -3514.0 3895.0
LMCD1 626.0 7819.0
LMNA -3761.0 4419.0
LMO7 -878.0 -4312.0
LONP2 -6433.0 1930.0
LRR1 -1151.0 824.0
LRRC41 2173.0 -7707.0
LRRC49 -973.0 7754.0
LSAMP -5416.0 3503.0
LTBP1 -2565.0 6504.0
LY6E 5141.0 7009.0
LYPD3 -322.0 8014.0
LYZ 3435.0 2601.0
MAGT1 -7502.0 6141.0
MAN1A1 -822.0 3981.5
MAN1A2 -6829.0 3261.0
MAN1B1 -3754.0 -5405.0
MAN1C1 2976.0 8306.0
MAN2A1 -771.0 -2613.0
MAN2A2 -2606.0 -6344.0
MANEA 4992.0 -4685.0
MAP3K7 4053.0 -1436.0
MARCH6 -3796.0 -5054.0
MARS -1561.0 -6190.0
MARS2 1940.0 5157.0
MAT2B 1615.0 480.0
MATN3 8614.0 -6247.0
MAVS -257.0 -6619.0
MBD1 -4557.0 3066.0
MBD5 -5501.0 3736.0
MBD6 -7184.0 -6384.0
MBOAT4 -1298.0 2944.0
MBTPS1 -6207.0 -2006.0
MBTPS2 3989.0 -3848.0
MCFD2 -7512.0 1718.0
MCRS1 -1251.0 -7391.0
MDC1 5047.0 -4787.0
MDGA1 4552.0 7272.0
MDM2 261.0 -6156.0
MDM4 -2436.0 -4571.0
MEN1 1465.0 2387.0
METTL10 7007.0 730.0
METTL21A 6186.0 -2577.0
METTL22 911.0 -886.0
MFGE8 6236.0 8162.0
MGAT1 -6869.0 4304.0
MGAT2 -3826.0 -2225.0
MGAT3 2410.0 6592.0
MGAT4A -5184.0 1285.0
MGAT4B -6766.0 -6729.0
MGAT5 -6044.0 -3553.0
MIA2 3686.0 -1456.0
MIA3 -7491.0 3738.0
MITF -663.0 8074.0
MLEC -7311.0 4129.0
MMP2 -5470.0 8154.0
MOGS -2193.0 -3572.0
MPDU1 4096.0 -7807.0
MPI 7374.0 2448.0
MRPL1 6524.0 -6713.0
MRPL10 3834.0 -3291.0
MRPL11 4345.0 -4727.0
MRPL12 3753.0 -6609.0
MRPL13 700.0 5002.0
MRPL14 -5105.0 793.0
MRPL15 1474.0 -7380.0
MRPL16 6532.0 -5733.0
MRPL17 6748.0 1810.0
MRPL18 -696.0 2505.0
MRPL19 698.0 -4541.0
MRPL2 7246.0 -4146.0
MRPL20 564.0 -5368.0
MRPL21 2531.0 -3196.0
MRPL22 -1806.0 -1902.0
MRPL23 -5016.0 -6836.0
MRPL24 8211.0 -4354.0
MRPL27 2922.0 -5927.0
MRPL28 1266.0 1476.0
MRPL3 -5334.0 -6731.0
MRPL32 -4354.0 -4512.0
MRPL33 -4327.0 1553.0
MRPL34 -4919.0 -2521.0
MRPL35 -3572.0 -4584.0
MRPL36 -2848.0 -3983.0
MRPL37 -2890.0 -5360.0
MRPL38 -959.0 -3615.0
MRPL39 -2207.0 -1813.0
MRPL4 -1410.0 -3584.0
MRPL40 -848.0 473.0
MRPL41 -4828.0 4494.0
MRPL42 3344.0 1001.0
MRPL43 943.0 849.0
MRPL44 -4262.0 -5073.0
MRPL45 -4258.0 -7050.0
MRPL46 -2826.0 -5390.0
MRPL47 -4977.0 -760.0
MRPL48 -3176.0 -5352.0
MRPL49 4248.0 -5644.0
MRPL50 -243.0 -5437.0
MRPL51 -4523.0 -5647.0
MRPL52 1822.0 -1572.0
MRPL53 -325.0 1513.0
MRPL54 -2988.0 -7523.0
MRPL55 6565.0 1734.0
MRPL9 -1042.0 -7090.0
MRPS10 -189.0 -3064.0
MRPS11 -2381.0 4014.0
MRPS12 -5674.0 1237.0
MRPS14 1039.0 -344.0
MRPS15 -5686.0 -6583.0
MRPS16 6429.0 -5861.0
MRPS17 2431.0 894.0
MRPS18A -765.0 -5069.0
MRPS18B -3942.0 -7376.0
MRPS18C -3728.0 -3104.0
MRPS2 -5011.0 -4617.0
MRPS21 5202.0 -1608.0
MRPS22 -3455.0 -1460.0
MRPS23 -2979.0 3129.0
MRPS25 8141.0 -3416.0
MRPS26 3568.0 -6970.0
MRPS27 2417.0 -7118.0
MRPS28 -1440.0 -4628.0
MRPS30 -1324.0 -5676.0
MRPS31 6859.0 2397.0
MRPS33 5350.0 -244.0
MRPS34 -2667.0 -5277.0
MRPS35 -1156.0 -6268.0
MRPS36 -3733.0 -4794.0
MRPS5 739.0 -6255.0
MRPS6 -5886.0 2522.0
MRPS7 1553.0 -6430.0
MRPS9 -962.0 -4300.0
MRRF -3313.0 -5794.0
MSLN 5328.0 -1430.0
MSRA -1516.0 -7076.0
MSRB1 1942.0 2691.0
MSRB2 6614.0 -587.0
MSRB3 125.0 7803.0
MTA1 1745.0 -6497.0
MTFMT 3529.0 1747.0
MTIF2 553.0 -6227.0
MTIF3 1029.0 -983.0
MTRF1L -5892.0 4596.0
MT-RNR1 711.0 1933.0
MT-RNR2 8019.0 3799.0
MT-TV -7131.0 -358.0
MUC12 -3494.0 6527.0
MUC13 -2475.0 7493.0
MUC15 6567.0 -6136.0
MUC20 -4639.0 6658.0
MUC3A 1160.0 8341.0
MUC5B 8751.0 -2208.0
MUC6 828.0 1365.0
MUL1 -6258.0 -1890.0
MVD 8659.0 -3281.0
MXRA8 -4120.0 2186.0
MYC 2009.0 -5587.0
MYO5A -3780.0 5345.0
MYRIP -602.0 3719.0
MYSM1 1222.0 -2717.0
N6AMT1 8424.0 -5795.0
N6AMT2 4445.0 -3388.0
NAE1 6584.0 -6312.0
NAGK 4867.0 6024.0
NANP 191.0 4870.0
NANS -7309.0 2967.0
NAPA -6217.0 6506.0
NAPB -254.0 3038.0
NAPG -3940.0 5222.0
NARS -1013.0 -2531.0
NARS2 2236.0 4951.0
NAT8 3701.0 6659.0
NCOA1 -4821.0 3973.0
NCOA2 5080.0 -7532.0
NCOR2 -4626.0 334.0
NCSTN -321.0 -6959.0
NDC1 -1208.0 -2073.0
NEDD8 747.0 738.0
NEU1 -7262.0 6490.0
NEU3 7764.0 1965.0
NEU4 8333.0 -7522.0
NEURL2 3503.0 -6858.0
NFKB2 -1248.0 7607.0
NFKBIA -6857.0 -7408.0
NFRKB -3830.0 -3538.0
NFYA -2170.0 5841.0
NFYB 5491.0 -2191.0
NFYC 352.0 -7567.0
NGLY1 -2840.0 -3002.0
NICN1 7513.0 -578.0
NOD1 4722.0 -492.0
NOD2 2130.0 8260.0
NOP56 -1126.0 -5490.0
NOP58 6235.0 -4117.0
NOTUM 7940.0 -7250.0
NPM1 -2293.0 -4829.0
NPPA 6787.0 2882.0
NR1H2 411.0 -7191.0
NR1H3 5117.0 -6351.0
NR1H4 -6340.0 -7816.0
NR1I2 6512.0 469.0
NR2C1 796.0 -2453.0
NR3C1 -4108.0 272.0
NR3C2 1566.0 7974.0
NR4A2 -4237.0 7671.0
NR5A1 -4985.0 -7501.0
NR5A2 -6515.0 3756.0
NRIP1 247.0 -5855.0
NSF -5027.0 -2147.0
NSMCE1 7779.0 -4420.0
NSMCE2 -4853.0 1470.0
NSMCE4A -1436.0 -433.0
NTNG2 7973.0 7691.0
NUB1 4292.0 2591.0
NUCB1 -5312.0 5652.0
NUDT14 -4533.0 5024.0
NUP107 6965.0 -4327.0
NUP133 1406.0 1305.0
NUP153 2805.0 1278.0
NUP155 5259.0 -95.0
NUP160 -271.0 -1749.0
NUP188 -5044.0 -3795.0
NUP205 -5514.0 -2051.0
NUP210 7824.0 -4030.0
NUP214 -1509.0 -4585.0
NUP35 6880.0 -2911.0
NUP37 8176.0 -4271.0
NUP43 2778.0 1270.0
NUP50 -4694.0 -4478.0
NUP54 3508.0 -1767.0
NUP62 -73.0 -4951.0
NUP85 4624.0 1161.0
NUP88 -4829.0 -5548.0
NUP93 6534.0 2994.0
NUP98 -3617.0 2992.0
NUPL2 -3453.0 1853.0
NUS1 -6675.0 -723.0
OBSL1 2423.0 -7727.0
ODAM 8640.0 -7709.0
OGT 7364.0 -5204.0
OS9 -7438.0 4312.0
OTUB1 -245.0 -6189.0
OTUB2 6377.0 4168.0
OTUD3 -2230.0 4243.0
OTUD5 -6392.0 491.0
OTUD7A -1077.0 7679.0
OTUD7B -1591.0 -4326.0
OXA1L 2411.0 -3518.0
P2RY2 -5499.0 7482.0
P4HB -7396.0 -45.0
PABPC1 -3531.0 -2220.0
PAF1 1677.0 -535.0
PAPPA 6697.0 -284.0
PARK2 8459.0 3339.0
PARK7 -2361.0 -1044.0
PARN -4954.0 -4136.0
PARP1 3108.0 5682.0
PARS2 8446.0 75.0
PAX6 4575.0 6934.0
PCGF2 -6603.0 -6094.0
PCMT1 -5925.0 6351.0
PCNA 7628.0 6650.0
PCSK9 8758.0 2816.0
PDCL -868.0 6962.0
PDIA3 -7547.0 -4672.0
PDIA5 646.0 -2828.0
PDIA6 -7567.0 300.0
PEX10 2273.0 -7469.0
PEX12 5128.0 -3142.0
PEX13 -720.0 -3825.0
PEX14 -3715.0 -7047.0
PEX2 4911.0 987.0
PEX5 -40.0 1549.0
PFDN1 5195.0 -6977.0
PFDN2 -3926.0 1797.0
PFDN4 3053.0 -4348.0
PFDN5 -2690.0 -2308.0
PFDN6 6536.0 1861.0
PGAP1 6950.0 4402.0
PGM3 -5818.0 2600.0
PHC1 -2942.0 4432.0
PHC2 3954.0 -5767.0
PHC3 599.0 -4130.0
PIAS1 -3023.0 1267.0
PIAS2 -183.0 161.0
PIAS3 -1625.0 331.0
PIAS4 -5206.0 -5014.0
PIGA -4489.0 4101.0
PIGB 3560.0 -5180.0
PIGC 2112.0 -278.0
PIGF 3830.0 4391.0
PIGG -6337.0 -3566.0
PIGH -2463.0 6828.0
PIGK 6919.0 2678.0
PIGL 6897.0 -4624.0
PIGM 5751.0 4942.0
PIGN -2219.0 5385.0
PIGO 2519.0 -7131.0
PIGP 3500.0 -1713.0
PIGQ 5096.0 5281.0
PIGS -380.0 4055.0
PIGT -1164.0 -1204.0
PIGU 1215.0 -6114.0
PIGV 4522.0 -1363.0
PIGW -6007.0 -7576.0
PIGX -469.0 6094.0
PIGZ 7866.0 -5786.0
PLA2G4B 4373.0 1787.0
PLAUR 6054.0 6602.0
PLG 8749.0 -4536.0
PML 1201.0 -510.0
PMM1 -2394.0 5436.0
PMM2 -5008.0 524.0
PNPLA2 -5707.0 713.0
POFUT2 -33.0 3192.0
POLB -4459.0 4998.0
POM121 -6619.0 -6903.0
POM121C -5801.0 -6560.0
POMGNT1 3443.0 -6073.0
POMGNT2 4706.0 5947.0
POMK 2711.0 -6396.0
POMT1 -4034.0 3650.0
POMT2 -7185.0 3349.0
PPA1 -1176.0 2410.0
PPA2 2586.0 -4444.0
PPARA -7143.0 5034.0
PPARG -3268.0 -6596.0
PPARGC1A -6141.0 -3013.0
PPP2R5B -5535.0 8233.0
PPP6C -5495.0 4806.0
PPP6R1 -6932.0 -1406.0
PPP6R3 -481.0 -1395.0
PREB 1351.0 6607.0
PRKCSH -6303.0 -4165.0
PRKDC -2101.0 759.0
PRMT3 6305.0 -5306.0
PROC 7853.0 -7564.0
PROS1 6797.0 -4877.0
PROZ 6923.0 -7404.0
PRSS23 6221.0 -377.0
PSENEN -1142.0 5970.0
PSMA1 -3927.0 -2398.0
PSMA2 15.0 1100.0
PSMA3 -2496.0 1979.0
PSMA4 -4169.0 -2695.0
PSMA5 -2402.0 558.0
PSMA6 1150.0 -3215.0
PSMA7 -849.0 -1558.0
PSMB1 1173.0 -728.0
PSMB10 -2296.0 -7082.0
PSMB2 1929.0 1160.0
PSMB3 -1875.0 -1567.0
PSMB4 -1015.0 -171.0
PSMB5 -499.0 -6359.0
PSMB6 -5085.0 -6160.0
PSMB7 -3738.0 -1108.0
PSMB8 5998.0 -6450.0
PSMB9 8274.0 7642.0
PSMC1 -2073.0 -2143.0
PSMC2 -2382.0 1413.0
PSMC3 -1326.0 -4739.5
PSMC4 -5097.0 -3313.0
PSMC5 -3886.0 -5049.0
PSMC6 -4958.0 -3262.0
PSMD1 -5546.0 4652.0
PSMD10 5116.0 -309.0
PSMD11 -258.0 -3176.0
PSMD12 4562.0 -101.0
PSMD13 -2467.0 5077.0
PSMD14 6651.0 -459.0
PSMD2 -6864.0 3474.0
PSMD3 -5826.0 236.0
PSMD4 4967.0 -4640.0
PSMD5 5607.0 -4170.0
PSMD6 -6300.0 2254.0
PSMD7 5850.0 -3019.0
PSMD8 -2768.0 537.0
PSMD9 -3221.0 368.0
PSME1 -2066.0 -2429.0
PSME2 -5564.0 1864.0
PSME3 -3725.0 -3020.5
PSME4 -6847.0 1983.0
PSMF1 -7076.0 -2659.0
PTCD3 1768.0 -1141.0
PTEN -4972.0 168.0
PTP4A2 -5371.0 1618.0
PTRH2 -5423.0 -991.0
PUM2 -5506.0 -5938.0
QARS -164.0 -3433.0
QSOX1 -1116.0 6855.0
RAB10 1472.0 -109.0
RAB11A 4837.0 5851.0
RAB11B -725.0 -7700.0
RAB12 415.0 1994.0
RAB13 4146.0 -697.0
RAB14 3928.0 788.0
RAB15 -3606.0 2277.0
RAB17 -7593.0 7160.0
RAB18 43.0 1094.0
RAB1A -3348.0 4508.0
RAB1B -3936.0 -6843.0
RAB20 -6988.0 4955.0
RAB21 2955.0 3293.0
RAB22A -6961.0 -1880.0
RAB23 4064.0 5110.0
RAB24 2116.0 1422.0
RAB26 4664.0 7900.0
RAB27A 4078.0 2901.0
RAB2A -5613.0 3089.0
RAB2B -1049.0 70.0
RAB30 782.0 7020.0
RAB31 -5814.0 8310.0
RAB32 -5401.0 -6784.0
RAB33A 1830.0 7462.0
RAB33B -2925.0 5286.0
RAB35 -5583.0 -3648.0
RAB36 6575.0 7329.0
RAB37 8312.0 7554.0
RAB39B -3579.0 8463.0
RAB3A 6846.0 8054.0
RAB3B -1787.0 8053.0
RAB3D 730.0 8088.0
RAB40B 4831.0 6783.0
RAB40C -5248.0 -335.0
RAB41 -2704.0 4628.0
RAB42 4826.0 -6561.0
RAB43 -6693.0 967.0
RAB4A -2519.0 -2935.0
RAB4B 1987.0 2428.0
RAB5A -5627.0 -651.0
RAB5B -226.0 -4234.0
RAB5C -1081.0 3457.0
RAB6A 1013.0 -67.0
RAB6B -6443.0 8344.0
RAB7A -6137.0 1245.0
RAB8A -2138.0 1259.0
RAB8B 5244.0 5679.0
RAB9A -6477.0 1946.0
RAB9B -2884.0 7550.0
RABGGTA -4888.0 -7318.0
RABGGTB -5481.0 -3254.0
RAD18 7259.0 1837.0
RAD21 712.0 -2997.0
RAD23A 8442.0 -6707.0
RAD23B 3228.0 -6749.0
RAD52 7129.0 -3616.0
RAE1 4684.0 -5543.0
RANBP2 471.0 501.0
RANGAP1 3828.0 867.0
RARA -6550.0 2359.0
RARS 2867.0 2819.0
RARS2 5552.0 -1337.0
RBBP5 101.0 3788.0
RBBP7 5468.0 3390.0
RBX1 -1688.0 -5910.0
RCE1 -1670.0 -3821.0
RCN1 3985.0 -7814.0
RECK 8451.0 7229.0
RELA -2600.0 -2650.0
RENBP -7009.0 7210.0
RFT1 5545.0 -5636.0
RFWD2 -1769.0 -3561.0
RGS11 1175.0 7048.0
RGS9 4771.0 7890.0
RHOA -5595.0 -610.0
RHOT1 4048.0 5889.0
RING1 1252.0 905.0
RIPK1 -2781.0 -6606.0
RIPK2 -6075.0 5462.0
RNF103 -6285.0 4554.0
RNF123 -4989.0 -3193.0
RNF128 -989.0 3246.0
RNF139 -2883.0 -826.0
RNF144A 4881.0 3567.0
RNF146 1003.0 -4639.0
RNF152 -1053.0 7059.0
RNF168 -3833.0 3966.0
RNF181 -5163.0 6368.0
RNF185 -6322.0 3615.0
RNF2 2695.0 -1709.0
RNF20 6192.0 1502.0
RNF40 -5636.0 -2320.0
RNF5 -7255.0 -905.0
RNF7 -507.0 -4114.0
RORA -6185.0 -607.0
RPA1 -5058.0 2897.0
RPL10 -5543.0 -4999.0
RPL10A -2566.0 -3948.0
RPL11 -5172.0 -2748.0
RPL12 -1507.0 -3084.0
RPL13 -471.0 -3317.0
RPL13A -2745.0 -2677.0
RPL14 -5527.0 -2682.0
RPL15 1849.0 -2009.0
RPL17 126.0 -3940.0
RPL18 -4183.0 -1071.0
RPL18A -5301.0 -585.0
RPL19 -5609.0 -3966.0
RPL21 -4209.0 -4036.5
RPL22 5249.0 -3942.0
RPL22L1 -160.0 -6353.5
RPL23 -1370.0 -2849.0
RPL23A -3454.0 -1887.0
RPL24 -1812.0 -3491.0
RPL26 -1365.0 -146.0
RPL26L1 -3945.0 1440.0
RPL27 -2005.0 -919.0
RPL27A -4506.0 -4250.0
RPL28 -3621.0 -752.0
RPL29 -4075.0 -3272.0
RPL3 -1503.0 -3206.0
RPL30 -4142.0 -2917.0
RPL31 981.0 -1139.0
RPL32 -3393.0 -1261.0
RPL34 -2770.0 -2030.0
RPL35 -2891.0 -1554.0
RPL35A -4369.0 -1415.0
RPL36 -3549.0 -3202.0
RPL36A 5630.0 -2965.0
RPL36AL -7445.0 -2641.0
RPL37 -3457.0 -2235.0
RPL37A -2415.0 -2945.0
RPL38 -1678.0 -1496.0
RPL39 -1636.0 842.0
RPL3L -4857.0 -260.0
RPL4 -2513.0 -3939.0
RPL41 1461.0 -3751.0
RPL5 -554.0 -2231.0
RPL6 -5151.0 -4811.0
RPL7 -1319.0 -3168.0
RPL7A -2609.0 -2165.0
RPL8 -3548.0 -2560.0
RPL9 -3114.0 -4301.0
RPLP0 -4427.0 -1121.0
RPLP1 -4373.0 -3370.0
RPLP2 -2777.0 -1899.0
RPN1 -7473.0 -3567.0
RPN2 -6500.0 -2540.0
RPS10 112.0 -1083.0
RPS11 -5078.0 -2933.0
RPS12 -4503.0 -2114.0
RPS13 -2629.0 -2290.0
RPS14 -3593.0 -2671.0
RPS15 -4564.0 -1911.0
RPS15A -3125.0 -197.0
RPS16 -3362.0 -2103.0
RPS18 -2870.0 -2001.0
RPS19 -4961.0 -2582.0
RPS2 -3922.0 -2651.0
RPS20 -1741.0 -1314.0
RPS21 -2922.0 -743.0
RPS23 -1789.0 -1850.0
RPS24 -2865.0 -1728.0
RPS25 -124.0 -980.0
RPS26 239.0 -3326.0
RPS27 -3410.0 -2769.0
RPS27A -2775.0 -2092.0
RPS27L -3395.0 -5791.0
RPS28 -3558.0 -1760.0
RPS29 -3554.0 19.0
RPS3 -2626.0 -1940.0
RPS3A 1310.0 -2352.0
RPS4X -3384.0 -3144.0
RPS4Y1 -2083.0 -2421.0
RPS5 -5073.0 439.0
RPS6 -2847.0 -2731.0
RPS7 -5915.0 -2189.0
RPS8 -1202.0 -2865.0
RPS9 -4220.0 -3027.0
RPSA -2539.0 -2294.0
RRAGA 2958.0 5429.0
RTF1 -1500.0 -2799.0
RTN4RL2 5152.0 7402.0
RUVBL1 5581.0 1520.0
RWDD3 6992.0 -5333.0
RXRA -4174.0 -4604.0
SAE1 1974.0 -1823.0
SAFB -6493.0 -6390.0
SAR1B -3073.0 4909.0
SARS -5625.0 -4637.0
SARS2 3996.0 -6809.0
SATB1 2474.0 8248.0
SATB2 -2470.0 6075.0
SBSPON 2850.0 2016.0
SCFD1 679.0 477.0
SCMH1 7591.0 -7594.0
SDC2 309.0 -7160.0
SEC11A -2987.0 -1061.0
SEC11C -7434.0 -226.0
SEC13 -7232.0 872.0
SEC16A -6282.0 810.0
SEC22A 4194.0 4163.0
SEC22B -1027.0 5026.0
SEC22C -1206.0 2162.0
SEC23A -2440.0 -5551.0
SEC23IP 361.0 2226.0
SEC24A -7222.0 3801.0
SEC24B -5726.0 -2796.0
SEC24C -6662.0 1672.0
SEC24D -7592.0 5523.0
SEC31A -6119.5 -6115.0
SEC61A1 -7486.0 -3284.0
SEC61A2 -228.0 7423.0
SEC61B -7405.0 -1370.0
SEC61G -4313.0 1345.0
SEH1L -4786.0 -5035.0
SEL1L -7581.0 6447.0
SENP1 -960.0 -2802.0
SENP2 -3898.0 5248.0
SENP5 -5341.0 2633.0
SENP8 7704.0 -2129.0
SERP1 -7394.0 85.0
SERPINA1 4353.0 -3340.0
SERPINA10 5008.0 -7831.0
SERPINC1 -6946.0 -6726.0
SERPIND1 7377.0 -7022.0
SHC1 -7366.0 6063.0
SHISA5 5466.0 -6824.0
SHPRH 6061.0 -3229.0
SIAH1 357.0 -4058.0
SIAH2 -7007.0 2324.0
SIN3A -6159.0 2287.0
SKIV2L 6496.0 2653.0
SKP1 65.0 5781.0
SKP2 6755.0 6897.0
SLC17A5 -7520.0 4661.0
SLC30A5 -3676.0 2910.0
SLC30A6 4561.0 -2326.0
SLC30A7 -7216.0 2831.0
SLC35A1 4302.0 4995.0
SLC35C1 -7105.0 -4212.0
SMAD1 6354.0 -7452.0
SMAD2 -4667.0 -2668.0
SMAD3 -6509.0 -3146.0
SMAD4 3477.0 -6861.0
SMAD7 3198.0 3062.0
SMC1A 844.0 -5605.0
SMC3 2651.0 142.0
SMC5 -1850.0 221.0
SMC6 2357.5 1395.0
SMURF2 -5337.0 -2728.0
SNX3 -5062.0 -385.0
SOCS2 -1552.0 -2318.0
SOCS3 8750.0 -6348.0
SOCS5 -7013.0 -1186.0
SOCS6 -5504.0 -7527.0
SORL1 -3513.0 -2292.0
SP100 -2173.0 -4996.0
SP3 -4839.0 -4156.0
SPCS1 2445.0 -153.0
SPCS2 -5875.0 -4003.0
SPCS3 -7033.0 985.0
SPHK1 -3118.0 -7767.0
SPON1 -7030.0 1362.0
SPON2 -6855.0 -7542.0
SPP1 -6250.0 -7019.0
SPRN 736.0 -6303.0
SPSB1 1090.0 6737.0
SPSB2 -1675.0 4954.0
SPSB3 -3066.0 -3914.0
SPTAN1 2399.0 5588.0
SPTB 5515.0 8432.0
SPTBN1 -5004.0 3454.0
SPTBN2 4535.0 6499.0
SPTBN4 3479.0 8004.0
SPTBN5 -6606.0 7045.0
SRD5A3 4857.0 -1414.0
SRP14 -6238.0 -4757.0
SRP19 -5678.0 1314.0
SRP54 -1869.0 5323.0
SRP68 -6776.0 -5056.0
SRP72 -5764.0 -5825.0
SRP9 6418.0 -949.0
SRPR -5013.0 -5070.0
SRPRB -7298.0 -2276.0
SSPO 7789.0 2196.0
SSR1 -7335.0 -1989.0
SSR2 -7198.0 536.0
SSR3 -7349.0 -873.0
SSR4 -7460.0 -2082.0
ST3GAL1 -6188.0 -2089.0
ST3GAL2 -3755.0 5881.0
ST3GAL3 6820.0 -7613.0
ST3GAL4 -7237.0 -1792.0
ST3GAL5 6537.0 8454.0
ST3GAL6 -3633.0 -3511.0
ST6GAL1 -1721.0 -7528.0
ST6GALNAC2 -6377.0 3122.0
ST6GALNAC4 -7211.0 5233.0
ST6GALNAC6 -5556.0 -5736.0
ST8SIA1 7115.0 6005.0
STAG1 -3906.0 -7041.0
STAG2 -3204.0 -6068.0
STAM 5057.0 2887.0
STAM2 3375.0 4732.0
STAMBP 6506.0 -1138.0
STAMBPL1 4276.0 -2870.0
STAT3 4493.0 1454.0
STC2 -6438.0 -6033.0
STS -4712.0 -7261.0
STT3A -7227.0 -5922.0
STX17 2592.0 -501.0
STX1A -2174.0 5205.0
STX5 -5692.0 787.0
SUDS3 -1448.0 5765.0
SUMF1 6981.0 -3681.0
SUMF2 970.0 -3295.0
SUMO1 3034.0 1628.0
SUMO2 2336.0 -2710.0
SUMO3 5055.5 -6375.0
SUZ12 -6.0 -850.0
SYVN1 -7570.0 4301.0
TAB1 7756.0 -5796.0
TADA2B -5714.0 -6139.0
TADA3 -968.0 -3090.0
TAF10 521.0 3768.0
TAF9B 6650.0 -5606.0
TARS -5974.0 -5754.0
TARS2 3016.0 1978.0
TATDN2 -6639.0 -4947.0
TBC1D20 -6651.0 6009.0
TBCA 4197.0 380.0
TBCB 2578.0 -5895.0
TBCC 2614.0 -3834.0
TBCD -3061.0 5317.0
TBCE 985.0 -364.0
TCF7L2 1096.0 -3486.0
TCP1 -5147.0 3821.0
TDG -3329.0 -4158.0
TECTA 3648.0 533.0
TECTB -7090.0 4510.0
TF 6802.0 -1830.0
TFG -5590.0 -1302.0
TFPT 2381.0 -5114.0
TGFA -4681.0 2453.0
TGFB1 -7392.0 7182.0
TGFBI -4745.0 -5872.0
TGFBR1 -2379.0 -3012.0
TGFBR2 -3644.0 -6778.0
TGOLN2 -1766.0 -4111.0
THBS1 6810.0 -5540.0
THBS2 4220.0 7389.0
THRA -3199.0 604.0
THRB -4020.0 -6194.0
THSD1 -6723.0 4651.0
THSD4 -7404.0 4457.0
TIMP1 -6733.0 3149.0
TLN1 -6564.0 -1483.0
TMED10 -6374.0 -3599.0
TMED2 -7514.0 3294.0
TMED3 -4017.0 -2943.0
TMED7 -7219.0 3543.0
TMED9 -6959.0 1408.0
TMEM115 -7174.0 -1105.0
TMEM129 5402.0 -7218.0
TMEM132A 2206.0 5988.0
TNFAIP3 4755.0 5847.0
TNIP1 -4536.0 -6857.0
TNIP2 -1334.0 -3323.0
TNKS -4684.0 547.0
TNKS2 -3122.0 1594.0
TOMM20 2204.0 -516.0
TOP1 -6835.0 3725.0
TOP2A 7984.0 -1877.0
TOP2B -3794.0 -4446.0
TOPORS -2633.0 932.0
TP53 -1887.0 -7411.0
TP53BP1 1930.0 5333.0
TPGS1 -5761.0 1803.0
TPGS2 6035.0 1755.0
TPP1 -6747.0 4470.0
TPR 610.0 -1079.0
TRAF2 -436.0 -2066.0
TRAF3 -88.0 4872.0
TRAF6 1921.0 197.0
TRAM1 -7465.0 -2243.0
TRAPPC1 3166.0 5001.0
TRAPPC10 -6708.0 -2673.0
TRAPPC2 3698.0 24.0
TRAPPC2L -4620.0 -2212.0
TRAPPC3 -4370.0 3438.5
TRAPPC4 1396.0 3456.0
TRAPPC5 2376.0 3264.0
TRAPPC6A 8600.0 3427.0
TRAPPC6B 2661.0 1950.0
TRAPPC9 5768.0 7114.0
TRIM13 1936.0 -6313.0
TRIM25 -5688.0 -183.0
TRIM27 -7005.0 -5019.0
TRIM28 -3038.0 -6228.0
TRMT112 -3724.0 -4119.0
TRRAP -3521.0 -1453.0
TSFM -767.0 1189.0
TSPAN14 -4809.0 5857.0
TSPAN15 5963.0 8312.0
TSPAN33 4854.0 7506.0
TSPAN5 -2814.0 6641.0
TSPYL2 -7191.0 2462.0
TSTA3 -4703.0 -2812.0
TTF1 5336.0 -4262.0
TTL -2547.0 5555.0
TTLL1 8210.0 3988.0
TTLL11 -6779.0 6605.0
TTLL12 -351.0 -4464.0
TTLL3 8239.0 1678.0
TTLL4 2065.0 -3882.0
TTLL5 -121.0 5767.0
TTLL6 656.0 7816.0
TTLL7 -6117.0 7986.0
TTR -3986.0 5461.0
TUBA1A 5390.0 7254.0
TUBA1B 7705.0 -3504.0
TUBA1C 7292.0 -2498.0
TUBA3D 813.0 -2848.0
TUBA4A -204.0 8231.0
TUBA4B -1017.0 8296.0
TUBA8 7490.0 -5838.0
TUBB1 2015.0 4399.0
TUBB2A 1912.0 5364.0
TUBB2B 5428.0 8400.0
TUBB3 2013.0 1601.0
TUBB4A 3744.0 8474.0
TUBB4B 7741.0 -118.0
TUBB6 -673.0 7572.0
TUFM -3389.0 -961.0
TULP4 -3581.0 1464.0
TUSC3 -2783.0 3600.0
TXN -3784.0 2934.0
UAP1 -634.0 1589.0
UBA1 718.0 2782.0
UBA2 -4188.0 -5653.0
UBA3 -1462.0 -140.0
UBA52 -5323.0 1252.0
UBA6 -2134.0 2622.0
UBB -3737.0 1627.0
UBC 931.0 -2324.0
UBE2A 3860.0 676.0
UBE2B -2507.0 1105.0
UBE2C 8387.0 -6017.0
UBE2D1 3789.0 4615.0
UBE2D2 -907.0 -4180.0
UBE2D3 -4046.0 -4321.0
UBE2E1 3856.0 -5800.0
UBE2E3 -3071.0 -1338.0
UBE2F -4436.0 4850.0
UBE2G1 -6107.0 2191.0
UBE2G2 -333.0 3082.0
UBE2H 5878.0 3090.0
UBE2I -311.0 -2998.0
UBE2J2 -6715.0 -4853.0
UBE2K 216.0 -497.0
UBE2L3 -1900.0 -5064.0
UBE2L6 8602.0 7253.0
UBE2M -4905.0 -3255.0
UBE2N 1643.0 1517.0
UBE2Q2 2642.0 -1753.0
UBE2R2 -402.0 -6452.0
UBE2S -1249.0 6715.0
UBE2T 6585.0 6964.0
UBE2V2 3705.0 -1418.0
UBE2W -1679.0 3971.0
UBE2Z -754.0 -6108.0
UBXN1 -5821.0 505.0
UBXN7 1368.0 -367.0
UCHL1 -6080.0 7371.0
UCHL3 -4622.0 5774.0
UCHL5 319.0 3501.0
UCN 7671.0 3581.0
UFD1L -2573.0 5076.0
UGGT1 -7364.0 -2124.0
UGGT2 1285.0 3828.0
UHRF2 -2410.0 -1157.0
UIMC1 -7045.0 -2566.0
USO1 -3638.0 -2678.0
USP10 910.0 -1482.0
USP11 2980.0 -2441.0
USP12 -3058.0 2331.0
USP13 6783.0 -7256.0
USP14 5517.0 4780.0
USP15 -4468.0 2945.0
USP16 -6886.0 -6466.0
USP18 5136.0 -1981.0
USP19 -2227.0 -5207.0
USP2 -5303.0 4905.0
USP20 1485.0 1015.0
USP21 3090.0 -6832.0
USP22 -5550.0 -7198.0
USP24 -2185.0 -4932.0
USP25 -300.0 -955.0
USP28 -1487.0 3376.0
USP3 -4016.0 -5293.0
USP30 7148.0 5270.0
USP33 2058.0 3451.0
USP34 -4747.0 -2366.0
USP37 2255.0 4033.0
USP4 1510.0 -6358.0
USP42 -5321.0 -2507.0
USP44 3251.0 6248.0
USP47 -1520.0 -3441.0
USP48 2535.0 2296.0
USP49 2114.0 2849.0
USP5 -2816.0 -6678.0
USP7 211.0 -5940.0
USP8 -3361.0 1315.0
USP9X -4461.0 1938.0
VAMP2 -4685.0 -4137.0
VARS -4865.0 -7001.0
VARS2 -6479.0 -7449.0
VBP1 -3340.0 -4305.0
VCAN -5882.0 -4231.0
VCP -7126.0 -4707.0
VCPIP1 -5152.0 -1759.0
VCPKMT 5834.0 -3385.0
VDAC1 -829.0 -4409.0
VDAC2 -1827.0 -948.0
VDAC3 121.0 1577.0
VDR 5311.0 8269.0
VGF -7393.0 7411.0
VHL -6722.0 -2506.0
VNN1 6914.0 -3267.0
VWA1 3184.0 3336.0
WAC -6281.0 -5355.0
WARS -7558.0 -6553.0
WARS2 4148.0 -7589.0
WDR20 -3877.0 -4404.0
WDR48 595.0 -4577.0
WDR5 2660.0 -533.0
WDR61 443.0 557.0
WDTC1 -993.0 6123.0
WFS1 -7560.0 6010.0
WIPI1 -7129.0 6656.0
WRAP53 2075.0 5415.0
WRN 3473.0 4087.0
WSB1 -4613.0 4745.0
WSB2 -7493.0 -4297.0
XBP1 6619.0 -7178.0
XPC 5608.0 -4221.0
XPNPEP2 7271.0 -4489.0
XRCC4 3850.0 -3103.0
XRN2 -3195.0 -5934.0
YARS 980.0 -6774.0
YARS2 -375.0 -7405.0
YIF1A 360.0 -1224.0
YKT6 -5114.0 4764.0
YOD1 -6523.0 833.0
YY1 -5405.0 -5164.0
ZBED1 3703.0 -7526.0
ZBTB17 -3355.0 3401.0
ZDHHC2 -1394.0 4826.0
ZNF131 -3716.0 -6188.0
ZNF350 1544.0 2637.0
ZRANB1 -6125.0 -1298.0



Processing of Capped Intron-Containing Pre-mRNA

metric value
setSize 233
pMANOVA 8.81e-27
p.adjustMANOVA 2.79e-24
s.dist 0.416
confESp NA
s.rna_LGvHG -0.17
s.rna_HGvHGV -0.379
p.rna_LGvHG 8.27e-06
p.rna_HGvHGV 1.95e-23




Gene rna_LGvHG rna_HGvHGV
SRSF4 -7312 -7491.0
ALYREF -7253 -6934.0
DDX5 -7024 -6523.0
POM121 -6619 -6903.0
HNRNPA2B1 -6801 -6562.0
CASC3 -6360 -6976.0
SRRT -6638 -6682.0
SRRM2 -6278 -7049.0
SNRPA -7008 -6083.0
HNRNPM -7192 -5669.0
RBMX -5407 -7349.0
POM121C -5801 -6560.0
SRSF3 -5573 -6803.0
SRSF1 -5869 -6395.0
NXF1 -6740 -5380.5
HSPA8 -4920 -6728.0
YBX1 -5901 -5024.0
SF1 -4537 -6386.0
U2AF1 -6942 -4162.0
DDX39A -7343 -3925.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
AAAS 3304.0 -6791.0
ALYREF -7253.0 -6934.0
AQR -2579.0 -543.0
BCAS2 -775.0 -72.0
BUD31 -5689.0 4899.0
CASC3 -6360.0 -6976.0
CCAR1 2999.0 -6944.0
CD2BP2 -4151.0 758.0
CDC40 -2272.0 2503.0
CDC5L -2427.0 -5167.0
CHERP -3874.0 -6191.0
CHTOP 3488.0 -6995.0
CLP1 -5836.0 4588.0
CPSF1 -4005.0 -5362.0
CPSF2 7234.0 -6822.0
CPSF3 6896.0 -1472.0
CPSF4 1809.0 2639.0
CPSF7 -2118.0 -7659.0
CRNKL1 -2541.0 -2203.0
CSTF1 1636.0 -2884.0
CSTF2 1495.0 -2237.0
CSTF2T 8100.0 -702.0
CSTF3 2463.0 3081.0
CTNNBL1 3259.0 4702.0
CWC15 -926.0 -5339.0
CWC22 -4074.0 -4930.0
CWC25 -3670.0 -2008.0
CWC27 -4440.0 -2358.0
DDX23 -3685.0 -4351.0
DDX39A -7343.0 -3925.0
DDX39B 2645.0 -6290.0
DDX42 6345.0 -5712.0
DDX46 -918.0 -3282.0
DDX5 -7024.0 -6523.0
DHX15 -1512.0 -4636.0
DHX16 -3597.0 3278.0
DHX38 -6640.0 -1536.0
DHX9 -4126.0 -6141.0
DNAJC8 1875.0 2177.0
EFTUD2 -2755.0 -2246.0
EIF4A3 1298.0 3126.0
EIF4E 2829.0 494.0
ELAVL1 -3143.0 -412.0
FIP1L1 -6400.0 -4052.0
FUS 8631.0 -5688.0
FYTTD1 -6194.0 5437.0
GCFC2 2497.0 -4268.0
GLE1 2414.0 -5346.0
GPKOW 3818.0 -3895.0
GTF2F1 -3019.0 -1117.0
GTF2F2 4860.0 1441.0
HNRNPA0 5689.0 -5592.0
HNRNPA1 808.0 -5324.0
HNRNPA2B1 -6801.0 -6562.0
HNRNPA3 -1817.0 -6492.0
HNRNPC 778.0 -4822.0
HNRNPD 3122.0 -7219.0
HNRNPF -7059.0 -4014.0
HNRNPH1 1765.0 -6192.0
HNRNPH2 2916.0 -3602.0
HNRNPK -2841.0 -6969.0
HNRNPL -3565.0 -7077.0
HNRNPM -7192.0 -5669.0
HNRNPR 1761.0 -6740.0
HNRNPU -3829.0 -6230.0
HNRNPUL1 -984.0 -7329.0
HSPA8 -4920.0 -6728.0
ISY1 -4820.0 -2333.0
LSM2 1512.0 -4000.0
LSM3 5371.0 -817.0
LSM4 8090.0 3333.0
LSM5 5741.0 -1754.0
LSM6 5582.0 -4311.0
LSM7 -3871.0 -6159.0
MAGOH -1096.0 -1098.0
MAGOHB 6510.0 -6663.0
METTL14 4920.0 378.0
METTL3 4153.0 -4335.0
NCBP1 -1858.0 1533.0
NCBP2 7854.0 -262.0
NDC1 -1208.0 -2073.0
NUDT21 2349.0 -2007.0
NUP107 6965.0 -4327.0
NUP133 1406.0 1305.0
NUP153 2805.0 1278.0
NUP155 5259.0 -95.0
NUP160 -271.0 -1749.0
NUP188 -5044.0 -3795.0
NUP205 -5514.0 -2051.0
NUP210 7824.0 -4030.0
NUP214 -1509.0 -4585.0
NUP35 6880.0 -2911.0
NUP37 8176.0 -4271.0
NUP43 2778.0 1270.0
NUP50 -4694.0 -4478.0
NUP54 3508.0 -1767.0
NUP62 -73.0 -4951.0
NUP85 4624.0 1161.0
NUP88 -4829.0 -5548.0
NUP93 6534.0 2994.0
NUP98 -3617.0 2992.0
NUPL2 -3453.0 1853.0
NXF1 -6740.0 -5380.5
NXT1 -1912.0 4157.0
PABPN1 176.0 -7478.0
PAPOLA -2921.0 467.0
PCBP1 -3840.0 -7004.0
PCBP2 2617.0 -6175.0
PCF11 -5164.0 -3300.0
PDCD7 -1056.0 -6407.0
PHF5A -396.0 -4188.0
PLRG1 -1479.0 3658.0
POLDIP3 1423.0 -7246.0
POLR2A 2948.0 -6306.0
POLR2B -3795.0 2880.0
POLR2C -3177.0 1582.0
POLR2D 1696.0 -2523.0
POLR2E -4282.5 3215.0
POLR2F -5560.0 4701.0
POLR2G 2153.0 1453.0
POLR2H -4010.0 -1665.0
POLR2I 4612.0 -3659.0
POLR2J -246.0 4188.0
POLR2K 6791.0 5504.0
POLR2L -5741.0 6784.0
POM121 -6619.0 -6903.0
POM121C -5801.0 -6560.0
PPIE 1706.0 -4763.0
PPIH 761.0 -4017.0
PPIL1 -4515.0 -5090.0
PPIL3 5458.0 1009.0
PPIL4 2337.0 -1236.0
PPWD1 3814.0 -3467.0
PQBP1 -4479.0 -5797.0
PRCC -6588.0 -3285.0
PRPF19 2853.0 343.0
PRPF3 -6121.0 -3150.0
PRPF31 2550.0 -5300.0
PRPF38A -1605.0 -4838.0
PRPF4 2294.0 2962.0
PRPF40A -4008.0 -2286.0
PRPF6 3930.0 -5023.0
PRPF8 -5026.0 -5652.0
PTBP1 -6440.0 -4372.0
PUF60 -3692.0 -7312.0
RAE1 4684.0 -5543.0
RANBP2 471.0 501.0
RBM17 -2766.0 -1173.0
RBM22 -3968.0 -5137.0
RBM5 6173.0 -7369.0
RBM8A 956.0 -5273.0
RBMX -5407.0 -7349.0
RNPC3 4829.0 -3201.0
RNPS1 -7272.0 -555.0
RNU12 -6661.0 -276.0
SARNP -2268.0 4054.0
SART1 -4976.0 -4440.0
SEC13 -7232.0 872.0
SEH1L -4786.0 -5035.0
SF1 -4537.0 -6386.0
SF3A1 -4276.0 -5926.0
SF3A2 -3288.0 -5060.0
SF3A3 -2906.0 4938.0
SF3B1 -217.0 -1958.0
SF3B2 -1534.0 -4075.0
SF3B3 -3791.0 -6401.0
SF3B4 -2944.0 -5113.0
SF3B5 -4446.0 4623.0
SLBP -6437.0 5526.0
SLU7 130.0 -1437.0
SMNDC1 -969.0 -5327.0
SNRNP200 -1652.0 -3577.0
SNRNP25 372.0 -1540.0
SNRNP27 1234.0 1808.0
SNRNP35 8393.0 -4400.0
SNRNP40 -5278.0 -3214.0
SNRNP48 -6731.0 6341.0
SNRNP70 -3481.0 -5255.0
SNRPA -7008.0 -6083.0
SNRPA1 -7218.0 812.0
SNRPB -1673.0 -3808.0
SNRPB2 907.0 -3411.0
SNRPC 824.0 -4410.0
SNRPD1 6304.0 -3405.0
SNRPD2 -3359.0 2762.0
SNRPD3 -6109.0 2670.0
SNRPE 4103.0 -3791.0
SNRPF 2390.0 -4080.0
SNRPG 864.0 2918.0
SNRPN 4924.0 1207.0
SNW1 -5749.0 -4537.0
SRRM1 236.0 -5520.0
SRRM2 -6278.0 -7049.0
SRRT -6638.0 -6682.0
SRSF1 -5869.0 -6395.0
SRSF10 -4936.0 -3062.0
SRSF11 -1542.0 -4010.0
SRSF2 623.0 -6578.0
SRSF3 -5573.0 -6803.0
SRSF4 -7312.0 -7491.0
SRSF5 7060.0 -7002.0
SRSF6 7330.0 -7363.0
SRSF7 2956.0 -6232.0
SRSF9 -4937.0 -4160.0
SUGP1 1519.0 -833.0
SYF2 -6533.0 -3945.0
SYMPK -34.0 -6687.0
TFIP11 -619.0 -2596.0
THOC1 435.0 -3212.0
THOC2 -1647.0 -1550.0
THOC3 3837.0 2313.0
THOC5 -3642.0 -6444.0
THOC6 3007.0 -7502.0
THOC7 1634.0 -5703.0
TPR 610.0 -1079.0
TRA2B -1076.0 -4606.0
TXNL4A -2889.0 2889.0
U2AF1 -6942.0 -4162.0
U2AF1L4 724.0 -5888.0
U2AF2 -928.0 -7743.0
U2SURP 2729.0 -3480.0
UPF3B 2835.0 -2132.0
USP39 -6054.0 4201.0
WBP11 -1814.0 -4776.0
WBP4 -1620.0 -1580.0
WDR33 -3532.0 -4687.0
WTAP -1796.0 -6044.0
XAB2 4322.0 2004.0
YBX1 -5901.0 -5024.0
ZC3H11A -716.0 -5756.0
ZCRB1 4997.0 4002.0
ZMAT5 -2716.0 1921.0
ZRSR2 -4101.0 -4088.0



rRNA processing in the nucleus and cytosol

metric value
setSize 186
pMANOVA 4.71e-26
p.adjustMANOVA 1.19e-23
s.dist 0.458
confESp NA
s.rna_LGvHG -0.285
s.rna_HGvHGV -0.358
p.rna_LGvHG 2.1e-11
p.rna_HGvHGV 3.65e-17




Gene rna_LGvHG rna_HGvHGV
EXOSC6 -6618 -6747.0
UTP14A -5810 -7129.0
CSNK1D -6047 -6638.0
DHX37 -5482 -7023.0
NOP14 -5380 -6917.0
EXOSC5 -4907 -6416.0
RPL10 -5543 -4999.0
WDR43 -4228 -6314.0
MPHOSPH10 -7389 -3593.0
IMP4 -5115 -5006.5
NOB1 -3671 -6762.0
RPL6 -5151 -4811.0
NOL9 -5107 -4710.0
NOP2 -3929 -5946.0
NOL12 -3884 -5985.0
GNL3 -5645 -4043.0
UTP18 -4480 -5004.0
RPL19 -5609 -3966.0
LTV1 -5754 -3627.0
PES1 -3448 -6032.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
BMS1 -4822 -1690.0
BOP1 -2079 -2856.0
BYSL -2390 -4949.0
C1D 1937 2500.0
CSNK1D -6047 -6638.0
CSNK1E 3315 2456.0
DCAF13 4844 -1935.0
DDX21 -111 -4414.0
DDX47 3960 -3582.0
DDX49 -7270 1638.0
DDX52 -4886 -1242.0
DHX37 -5482 -7023.0
DIEXF -3206 -5671.0
DIMT1 2158 -4456.0
DIS3 -1501 2302.0
DKC1 -1036 -7546.0
EBNA1BP2 -3618 917.0
EMG1 7798 -6511.0
ERI1 -2096 5585.0
EXOSC1 3614 -3532.0
EXOSC10 -142 -6920.0
EXOSC2 3961 313.0
EXOSC3 -2961 1286.0
EXOSC4 2801 -4513.0
EXOSC5 -4907 -6416.0
EXOSC6 -6618 -6747.0
EXOSC7 5542 -5377.0
EXOSC8 412 -7068.0
EXOSC9 3277 1337.0
FAU -5465 -1439.0
FBL -1464 -869.0
FCF1 -2147 -2175.0
FTSJ3 2188 -5738.0
GAR1 -2893 -6214.0
GNL3 -5645 -4043.0
HEATR1 -1439 -4988.0
IMP3 -4746 2697.0
IMP4 -5115 -5006.5
ISG20L2 -3740 6098.0
KRR1 1404 -3257.0
LAS1L 8194 -3709.0
LTV1 -5754 -3627.0
MPHOSPH10 -7389 -3593.0
MPHOSPH6 6361 876.0
NAT10 3697 -6536.0
NCL -1691 -6949.0
NHP2 -2850 -2568.0
NIP7 -1876 -4614.0
NOB1 -3671 -6762.0
NOC4L -1762 -416.0
NOL11 4442 -4884.0
NOL12 -3884 -5985.0
NOL6 2264 535.0
NOL9 -5107 -4710.0
NOP10 -5228 1281.0
NOP14 -5380 -6917.0
NOP2 -3929 -5946.0
NOP56 -1126 -5490.0
NOP58 6235 -4117.0
PDCD11 3374 -5557.0
PELP1 -2911 -4848.0
PES1 -3448 -6032.0
PNO1 -6059 -1025.0
PWP2 1329 397.0
RBM28 283 -3818.0
RCL1 -1093 -1771.0
RIOK1 2469 530.0
RIOK2 -4274 -1347.0
RIOK3 -6729 5636.0
RPL10 -5543 -4999.0
RPL10A -2566 -3948.0
RPL11 -5172 -2748.0
RPL12 -1507 -3084.0
RPL13 -471 -3317.0
RPL13A -2745 -2677.0
RPL14 -5527 -2682.0
RPL15 1849 -2009.0
RPL17 126 -3940.0
RPL18 -4183 -1071.0
RPL18A -5301 -585.0
RPL19 -5609 -3966.0
RPL21 -4209 -4036.5
RPL22 5249 -3942.0
RPL22L1 -160 -6353.5
RPL23 -1370 -2849.0
RPL23A -3454 -1887.0
RPL24 -1812 -3491.0
RPL26 -1365 -146.0
RPL26L1 -3945 1440.0
RPL27 -2005 -919.0
RPL27A -4506 -4250.0
RPL28 -3621 -752.0
RPL29 -4075 -3272.0
RPL3 -1503 -3206.0
RPL30 -4142 -2917.0
RPL31 981 -1139.0
RPL32 -3393 -1261.0
RPL34 -2770 -2030.0
RPL35 -2891 -1554.0
RPL35A -4369 -1415.0
RPL36 -3549 -3202.0
RPL36A 5630 -2965.0
RPL36AL -7445 -2641.0
RPL37 -3457 -2235.0
RPL37A -2415 -2945.0
RPL38 -1678 -1496.0
RPL39 -1636 842.0
RPL3L -4857 -260.0
RPL4 -2513 -3939.0
RPL41 1461 -3751.0
RPL5 -554 -2231.0
RPL6 -5151 -4811.0
RPL7 -1319 -3168.0
RPL7A -2609 -2165.0
RPL8 -3548 -2560.0
RPL9 -3114 -4301.0
RPLP0 -4427 -1121.0
RPLP1 -4373 -3370.0
RPLP2 -2777 -1899.0
RPP14 107 -2044.0
RPP21 1993 -3121.0
RPP25 5023 7108.0
RPP30 1743 3043.0
RPP38 633 -2188.0
RPP40 2305 -6456.0
RPS10 112 -1083.0
RPS11 -5078 -2933.0
RPS12 -4503 -2114.0
RPS13 -2629 -2290.0
RPS14 -3593 -2671.0
RPS15 -4564 -1911.0
RPS15A -3125 -197.0
RPS16 -3362 -2103.0
RPS18 -2870 -2001.0
RPS19 -4961 -2582.0
RPS2 -3922 -2651.0
RPS20 -1741 -1314.0
RPS21 -2922 -743.0
RPS23 -1789 -1850.0
RPS24 -2865 -1728.0
RPS25 -124 -980.0
RPS26 239 -3326.0
RPS27 -3410 -2769.0
RPS27A -2775 -2092.0
RPS27L -3395 -5791.0
RPS28 -3558 -1760.0
RPS29 -3554 19.0
RPS3 -2626 -1940.0
RPS3A 1310 -2352.0
RPS4X -3384 -3144.0
RPS4Y1 -2083 -2421.0
RPS5 -5073 439.0
RPS6 -2847 -2731.0
RPS7 -5915 -2189.0
RPS8 -1202 -2865.0
RPS9 -4220 -3027.0
RPSA -2539 -2294.0
RRP1 -5330 -3896.0
RRP36 -6725 707.0
RRP7A 1747 -2435.0
RRP9 -2392 -3624.0
SENP3 440 1030.0
SNORD3A -335 819.0
TBL3 3281 -3098.0
TEX10 -4066 2308.0
THUMPD1 1549 -890.0
TRMT112 -3724 -4119.0
TSR1 -1745 -7045.0
TSR3 -649 -4935.0
UBA52 -5323 1252.0
UTP14A -5810 -7129.0
UTP14C -6428 3119.0
UTP15 -3037 -1583.0
UTP18 -4480 -5004.0
UTP20 -2864 -7232.0
UTP3 4557 2878.0
UTP6 -1775 -3426.0
WBSCR22 -4690 -2603.0
WDR12 3926 -5704.0
WDR18 2475 -7484.0
WDR3 6367 -1606.0
WDR36 6307 -4522.0
WDR43 -4228 -6314.0
WDR46 1073 -1929.0
WDR75 3713 -4133.0
XRN2 -3195 -5934.0



rRNA processing

metric value
setSize 218
pMANOVA 8.66e-25
p.adjustMANOVA 1.83e-22
s.dist 0.413
confESp NA
s.rna_LGvHG -0.242
s.rna_HGvHGV -0.335
p.rna_LGvHG 8.19e-10
p.rna_HGvHGV 1.79e-17




Gene rna_LGvHG rna_HGvHGV
EXOSC6 -6618 -6747.0
UTP14A -5810 -7129.0
CSNK1D -6047 -6638.0
DHX37 -5482 -7023.0
NOP14 -5380 -6917.0
EXOSC5 -4907 -6416.0
ELAC2 -5422 -5441.0
RPL10 -5543 -4999.0
WDR43 -4228 -6314.0
MPHOSPH10 -7389 -3593.0
IMP4 -5115 -5006.5
NOB1 -3671 -6762.0
RPL6 -5151 -4811.0
NOL9 -5107 -4710.0
NOP2 -3929 -5946.0
NOL12 -3884 -5985.0
GNL3 -5645 -4043.0
UTP18 -4480 -5004.0
RPL19 -5609 -3966.0
MT-TL1 -7531 -2842.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
BMS1 -4822 -1690.0
BOP1 -2079 -2856.0
BYSL -2390 -4949.0
C1D 1937 2500.0
CSNK1D -6047 -6638.0
CSNK1E 3315 2456.0
DCAF13 4844 -1935.0
DDX21 -111 -4414.0
DDX47 3960 -3582.0
DDX49 -7270 1638.0
DDX52 -4886 -1242.0
DHX37 -5482 -7023.0
DIEXF -3206 -5671.0
DIMT1 2158 -4456.0
DIS3 -1501 2302.0
DKC1 -1036 -7546.0
EBNA1BP2 -3618 917.0
ELAC2 -5422 -5441.0
EMG1 7798 -6511.0
ERI1 -2096 5585.0
EXOSC1 3614 -3532.0
EXOSC10 -142 -6920.0
EXOSC2 3961 313.0
EXOSC3 -2961 1286.0
EXOSC4 2801 -4513.0
EXOSC5 -4907 -6416.0
EXOSC6 -6618 -6747.0
EXOSC7 5542 -5377.0
EXOSC8 412 -7068.0
EXOSC9 3277 1337.0
FAU -5465 -1439.0
FBL -1464 -869.0
FCF1 -2147 -2175.0
FTSJ3 2188 -5738.0
GAR1 -2893 -6214.0
GNL3 -5645 -4043.0
HEATR1 -1439 -4988.0
HSD17B10 -4774 5391.0
IMP3 -4746 2697.0
IMP4 -5115 -5006.5
ISG20L2 -3740 6098.0
KIAA0391 -4444 -2733.0
KRR1 1404 -3257.0
LAS1L 8194 -3709.0
LTV1 -5754 -3627.0
MPHOSPH10 -7389 -3593.0
MPHOSPH6 6361 876.0
MRM1 4828 -6418.0
MT-ATP6 6587 -3233.0
MT-ATP8 7439 -3191.0
MT-CO1 7382 -2264.0
MT-CO2 1065 -1198.0
MT-CO3 8645 -1168.0
MT-CYB 8161 -3327.0
MT-ND1 -4982 -2594.0
MT-ND2 -1328 -3781.0
MT-ND3 3754 -209.0
MT-ND4 3208 -2413.0
MT-ND4L 1757 -1711.0
MT-ND5 3683 -3785.0
MT-RNR1 711 1933.0
MT-RNR2 8019 3799.0
MT-TD -7360 -139.0
MT-TF -7368 2105.0
MT-TG 3547 -819.0
MT-TH 1319 -2462.0
MT-TI -7541 -1150.0
MT-TL1 -7531 -2842.0
MT-TL2 1538 -374.0
MT-TM -7383 2817.0
MT-TT 3440 429.0
MT-TV -7131 -358.0
MT-TW 2032 -731.0
NAT10 3697 -6536.0
NCL -1691 -6949.0
NHP2 -2850 -2568.0
NIP7 -1876 -4614.0
NOB1 -3671 -6762.0
NOC4L -1762 -416.0
NOL11 4442 -4884.0
NOL12 -3884 -5985.0
NOL6 2264 535.0
NOL9 -5107 -4710.0
NOP10 -5228 1281.0
NOP14 -5380 -6917.0
NOP2 -3929 -5946.0
NOP56 -1126 -5490.0
NOP58 6235 -4117.0
NSUN4 4169 -6385.0
PDCD11 3374 -5557.0
PELP1 -2911 -4848.0
PES1 -3448 -6032.0
PNO1 -6059 -1025.0
PWP2 1329 397.0
RBM28 283 -3818.0
RCL1 -1093 -1771.0
RIOK1 2469 530.0
RIOK2 -4274 -1347.0
RIOK3 -6729 5636.0
RPL10 -5543 -4999.0
RPL10A -2566 -3948.0
RPL11 -5172 -2748.0
RPL12 -1507 -3084.0
RPL13 -471 -3317.0
RPL13A -2745 -2677.0
RPL14 -5527 -2682.0
RPL15 1849 -2009.0
RPL17 126 -3940.0
RPL18 -4183 -1071.0
RPL18A -5301 -585.0
RPL19 -5609 -3966.0
RPL21 -4209 -4036.5
RPL22 5249 -3942.0
RPL22L1 -160 -6353.5
RPL23 -1370 -2849.0
RPL23A -3454 -1887.0
RPL24 -1812 -3491.0
RPL26 -1365 -146.0
RPL26L1 -3945 1440.0
RPL27 -2005 -919.0
RPL27A -4506 -4250.0
RPL28 -3621 -752.0
RPL29 -4075 -3272.0
RPL3 -1503 -3206.0
RPL30 -4142 -2917.0
RPL31 981 -1139.0
RPL32 -3393 -1261.0
RPL34 -2770 -2030.0
RPL35 -2891 -1554.0
RPL35A -4369 -1415.0
RPL36 -3549 -3202.0
RPL36A 5630 -2965.0
RPL36AL -7445 -2641.0
RPL37 -3457 -2235.0
RPL37A -2415 -2945.0
RPL38 -1678 -1496.0
RPL39 -1636 842.0
RPL3L -4857 -260.0
RPL4 -2513 -3939.0
RPL41 1461 -3751.0
RPL5 -554 -2231.0
RPL6 -5151 -4811.0
RPL7 -1319 -3168.0
RPL7A -2609 -2165.0
RPL8 -3548 -2560.0
RPL9 -3114 -4301.0
RPLP0 -4427 -1121.0
RPLP1 -4373 -3370.0
RPLP2 -2777 -1899.0
RPP14 107 -2044.0
RPP21 1993 -3121.0
RPP25 5023 7108.0
RPP30 1743 3043.0
RPP38 633 -2188.0
RPP40 2305 -6456.0
RPS10 112 -1083.0
RPS11 -5078 -2933.0
RPS12 -4503 -2114.0
RPS13 -2629 -2290.0
RPS14 -3593 -2671.0
RPS15 -4564 -1911.0
RPS15A -3125 -197.0
RPS16 -3362 -2103.0
RPS18 -2870 -2001.0
RPS19 -4961 -2582.0
RPS2 -3922 -2651.0
RPS20 -1741 -1314.0
RPS21 -2922 -743.0
RPS23 -1789 -1850.0
RPS24 -2865 -1728.0
RPS25 -124 -980.0
RPS26 239 -3326.0
RPS27 -3410 -2769.0
RPS27A -2775 -2092.0
RPS27L -3395 -5791.0
RPS28 -3558 -1760.0
RPS29 -3554 19.0
RPS3 -2626 -1940.0
RPS3A 1310 -2352.0
RPS4X -3384 -3144.0
RPS4Y1 -2083 -2421.0
RPS5 -5073 439.0
RPS6 -2847 -2731.0
RPS7 -5915 -2189.0
RPS8 -1202 -2865.0
RPS9 -4220 -3027.0
RPSA -2539 -2294.0
RRP1 -5330 -3896.0
RRP36 -6725 707.0
RRP7A 1747 -2435.0
RRP9 -2392 -3624.0
SENP3 440 1030.0
SNORD3A -335 819.0
TBL3 3281 -3098.0
TEX10 -4066 2308.0
TFB1M 665 1451.0
THUMPD1 1549 -890.0
TRMT10C 5497 1534.0
TRMT112 -3724 -4119.0
TSR1 -1745 -7045.0
TSR3 -649 -4935.0
UBA52 -5323 1252.0
UTP14A -5810 -7129.0
UTP14C -6428 3119.0
UTP15 -3037 -1583.0
UTP18 -4480 -5004.0
UTP20 -2864 -7232.0
UTP3 4557 2878.0
UTP6 -1775 -3426.0
WBSCR22 -4690 -2603.0
WDR12 3926 -5704.0
WDR18 2475 -7484.0
WDR3 6367 -1606.0
WDR36 6307 -4522.0
WDR43 -4228 -6314.0
WDR46 1073 -1929.0
WDR75 3713 -4133.0
XRN2 -3195 -5934.0



Major pathway of rRNA processing in the nucleolus and cytosol

metric value
setSize 176
pMANOVA 5.91e-24
p.adjustMANOVA 1.07e-21
s.dist 0.451
confESp NA
s.rna_LGvHG -0.288
s.rna_HGvHGV -0.347
p.rna_LGvHG 4.58e-11
p.rna_HGvHGV 2.19e-15




Gene rna_LGvHG rna_HGvHGV
EXOSC6 -6618 -6747.0
UTP14A -5810 -7129.0
CSNK1D -6047 -6638.0
DHX37 -5482 -7023.0
NOP14 -5380 -6917.0
EXOSC5 -4907 -6416.0
RPL10 -5543 -4999.0
WDR43 -4228 -6314.0
MPHOSPH10 -7389 -3593.0
IMP4 -5115 -5006.5
NOB1 -3671 -6762.0
RPL6 -5151 -4811.0
NOL9 -5107 -4710.0
NOL12 -3884 -5985.0
GNL3 -5645 -4043.0
UTP18 -4480 -5004.0
RPL19 -5609 -3966.0
LTV1 -5754 -3627.0
PES1 -3448 -6032.0
RRP1 -5330 -3896.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
BMS1 -4822 -1690.0
BOP1 -2079 -2856.0
BYSL -2390 -4949.0
C1D 1937 2500.0
CSNK1D -6047 -6638.0
CSNK1E 3315 2456.0
DCAF13 4844 -1935.0
DDX21 -111 -4414.0
DDX47 3960 -3582.0
DDX49 -7270 1638.0
DDX52 -4886 -1242.0
DHX37 -5482 -7023.0
DIEXF -3206 -5671.0
DIS3 -1501 2302.0
EBNA1BP2 -3618 917.0
EMG1 7798 -6511.0
ERI1 -2096 5585.0
EXOSC1 3614 -3532.0
EXOSC10 -142 -6920.0
EXOSC2 3961 313.0
EXOSC3 -2961 1286.0
EXOSC4 2801 -4513.0
EXOSC5 -4907 -6416.0
EXOSC6 -6618 -6747.0
EXOSC7 5542 -5377.0
EXOSC8 412 -7068.0
EXOSC9 3277 1337.0
FAU -5465 -1439.0
FBL -1464 -869.0
FCF1 -2147 -2175.0
FTSJ3 2188 -5738.0
GNL3 -5645 -4043.0
HEATR1 -1439 -4988.0
IMP3 -4746 2697.0
IMP4 -5115 -5006.5
ISG20L2 -3740 6098.0
KRR1 1404 -3257.0
LAS1L 8194 -3709.0
LTV1 -5754 -3627.0
MPHOSPH10 -7389 -3593.0
MPHOSPH6 6361 876.0
NCL -1691 -6949.0
NIP7 -1876 -4614.0
NOB1 -3671 -6762.0
NOC4L -1762 -416.0
NOL11 4442 -4884.0
NOL12 -3884 -5985.0
NOL6 2264 535.0
NOL9 -5107 -4710.0
NOP14 -5380 -6917.0
NOP56 -1126 -5490.0
NOP58 6235 -4117.0
PDCD11 3374 -5557.0
PELP1 -2911 -4848.0
PES1 -3448 -6032.0
PNO1 -6059 -1025.0
PWP2 1329 397.0
RBM28 283 -3818.0
RCL1 -1093 -1771.0
RIOK1 2469 530.0
RIOK2 -4274 -1347.0
RIOK3 -6729 5636.0
RPL10 -5543 -4999.0
RPL10A -2566 -3948.0
RPL11 -5172 -2748.0
RPL12 -1507 -3084.0
RPL13 -471 -3317.0
RPL13A -2745 -2677.0
RPL14 -5527 -2682.0
RPL15 1849 -2009.0
RPL17 126 -3940.0
RPL18 -4183 -1071.0
RPL18A -5301 -585.0
RPL19 -5609 -3966.0
RPL21 -4209 -4036.5
RPL22 5249 -3942.0
RPL22L1 -160 -6353.5
RPL23 -1370 -2849.0
RPL23A -3454 -1887.0
RPL24 -1812 -3491.0
RPL26 -1365 -146.0
RPL26L1 -3945 1440.0
RPL27 -2005 -919.0
RPL27A -4506 -4250.0
RPL28 -3621 -752.0
RPL29 -4075 -3272.0
RPL3 -1503 -3206.0
RPL30 -4142 -2917.0
RPL31 981 -1139.0
RPL32 -3393 -1261.0
RPL34 -2770 -2030.0
RPL35 -2891 -1554.0
RPL35A -4369 -1415.0
RPL36 -3549 -3202.0
RPL36A 5630 -2965.0
RPL36AL -7445 -2641.0
RPL37 -3457 -2235.0
RPL37A -2415 -2945.0
RPL38 -1678 -1496.0
RPL39 -1636 842.0
RPL3L -4857 -260.0
RPL4 -2513 -3939.0
RPL41 1461 -3751.0
RPL5 -554 -2231.0
RPL6 -5151 -4811.0
RPL7 -1319 -3168.0
RPL7A -2609 -2165.0
RPL8 -3548 -2560.0
RPL9 -3114 -4301.0
RPLP0 -4427 -1121.0
RPLP1 -4373 -3370.0
RPLP2 -2777 -1899.0
RPP14 107 -2044.0
RPP21 1993 -3121.0
RPP25 5023 7108.0
RPP30 1743 3043.0
RPP38 633 -2188.0
RPP40 2305 -6456.0
RPS10 112 -1083.0
RPS11 -5078 -2933.0
RPS12 -4503 -2114.0
RPS13 -2629 -2290.0
RPS14 -3593 -2671.0
RPS15 -4564 -1911.0
RPS15A -3125 -197.0
RPS16 -3362 -2103.0
RPS18 -2870 -2001.0
RPS19 -4961 -2582.0
RPS2 -3922 -2651.0
RPS20 -1741 -1314.0
RPS21 -2922 -743.0
RPS23 -1789 -1850.0
RPS24 -2865 -1728.0
RPS25 -124 -980.0
RPS26 239 -3326.0
RPS27 -3410 -2769.0
RPS27A -2775 -2092.0
RPS27L -3395 -5791.0
RPS28 -3558 -1760.0
RPS29 -3554 19.0
RPS3 -2626 -1940.0
RPS3A 1310 -2352.0
RPS4X -3384 -3144.0
RPS4Y1 -2083 -2421.0
RPS5 -5073 439.0
RPS6 -2847 -2731.0
RPS7 -5915 -2189.0
RPS8 -1202 -2865.0
RPS9 -4220 -3027.0
RPSA -2539 -2294.0
RRP1 -5330 -3896.0
RRP36 -6725 707.0
RRP7A 1747 -2435.0
RRP9 -2392 -3624.0
SENP3 440 1030.0
SNORD3A -335 819.0
TBL3 3281 -3098.0
TEX10 -4066 2308.0
TSR1 -1745 -7045.0
UBA52 -5323 1252.0
UTP14A -5810 -7129.0
UTP14C -6428 3119.0
UTP15 -3037 -1583.0
UTP18 -4480 -5004.0
UTP20 -2864 -7232.0
UTP3 4557 2878.0
UTP6 -1775 -3426.0
WBSCR22 -4690 -2603.0
WDR12 3926 -5704.0
WDR18 2475 -7484.0
WDR3 6367 -1606.0
WDR36 6307 -4522.0
WDR43 -4228 -6314.0
WDR46 1073 -1929.0
WDR75 3713 -4133.0
XRN2 -3195 -5934.0



mRNA Splicing - Major Pathway

metric value
setSize 174
pMANOVA 8.93e-24
p.adjustMANOVA 1.41e-21
s.dist 0.452
confESp NA
s.rna_LGvHG -0.203
s.rna_HGvHGV -0.404
p.rna_LGvHG 4.1e-06
p.rna_HGvHGV 4.12e-20




Gene rna_LGvHG rna_HGvHGV
SRSF4 -7312 -7491
ALYREF -7253 -6934
DDX5 -7024 -6523
HNRNPA2B1 -6801 -6562
CASC3 -6360 -6976
SRRT -6638 -6682
SRRM2 -6278 -7049
SNRPA -7008 -6083
HNRNPM -7192 -5669
RBMX -5407 -7349
SRSF3 -5573 -6803
SRSF1 -5869 -6395
HSPA8 -4920 -6728
YBX1 -5901 -5024
SF1 -4537 -6386
U2AF1 -6942 -4162
PRPF8 -5026 -5652
HNRNPF -7059 -4014
PTBP1 -6440 -4372
PUF60 -3692 -7312

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
ALYREF -7253.0 -6934
AQR -2579.0 -543
BCAS2 -775.0 -72
BUD31 -5689.0 4899
CASC3 -6360.0 -6976
CCAR1 2999.0 -6944
CD2BP2 -4151.0 758
CDC40 -2272.0 2503
CDC5L -2427.0 -5167
CHERP -3874.0 -6191
CLP1 -5836.0 4588
CPSF1 -4005.0 -5362
CPSF2 7234.0 -6822
CPSF3 6896.0 -1472
CPSF4 1809.0 2639
CPSF7 -2118.0 -7659
CRNKL1 -2541.0 -2203
CSTF1 1636.0 -2884
CSTF2 1495.0 -2237
CSTF2T 8100.0 -702
CSTF3 2463.0 3081
CTNNBL1 3259.0 4702
CWC15 -926.0 -5339
CWC22 -4074.0 -4930
CWC25 -3670.0 -2008
CWC27 -4440.0 -2358
DDX23 -3685.0 -4351
DDX42 6345.0 -5712
DDX46 -918.0 -3282
DDX5 -7024.0 -6523
DHX15 -1512.0 -4636
DHX16 -3597.0 3278
DHX38 -6640.0 -1536
DHX9 -4126.0 -6141
DNAJC8 1875.0 2177
EFTUD2 -2755.0 -2246
EIF4A3 1298.0 3126
ELAVL1 -3143.0 -412
FIP1L1 -6400.0 -4052
FUS 8631.0 -5688
GCFC2 2497.0 -4268
GPKOW 3818.0 -3895
GTF2F1 -3019.0 -1117
GTF2F2 4860.0 1441
HNRNPA0 5689.0 -5592
HNRNPA1 808.0 -5324
HNRNPA2B1 -6801.0 -6562
HNRNPA3 -1817.0 -6492
HNRNPC 778.0 -4822
HNRNPD 3122.0 -7219
HNRNPF -7059.0 -4014
HNRNPH1 1765.0 -6192
HNRNPH2 2916.0 -3602
HNRNPK -2841.0 -6969
HNRNPL -3565.0 -7077
HNRNPM -7192.0 -5669
HNRNPR 1761.0 -6740
HNRNPU -3829.0 -6230
HNRNPUL1 -984.0 -7329
HSPA8 -4920.0 -6728
ISY1 -4820.0 -2333
LSM2 1512.0 -4000
LSM3 5371.0 -817
LSM4 8090.0 3333
LSM5 5741.0 -1754
LSM6 5582.0 -4311
LSM7 -3871.0 -6159
MAGOH -1096.0 -1098
MAGOHB 6510.0 -6663
NCBP1 -1858.0 1533
NCBP2 7854.0 -262
NUDT21 2349.0 -2007
PABPN1 176.0 -7478
PAPOLA -2921.0 467
PCBP1 -3840.0 -7004
PCBP2 2617.0 -6175
PCF11 -5164.0 -3300
PHF5A -396.0 -4188
PLRG1 -1479.0 3658
POLR2A 2948.0 -6306
POLR2B -3795.0 2880
POLR2C -3177.0 1582
POLR2D 1696.0 -2523
POLR2E -4282.5 3215
POLR2F -5560.0 4701
POLR2G 2153.0 1453
POLR2H -4010.0 -1665
POLR2I 4612.0 -3659
POLR2J -246.0 4188
POLR2K 6791.0 5504
POLR2L -5741.0 6784
PPIE 1706.0 -4763
PPIH 761.0 -4017
PPIL1 -4515.0 -5090
PPIL3 5458.0 1009
PPIL4 2337.0 -1236
PPWD1 3814.0 -3467
PQBP1 -4479.0 -5797
PRCC -6588.0 -3285
PRPF19 2853.0 343
PRPF3 -6121.0 -3150
PRPF31 2550.0 -5300
PRPF38A -1605.0 -4838
PRPF4 2294.0 2962
PRPF40A -4008.0 -2286
PRPF6 3930.0 -5023
PRPF8 -5026.0 -5652
PTBP1 -6440.0 -4372
PUF60 -3692.0 -7312
RBM17 -2766.0 -1173
RBM22 -3968.0 -5137
RBM5 6173.0 -7369
RBM8A 956.0 -5273
RBMX -5407.0 -7349
RNPS1 -7272.0 -555
SART1 -4976.0 -4440
SF1 -4537.0 -6386
SF3A1 -4276.0 -5926
SF3A2 -3288.0 -5060
SF3A3 -2906.0 4938
SF3B1 -217.0 -1958
SF3B2 -1534.0 -4075
SF3B3 -3791.0 -6401
SF3B4 -2944.0 -5113
SF3B5 -4446.0 4623
SLU7 130.0 -1437
SMNDC1 -969.0 -5327
SNRNP200 -1652.0 -3577
SNRNP27 1234.0 1808
SNRNP40 -5278.0 -3214
SNRNP70 -3481.0 -5255
SNRPA -7008.0 -6083
SNRPA1 -7218.0 812
SNRPB -1673.0 -3808
SNRPB2 907.0 -3411
SNRPC 824.0 -4410
SNRPD1 6304.0 -3405
SNRPD2 -3359.0 2762
SNRPD3 -6109.0 2670
SNRPE 4103.0 -3791
SNRPF 2390.0 -4080
SNRPG 864.0 2918
SNRPN 4924.0 1207
SNW1 -5749.0 -4537
SRRM1 236.0 -5520
SRRM2 -6278.0 -7049
SRRT -6638.0 -6682
SRSF1 -5869.0 -6395
SRSF10 -4936.0 -3062
SRSF11 -1542.0 -4010
SRSF2 623.0 -6578
SRSF3 -5573.0 -6803
SRSF4 -7312.0 -7491
SRSF5 7060.0 -7002
SRSF6 7330.0 -7363
SRSF7 2956.0 -6232
SRSF9 -4937.0 -4160
SUGP1 1519.0 -833
SYF2 -6533.0 -3945
SYMPK -34.0 -6687
TFIP11 -619.0 -2596
TRA2B -1076.0 -4606
TXNL4A -2889.0 2889
U2AF1 -6942.0 -4162
U2AF1L4 724.0 -5888
U2AF2 -928.0 -7743
U2SURP 2729.0 -3480
UPF3B 2835.0 -2132
USP39 -6054.0 4201
WBP11 -1814.0 -4776
WBP4 -1620.0 -1580
WDR33 -3532.0 -4687
XAB2 4322.0 2004
YBX1 -5901.0 -5024



mRNA Splicing

metric value
setSize 183
pMANOVA 1.47e-23
p.adjustMANOVA 2.06e-21
s.dist 0.438
confESp NA
s.rna_LGvHG -0.198
s.rna_HGvHGV -0.391
p.rna_LGvHG 3.89e-06
p.rna_HGvHGV 7.16e-20




Gene rna_LGvHG rna_HGvHGV
SRSF4 -7312 -7491
ALYREF -7253 -6934
DDX5 -7024 -6523
HNRNPA2B1 -6801 -6562
CASC3 -6360 -6976
SRRT -6638 -6682
SRRM2 -6278 -7049
SNRPA -7008 -6083
HNRNPM -7192 -5669
RBMX -5407 -7349
SRSF3 -5573 -6803
SRSF1 -5869 -6395
HSPA8 -4920 -6728
YBX1 -5901 -5024
SF1 -4537 -6386
U2AF1 -6942 -4162
PRPF8 -5026 -5652
HNRNPF -7059 -4014
PTBP1 -6440 -4372
PUF60 -3692 -7312

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
ALYREF -7253.0 -6934
AQR -2579.0 -543
BCAS2 -775.0 -72
BUD31 -5689.0 4899
CASC3 -6360.0 -6976
CCAR1 2999.0 -6944
CD2BP2 -4151.0 758
CDC40 -2272.0 2503
CDC5L -2427.0 -5167
CHERP -3874.0 -6191
CLP1 -5836.0 4588
CPSF1 -4005.0 -5362
CPSF2 7234.0 -6822
CPSF3 6896.0 -1472
CPSF4 1809.0 2639
CPSF7 -2118.0 -7659
CRNKL1 -2541.0 -2203
CSTF1 1636.0 -2884
CSTF2 1495.0 -2237
CSTF2T 8100.0 -702
CSTF3 2463.0 3081
CTNNBL1 3259.0 4702
CWC15 -926.0 -5339
CWC22 -4074.0 -4930
CWC25 -3670.0 -2008
CWC27 -4440.0 -2358
DDX23 -3685.0 -4351
DDX42 6345.0 -5712
DDX46 -918.0 -3282
DDX5 -7024.0 -6523
DHX15 -1512.0 -4636
DHX16 -3597.0 3278
DHX38 -6640.0 -1536
DHX9 -4126.0 -6141
DNAJC8 1875.0 2177
EFTUD2 -2755.0 -2246
EIF4A3 1298.0 3126
ELAVL1 -3143.0 -412
FIP1L1 -6400.0 -4052
FUS 8631.0 -5688
GCFC2 2497.0 -4268
GPKOW 3818.0 -3895
GTF2F1 -3019.0 -1117
GTF2F2 4860.0 1441
HNRNPA0 5689.0 -5592
HNRNPA1 808.0 -5324
HNRNPA2B1 -6801.0 -6562
HNRNPA3 -1817.0 -6492
HNRNPC 778.0 -4822
HNRNPD 3122.0 -7219
HNRNPF -7059.0 -4014
HNRNPH1 1765.0 -6192
HNRNPH2 2916.0 -3602
HNRNPK -2841.0 -6969
HNRNPL -3565.0 -7077
HNRNPM -7192.0 -5669
HNRNPR 1761.0 -6740
HNRNPU -3829.0 -6230
HNRNPUL1 -984.0 -7329
HSPA8 -4920.0 -6728
ISY1 -4820.0 -2333
LSM2 1512.0 -4000
LSM3 5371.0 -817
LSM4 8090.0 3333
LSM5 5741.0 -1754
LSM6 5582.0 -4311
LSM7 -3871.0 -6159
MAGOH -1096.0 -1098
MAGOHB 6510.0 -6663
NCBP1 -1858.0 1533
NCBP2 7854.0 -262
NUDT21 2349.0 -2007
PABPN1 176.0 -7478
PAPOLA -2921.0 467
PCBP1 -3840.0 -7004
PCBP2 2617.0 -6175
PCF11 -5164.0 -3300
PDCD7 -1056.0 -6407
PHF5A -396.0 -4188
PLRG1 -1479.0 3658
POLR2A 2948.0 -6306
POLR2B -3795.0 2880
POLR2C -3177.0 1582
POLR2D 1696.0 -2523
POLR2E -4282.5 3215
POLR2F -5560.0 4701
POLR2G 2153.0 1453
POLR2H -4010.0 -1665
POLR2I 4612.0 -3659
POLR2J -246.0 4188
POLR2K 6791.0 5504
POLR2L -5741.0 6784
PPIE 1706.0 -4763
PPIH 761.0 -4017
PPIL1 -4515.0 -5090
PPIL3 5458.0 1009
PPIL4 2337.0 -1236
PPWD1 3814.0 -3467
PQBP1 -4479.0 -5797
PRCC -6588.0 -3285
PRPF19 2853.0 343
PRPF3 -6121.0 -3150
PRPF31 2550.0 -5300
PRPF38A -1605.0 -4838
PRPF4 2294.0 2962
PRPF40A -4008.0 -2286
PRPF6 3930.0 -5023
PRPF8 -5026.0 -5652
PTBP1 -6440.0 -4372
PUF60 -3692.0 -7312
RBM17 -2766.0 -1173
RBM22 -3968.0 -5137
RBM5 6173.0 -7369
RBM8A 956.0 -5273
RBMX -5407.0 -7349
RNPC3 4829.0 -3201
RNPS1 -7272.0 -555
RNU12 -6661.0 -276
SART1 -4976.0 -4440
SF1 -4537.0 -6386
SF3A1 -4276.0 -5926
SF3A2 -3288.0 -5060
SF3A3 -2906.0 4938
SF3B1 -217.0 -1958
SF3B2 -1534.0 -4075
SF3B3 -3791.0 -6401
SF3B4 -2944.0 -5113
SF3B5 -4446.0 4623
SLU7 130.0 -1437
SMNDC1 -969.0 -5327
SNRNP200 -1652.0 -3577
SNRNP25 372.0 -1540
SNRNP27 1234.0 1808
SNRNP35 8393.0 -4400
SNRNP40 -5278.0 -3214
SNRNP48 -6731.0 6341
SNRNP70 -3481.0 -5255
SNRPA -7008.0 -6083
SNRPA1 -7218.0 812
SNRPB -1673.0 -3808
SNRPB2 907.0 -3411
SNRPC 824.0 -4410
SNRPD1 6304.0 -3405
SNRPD2 -3359.0 2762
SNRPD3 -6109.0 2670
SNRPE 4103.0 -3791
SNRPF 2390.0 -4080
SNRPG 864.0 2918
SNRPN 4924.0 1207
SNW1 -5749.0 -4537
SRRM1 236.0 -5520
SRRM2 -6278.0 -7049
SRRT -6638.0 -6682
SRSF1 -5869.0 -6395
SRSF10 -4936.0 -3062
SRSF11 -1542.0 -4010
SRSF2 623.0 -6578
SRSF3 -5573.0 -6803
SRSF4 -7312.0 -7491
SRSF5 7060.0 -7002
SRSF6 7330.0 -7363
SRSF7 2956.0 -6232
SRSF9 -4937.0 -4160
SUGP1 1519.0 -833
SYF2 -6533.0 -3945
SYMPK -34.0 -6687
TFIP11 -619.0 -2596
TRA2B -1076.0 -4606
TXNL4A -2889.0 2889
U2AF1 -6942.0 -4162
U2AF1L4 724.0 -5888
U2AF2 -928.0 -7743
U2SURP 2729.0 -3480
UPF3B 2835.0 -2132
USP39 -6054.0 4201
WBP11 -1814.0 -4776
WBP4 -1620.0 -1580
WDR33 -3532.0 -4687
XAB2 4322.0 2004
YBX1 -5901.0 -5024
ZCRB1 4997.0 4002
ZMAT5 -2716.0 1921
ZRSR2 -4101.0 -4088



SRP-dependent cotranslational protein targeting to membrane

metric value
setSize 108
pMANOVA 5.71e-23
p.adjustMANOVA 7.22e-21
s.dist 0.562
confESp NA
s.rna_LGvHG -0.478
s.rna_HGvHGV -0.295
p.rna_LGvHG 8.76e-18
p.rna_HGvHGV 1.19e-07




Gene rna_LGvHG rna_HGvHGV
SRP68 -6776 -5056.0
SRP72 -5764 -5825.0
SRP14 -6238 -4757.0
RPL10 -5543 -4999.0
RPN1 -7473 -3567.0
DDOST -6834 -3695.0
RPL6 -5151 -4811.0
SEC61A1 -7486 -3284.0
SPCS2 -5875 -4003.0
RPL19 -5609 -3966.0
RPL36AL -7445 -2641.0
RPS27L -3395 -5791.0
RPL27A -4506 -4250.0
RPL21 -4209 -4036.5
TRAM1 -7465 -2243.0
SRPRB -7298 -2276.0
RPN2 -6500 -2540.0
SSR4 -7460 -2082.0
RPS11 -5078 -2933.0
RPL14 -5527 -2682.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
DDOST -6834 -3695.0
FAU -5465 -1439.0
RPL10 -5543 -4999.0
RPL10A -2566 -3948.0
RPL11 -5172 -2748.0
RPL12 -1507 -3084.0
RPL13 -471 -3317.0
RPL13A -2745 -2677.0
RPL14 -5527 -2682.0
RPL15 1849 -2009.0
RPL17 126 -3940.0
RPL18 -4183 -1071.0
RPL18A -5301 -585.0
RPL19 -5609 -3966.0
RPL21 -4209 -4036.5
RPL22 5249 -3942.0
RPL22L1 -160 -6353.5
RPL23 -1370 -2849.0
RPL23A -3454 -1887.0
RPL24 -1812 -3491.0
RPL26 -1365 -146.0
RPL26L1 -3945 1440.0
RPL27 -2005 -919.0
RPL27A -4506 -4250.0
RPL28 -3621 -752.0
RPL29 -4075 -3272.0
RPL3 -1503 -3206.0
RPL30 -4142 -2917.0
RPL31 981 -1139.0
RPL32 -3393 -1261.0
RPL34 -2770 -2030.0
RPL35 -2891 -1554.0
RPL35A -4369 -1415.0
RPL36 -3549 -3202.0
RPL36A 5630 -2965.0
RPL36AL -7445 -2641.0
RPL37 -3457 -2235.0
RPL37A -2415 -2945.0
RPL38 -1678 -1496.0
RPL39 -1636 842.0
RPL3L -4857 -260.0
RPL4 -2513 -3939.0
RPL41 1461 -3751.0
RPL5 -554 -2231.0
RPL6 -5151 -4811.0
RPL7 -1319 -3168.0
RPL7A -2609 -2165.0
RPL8 -3548 -2560.0
RPL9 -3114 -4301.0
RPLP0 -4427 -1121.0
RPLP1 -4373 -3370.0
RPLP2 -2777 -1899.0
RPN1 -7473 -3567.0
RPN2 -6500 -2540.0
RPS10 112 -1083.0
RPS11 -5078 -2933.0
RPS12 -4503 -2114.0
RPS13 -2629 -2290.0
RPS14 -3593 -2671.0
RPS15 -4564 -1911.0
RPS15A -3125 -197.0
RPS16 -3362 -2103.0
RPS18 -2870 -2001.0
RPS19 -4961 -2582.0
RPS2 -3922 -2651.0
RPS20 -1741 -1314.0
RPS21 -2922 -743.0
RPS23 -1789 -1850.0
RPS24 -2865 -1728.0
RPS25 -124 -980.0
RPS26 239 -3326.0
RPS27 -3410 -2769.0
RPS27A -2775 -2092.0
RPS27L -3395 -5791.0
RPS28 -3558 -1760.0
RPS29 -3554 19.0
RPS3 -2626 -1940.0
RPS3A 1310 -2352.0
RPS4X -3384 -3144.0
RPS4Y1 -2083 -2421.0
RPS5 -5073 439.0
RPS6 -2847 -2731.0
RPS7 -5915 -2189.0
RPS8 -1202 -2865.0
RPS9 -4220 -3027.0
RPSA -2539 -2294.0
SEC11A -2987 -1061.0
SEC11C -7434 -226.0
SEC61A1 -7486 -3284.0
SEC61A2 -228 7423.0
SEC61B -7405 -1370.0
SEC61G -4313 1345.0
SPCS1 2445 -153.0
SPCS2 -5875 -4003.0
SPCS3 -7033 985.0
SRP14 -6238 -4757.0
SRP19 -5678 1314.0
SRP54 -1869 5323.0
SRP68 -6776 -5056.0
SRP72 -5764 -5825.0
SRP9 6418 -949.0
SRPRB -7298 -2276.0
SSR1 -7335 -1989.0
SSR2 -7198 536.0
SSR3 -7349 -873.0
SSR4 -7460 -2082.0
TRAM1 -7465 -2243.0
UBA52 -5323 1252.0



Cap-dependent Translation Initiation

metric value
setSize 116
pMANOVA 4.08e-21
p.adjustMANOVA 4.3e-19
s.dist 0.519
confESp NA
s.rna_LGvHG -0.379
s.rna_HGvHGV -0.354
p.rna_LGvHG 1.7e-12
p.rna_HGvHGV 4.32e-11




Gene rna_LGvHG rna_HGvHGV
EIF4B -6017 -7498.0
EIF5 -6424 -6989.0
EIF4G1 -6162 -7098.0
EIF3A -7417 -4849.0
EIF3B -5113 -5476.0
EIF3J -4525 -6126.0
RPL10 -5543 -4999.0
EIF2B5 -4978 -5455.0
EIF2S2 -4423 -5981.0
RPL6 -5151 -4811.0
EIF4H -4861 -4850.0
EIF3G -4897 -4671.0
RPL19 -5609 -3966.0
EIF3D -3836 -5783.0
RPL36AL -7445 -2641.0
RPS27L -3395 -5791.0
RPL27A -4506 -4250.0
RPL21 -4209 -4036.5
RPS11 -5078 -2933.0
RPL14 -5527 -2682.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
EIF1AX 1986 3709.0
EIF2B1 100 -487.0
EIF2B2 -5024 3183.0
EIF2B3 5865 1208.0
EIF2B4 475 -6680.0
EIF2B5 -4978 -5455.0
EIF2S1 -5366 2409.0
EIF2S2 -4423 -5981.0
EIF2S3 -3280 -1720.0
EIF3A -7417 -4849.0
EIF3B -5113 -5476.0
EIF3C 1948 -5119.0
EIF3D -3836 -5783.0
EIF3E 3525 -2684.0
EIF3F -612 -5160.0
EIF3G -4897 -4671.0
EIF3H 1030 -953.0
EIF3I -5628 -499.0
EIF3J -4525 -6126.0
EIF3K -2175 -767.0
EIF3L -2260 -3369.0
EIF3M -4437 -1125.0
EIF4A1 241 -4341.0
EIF4A2 5877 -5660.0
EIF4B -6017 -7498.0
EIF4E 2829 494.0
EIF4EBP1 5449 -7559.0
EIF4G1 -6162 -7098.0
EIF4H -4861 -4850.0
EIF5 -6424 -6989.0
EIF5B 3470 673.0
FAU -5465 -1439.0
PABPC1 -3531 -2220.0
RPL10 -5543 -4999.0
RPL10A -2566 -3948.0
RPL11 -5172 -2748.0
RPL12 -1507 -3084.0
RPL13 -471 -3317.0
RPL13A -2745 -2677.0
RPL14 -5527 -2682.0
RPL15 1849 -2009.0
RPL17 126 -3940.0
RPL18 -4183 -1071.0
RPL18A -5301 -585.0
RPL19 -5609 -3966.0
RPL21 -4209 -4036.5
RPL22 5249 -3942.0
RPL22L1 -160 -6353.5
RPL23 -1370 -2849.0
RPL23A -3454 -1887.0
RPL24 -1812 -3491.0
RPL26 -1365 -146.0
RPL26L1 -3945 1440.0
RPL27 -2005 -919.0
RPL27A -4506 -4250.0
RPL28 -3621 -752.0
RPL29 -4075 -3272.0
RPL3 -1503 -3206.0
RPL30 -4142 -2917.0
RPL31 981 -1139.0
RPL32 -3393 -1261.0
RPL34 -2770 -2030.0
RPL35 -2891 -1554.0
RPL35A -4369 -1415.0
RPL36 -3549 -3202.0
RPL36A 5630 -2965.0
RPL36AL -7445 -2641.0
RPL37 -3457 -2235.0
RPL37A -2415 -2945.0
RPL38 -1678 -1496.0
RPL39 -1636 842.0
RPL3L -4857 -260.0
RPL4 -2513 -3939.0
RPL41 1461 -3751.0
RPL5 -554 -2231.0
RPL6 -5151 -4811.0
RPL7 -1319 -3168.0
RPL7A -2609 -2165.0
RPL8 -3548 -2560.0
RPL9 -3114 -4301.0
RPLP0 -4427 -1121.0
RPLP1 -4373 -3370.0
RPLP2 -2777 -1899.0
RPS10 112 -1083.0
RPS11 -5078 -2933.0
RPS12 -4503 -2114.0
RPS13 -2629 -2290.0
RPS14 -3593 -2671.0
RPS15 -4564 -1911.0
RPS15A -3125 -197.0
RPS16 -3362 -2103.0
RPS18 -2870 -2001.0
RPS19 -4961 -2582.0
RPS2 -3922 -2651.0
RPS20 -1741 -1314.0
RPS21 -2922 -743.0
RPS23 -1789 -1850.0
RPS24 -2865 -1728.0
RPS25 -124 -980.0
RPS26 239 -3326.0
RPS27 -3410 -2769.0
RPS27A -2775 -2092.0
RPS27L -3395 -5791.0
RPS28 -3558 -1760.0
RPS29 -3554 19.0
RPS3 -2626 -1940.0
RPS3A 1310 -2352.0
RPS4X -3384 -3144.0
RPS4Y1 -2083 -2421.0
RPS5 -5073 439.0
RPS6 -2847 -2731.0
RPS7 -5915 -2189.0
RPS8 -1202 -2865.0
RPS9 -4220 -3027.0
RPSA -2539 -2294.0
UBA52 -5323 1252.0



Eukaryotic Translation Initiation

metric value
setSize 116
pMANOVA 4.08e-21
p.adjustMANOVA 4.3e-19
s.dist 0.519
confESp NA
s.rna_LGvHG -0.379
s.rna_HGvHGV -0.354
p.rna_LGvHG 1.7e-12
p.rna_HGvHGV 4.32e-11




Gene rna_LGvHG rna_HGvHGV
EIF4B -6017 -7498.0
EIF5 -6424 -6989.0
EIF4G1 -6162 -7098.0
EIF3A -7417 -4849.0
EIF3B -5113 -5476.0
EIF3J -4525 -6126.0
RPL10 -5543 -4999.0
EIF2B5 -4978 -5455.0
EIF2S2 -4423 -5981.0
RPL6 -5151 -4811.0
EIF4H -4861 -4850.0
EIF3G -4897 -4671.0
RPL19 -5609 -3966.0
EIF3D -3836 -5783.0
RPL36AL -7445 -2641.0
RPS27L -3395 -5791.0
RPL27A -4506 -4250.0
RPL21 -4209 -4036.5
RPS11 -5078 -2933.0
RPL14 -5527 -2682.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
EIF1AX 1986 3709.0
EIF2B1 100 -487.0
EIF2B2 -5024 3183.0
EIF2B3 5865 1208.0
EIF2B4 475 -6680.0
EIF2B5 -4978 -5455.0
EIF2S1 -5366 2409.0
EIF2S2 -4423 -5981.0
EIF2S3 -3280 -1720.0
EIF3A -7417 -4849.0
EIF3B -5113 -5476.0
EIF3C 1948 -5119.0
EIF3D -3836 -5783.0
EIF3E 3525 -2684.0
EIF3F -612 -5160.0
EIF3G -4897 -4671.0
EIF3H 1030 -953.0
EIF3I -5628 -499.0
EIF3J -4525 -6126.0
EIF3K -2175 -767.0
EIF3L -2260 -3369.0
EIF3M -4437 -1125.0
EIF4A1 241 -4341.0
EIF4A2 5877 -5660.0
EIF4B -6017 -7498.0
EIF4E 2829 494.0
EIF4EBP1 5449 -7559.0
EIF4G1 -6162 -7098.0
EIF4H -4861 -4850.0
EIF5 -6424 -6989.0
EIF5B 3470 673.0
FAU -5465 -1439.0
PABPC1 -3531 -2220.0
RPL10 -5543 -4999.0
RPL10A -2566 -3948.0
RPL11 -5172 -2748.0
RPL12 -1507 -3084.0
RPL13 -471 -3317.0
RPL13A -2745 -2677.0
RPL14 -5527 -2682.0
RPL15 1849 -2009.0
RPL17 126 -3940.0
RPL18 -4183 -1071.0
RPL18A -5301 -585.0
RPL19 -5609 -3966.0
RPL21 -4209 -4036.5
RPL22 5249 -3942.0
RPL22L1 -160 -6353.5
RPL23 -1370 -2849.0
RPL23A -3454 -1887.0
RPL24 -1812 -3491.0
RPL26 -1365 -146.0
RPL26L1 -3945 1440.0
RPL27 -2005 -919.0
RPL27A -4506 -4250.0
RPL28 -3621 -752.0
RPL29 -4075 -3272.0
RPL3 -1503 -3206.0
RPL30 -4142 -2917.0
RPL31 981 -1139.0
RPL32 -3393 -1261.0
RPL34 -2770 -2030.0
RPL35 -2891 -1554.0
RPL35A -4369 -1415.0
RPL36 -3549 -3202.0
RPL36A 5630 -2965.0
RPL36AL -7445 -2641.0
RPL37 -3457 -2235.0
RPL37A -2415 -2945.0
RPL38 -1678 -1496.0
RPL39 -1636 842.0
RPL3L -4857 -260.0
RPL4 -2513 -3939.0
RPL41 1461 -3751.0
RPL5 -554 -2231.0
RPL6 -5151 -4811.0
RPL7 -1319 -3168.0
RPL7A -2609 -2165.0
RPL8 -3548 -2560.0
RPL9 -3114 -4301.0
RPLP0 -4427 -1121.0
RPLP1 -4373 -3370.0
RPLP2 -2777 -1899.0
RPS10 112 -1083.0
RPS11 -5078 -2933.0
RPS12 -4503 -2114.0
RPS13 -2629 -2290.0
RPS14 -3593 -2671.0
RPS15 -4564 -1911.0
RPS15A -3125 -197.0
RPS16 -3362 -2103.0
RPS18 -2870 -2001.0
RPS19 -4961 -2582.0
RPS2 -3922 -2651.0
RPS20 -1741 -1314.0
RPS21 -2922 -743.0
RPS23 -1789 -1850.0
RPS24 -2865 -1728.0
RPS25 -124 -980.0
RPS26 239 -3326.0
RPS27 -3410 -2769.0
RPS27A -2775 -2092.0
RPS27L -3395 -5791.0
RPS28 -3558 -1760.0
RPS29 -3554 19.0
RPS3 -2626 -1940.0
RPS3A 1310 -2352.0
RPS4X -3384 -3144.0
RPS4Y1 -2083 -2421.0
RPS5 -5073 439.0
RPS6 -2847 -2731.0
RPS7 -5915 -2189.0
RPS8 -1202 -2865.0
RPS9 -4220 -3027.0
RPSA -2539 -2294.0
UBA52 -5323 1252.0



GTP hydrolysis and joining of the 60S ribosomal subunit

metric value
setSize 109
pMANOVA 7.4e-21
p.adjustMANOVA 7.2e-19
s.dist 0.532
confESp NA
s.rna_LGvHG -0.397
s.rna_HGvHGV -0.354
p.rna_LGvHG 7.93e-13
p.rna_HGvHGV 1.7e-10




Gene rna_LGvHG rna_HGvHGV
EIF4B -6017 -7498.0
EIF5 -6424 -6989.0
EIF4G1 -6162 -7098.0
EIF3A -7417 -4849.0
EIF3B -5113 -5476.0
EIF3J -4525 -6126.0
RPL10 -5543 -4999.0
EIF2S2 -4423 -5981.0
RPL6 -5151 -4811.0
EIF4H -4861 -4850.0
EIF3G -4897 -4671.0
RPL19 -5609 -3966.0
EIF3D -3836 -5783.0
RPL36AL -7445 -2641.0
RPS27L -3395 -5791.0
RPL27A -4506 -4250.0
RPL21 -4209 -4036.5
RPS11 -5078 -2933.0
RPL14 -5527 -2682.0
RPLP1 -4373 -3370.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
EIF1AX 1986 3709.0
EIF2S1 -5366 2409.0
EIF2S2 -4423 -5981.0
EIF2S3 -3280 -1720.0
EIF3A -7417 -4849.0
EIF3B -5113 -5476.0
EIF3C 1948 -5119.0
EIF3D -3836 -5783.0
EIF3E 3525 -2684.0
EIF3F -612 -5160.0
EIF3G -4897 -4671.0
EIF3H 1030 -953.0
EIF3I -5628 -499.0
EIF3J -4525 -6126.0
EIF3K -2175 -767.0
EIF3L -2260 -3369.0
EIF3M -4437 -1125.0
EIF4A1 241 -4341.0
EIF4A2 5877 -5660.0
EIF4B -6017 -7498.0
EIF4E 2829 494.0
EIF4G1 -6162 -7098.0
EIF4H -4861 -4850.0
EIF5 -6424 -6989.0
EIF5B 3470 673.0
FAU -5465 -1439.0
RPL10 -5543 -4999.0
RPL10A -2566 -3948.0
RPL11 -5172 -2748.0
RPL12 -1507 -3084.0
RPL13 -471 -3317.0
RPL13A -2745 -2677.0
RPL14 -5527 -2682.0
RPL15 1849 -2009.0
RPL17 126 -3940.0
RPL18 -4183 -1071.0
RPL18A -5301 -585.0
RPL19 -5609 -3966.0
RPL21 -4209 -4036.5
RPL22 5249 -3942.0
RPL22L1 -160 -6353.5
RPL23 -1370 -2849.0
RPL23A -3454 -1887.0
RPL24 -1812 -3491.0
RPL26 -1365 -146.0
RPL26L1 -3945 1440.0
RPL27 -2005 -919.0
RPL27A -4506 -4250.0
RPL28 -3621 -752.0
RPL29 -4075 -3272.0
RPL3 -1503 -3206.0
RPL30 -4142 -2917.0
RPL31 981 -1139.0
RPL32 -3393 -1261.0
RPL34 -2770 -2030.0
RPL35 -2891 -1554.0
RPL35A -4369 -1415.0
RPL36 -3549 -3202.0
RPL36A 5630 -2965.0
RPL36AL -7445 -2641.0
RPL37 -3457 -2235.0
RPL37A -2415 -2945.0
RPL38 -1678 -1496.0
RPL39 -1636 842.0
RPL3L -4857 -260.0
RPL4 -2513 -3939.0
RPL41 1461 -3751.0
RPL5 -554 -2231.0
RPL6 -5151 -4811.0
RPL7 -1319 -3168.0
RPL7A -2609 -2165.0
RPL8 -3548 -2560.0
RPL9 -3114 -4301.0
RPLP0 -4427 -1121.0
RPLP1 -4373 -3370.0
RPLP2 -2777 -1899.0
RPS10 112 -1083.0
RPS11 -5078 -2933.0
RPS12 -4503 -2114.0
RPS13 -2629 -2290.0
RPS14 -3593 -2671.0
RPS15 -4564 -1911.0
RPS15A -3125 -197.0
RPS16 -3362 -2103.0
RPS18 -2870 -2001.0
RPS19 -4961 -2582.0
RPS2 -3922 -2651.0
RPS20 -1741 -1314.0
RPS21 -2922 -743.0
RPS23 -1789 -1850.0
RPS24 -2865 -1728.0
RPS25 -124 -980.0
RPS26 239 -3326.0
RPS27 -3410 -2769.0
RPS27A -2775 -2092.0
RPS27L -3395 -5791.0
RPS28 -3558 -1760.0
RPS29 -3554 19.0
RPS3 -2626 -1940.0
RPS3A 1310 -2352.0
RPS4X -3384 -3144.0
RPS4Y1 -2083 -2421.0
RPS5 -5073 439.0
RPS6 -2847 -2731.0
RPS7 -5915 -2189.0
RPS8 -1202 -2865.0
RPS9 -4220 -3027.0
RPSA -2539 -2294.0
UBA52 -5323 1252.0



L13a-mediated translational silencing of Ceruloplasmin expression

metric value
setSize 108
pMANOVA 8.64e-21
p.adjustMANOVA 7.8e-19
s.dist 0.534
confESp NA
s.rna_LGvHG -0.401
s.rna_HGvHGV -0.352
p.rna_LGvHG 6.24e-13
p.rna_HGvHGV 2.53e-10




Gene rna_LGvHG rna_HGvHGV
EIF4B -6017 -7498.0
EIF4G1 -6162 -7098.0
EIF3A -7417 -4849.0
EIF3B -5113 -5476.0
EIF3J -4525 -6126.0
RPL10 -5543 -4999.0
EIF2S2 -4423 -5981.0
RPL6 -5151 -4811.0
EIF4H -4861 -4850.0
EIF3G -4897 -4671.0
RPL19 -5609 -3966.0
EIF3D -3836 -5783.0
RPL36AL -7445 -2641.0
RPS27L -3395 -5791.0
RPL27A -4506 -4250.0
RPL21 -4209 -4036.5
RPS11 -5078 -2933.0
RPL14 -5527 -2682.0
RPLP1 -4373 -3370.0
RPL11 -5172 -2748.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
EIF1AX 1986 3709.0
EIF2S1 -5366 2409.0
EIF2S2 -4423 -5981.0
EIF2S3 -3280 -1720.0
EIF3A -7417 -4849.0
EIF3B -5113 -5476.0
EIF3C 1948 -5119.0
EIF3D -3836 -5783.0
EIF3E 3525 -2684.0
EIF3F -612 -5160.0
EIF3G -4897 -4671.0
EIF3H 1030 -953.0
EIF3I -5628 -499.0
EIF3J -4525 -6126.0
EIF3K -2175 -767.0
EIF3L -2260 -3369.0
EIF3M -4437 -1125.0
EIF4A1 241 -4341.0
EIF4A2 5877 -5660.0
EIF4B -6017 -7498.0
EIF4E 2829 494.0
EIF4G1 -6162 -7098.0
EIF4H -4861 -4850.0
FAU -5465 -1439.0
PABPC1 -3531 -2220.0
RPL10 -5543 -4999.0
RPL10A -2566 -3948.0
RPL11 -5172 -2748.0
RPL12 -1507 -3084.0
RPL13 -471 -3317.0
RPL13A -2745 -2677.0
RPL14 -5527 -2682.0
RPL15 1849 -2009.0
RPL17 126 -3940.0
RPL18 -4183 -1071.0
RPL18A -5301 -585.0
RPL19 -5609 -3966.0
RPL21 -4209 -4036.5
RPL22 5249 -3942.0
RPL22L1 -160 -6353.5
RPL23 -1370 -2849.0
RPL23A -3454 -1887.0
RPL24 -1812 -3491.0
RPL26 -1365 -146.0
RPL26L1 -3945 1440.0
RPL27 -2005 -919.0
RPL27A -4506 -4250.0
RPL28 -3621 -752.0
RPL29 -4075 -3272.0
RPL3 -1503 -3206.0
RPL30 -4142 -2917.0
RPL31 981 -1139.0
RPL32 -3393 -1261.0
RPL34 -2770 -2030.0
RPL35 -2891 -1554.0
RPL35A -4369 -1415.0
RPL36 -3549 -3202.0
RPL36A 5630 -2965.0
RPL36AL -7445 -2641.0
RPL37 -3457 -2235.0
RPL37A -2415 -2945.0
RPL38 -1678 -1496.0
RPL39 -1636 842.0
RPL3L -4857 -260.0
RPL4 -2513 -3939.0
RPL41 1461 -3751.0
RPL5 -554 -2231.0
RPL6 -5151 -4811.0
RPL7 -1319 -3168.0
RPL7A -2609 -2165.0
RPL8 -3548 -2560.0
RPL9 -3114 -4301.0
RPLP0 -4427 -1121.0
RPLP1 -4373 -3370.0
RPLP2 -2777 -1899.0
RPS10 112 -1083.0
RPS11 -5078 -2933.0
RPS12 -4503 -2114.0
RPS13 -2629 -2290.0
RPS14 -3593 -2671.0
RPS15 -4564 -1911.0
RPS15A -3125 -197.0
RPS16 -3362 -2103.0
RPS18 -2870 -2001.0
RPS19 -4961 -2582.0
RPS2 -3922 -2651.0
RPS20 -1741 -1314.0
RPS21 -2922 -743.0
RPS23 -1789 -1850.0
RPS24 -2865 -1728.0
RPS25 -124 -980.0
RPS26 239 -3326.0
RPS27 -3410 -2769.0
RPS27A -2775 -2092.0
RPS27L -3395 -5791.0
RPS28 -3558 -1760.0
RPS29 -3554 19.0
RPS3 -2626 -1940.0
RPS3A 1310 -2352.0
RPS4X -3384 -3144.0
RPS4Y1 -2083 -2421.0
RPS5 -5073 439.0
RPS6 -2847 -2731.0
RPS7 -5915 -2189.0
RPS8 -1202 -2865.0
RPS9 -4220 -3027.0
RPSA -2539 -2294.0
UBA52 -5323 1252.0



Chromatin modifying enzymes

metric value
setSize 205
pMANOVA 3.66e-19
p.adjustMANOVA 2.77e-17
s.dist 0.373
confESp NA
s.rna_LGvHG -0.209
s.rna_HGvHGV -0.309
p.rna_LGvHG 2.72e-07
p.rna_HGvHGV 2.69e-14




Gene rna_LGvHG rna_HGvHGV
BRPF3 -6925 -7856
SETD1B -6956 -7248
JADE2 -6421 -7779
HCFC1 -6304 -7822
MSL1 -6624 -7322
SETD1A -7140 -6330
KAT6B -5235 -7804
ELP5 -6617 -6149
BRD1 -5295 -7657
USP22 -5550 -7198
KANSL1 -5379 -7302
EP300 -6798 -5744
HIST1H2BC -6692 -5821
KMT2D -6680 -5675
ING5 -4914 -7621
TADA2B -5714 -6139
KDM4A -6541 -5359
PBRM1 -5946 -5725
MBD3 -4199 -7643
KDM6B -7406 -4219

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
ACTB -5090 3901.0
ACTL6A -863 -1364.0
AEBP2 2715 395.0
ARID1A -4208 -6829.0
ARID1B -1771 -7788.0
ARID2 -3315 -6665.0
ARID4A -15 515.0
ARID4B 465 612.0
ARID5B -1519 -7316.0
ASH1L -3299 -4749.0
ASH2L 5272 -2930.0
ATF2 -6484 -44.0
ATF7IP 7847 -5511.0
ATXN7 -4962 -4471.0
ATXN7L3 -6252 -4851.0
BRD1 -5295 -7657.0
BRD8 3520 -6581.0
BRMS1 -6592 2713.0
BRPF1 -5200 -172.0
BRPF3 -6925 -7856.0
BRWD1 -950 25.0
CARM1 3049 -5243.0
CCND1 -31 5200.0
CDK4 -5584 -3415.0
CHD3 -1154 -128.0
CHD4 -4999 -3188.0
CLOCK -1387 -3152.0
COPRS -6476 183.0
CREBBP -3983 -7682.0
DMAP1 -2151 -3289.0
DNMT3A 4273 -7775.0
DOT1L -6821 -3999.0
DPY30 8005 2265.0
DR1 -5765 3253.0
EED 2797 2087.0
EHMT1 -1449 -5183.0
EHMT2 1888 -5881.0
ELP2 2099 2036.0
ELP3 -1102 -5127.0
ELP4 6780 1859.0
ELP5 -6617 -6149.0
ELP6 -803 -5622.0
ENY2 2668 -2343.0
EP300 -6798 -5744.0
EP400 -3822 -597.0
EPC1 -3814 -7719.0
EZH2 -5851 5827.0
GATAD2A -4196 173.0
GATAD2B -555 -3472.0
GPS2 -5443 4585.0
H2AFJ 3150 7490.0
H2AFV 4868 2413.0
H2AFX 5969 1647.0
H2AFZ -68 1841.0
HAT1 5603 4551.0
HCFC1 -6304 -7822.0
HDAC1 -2602 6418.0
HDAC10 -378 -5348.0
HDAC2 -276 2709.0
HDAC3 173 5878.0
HDAC8 4062 -3350.0
HIST1H2AC -5947 -2079.0
HIST1H2AG 3920 6130.0
HIST1H2BC -6692 -5821.0
HIST1H2BD -5110 1201.0
HIST1H2BJ 3107 -2505.0
HIST1H2BK -3274 1539.0
HIST1H2BL 2052 3360.0
HIST1H2BN 6987 948.0
HIST1H2BO 2159 -847.0
HIST2H2AC -983 346.0
HIST2H2BE -6945 4840.0
HMG20B -3602 7553.0
IKBKAP -7166 -4290.0
ING3 -345 -6529.0
ING4 6066 -6467.0
ING5 -4914 -7621.0
JADE1 6782 -6958.0
JADE2 -6421 -7779.0
JADE3 -1215 -5449.0
JAK2 -2499 3365.0
JMJD6 -7050 1388.0
KANSL1 -5379 -7302.0
KANSL2 -3331 -6823.0
KANSL3 -3935 -5037.0
KAT2A 5270 -7676.0
KAT2B -5350 6867.0
KAT5 575 -7303.0
KAT6A -5795 544.0
KAT6B -5235 -7804.0
KAT7 -1368 -6907.0
KAT8 5255 -6957.0
KDM1A 4202 244.0
KDM1B -4979 7408.0
KDM2A -6157 414.0
KDM2B -3948 1116.0
KDM3A -6759 790.0
KDM3B -2050 -7015.0
KDM4A -6541 -5359.0
KDM4B 423 -1028.0
KDM4C -5216 -164.0
KDM4D 5748 -3652.0
KDM5A -5984 1925.0
KDM5B -542 3644.0
KDM5C -4847 -5343.0
KDM5D 6843 -5989.0
KDM6A -6447 -2646.0
KDM6B -7406 -4219.0
KDM7A -6480 -2481.0
KMT2A -3079 -23.0
KMT2B 403 -2083.0
KMT2C -6873 4945.0
KMT2D -6680 -5675.0
KMT2E -2340 -1598.0
MBD3 -4199 -7643.0
MBIP -721 -5297.0
MCRS1 -1251 -7391.0
MEAF6 7 -2573.0
MECOM -1590 4917.0
MINA 63 -6649.0
MORF4L1 1338 -5290.0
MORF4L2 -3421 4837.0
MRGBP -2182 -3219.0
MSL1 -6624 -7322.0
MSL2 -2991 -4745.0
MSL3 -1596 -3955.0
MTA1 1745 -6497.0
MTA2 -5977 -5117.0
MTA3 7062 -7000.0
NCOA1 -4821 3973.0
NCOA2 5080 -7532.0
NCOR1 -4491 -5805.0
NCOR2 -4626 334.0
NFKB1 -3533 -7777.0
NFKB2 -1248 7607.0
OGT 7364 -5204.0
PBRM1 -5946 -5725.0
PHF2 2277 -6628.0
PHF20 3012 3734.0
PHF21A -1070 -5656.0
PHF8 -3779 -7720.0
PRDM16 -4726 6361.0
PRMT1 -4379 -5473.0
PRMT3 6305 -5306.0
PRMT5 -1496 -4582.0
PRMT6 7282 -3736.0
PRMT7 7563 -5344.0
RBBP4 -3891 -6664.0
RBBP5 101 3788.0
RBBP7 5468 3390.0
RCOR1 -3423 4935.0
RELA -2600 -2650.0
REST -384 -5731.0
RPS2 -3922 -2651.0
RUVBL1 5581 1520.0
RUVBL2 2568 4642.0
SAP130 -5493 3762.0
SAP18 -3540 1450.0
SAP30 -5806 5182.0
SAP30L -3979 4235.0
SETD1A -7140 -6330.0
SETD1B -6956 -7248.0
SETD2 -4755 -5563.0
SETD3 -5766 6229.0
SETD6 2619 -5522.0
SETD7 5766 7973.0
SETDB1 615 -7164.0
SETDB2 -3601 -4267.0
SMARCA2 6440 3710.0
SMARCA4 -3174 -6551.0
SMARCB1 -2074 -7766.0
SMARCC1 -565 -7145.0
SMARCC2 4774 -5075.0
SMARCD1 -3133 -7057.0
SMARCD2 567 -2846.0
SMARCD3 4061 8031.0
SMARCE1 5855 -7100.0
SMYD2 -3246 -4493.0
SMYD3 6211 6436.0
SUDS3 -1448 5765.0
SUPT20H 1808 1687.0
SUPT3H 3264 -6242.0
SUPT7L 901 -6082.0
SUV39H1 -591 -6517.0
SUV39H2 165 -1089.0
SUZ12 -6 -850.0
TADA1 3043 -6148.0
TADA2A 7425 -7468.0
TADA2B -5714 -6139.0
TADA3 -968 -3090.0
TAF10 521 3768.0
TAF12 7665 6137.0
TAF5L -2465 -3703.5
TAF6L -5976 -5034.0
TAF9 67 -6896.0
TBL1X -1420 -6140.0
TBL1XR1 1409 -5784.0
TRRAP -3521 -1453.0
USP22 -5550 -7198.0
VPS72 5425 -4492.0
WDR5 2660 -533.0
WDR77 1078 -4517.0
YEATS2 1886 101.0
YEATS4 4766 -3412.0
ZZZ3 -1543 -5811.0



Chromatin organization

metric value
setSize 205
pMANOVA 3.66e-19
p.adjustMANOVA 2.77e-17
s.dist 0.373
confESp NA
s.rna_LGvHG -0.209
s.rna_HGvHGV -0.309
p.rna_LGvHG 2.72e-07
p.rna_HGvHGV 2.69e-14




Gene rna_LGvHG rna_HGvHGV
BRPF3 -6925 -7856
SETD1B -6956 -7248
JADE2 -6421 -7779
HCFC1 -6304 -7822
MSL1 -6624 -7322
SETD1A -7140 -6330
KAT6B -5235 -7804
ELP5 -6617 -6149
BRD1 -5295 -7657
USP22 -5550 -7198
KANSL1 -5379 -7302
EP300 -6798 -5744
HIST1H2BC -6692 -5821
KMT2D -6680 -5675
ING5 -4914 -7621
TADA2B -5714 -6139
KDM4A -6541 -5359
PBRM1 -5946 -5725
MBD3 -4199 -7643
KDM6B -7406 -4219

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
ACTB -5090 3901.0
ACTL6A -863 -1364.0
AEBP2 2715 395.0
ARID1A -4208 -6829.0
ARID1B -1771 -7788.0
ARID2 -3315 -6665.0
ARID4A -15 515.0
ARID4B 465 612.0
ARID5B -1519 -7316.0
ASH1L -3299 -4749.0
ASH2L 5272 -2930.0
ATF2 -6484 -44.0
ATF7IP 7847 -5511.0
ATXN7 -4962 -4471.0
ATXN7L3 -6252 -4851.0
BRD1 -5295 -7657.0
BRD8 3520 -6581.0
BRMS1 -6592 2713.0
BRPF1 -5200 -172.0
BRPF3 -6925 -7856.0
BRWD1 -950 25.0
CARM1 3049 -5243.0
CCND1 -31 5200.0
CDK4 -5584 -3415.0
CHD3 -1154 -128.0
CHD4 -4999 -3188.0
CLOCK -1387 -3152.0
COPRS -6476 183.0
CREBBP -3983 -7682.0
DMAP1 -2151 -3289.0
DNMT3A 4273 -7775.0
DOT1L -6821 -3999.0
DPY30 8005 2265.0
DR1 -5765 3253.0
EED 2797 2087.0
EHMT1 -1449 -5183.0
EHMT2 1888 -5881.0
ELP2 2099 2036.0
ELP3 -1102 -5127.0
ELP4 6780 1859.0
ELP5 -6617 -6149.0
ELP6 -803 -5622.0
ENY2 2668 -2343.0
EP300 -6798 -5744.0
EP400 -3822 -597.0
EPC1 -3814 -7719.0
EZH2 -5851 5827.0
GATAD2A -4196 173.0
GATAD2B -555 -3472.0
GPS2 -5443 4585.0
H2AFJ 3150 7490.0
H2AFV 4868 2413.0
H2AFX 5969 1647.0
H2AFZ -68 1841.0
HAT1 5603 4551.0
HCFC1 -6304 -7822.0
HDAC1 -2602 6418.0
HDAC10 -378 -5348.0
HDAC2 -276 2709.0
HDAC3 173 5878.0
HDAC8 4062 -3350.0
HIST1H2AC -5947 -2079.0
HIST1H2AG 3920 6130.0
HIST1H2BC -6692 -5821.0
HIST1H2BD -5110 1201.0
HIST1H2BJ 3107 -2505.0
HIST1H2BK -3274 1539.0
HIST1H2BL 2052 3360.0
HIST1H2BN 6987 948.0
HIST1H2BO 2159 -847.0
HIST2H2AC -983 346.0
HIST2H2BE -6945 4840.0
HMG20B -3602 7553.0
IKBKAP -7166 -4290.0
ING3 -345 -6529.0
ING4 6066 -6467.0
ING5 -4914 -7621.0
JADE1 6782 -6958.0
JADE2 -6421 -7779.0
JADE3 -1215 -5449.0
JAK2 -2499 3365.0
JMJD6 -7050 1388.0
KANSL1 -5379 -7302.0
KANSL2 -3331 -6823.0
KANSL3 -3935 -5037.0
KAT2A 5270 -7676.0
KAT2B -5350 6867.0
KAT5 575 -7303.0
KAT6A -5795 544.0
KAT6B -5235 -7804.0
KAT7 -1368 -6907.0
KAT8 5255 -6957.0
KDM1A 4202 244.0
KDM1B -4979 7408.0
KDM2A -6157 414.0
KDM2B -3948 1116.0
KDM3A -6759 790.0
KDM3B -2050 -7015.0
KDM4A -6541 -5359.0
KDM4B 423 -1028.0
KDM4C -5216 -164.0
KDM4D 5748 -3652.0
KDM5A -5984 1925.0
KDM5B -542 3644.0
KDM5C -4847 -5343.0
KDM5D 6843 -5989.0
KDM6A -6447 -2646.0
KDM6B -7406 -4219.0
KDM7A -6480 -2481.0
KMT2A -3079 -23.0
KMT2B 403 -2083.0
KMT2C -6873 4945.0
KMT2D -6680 -5675.0
KMT2E -2340 -1598.0
MBD3 -4199 -7643.0
MBIP -721 -5297.0
MCRS1 -1251 -7391.0
MEAF6 7 -2573.0
MECOM -1590 4917.0
MINA 63 -6649.0
MORF4L1 1338 -5290.0
MORF4L2 -3421 4837.0
MRGBP -2182 -3219.0
MSL1 -6624 -7322.0
MSL2 -2991 -4745.0
MSL3 -1596 -3955.0
MTA1 1745 -6497.0
MTA2 -5977 -5117.0
MTA3 7062 -7000.0
NCOA1 -4821 3973.0
NCOA2 5080 -7532.0
NCOR1 -4491 -5805.0
NCOR2 -4626 334.0
NFKB1 -3533 -7777.0
NFKB2 -1248 7607.0
OGT 7364 -5204.0
PBRM1 -5946 -5725.0
PHF2 2277 -6628.0
PHF20 3012 3734.0
PHF21A -1070 -5656.0
PHF8 -3779 -7720.0
PRDM16 -4726 6361.0
PRMT1 -4379 -5473.0
PRMT3 6305 -5306.0
PRMT5 -1496 -4582.0
PRMT6 7282 -3736.0
PRMT7 7563 -5344.0
RBBP4 -3891 -6664.0
RBBP5 101 3788.0
RBBP7 5468 3390.0
RCOR1 -3423 4935.0
RELA -2600 -2650.0
REST -384 -5731.0
RPS2 -3922 -2651.0
RUVBL1 5581 1520.0
RUVBL2 2568 4642.0
SAP130 -5493 3762.0
SAP18 -3540 1450.0
SAP30 -5806 5182.0
SAP30L -3979 4235.0
SETD1A -7140 -6330.0
SETD1B -6956 -7248.0
SETD2 -4755 -5563.0
SETD3 -5766 6229.0
SETD6 2619 -5522.0
SETD7 5766 7973.0
SETDB1 615 -7164.0
SETDB2 -3601 -4267.0
SMARCA2 6440 3710.0
SMARCA4 -3174 -6551.0
SMARCB1 -2074 -7766.0
SMARCC1 -565 -7145.0
SMARCC2 4774 -5075.0
SMARCD1 -3133 -7057.0
SMARCD2 567 -2846.0
SMARCD3 4061 8031.0
SMARCE1 5855 -7100.0
SMYD2 -3246 -4493.0
SMYD3 6211 6436.0
SUDS3 -1448 5765.0
SUPT20H 1808 1687.0
SUPT3H 3264 -6242.0
SUPT7L 901 -6082.0
SUV39H1 -591 -6517.0
SUV39H2 165 -1089.0
SUZ12 -6 -850.0
TADA1 3043 -6148.0
TADA2A 7425 -7468.0
TADA2B -5714 -6139.0
TADA3 -968 -3090.0
TAF10 521 3768.0
TAF12 7665 6137.0
TAF5L -2465 -3703.5
TAF6L -5976 -5034.0
TAF9 67 -6896.0
TBL1X -1420 -6140.0
TBL1XR1 1409 -5784.0
TRRAP -3521 -1453.0
USP22 -5550 -7198.0
VPS72 5425 -4492.0
WDR5 2660 -533.0
WDR77 1078 -4517.0
YEATS2 1886 101.0
YEATS4 4766 -3412.0
ZZZ3 -1543 -5811.0



Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

metric value
setSize 111
pMANOVA 3.94e-19
p.adjustMANOVA 2.77e-17
s.dist 0.504
confESp NA
s.rna_LGvHG -0.375
s.rna_HGvHGV -0.337
p.rna_LGvHG 8.36e-12
p.rna_HGvHGV 9.05e-10




Gene rna_LGvHG rna_HGvHGV
CASC3 -6360 -6976.0
EIF4G1 -6162 -7098.0
UPF3A -6321 -6411.0
PPP2R1A -4930 -6343.0
RPL10 -5543 -4999.0
UPF1 -4750 -5252.0
RPL6 -5151 -4811.0
RPL19 -5609 -3966.0
SMG8 -3654 -5893.0
RPL36AL -7445 -2641.0
RPS27L -3395 -5791.0
RPL27A -4506 -4250.0
RPL21 -4209 -4036.5
RPS11 -5078 -2933.0
UPF2 -3727 -3988.0
RPL14 -5527 -2682.0
RPLP1 -4373 -3370.0
RPL11 -5172 -2748.0
RPL9 -3114 -4301.0
RPL29 -4075 -3272.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
CASC3 -6360 -6976.0
DCP1A 54 -5358.0
EIF4A3 1298 3126.0
EIF4G1 -6162 -7098.0
ETF1 -7375 1850.0
FAU -5465 -1439.0
GSPT1 -7249 3458.0
MAGOH -1096 -1098.0
MAGOHB 6510 -6663.0
NCBP1 -1858 1533.0
NCBP2 7854 -262.0
PABPC1 -3531 -2220.0
PNRC2 3816 3638.0
PPP2CA -4705 -1300.0
PPP2R1A -4930 -6343.0
PPP2R2A 6243 3520.0
RBM8A 956 -5273.0
RNPS1 -7272 -555.0
RPL10 -5543 -4999.0
RPL10A -2566 -3948.0
RPL11 -5172 -2748.0
RPL12 -1507 -3084.0
RPL13 -471 -3317.0
RPL13A -2745 -2677.0
RPL14 -5527 -2682.0
RPL15 1849 -2009.0
RPL17 126 -3940.0
RPL18 -4183 -1071.0
RPL18A -5301 -585.0
RPL19 -5609 -3966.0
RPL21 -4209 -4036.5
RPL22 5249 -3942.0
RPL22L1 -160 -6353.5
RPL23 -1370 -2849.0
RPL23A -3454 -1887.0
RPL24 -1812 -3491.0
RPL26 -1365 -146.0
RPL26L1 -3945 1440.0
RPL27 -2005 -919.0
RPL27A -4506 -4250.0
RPL28 -3621 -752.0
RPL29 -4075 -3272.0
RPL3 -1503 -3206.0
RPL30 -4142 -2917.0
RPL31 981 -1139.0
RPL32 -3393 -1261.0
RPL34 -2770 -2030.0
RPL35 -2891 -1554.0
RPL35A -4369 -1415.0
RPL36 -3549 -3202.0
RPL36A 5630 -2965.0
RPL36AL -7445 -2641.0
RPL37 -3457 -2235.0
RPL37A -2415 -2945.0
RPL38 -1678 -1496.0
RPL39 -1636 842.0
RPL3L -4857 -260.0
RPL4 -2513 -3939.0
RPL41 1461 -3751.0
RPL5 -554 -2231.0
RPL6 -5151 -4811.0
RPL7 -1319 -3168.0
RPL7A -2609 -2165.0
RPL8 -3548 -2560.0
RPL9 -3114 -4301.0
RPLP0 -4427 -1121.0
RPLP1 -4373 -3370.0
RPLP2 -2777 -1899.0
RPS10 112 -1083.0
RPS11 -5078 -2933.0
RPS12 -4503 -2114.0
RPS13 -2629 -2290.0
RPS14 -3593 -2671.0
RPS15 -4564 -1911.0
RPS15A -3125 -197.0
RPS16 -3362 -2103.0
RPS18 -2870 -2001.0
RPS19 -4961 -2582.0
RPS2 -3922 -2651.0
RPS20 -1741 -1314.0
RPS21 -2922 -743.0
RPS23 -1789 -1850.0
RPS24 -2865 -1728.0
RPS25 -124 -980.0
RPS26 239 -3326.0
RPS27 -3410 -2769.0
RPS27A -2775 -2092.0
RPS27L -3395 -5791.0
RPS28 -3558 -1760.0
RPS29 -3554 19.0
RPS3 -2626 -1940.0
RPS3A 1310 -2352.0
RPS4X -3384 -3144.0
RPS4Y1 -2083 -2421.0
RPS5 -5073 439.0
RPS6 -2847 -2731.0
RPS7 -5915 -2189.0
RPS8 -1202 -2865.0
RPS9 -4220 -3027.0
RPSA -2539 -2294.0
SMG1 -2569 -131.0
SMG5 -557 -7060.0
SMG6 -1160 -5907.0
SMG7 -2472 -2619.0
SMG8 -3654 -5893.0
SMG9 3963 -7282.0
UBA52 -5323 1252.0
UPF1 -4750 -5252.0
UPF2 -3727 -3988.0
UPF3A -6321 -6411.0
UPF3B 2835 -2132.0



Nonsense-Mediated Decay (NMD)

metric value
setSize 111
pMANOVA 3.94e-19
p.adjustMANOVA 2.77e-17
s.dist 0.504
confESp NA
s.rna_LGvHG -0.375
s.rna_HGvHGV -0.337
p.rna_LGvHG 8.36e-12
p.rna_HGvHGV 9.05e-10




Gene rna_LGvHG rna_HGvHGV
CASC3 -6360 -6976.0
EIF4G1 -6162 -7098.0
UPF3A -6321 -6411.0
PPP2R1A -4930 -6343.0
RPL10 -5543 -4999.0
UPF1 -4750 -5252.0
RPL6 -5151 -4811.0
RPL19 -5609 -3966.0
SMG8 -3654 -5893.0
RPL36AL -7445 -2641.0
RPS27L -3395 -5791.0
RPL27A -4506 -4250.0
RPL21 -4209 -4036.5
RPS11 -5078 -2933.0
UPF2 -3727 -3988.0
RPL14 -5527 -2682.0
RPLP1 -4373 -3370.0
RPL11 -5172 -2748.0
RPL9 -3114 -4301.0
RPL29 -4075 -3272.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
CASC3 -6360 -6976.0
DCP1A 54 -5358.0
EIF4A3 1298 3126.0
EIF4G1 -6162 -7098.0
ETF1 -7375 1850.0
FAU -5465 -1439.0
GSPT1 -7249 3458.0
MAGOH -1096 -1098.0
MAGOHB 6510 -6663.0
NCBP1 -1858 1533.0
NCBP2 7854 -262.0
PABPC1 -3531 -2220.0
PNRC2 3816 3638.0
PPP2CA -4705 -1300.0
PPP2R1A -4930 -6343.0
PPP2R2A 6243 3520.0
RBM8A 956 -5273.0
RNPS1 -7272 -555.0
RPL10 -5543 -4999.0
RPL10A -2566 -3948.0
RPL11 -5172 -2748.0
RPL12 -1507 -3084.0
RPL13 -471 -3317.0
RPL13A -2745 -2677.0
RPL14 -5527 -2682.0
RPL15 1849 -2009.0
RPL17 126 -3940.0
RPL18 -4183 -1071.0
RPL18A -5301 -585.0
RPL19 -5609 -3966.0
RPL21 -4209 -4036.5
RPL22 5249 -3942.0
RPL22L1 -160 -6353.5
RPL23 -1370 -2849.0
RPL23A -3454 -1887.0
RPL24 -1812 -3491.0
RPL26 -1365 -146.0
RPL26L1 -3945 1440.0
RPL27 -2005 -919.0
RPL27A -4506 -4250.0
RPL28 -3621 -752.0
RPL29 -4075 -3272.0
RPL3 -1503 -3206.0
RPL30 -4142 -2917.0
RPL31 981 -1139.0
RPL32 -3393 -1261.0
RPL34 -2770 -2030.0
RPL35 -2891 -1554.0
RPL35A -4369 -1415.0
RPL36 -3549 -3202.0
RPL36A 5630 -2965.0
RPL36AL -7445 -2641.0
RPL37 -3457 -2235.0
RPL37A -2415 -2945.0
RPL38 -1678 -1496.0
RPL39 -1636 842.0
RPL3L -4857 -260.0
RPL4 -2513 -3939.0
RPL41 1461 -3751.0
RPL5 -554 -2231.0
RPL6 -5151 -4811.0
RPL7 -1319 -3168.0
RPL7A -2609 -2165.0
RPL8 -3548 -2560.0
RPL9 -3114 -4301.0
RPLP0 -4427 -1121.0
RPLP1 -4373 -3370.0
RPLP2 -2777 -1899.0
RPS10 112 -1083.0
RPS11 -5078 -2933.0
RPS12 -4503 -2114.0
RPS13 -2629 -2290.0
RPS14 -3593 -2671.0
RPS15 -4564 -1911.0
RPS15A -3125 -197.0
RPS16 -3362 -2103.0
RPS18 -2870 -2001.0
RPS19 -4961 -2582.0
RPS2 -3922 -2651.0
RPS20 -1741 -1314.0
RPS21 -2922 -743.0
RPS23 -1789 -1850.0
RPS24 -2865 -1728.0
RPS25 -124 -980.0
RPS26 239 -3326.0
RPS27 -3410 -2769.0
RPS27A -2775 -2092.0
RPS27L -3395 -5791.0
RPS28 -3558 -1760.0
RPS29 -3554 19.0
RPS3 -2626 -1940.0
RPS3A 1310 -2352.0
RPS4X -3384 -3144.0
RPS4Y1 -2083 -2421.0
RPS5 -5073 439.0
RPS6 -2847 -2731.0
RPS7 -5915 -2189.0
RPS8 -1202 -2865.0
RPS9 -4220 -3027.0
RPSA -2539 -2294.0
SMG1 -2569 -131.0
SMG5 -557 -7060.0
SMG6 -1160 -5907.0
SMG7 -2472 -2619.0
SMG8 -3654 -5893.0
SMG9 3963 -7282.0
UBA52 -5323 1252.0
UPF1 -4750 -5252.0
UPF2 -3727 -3988.0
UPF3A -6321 -6411.0
UPF3B 2835 -2132.0



Asparagine N-linked glycosylation

metric value
setSize 259
pMANOVA 8.27e-19
p.adjustMANOVA 5.51e-17
s.dist 0.33
confESp NA
s.rna_LGvHG -0.33
s.rna_HGvHGV -0.00156
p.rna_LGvHG 7.17e-20
p.rna_HGvHGV 0.966




Gene rna_LGvHG rna_HGvHGV
MGAT4B -6766.0 -6729
DERL2 -7492.0 -5988
STT3A -7227.0 -5922
ALG3 -7029.0 -6014
CSNK1D -6047.0 -6638
SEC31A -6119.5 -6115
CANX -7544.0 -4761
PDIA3 -7547.0 -4672
VCP -7126.0 -4707
DOLPP1 -5154.0 -6400
ST6GALNAC6 -5556.0 -5736
SLC35C1 -7105.0 -4212
ALG1 -5009.0 -5823
ALG5 -6875.0 -4101
RAB1B -3936.0 -6843
RPN1 -7473.0 -3567
ALG14 -3538.0 -7525
ALG12 -6210.0 -4252
PRKCSH -6303.0 -4165
DDOST -6834.0 -3695

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
ACTR10 5929.0 3416.0
ACTR1A -5316.0 2228.0
ALG1 -5009.0 -5823.0
ALG10 2923.0 -1386.0
ALG10B 2823.0 -781.0
ALG11 -6016.0 291.0
ALG12 -6210.0 -4252.0
ALG13 1926.0 -5990.0
ALG14 -3538.0 -7525.0
ALG2 -6917.0 2798.0
ALG3 -7029.0 -6014.0
ALG5 -6875.0 -4101.0
ALG6 5729.0 -763.0
ALG8 1178.0 -6180.0
ALG9 5076.0 -3459.0
AMDHD2 2811.0 2011.0
AMFR -4049.0 -1070.0
ANK1 -6391.0 2812.0
ANK2 -7224.0 51.0
ANKRD28 4357.0 -2177.0
ARCN1 -6802.0 302.0
ARF1 -6423.0 -2087.0
ARF3 -1003.0 5883.0
ARF4 -6167.0 3039.0
ARF5 4666.0 -22.0
ARFGAP1 -1453.0 6493.0
ARFGAP2 1204.0 -7010.0
ARFGAP3 -4781.0 -4008.0
ASGR1 -1718.0 -7024.0
ASGR2 -2734.0 -7317.0
B4GALT1 48.0 1499.0
B4GALT2 -2599.0 -7179.0
B4GALT3 -5032.0 -3029.0
B4GALT4 2121.0 -914.0
B4GALT5 7803.0 1732.0
B4GALT6 3733.0 3714.0
BET1 105.0 -288.0
BET1L 4582.0 -4015.0
CALR -7600.0 3622.0
CANX -7544.0 -4761.0
CAPZA1 -4971.0 -2164.0
CAPZA2 -1816.0 -945.0
CAPZB -1014.0 1559.0
CD55 -6972.0 1417.0
CD59 -3108.0 2472.0
CHST10 8077.0 -6278.0
CMAS 6332.0 4477.0
CNIH1 -1930.0 -4529.0
CNIH2 1000.0 8087.0
CNIH3 -2322.0 -719.0
COG1 4646.0 -5650.0
COG2 -4190.0 2566.0
COG3 -6158.0 -3633.0
COG4 2405.0 -4428.0
COG5 -3955.0 2267.0
COG6 3676.0 4580.0
COG7 5531.0 -3351.0
COG8 4941.0 -6563.0
COL7A1 5570.0 1184.0
COPA -3832.0 2432.0
COPB1 -4161.0 2152.0
COPB2 -6846.0 5256.0
COPE -6517.0 308.0
COPG1 -5353.0 -1531.0
COPG2 5720.0 -6498.0
COPZ1 983.0 -5195.0
COPZ2 685.0 5529.0
CSNK1D -6047.0 -6638.0
CTSA -6425.0 -520.0
CTSC -4835.0 -2345.0
CTSZ -4455.0 3214.0
DAD1 -6631.0 5875.0
DCTN1 -1103.0 -1008.0
DCTN2 -4024.0 -2440.0
DCTN3 1539.0 6556.0
DCTN4 -1760.0 -5497.0
DCTN5 -6284.0 -840.0
DCTN6 -916.0 -6365.0
DDOST -6834.0 -3695.0
DERL1 -6455.0 4785.0
DERL2 -7492.0 -5988.0
DHDDS 2834.0 523.0
DOLK 103.0 845.0
DOLPP1 -5154.0 -6400.0
DPAGT1 -6349.0 582.0
DPM1 -1240.0 4822.0
DPM2 -2097.0 4820.0
DPM3 3712.0 -1275.0
DYNC1H1 -3663.0 2932.0
DYNC1I2 -2145.0 770.0
DYNC1LI1 -2027.0 -4249.0
DYNC1LI2 -4501.0 -188.0
DYNLL1 2580.0 -4168.0
DYNLL2 6616.0 1920.0
EDEM1 -7562.0 4754.0
EDEM2 -5920.0 3449.0
EDEM3 -1724.0 3539.0
ENGASE 7406.0 4933.0
F5 992.0 -4065.0
F8 2119.0 3053.0
FPGT 7182.0 4727.0
FUCA1 2710.0 6102.0
FUK 5045.0 105.0
FUOM 2984.0 -1162.0
FUT3 -7507.0 6151.0
FUT8 -4951.0 7570.0
GANAB 2891.0 -5477.0
GBF1 -5240.0 5965.0
GFPT1 -7494.0 -2011.0
GFPT2 -4963.0 8394.0
GLB1 1661.0 -2070.0
GMDS -3504.0 -2597.0
GMPPA -6805.0 5075.0
GMPPB -4727.0 1381.0
GNE 6823.0 1276.0
GNPNAT1 2281.0 -3877.0
GOLGA2 -5615.0 1334.0
GOLGB1 -3507.0 -85.0
GORASP1 1996.0 -252.0
GOSR1 457.0 -6788.0
GOSR2 394.0 2541.0
KDELR1 -5247.0 -3829.0
KDELR2 -6140.0 2257.0
KDELR3 1081.0 6871.0
LMAN1 -3493.0 -2265.0
LMAN2 -7000.0 -1431.0
LMAN2L -3514.0 3895.0
MAGT1 -7502.0 6141.0
MAN1A1 -822.0 3981.5
MAN1A2 -6829.0 3261.0
MAN1B1 -3754.0 -5405.0
MAN1C1 2976.0 8306.0
MAN2A1 -771.0 -2613.0
MAN2A2 -2606.0 -6344.0
MANEA 4992.0 -4685.0
MARCH6 -3796.0 -5054.0
MCFD2 -7512.0 1718.0
MGAT1 -6869.0 4304.0
MGAT2 -3826.0 -2225.0
MGAT3 2410.0 6592.0
MGAT4A -5184.0 1285.0
MGAT4B -6766.0 -6729.0
MGAT5 -6044.0 -3553.0
MIA2 3686.0 -1456.0
MIA3 -7491.0 3738.0
MLEC -7311.0 4129.0
MOGS -2193.0 -3572.0
MPDU1 4096.0 -7807.0
MPI 7374.0 2448.0
MVD 8659.0 -3281.0
NAGK 4867.0 6024.0
NANP 191.0 4870.0
NANS -7309.0 2967.0
NAPA -6217.0 6506.0
NAPB -254.0 3038.0
NAPG -3940.0 5222.0
NEU1 -7262.0 6490.0
NEU3 7764.0 1965.0
NEU4 8333.0 -7522.0
NGLY1 -2840.0 -3002.0
NSF -5027.0 -2147.0
NUDT14 -4533.0 5024.0
NUS1 -6675.0 -723.0
OS9 -7438.0 4312.0
PDIA3 -7547.0 -4672.0
PGM3 -5818.0 2600.0
PMM1 -2394.0 5436.0
PMM2 -5008.0 524.0
PPP6C -5495.0 4806.0
PPP6R1 -6932.0 -1406.0
PPP6R3 -481.0 -1395.0
PREB 1351.0 6607.0
PRKCSH -6303.0 -4165.0
PSMC1 -2073.0 -2143.0
RAB1A -3348.0 4508.0
RAB1B -3936.0 -6843.0
RAD23B 3228.0 -6749.0
RENBP -7009.0 7210.0
RFT1 5545.0 -5636.0
RNF103 -6285.0 4554.0
RNF139 -2883.0 -826.0
RNF185 -6322.0 3615.0
RNF5 -7255.0 -905.0
RPN1 -7473.0 -3567.0
RPN2 -6500.0 -2540.0
RPS27A -2775.0 -2092.0
SAR1B -3073.0 4909.0
SCFD1 679.0 477.0
SEC13 -7232.0 872.0
SEC16A -6282.0 810.0
SEC22A 4194.0 4163.0
SEC22B -1027.0 5026.0
SEC22C -1206.0 2162.0
SEC23A -2440.0 -5551.0
SEC23IP 361.0 2226.0
SEC24A -7222.0 3801.0
SEC24B -5726.0 -2796.0
SEC24C -6662.0 1672.0
SEC24D -7592.0 5523.0
SEC31A -6119.5 -6115.0
SEL1L -7581.0 6447.0
SERPINA1 4353.0 -3340.0
SLC17A5 -7520.0 4661.0
SLC35A1 4302.0 4995.0
SLC35C1 -7105.0 -4212.0
SPTAN1 2399.0 5588.0
SPTB 5515.0 8432.0
SPTBN1 -5004.0 3454.0
SPTBN2 4535.0 6499.0
SPTBN4 3479.0 8004.0
SPTBN5 -6606.0 7045.0
SRD5A3 4857.0 -1414.0
ST3GAL1 -6188.0 -2089.0
ST3GAL2 -3755.0 5881.0
ST3GAL3 6820.0 -7613.0
ST3GAL4 -7237.0 -1792.0
ST3GAL5 6537.0 8454.0
ST3GAL6 -3633.0 -3511.0
ST6GAL1 -1721.0 -7528.0
ST6GALNAC2 -6377.0 3122.0
ST6GALNAC4 -7211.0 5233.0
ST6GALNAC6 -5556.0 -5736.0
ST8SIA1 7115.0 6005.0
STT3A -7227.0 -5922.0
STX17 2592.0 -501.0
STX5 -5692.0 787.0
SYVN1 -7570.0 4301.0
TBC1D20 -6651.0 6009.0
TFG -5590.0 -1302.0
TGFA -4681.0 2453.0
TMED10 -6374.0 -3599.0
TMED2 -7514.0 3294.0
TMED3 -4017.0 -2943.0
TMED7 -7219.0 3543.0
TMED9 -6959.0 1408.0
TMEM115 -7174.0 -1105.0
TRAPPC1 3166.0 5001.0
TRAPPC10 -6708.0 -2673.0
TRAPPC2 3698.0 24.0
TRAPPC2L -4620.0 -2212.0
TRAPPC3 -4370.0 3438.5
TRAPPC4 1396.0 3456.0
TRAPPC5 2376.0 3264.0
TRAPPC6A 8600.0 3427.0
TRAPPC6B 2661.0 1950.0
TRAPPC9 5768.0 7114.0
TRIM13 1936.0 -6313.0
TSTA3 -4703.0 -2812.0
TUSC3 -2783.0 3600.0
UAP1 -634.0 1589.0
UBA52 -5323.0 1252.0
UBB -3737.0 1627.0
UBC 931.0 -2324.0
UBXN1 -5821.0 505.0
UGGT1 -7364.0 -2124.0
UGGT2 1285.0 3828.0
USO1 -3638.0 -2678.0
VCP -7126.0 -4707.0
YKT6 -5114.0 4764.0



Signal Transduction

metric value
setSize 1625
pMANOVA 1.75e-18
p.adjustMANOVA 1.11e-16
s.dist 0.137
confESp NA
s.rna_LGvHG -0.109
s.rna_HGvHGV 0.0823
p.rna_LGvHG 4.77e-13
p.rna_HGvHGV 4.79e-08




Gene rna_LGvHG rna_HGvHGV
RRAGD -7466 8503
CCL20 -7326 7960
ATP6V1C2 -7299 7568
DUSP4 -6799 7976
PGF -7503 7130
TGFB1 -7392 7182
ATP6V0D1 -7372 7138
PLCG2 -6234 8407
ARAP3 -6211 8386
PTPRJ -6485 8011
TLE4 -6995 7419
RAMP1 -7553 6866
FLNA -7276 7066
ATP6V0A1 -7400 6911
SNAI1 -6096 8327
CAMKK1 -7103 7106
LCK -6978 7220
FZD9 -6878 7232
DUSP5 -6088 8150
CRABP2 -5887 8372

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
A2M 1169.0 -5001.0
AATF -5960.0 -6009.0
ABCA4 1573.0 6946.0
ABHD12 -6689.0 3932.0
ABHD6 1113.0 7755.0
ABI1 -4591.0 -3147.0
ABI2 -1062.0 6352.0
ABL1 2084.0 -5956.0
ABR -1752.0 -58.0
ACTA2 8726.0 -6850.0
ACTB -5090.0 3901.0
ACTG1 -7285.0 3109.0
ACTN2 6777.0 6772.0
ACTR2 1682.0 963.0
ACTR3 -5520.0 -5217.0
ACVR1B 4641.0 4606.0
ACVR1C -4107.0 6481.0
ACVR2A 1098.0 3898.0
ACVR2B 1155.0 -6900.0
ADAM10 -2895.0 1951.0
ADAM17 -6042.0 -1409.0
ADCY1 5005.0 6062.0
ADCY10 -4140.0 6526.0
ADCY3 1790.0 7964.0
ADCY4 -2129.0 8096.0
ADCY5 404.0 6796.0
ADCY6 -2788.0 4142.0
ADCY7 4340.0 7148.0
ADCY9 4596.0 234.0
ADH1A 8244.0 -7274.0
ADH4 8689.0 -7771.0
ADM -2857.0 6280.0
ADM2 -6582.0 -4924.0
ADORA2A -5369.0 489.0
ADORA2B 6155.0 6015.0
ADRA1D 6796.0 629.0
ADRA2C -6899.0 -5884.0
AES 4726.0 -6544.0
AGO1 4294.0 -2767.0
AGO2 -7141.0 -4817.0
AGO3 -6229.0 775.0
AGO4 7465.0 -2163.0
AGRN -2343.0 3888.0
AGT 8382.0 -5389.0
AGTR1 2457.0 6353.0
AHCTF1 -4033.0 -1367.0
AHCYL1 5346.0 4582.0
AKAP13 -6859.0 5737.0
AKR1B10 -7577.0 -7615.0
AKR1C1 -7566.0 -6322.0
AKR1C3 1231.0 -6662.0
AKR1C4 6259.0 -2719.0
AKT1 -3317.0 -4920.0
AKT1S1 -6387.0 -7812.0
AKT2 -1566.0 -7063.0
AKT3 -1567.0 8376.0
ALDH1A1 -5144.0 6638.0
ALDH1A2 -4366.0 28.0
ALDH8A1 5740.0 2813.0
AMER1 5192.0 -5288.0
AMHR2 -5847.0 7337.0
AMOT 2726.0 8201.0
AMOTL1 3390.0 8274.0
AMOTL2 -7411.0 -5951.0
AP2A1 -1890.0 7105.0
AP2A2 322.0 -524.0
AP2B1 2041.0 -93.0
AP2M1 -4715.0 -531.0
AP2S1 -2772.0 6948.0
APC -1560.0 -768.0
APH1A 947.0 -3600.0
APH1B 7683.0 7233.0
APITD1 -1284.0 6128.0
APOA1 8183.0 -1786.0
APOA2 -6685.0 -7208.0
APOA4 153.0 2489.0
APOB -2854.0 -1884.0
APOC2 8041.0 -4889.0
APOC3 8733.0 -6468.0
APOE -3825.0 -4712.5
APOM 5055.5 -1136.0
APP -6870.0 -216.0
ARAF -5412.0 -6660.0
ARAP1 -1612.0 6044.0
ARAP2 -1428.0 3749.0
ARAP3 -6211.0 8386.0
ARF6 -6460.0 -4045.0
ARHGAP1 2800.0 -5464.0
ARHGAP10 548.0 7255.0
ARHGAP11A 5278.0 -4562.0
ARHGAP11B 7116.0 -1722.0
ARHGAP12 -1253.0 1458.0
ARHGAP17 -3496.0 -5976.0
ARHGAP18 -1069.0 2240.0
ARHGAP19 7801.0 2999.0
ARHGAP21 -4602.0 -4053.0
ARHGAP22 -1295.0 7314.0
ARHGAP23 -4410.0 8446.0
ARHGAP26 -2837.0 7184.0
ARHGAP27 5960.0 -1538.0
ARHGAP29 5401.0 6018.0
ARHGAP30 4296.0 5680.0
ARHGAP31 -5299.5 2222.0
ARHGAP32 -7330.0 3328.0
ARHGAP33 6645.0 6774.0
ARHGAP35 -6775.0 -3710.0
ARHGAP39 -6809.0 6340.0
ARHGAP4 1665.0 4593.0
ARHGAP40 316.0 6172.0
ARHGAP42 -5930.0 4718.0
ARHGAP44 7620.0 7746.0
ARHGAP5 -4628.0 -2112.0
ARHGAP9 -2534.0 4934.0
ARHGDIA -5849.0 -462.0
ARHGDIG 5917.0 5468.0
ARHGEF1 68.0 -2432.0
ARHGEF10L 6161.0 -7174.0
ARHGEF11 -5287.0 -6564.0
ARHGEF12 -808.0 2603.0
ARHGEF16 -3992.0 -7751.0
ARHGEF17 405.0 -7251.0
ARHGEF18 294.0 3169.0
ARHGEF19 -1792.0 6852.0
ARHGEF2 -7444.0 4027.0
ARHGEF25 -2792.0 -4775.0
ARHGEF26 2563.0 6221.0
ARHGEF3 4027.0 -286.0
ARHGEF37 1845.0 7298.0
ARHGEF39 4513.0 1089.0
ARHGEF4 368.0 7043.0
ARHGEF40 7524.0 -6763.0
ARHGEF5 -3710.0 -4411.0
ARHGEF7 -2821.0 -2817.0
ARHGEF9 6574.0 5088.0
ARPC1A 2688.0 3580.0
ARPC1B -4400.0 3789.0
ARPC2 -2088.0 3826.0
ARPC3 3808.0 -4144.0
ARPC4 -6131.0 -4864.0
ARPC5 -1179.0 5483.0
ARRB1 -7510.0 3468.0
ARRB2 -3291.0 6469.0
ARTN 2117.0 6540.0
ASH2L 5272.0 -2930.0
ATF1 -5256.0 -7059.0
ATF2 -6484.0 -44.0
ATN1 -4462.0 -7604.0
ATP2A1 4478.0 3460.0
ATP2A2 -7574.0 -4986.0
ATP2A3 5197.0 8247.0
ATP6AP1 -6636.0 -3258.0
ATP6V0A1 -7400.0 6911.0
ATP6V0A2 -7288.0 -5276.0
ATP6V0A4 -1514.0 8045.0
ATP6V0B -7527.0 4877.0
ATP6V0C -3600.0 -2751.0
ATP6V0D1 -7372.0 7138.0
ATP6V0E1 -7056.0 5745.0
ATP6V0E2 6222.0 -4429.0
ATP6V1A -3869.0 6191.0
ATP6V1B1 6426.0 4649.0
ATP6V1B2 -5777.0 4883.0
ATP6V1C1 -4984.0 3557.0
ATP6V1C2 -7299.0 7568.0
ATP6V1D -7342.0 6245.0
ATP6V1E1 -6599.0 6485.0
ATP6V1E2 -514.0 -1244.0
ATP6V1F -1466.0 6142.0
ATP6V1G1 -5622.0 -198.0
ATP6V1G2 5807.0 7404.0
ATP6V1H -4617.0 4704.0
AURKB 8013.0 2208.0
AXIN1 -4408.0 -5939.0
AXIN2 -5592.0 -6378.0
AXL -2910.0 -6814.0
B4GALT1 48.0 1499.0
B9D2 -5431.0 -3746.0
BAD -6255.0 6879.0
BAG4 4164.0 356.0
BAIAP2 -317.0 49.0
BAMBI 84.0 -3529.0
BAX 5172.0 -3514.0
BCAR1 -7395.0 -1488.0
BCL2 2988.0 5219.0
BCL2L11 -3808.0 -3140.0
BCL9 -6182.0 5563.0
BCL9L -7240.0 3800.0
BCO2 -4035.0 3426.0
BCR -2329.0 3064.0
BIRC2 -327.0 -2178.0
BIRC3 5158.0 5808.0
BIRC5 6069.0 -1684.0
BMI1 -4122.0 -5850.0
BMP2 -47.0 7169.0
BMPR1A 27.0 -925.0
BMPR2 2167.0 3338.0
BRAF -5054.0 -2909.0
BRAP 1077.0 -3774.0
BRK1 -5509.0 2276.0
BTRC 1585.0 -4432.0
BUB1 3644.0 -31.0
BUB1B 7993.0 -4129.0
BUB3 1284.0 1782.0
C3 8728.0 -6117.0
C5 8502.0 -4693.0
C5AR1 7700.0 -4399.0
C5AR2 3105.0 7415.0
CAB39 -5034.0 4709.0
CAB39L 426.0 -7334.0
CALCRL 7681.0 7595.0
CALM1 -753.0 8197.0
CAMK2A 5357.0 -1320.0
CAMK2B 6686.0 5597.0
CAMK2D 1887.0 241.0
CAMK2G 2599.0 3028.0
CAMKK1 -7103.0 7106.0
CAMKK2 4218.0 -6666.0
CAMKMT 897.0 4135.0
CARM1 3049.0 -5243.0
CASP10 -5616.0 4481.0
CASP2 4394.0 -2279.0
CASP3 -5479.0 3769.0
CASP8 3042.0 -1356.0
CASP9 -5452.0 2551.0
CAV1 -1794.0 7710.0
CAV2 2198.0 7854.0
CBFB -6742.0 4156.0
CBL -6179.0 5753.0
CBX2 8031.0 1352.0
CBX4 -4232.5 -4187.0
CBX6 3128.0 3570.0
CBX8 -4432.0 336.0
CBY1 6193.0 3647.0
CCDC88C -1961.0 2120.0
CCL16 4028.0 -7557.0
CCL20 -7326.0 7960.0
CCL23 1293.0 -4622.0
CCNC -2058.0 1145.0
CCND1 -31.0 5200.0
CCND3 -3296.0 8309.0
CCNE1 2957.0 7818.0
CCNK -1252.0 1200.0
CCNT1 -4791.0 -108.0
CCNT2 4252.0 -5244.0
CCR10 2310.0 3327.0
CCR7 4855.0 -4439.0
CD19 3213.0 7350.0
CD55 -6972.0 1417.0
CD97 807.0 3012.0
CDC14A 1107.0 7024.0
CDC14B 3775.0 4810.0
CDC20 6337.0 -3782.0
CDC25C 7892.0 -3638.0
CDC37 -5492.0 6599.0
CDC42 -1043.0 1514.0
CDC42EP2 -5830.0 4932.0
CDC42EP3 329.0 8322.0
CDC42EP5 6369.0 7795.0
CDC73 -4811.0 -532.0
CDCA8 7748.0 -3346.0
CDH1 8639.0 8336.0
CDH5 6998.0 6392.0
CDK1 8557.0 4062.0
CDK2 4500.0 6252.0
CDK4 -5584.0 -3415.0
CDK5 -1190.0 7552.0
CDK5R1 -149.0 -5571.0
CDK8 -4193.0 4124.0
CDK9 2693.0 2114.0
CDKN1A -5194.0 5171.0
CDKN1B -560.0 -3957.0
CDKN2B 2129.0 2833.0
CDON 2313.0 7434.0
CENPA 5024.0 -1109.0
CENPC 4946.0 -4458.0
CENPE 6430.0 3284.0
CENPF 4665.0 -2648.0
CENPH 7252.0 2368.0
CENPI 7511.0 4567.0
CENPK 8391.0 3890.0
CENPL 1190.0 -579.0
CENPM 5959.0 -547.0
CENPN 2838.0 61.0
CENPO 631.0 -2791.0
CENPP 743.0 -599.0
CENPQ 6703.0 2136.0
CENPT 5225.0 -2047.0
CENPU 6060.0 5069.0
CFL1 -6105.0 3778.0
CFLAR -1356.0 -7835.0
CGN 1475.0 8470.0
CHD1 -3351.0 -475.0
CHD3 -1154.0 -128.0
CHD4 -4999.0 -3188.0
CHD8 -4641.0 -1055.0
CHEK1 6372.0 -187.0
CHN1 -1525.0 6041.0
CHN2 -5427.0 1406.0
CHRM4 -501.0 8433.0
CHUK -3298.0 5946.0
CIT 6839.0 -1057.0
CKAP5 7437.0 -317.0
CLASP1 1611.0 -1988.0
CLASP2 -4528.0 1648.0
CLIP1 -6435.0 -6757.0
CLIP3 7534.0 2274.0
CLTA -6861.0 -1169.0
CLTB -6535.0 7375.0
CLTC -6446.0 46.0
CNGA1 -3911.0 3813.0
CNGB1 1934.0 6297.0
CNKSR1 3725.0 -3846.0
CNOT6L 6895.0 -880.0
COL4A5 7687.0 -2075.0
COL6A1 8663.0 6803.0
COL6A2 3946.0 8439.0
COL9A2 8719.0 -525.0
COL9A3 8343.0 -6872.0
CORT 1430.0 435.0
CPT1A 8296.0 -6668.0
CPT1B 3586.0 -6161.0
CRABP2 -5887.0 8372.0
CREB1 1456.0 -5500.0
CREBBP -3983.0 -7682.0
CRK -5942.0 3696.0
CRKL 662.0 -3738.0
CSK -4377.0 -3447.0
CSNK1A1 -6538.0 -2808.0
CSNK1E 3315.0 2456.0
CSNK1G2 -1028.0 13.0
CSNK2A1 -4165.0 -4925.0
CSNK2A2 -4677.0 -4027.0
CSNK2B -2785.0 -4104.0
CTBP1 136.0 -7454.0
CTBP2 -6495.0 7331.0
CTNNA1 -5839.0 1680.0
CTNNB1 3313.0 -2713.0
CTNNBIP1 3593.0 -1947.0
CTNND1 8276.0 -3733.0
CTSD 3616.0 -1973.0
CTTN 1171.0 -5758.0
CUL1 -4043.0 -7818.0
CUL3 -3083.0 -3669.0
CUL5 -879.0 -5374.0
CX3CL1 -7488.0 -7829.0
CXCL16 -6150.0 -1284.0
CXCR4 -148.0 7179.0
CXXC5 -6325.0 4609.0
CYBA 2721.0 -812.0
CYFIP1 1828.0 -6866.0
CYFIP2 7159.0 6775.0
CYLD -6439.0 6890.0
CYP26B1 -5472.0 8435.0
CYP4V2 4812.0 -1468.0
DAAM1 -4615.0 5766.0
DAB2IP -6593.0 -3475.0
DAGLA -7287.0 4051.0
DAGLB -4303.0 6669.0
DDX5 -7024.0 -6523.0
DEPDC1B 6771.0 -1171.0
DEPDC7 -2136.0 459.0
DERL2 -7492.0 -5988.0
DGKA 7306.0 8110.0
DGKD -2395.0 568.0
DGKE -6441.0 4008.0
DGKG 1760.0 3885.0
DGKH 3524.0 7685.0
DGKK 7740.0 -7263.0
DGKQ -2062.0 5700.0
DGKZ -6347.0 5775.0
DHRS3 3459.0 -7849.0
DHRS4 6432.0 -7667.0
DIAPH1 -6171.0 5326.0
DIAPH2 3044.0 -4215.0
DIAPH3 5610.0 4537.0
DISP2 -739.0 8257.0
DKK1 4680.0 6953.0
DLAT -1429.0 -4566.0
DLC1 -6895.0 -1825.0
DLD 4543.0 3320.0
DLG1 -3949.0 -1876.0
DLG2 -3405.0 4538.0
DLG3 5519.0 5621.0
DLG4 6509.0 6462.0
DLGAP5 6421.0 1710.0
DLK1 3756.0 -3275.0
DLL1 -966.0 7365.0
DLL4 6422.0 8027.0
DNAJB1 -6736.0 6082.0
DNAL4 7891.0 3418.0
DNM1 8526.0 8493.0
DNM2 -6950.0 3033.0
DOCK1 3791.0 -7487.0
DOCK3 3377.0 2445.0
DOCK7 4144.0 -2256.0
DOK1 5457.0 7677.0
DRAP1 2906.0 6156.0
DRD4 7048.0 333.0
DSN1 8076.0 4653.0
DTX2 -3707.0 4681.0
DTX4 3094.0 8191.0
DUSP1 -5848.0 6289.0
DUSP10 -5663.0 6570.0
DUSP16 -2388.0 -2416.0
DUSP3 -6905.0 -6818.0
DUSP4 -6799.0 7976.0
DUSP5 -6088.0 8150.0
DUSP6 -3238.0 6486.0
DUSP7 -3804.0 6381.0
DUSP8 -5793.0 7689.0
DUSP9 -64.0 -7654.0
DVL1 -2143.0 -5827.0
DVL2 -708.0 2741.0
DVL3 -7421.0 -6758.0
DYNC1H1 -3663.0 2932.0
DYNC1I2 -2145.0 770.0
DYNC1LI1 -2027.0 -4249.0
DYNC1LI2 -4501.0 -188.0
DYNC2H1 -6763.0 6482.0
DYNLL1 2580.0 -4168.0
DYNLL2 6616.0 1920.0
DZIP1 5972.0 6811.0
E2F1 8361.0 6309.0
E2F3 717.0 -2316.0
E2F4 -2932.0 -3787.0
E2F5 750.0 -3605.0
EBAG9 1782.0 -1575.0
ECE1 -5897.0 5713.0
ECE2 -4082.0 -1203.0
ECT2 -5111.0 2083.0
EDN1 8103.0 -6860.0
EED 2797.0 2087.0
EEF2K 7781.0 -290.0
EFCAB7 8059.0 2701.0
EGFR -5364.0 -4805.0
EGR1 -1311.0 7939.0
EIF4B -6017.0 -7498.0
EIF4E 2829.0 494.0
EIF4EBP1 5449.0 -7559.0
EIF4G1 -6162.0 -7098.0
ELF3 4013.0 -1586.0
ELK1 -6081.0 1479.0
ELMO1 -4026.0 5095.0
ELMO2 1057.0 -2035.0
EP300 -6798.0 -5744.0
EPAS1 -5121.0 5176.0
EPN1 -670.0 1658.0
EPO 2219.0 -2543.0
EPOR 5524.0 7563.0
EPS15 1502.0 84.0
EPS15L1 3752.0 -3779.0
ERBB2 5794.0 -7560.0
ERBB3 4475.0 -7842.0
ERCC6L -738.0 3744.0
EREG 6431.0 -2497.0
ERLEC1 -6537.0 -1557.0
ESRP1 1656.0 7665.0
ESRP2 -2435.0 -4734.0
ETV4 -5120.0 -7601.0
EVC 6944.0 -5192.0
EVL 2737.0 6546.0
EZH2 -5851.0 5827.0
F11R 8170.0 5209.0
F2 720.0 -6133.0
F2R 4090.0 7630.0
F2RL1 -7373.0 6389.0
FADD 1085.0 217.0
FAM13A 2203.0 4726.0
FAM13B -5433.0 -2839.0
FAS 3749.0 -7569.0
FBXW7 -1728.0 4244.0
FER 4942.0 591.0
FES 6316.0 -1183.0
FGA 8712.0 -6806.0
FGB 8516.0 -5044.0
FGD1 -3244.0 4064.0
FGD3 8675.0 3220.0
FGD4 7530.0 -4576.0
FGF17 -4280.0 6192.0
FGF2 2108.0 8222.0
FGF22 1377.0 1235.0
FGFBP3 7816.0 4943.0
FGFR1 -6406.0 -2041.0
FGFR2 8421.0 6896.0
FGFR3 -844.0 -2775.0
FGFR4 -2686.0 -6584.0
FGFRL1 -3839.0 6284.0
FGG 7721.0 -7323.0
FKBP1A -4841.0 4175.0
FKBP4 -6202.0 -3764.0
FKBP5 5659.0 6942.0
FLNA -7276.0 7066.0
FLRT1 -30.0 6459.0
FLRT3 8638.0 2761.0
FMNL1 -2567.0 7924.0
FMNL2 -4143.0 1537.0
FMNL3 3173.0 4843.0
FN1 -3350.0 -4096.0
FNTA -6369.0 -4955.0
FNTB -1402.0 -7110.0
FOS -5517.0 7750.0
FOSB -7027.0 6253.0
FOXA1 6495.0 -7550.0
FOXO1 5827.0 63.0
FOXO3 1586.0 -1088.0
FOXO4 -2011.0 6287.0
FOXO6 2732.0 8017.0
FRAT1 5896.0 -857.0
FRAT2 -5277.0 729.0
FRK -5211.0 6328.0
FRS2 -3852.0 1659.0
FRS3 2419.0 3671.0
FST -2214.0 -7853.0
FSTL3 -5743.0 6270.0
FURIN -7130.0 -6700.0
FUZ 1476.0 3389.0
FYN 2107.0 8121.0
FZD1 5935.0 7935.0
FZD2 -2793.0 8302.0
FZD3 1243.0 5877.0
FZD4 7807.0 -6394.0
FZD5 5142.0 -6647.0
FZD6 7146.0 -877.0
FZD7 7669.0 7990.0
FZD8 2911.0 7537.0
FZD9 -6878.0 7232.0
GAB1 1976.0 -5914.0
GAB2 -4212.0 -1124.0
GABBR1 7885.0 8465.0
GALNT3 -4889.0 5329.0
GALR2 -6590.0 6609.0
GAS8 2754.0 3791.0
GATAD2A -4196.0 173.0
GATAD2B -555.0 -3472.0
GCGR 7604.0 6949.0
GDI1 -139.0 6429.0
GDI2 -1736.0 -5161.0
GDNF -5006.0 2781.0
GFAP 389.0 7965.0
GFRA3 6858.0 8067.0
GGA3 4516.0 -5364.0
GHRL 1133.0 -5118.0
GIPR 6450.0 8363.0
GLI1 -4454.0 8120.0
GLP2R -714.0 4208.0
GMIP 7133.0 3459.0
GNA11 -6271.0 5029.0
GNA12 -6726.0 3499.5
GNA13 -7014.0 -1656.0
GNAI1 -3147.0 7957.0
GNAI2 -4148.0 6292.0
GNAI3 -4547.0 2520.0
GNAL 5208.0 5528.0
GNAO1 6529.0 8371.0
GNAQ 1257.0 -6105.0
GNAS 586.0 -5916.0
GNAT1 2087.0 4964.0
GNAT2 -5704.0 502.0
GNAZ -3834.0 7372.0
GNB1 -2877.0 -1486.0
GNB2 -4780.0 3055.0
GNB3 -1447.0 -2464.0
GNB5 888.0 5876.0
GNG12 -126.0 8472.0
GNG3 -5739.0 -774.0
GNG4 6956.0 -2620.0
GNG5 5211.0 -7517.0
GNG7 4509.0 7629.0
GNRH1 -4058.0 3302.0
GNRHR2 3249.0 6821.0
GOPC 2135.0 -566.0
GPAM 7999.0 -7593.0
GPBAR1 -2456.0 -2705.0
GPC1 5564.0 7586.0
GPC2 7686.0 7994.0
GPC3 4501.0 -1909.0
GPC4 2228.0 5221.0
GPC5 413.0 7569.0
GPC6 4712.0 -5815.0
GPER1 -7451.0 -7834.0
GPHA2 -4007.0 -1264.0
GPNMB 6769.0 -1020.0
GPR143 -3026.0 1144.0
GPR161 -3609.0 8015.0
GPR176 7499.0 8173.0
GPR35 -2299.0 -5418.0
GPR39 -752.0 5698.0
GPR4 253.0 7313.0
GPR68 -461.0 3645.0
GPR83 858.0 158.0
GPSM1 855.0 8445.0
GPSM2 1318.0 6684.0
GPSM3 -4838.0 6441.0
GRB10 -5938.0 -5495.0
GRB2 -3760.0 4572.0
GRB7 -4081.0 -7345.0
GREB1 7753.0 -7679.0
GRIN1 -399.0 8437.0
GRIN2B 1815.0 -2820.0
GRIN2D -6063.0 7832.0
GRK4 4380.0 7509.0
GRK5 -159.0 7358.0
GRK6 1370.0 6187.0
GSK3A -3050.0 -3953.0
GSK3B -5324.0 2811.0
GTF2A1 616.0 2731.0
GTF2A2 5961.0 4807.0
GTF2F1 -3019.0 -1117.0
GTF2F2 4860.0 1441.0
GUCA1B 555.0 471.0
H2AFJ 3150.0 7490.0
H2AFV 4868.0 2413.0
H2AFX 5969.0 1647.0
H2AFZ -68.0 1841.0
H3F3A 534.0 -2193.0
HBEGF -4949.0 7299.0
HCAR1 2283.0 7222.0
HCAR2 5585.0 5477.0
HCAR3 941.0 6083.0
HDAC1 -2602.0 6418.0
HDAC10 -378.0 -5348.0
HDAC11 1254.0 5616.0
HDAC2 -276.0 2709.0
HDAC3 173.0 5878.0
HDAC4 -1128.0 -4470.0
HDAC5 -3972.0 -4950.0
HDAC6 6642.0 -794.0
HDAC7 483.0 -6229.0
HDAC8 4062.0 -3350.0
HEBP1 -6718.0 6104.0
HES1 8603.0 437.0
HEY1 -4552.0 5950.0
HEY2 1998.0 7543.0
HEYL 4592.0 6919.0
HGFAC 7868.0 -6549.0
HGS -4381.0 943.0
HHAT 5239.5 -6257.0
HIF1A -4062.0 -1633.0
HIST1H2AC -5947.0 -2079.0
HIST1H2BC -6692.0 -5821.0
HIST1H2BD -5110.0 1201.0
HIST1H2BJ 3107.0 -2505.0
HIST1H2BK -3274.0 1539.0
HIST1H2BL 2052.0 3360.0
HIST1H2BN 6987.0 948.0
HIST1H2BO 2159.0 -847.0
HIST2H2AC -983.0 346.0
HIST2H2BE -6945.0 4840.0
HMHA1 -5488.0 8068.0
HNRNPA1 808.0 -5324.0
HNRNPF -7059.0 -4014.0
HNRNPH1 1765.0 -6192.0
HNRNPM -7192.0 -5669.0
HPN 8057.0 -7276.0
HRAS -6243.0 2943.0
HSD17B1 64.0 -2141.0
HSD17B6 8447.0 5720.0
HSP90AA1 -1010.0 -966.0
HSP90AB1 -4565.0 -3077.0
HSPB1 -3333.0 4757.0
HSPG2 8395.0 4466.0
HTR1D 1814.0 -2071.0
HTR7 -7111.0 159.0
IER3 -7269.0 6372.0
IFT122 3290.0 6255.0
IFT140 4783.0 1473.0
IFT172 3690.0 -7215.0
IFT52 2676.0 5839.0
IFT57 -700.0 7863.0
IFT88 6467.0 3745.0
IGF1R -2603.0 -1706.5
IGF2 8755.0 -5186.0
IGF2BP1 -4722.0 -7794.0
IHH -6206.0 5747.0
IKBKB -2851.0 1275.0
IKBKG -6257.0 -7466.0
IL17RD 6659.0 8351.0
IL1RAP 5782.0 4670.0
IL2RB -3672.0 6544.0
IL2RG -1740.0 6294.0
IL3RA -6313.0 5065.0
IL6R -5291.0 -7663.0
IL6ST 2365.0 -523.0
INCENP 5826.0 2009.0
INHBB -3000.0 4171.0
INPP5B 7076.0 1446.0
INSL3 -729.0 -1354.0
INSR -5354.0 -2269.0
INTU 6983.0 -1797.0
IQCE -4590.0 7718.0
IQGAP1 -5978.0 6515.0
IQGAP2 -5578.0 -5792.0
IQGAP3 8144.0 4918.0
IRAK1 -2078.0 -7142.0
IRAK4 1697.0 2007.0
IRS1 3723.0 -7533.0
IRS2 -6914.0 5124.0
ITCH -6368.0 -3395.0
ITGA2 -6514.0 4478.0
ITGA2B 3570.0 8287.0
ITGA3 -3001.0 8421.0
ITGAV -4482.0 2291.0
ITGB1 -4695.0 2131.0
ITGB3BP 7746.0 1733.0
ITPR1 -4460.0 7498.0
ITPR2 1932.0 -4504.0
ITPR3 -6578.0 6716.0
ITSN1 122.0 4798.0
JAG1 -7345.0 2808.0
JAG2 -173.0 8447.0
JAK1 -5081.0 1908.0
JAK2 -2499.0 3365.0
JAK3 8680.0 -7553.0
JUN -2834.0 6701.0
JUNB -4027.0 5267.0
JUND 4982.0 5999.0
JUP 2534.0 5446.0
KALRN 451.0 4270.0
KANK1 4926.0 -7390.0
KAT2A 5270.0 -7676.0
KAT2B -5350.0 6867.0
KAT5 575.0 -7303.0
KBTBD7 7901.0 -5188.0
KCTD6 86.0 5678.0
KDM1A 4202.0 244.0
KDM4B 423.0 -1028.0
KDM4C -5216.0 -164.0
KHDRBS1 1459.0 -1941.0
KHDRBS3 -3385.0 4192.0
KIDINS220 -6542.0 5548.0
KIF14 6149.0 2570.0
KIF18A 6977.0 695.0
KIF2A -6003.0 3766.0
KIF2C 6685.0 398.0
KIF3A 3066.0 7188.0
KIF5A -7093.0 4787.0
KIF5B -5653.0 -1811.0
KIF7 7213.0 3287.0
KISS1 -3849.0 7032.0
KISS1R 3334.0 2584.0
KITLG -314.0 7278.0
KLB -3988.0 -2868.0
KLC1 4030.0 1369.0
KLC2 -3628.0 5186.0
KLC3 1438.0 8368.0
KLC4 3884.0 -6590.0
KLHL12 7897.0 -3847.0
KMT2D -6680.0 -5675.0
KNG1 8754.0 -4742.0
KNTC1 6813.0 4550.0
KPNA2 -4910.0 5213.0
KRAS -1531.0 5656.0
KREMEN1 578.0 7565.0
KREMEN2 1773.0 8190.0
KSR1 -263.0 5793.0
KSR2 1507.0 6178.0
KTN1 -3210.0 -2057.0
LAMA1 -362.0 4856.0
LAMA2 -5709.0 -602.0
LAMA3 -5874.0 -184.0
LAMA5 7734.0 -4486.0
LAMB1 3829.0 -5043.0
LAMB2 680.0 -4322.0
LAMB3 -1338.0 5235.0
LAMC1 -942.0 -396.0
LAMC3 3250.0 7744.0
LAMTOR1 -608.0 -5616.0
LAMTOR2 -128.0 700.0
LAMTOR3 -2494.0 5335.0
LAMTOR4 2100.0 -445.0
LAMTOR5 -5632.0 -3864.0
LAT -3439.0 2065.0
LATS1 -3365.0 -6226.0
LATS2 -6525.0 -1613.0
LCK -6978.0 7220.0
LDLR 5732.0 -6038.0
LEF1 -116.0 6700.0
LEO1 -3047.0 -4611.0
LEPR 1137.0 -4029.0
LFNG -1635.0 8161.0
LGR4 -152.0 606.0
LGR5 -1087.0 -5654.0
LIMK1 1420.5 5880.0
LIMK2 7573.0 -3430.0
LIN7B 3382.0 3077.0
LINGO1 1317.0 8112.0
LPAR2 4730.0 3201.0
LPAR5 7512.0 7321.0
LPAR6 8052.0 -3048.0
LRIG1 -6778.0 4641.0
LRP1 -2477.0 1296.0
LRP10 -5325.0 4155.0
LRP12 4451.0 7810.0
LRP2 1838.0 8484.0
LRP5 -2054.0 -4658.0
LRP6 -4929.0 -3460.0
LRP8 4361.0 5886.0
LRRC7 7459.0 -3727.0
LTB4R -422.0 6847.0
LTB4R2 1161.0 5777.0
LYN -3219.0 5319.0
MAD1L1 4495.0 -5205.0
MAD2L1 8252.0 -241.0
MADD -5933.0 5608.0
MAF1 -6183.0 -7162.0
MAGED1 6632.0 5054.0
MAML1 -2125.0 -5873.0
MAML2 7991.0 -808.0
MAML3 6151.0 6851.0
MAMLD1 -1548.0 7590.0
MAP2K1 -3910.0 4421.0
MAP2K2 -6521.0 -2314.0
MAP2K5 -2186.0 -6282.0
MAP3K11 -4435.0 -7733.0
MAP3K7 4053.0 -1436.0
MAPK1 -5238.0 2381.0
MAPK11 882.0 8360.0
MAPK12 -5089.0 4395.0
MAPK13 -2796.0 -7749.0
MAPK14 2288.0 2138.0
MAPK3 7820.0 18.0
MAPK6 -6700.0 -3436.0
MAPK7 -4609.0 -932.0
MAPK8 -386.0 4145.0
MAPKAP1 -6274.0 -1518.0
MAPKAPK2 -6924.0 5257.0
MAPKAPK3 -6154.0 -5586.0
MAPKAPK5 -5195.0 -4984.0
MAPRE1 -3863.0 -1013.0
MARK3 -3977.0 1117.0
MATK 935.0 8102.0
MBD3 -4199.0 -7643.0
MC1R 1366.0 -1820.0
MCF2L 696.0 5040.0
MCHR1 -6339.0 6947.0
MDK 5125.0 -4106.0
MDM2 261.0 -6156.0
MECOM -1590.0 4917.0
MED1 -5599.0 -4352.0
MEF2A -3266.0 2577.0
MEMO1 -147.0 496.0
MEN1 1465.0 2387.0
MET -7310.0 301.0
METAP1 -3645.0 3708.0
METAP2 -1800.0 -3134.0
MFNG 8023.0 4406.0
MIB1 1766.0 1719.0
MIB2 -4653.0 2233.0
MIR25 -1651.0 -4442.0
MIS12 -6632.0 1142.0
MKNK1 -2309.0 2743.0
MKRN1 -6068.0 -2908.0
MKS1 7626.0 -3087.0
MLST8 1867.0 -6639.0
MMP2 -5470.0 8154.0
MMP3 -1893.0 -3464.0
MMP9 1516.0 6868.0
MOB1A 731.0 -1426.0
MOB1B 3153.0 -1241.0
MOV10 7256.0 -7762.0
MST1 -4056.0 -6888.0
MST1R 7821.0 6765.0
MTA1 1745.0 -6497.0
MTA2 -5977.0 -5117.0
MTA3 7062.0 -7000.0
MTMR4 -7565.0 -1379.0
MTOR -3860.0 3329.0
MT-RNR2 8019.0 3799.0
MUC20 -4639.0 6658.0
MYC 2009.0 -5587.0
MYD88 6626.0 -7806.0
MYH10 2562.0 5053.0
MYH11 -3965.0 3822.0
MYH14 6123.0 6626.0
MYH9 -4885.0 2788.0
MYL12B -6985.0 6165.0
MYL6 -6780.0 6434.0
MYL9 4545.0 4973.0
MYLK 4416.0 -7231.0
MYO7A -2013.0 8059.0
MYO9A -1124.0 4791.0
MYO9B -6205.0 5930.0
NAPEPLD -1576.0 4106.0
NCAM1 7889.0 8243.0
NCBP1 -1858.0 1533.0
NCBP2 7854.0 -262.0
NCF2 -6987.0 -2090.0
NCK1 1692.0 112.0
NCK2 -3924.0 1770.0
NCKAP1 -2587.0 -3065.0
NCKIPSD 6169.5 1778.0
NCOA1 -4821.0 3973.0
NCOA2 5080.0 -7532.0
NCOA3 -2297.0 1563.0
NCOR1 -4491.0 -5805.0
NCOR2 -4626.0 334.0
NCSTN -321.0 -6959.0
NDC80 8453.0 -3958.0
NDE1 -2489.0 3954.0
NDEL1 -5762.0 6548.0
NEDD4 -3360.0 -82.0
NEDD4L 8357.0 -5776.0
NEDD8 747.0 738.0
NELFB -2195.0 -3357.0
NET1 -6050.0 3444.0
NEURL1 -4350.0 7549.0
NEURL1B 5848.0 8358.0
NF1 1707.0 -4035.0
NF2 -6890.0 -35.0
NFATC1 2649.0 8289.0
NFKB1 -3533.0 -7777.0
NFKBIA -6857.0 -7408.0
NGEF 8184.0 -7726.0
NGFR -940.0 5251.0
NLK -715.0 4971.0
NLN 3673.0 -3672.0
NMB -536.0 5184.0
NMT1 -2056.0 -6253.0
NMT2 1612.0 1889.0
NOS3 -5605.0 3817.0
NOTCH1 -4469.0 7923.0
NOTCH2 6971.0 6567.0
NOTCH3 6581.0 8500.0
NOTCH4 5633.0 3829.0
NOTUM 7940.0 -7250.0
NOX3 -6058.0 -4198.0
NOXA1 7165.0 -733.0
NPHP4 -1411.0 5724.0
NPW -3774.0 6004.0
NR3C1 -4108.0 272.0
NR4A1 2909.0 3030.0
NR5A2 -6515.0 3756.0
NRAS 2326.0 1987.0
NRG1 3176.0 6712.0
NRG2 3139.0 8062.0
NRG4 -1082.0 -1905.0
NRIP1 247.0 -5855.0
NRP1 1771.0 -4310.0
NRP2 -5510.0 5994.0
NRTN 4643.0 4315.0
NSL1 3784.0 -1581.0
NSMAF 397.0 -7758.0
NTSR1 -2124.0 5840.0
NUDC -7092.0 4290.0
NUF2 8222.0 -2368.0
NUMB -5540.0 868.0
NUP107 6965.0 -4327.0
NUP133 1406.0 1305.0
NUP160 -271.0 -1749.0
NUP37 8176.0 -4271.0
NUP43 2778.0 1270.0
NUP85 4624.0 1161.0
NUP98 -3617.0 2992.0
OBSCN 6460.0 7925.0
OCRL 7939.0 -4230.0
OFD1 536.0 -4886.0
OPHN1 7183.0 1763.0
OPN1SW -3036.0 2569.0
OPN3 6264.0 -381.0
OPRL1 5752.0 7104.0
OR2B6 1300.5 -3051.0
OR2I1P 7916.0 -6245.0
OS9 -7438.0 4312.0
OTUD3 -2230.0 4243.0
OTUD7B -1591.0 -4326.0
OXER1 6212.0 -4209.0
OXTR -3550.0 7017.0
P2RY11 -6450.0 -4501.0
P2RY2 -5499.0 7482.0
P4HB -7396.0 -45.0
PAFAH1B1 -1522.0 -1936.0
PAG1 4531.0 8179.0
PAK1 706.0 7700.0
PAK2 -4864.0 -3666.0
PAK3 -3239.0 7424.0
PAQR3 4865.0 6380.0
PARD3 -6504.0 -7587.0
PARD6A 7170.0 56.0
PARP1 3108.0 5682.0
PBX1 5339.0 7866.0
PCP2 5427.0 -967.0
PCSK5 -2560.0 7800.0
PCSK6 4940.0 -7626.0
PDE11A 6240.0 7831.0
PDE2A -631.0 5694.0
PDE3A -6579.0 -7265.0
PDE3B -5670.0 1391.0
PDE4A -3062.0 -56.0
PDE4C 4317.0 8132.0
PDE4D -6773.0 -7026.0
PDE6G 446.0 1899.0
PDE7A -1136.0 5282.0
PDE8A -4711.0 -1547.0
PDE8B 6406.0 4366.0
PDGFA -3308.0 6598.0
PDGFB 8315.0 -1074.0
PDGFC -5529.0 4121.0
PDGFD 2078.0 4685.0
PDGFRA 3282.0 7488.0
PDGFRB -7284.0 3078.0
PDHA1 -1602.0 5006.0
PDHB 1719.0 -3930.0
PDHX -5093.0 3007.0
PDK1 2587.0 784.0
PDK2 7476.0 4818.0
PDK3 -2154.0 6396.0
PDK4 7147.0 4610.0
PDPK1 1196.0 -7447.0
PEA15 3233.0 7121.0
PEBP1 -7430.0 -5489.0
PELP1 -2911.0 -4848.0
PFN1 -6745.0 -4521.0
PFN2 7972.0 2946.0
PGF -7503.0 7130.0
PHB -5786.0 -1432.0
PHC1 -2942.0 4432.0
PHC2 3954.0 -5767.0
PHC3 599.0 -4130.0
PHLPP1 -5203.0 -5695.0
PHLPP2 -4001.0 631.0
PIK3AP1 -7403.0 -6519.0
PIK3C3 -5508.0 2863.0
PIK3CA -3651.0 -657.0
PIK3CB -2338.0 1402.0
PIK3CD -5125.0 -5801.0
PIK3R1 -4428.0 2625.0
PIK3R3 -5263.0 7967.0
PIK3R4 1082.0 1676.0
PIN1 3402.0 4072.0
PIP4K2A -5587.0 6686.0
PIP4K2B 2921.0 -4551.0
PIP4K2C -6782.0 6415.0
PIP5K1A -1419.0 -205.0
PIP5K1B 1428.0 -3919.0
PIP5K1C -3187.0 5444.0
PKN1 -4923.0 -2645.0
PKN2 919.0 -4155.0
PKN3 3510.0 -7223.0
PLAT 7446.0 1639.0
PLB1 77.0 5814.0
PLCB1 -6713.0 567.0
PLCB3 -2495.0 7155.0
PLCG1 2511.0 1941.0
PLCG2 -6234.0 8407.0
PLEKHG2 -5153.0 4746.0
PLEKHG5 -108.0 7075.0
PLG 8749.0 -4536.0
PLK1 5435.0 -6912.0
PLXNB1 -746.0 -7141.0
PLXND1 -6078.0 6940.0
PMEPA1 -4186.0 7737.0
PMF1 -1024.0 -7817.0
PML 1201.0 -510.0
POFUT1 4016.0 -2963.0
POGLUT1 -6752.0 -4670.0
POLR2A 2948.0 -6306.0
POLR2B -3795.0 2880.0
POLR2C -3177.0 1582.0
POLR2D 1696.0 -2523.0
POLR2E -4282.5 3215.0
POLR2F -5560.0 4701.0
POLR2G 2153.0 1453.0
POLR2H -4010.0 -1665.0
POLR2I 4612.0 -3659.0
POLR2J -246.0 4188.0
POLR2K 6791.0 5504.0
POLR2L -5741.0 6784.0
PORCN 1168.0 7263.0
POU2F1 1628.0 423.0
PPARD -676.0 7654.0
PPARG -3268.0 -6596.0
PPID -4304.0 264.0
PPM1A -5997.0 -3135.0
PPP1CA -5610.0 -2317.0
PPP1CB -3213.0 -2745.0
PPP1CC -3386.0 2425.0
PPP1R12A 1646.0 -2391.0
PPP1R12B -4441.0 5211.0
PPP1R15A -7247.0 -653.0
PPP1R1B 6217.0 8462.0
PPP2CA -4705.0 -1300.0
PPP2CB -4606.0 3107.0
PPP2R1A -4930.0 -6343.0
PPP2R1B 4738.0 344.0
PPP2R5A -6040.0 1378.0
PPP2R5B -5535.0 8233.0
PPP2R5C 2799.0 5288.0
PPP2R5D -2221.0 407.0
PPP2R5E 399.0 -2518.0
PPP3CA 395.0 6397.0
PPP3CB -4113.0 1568.0
PPP3CC -3015.0 2346.0
PPP3R1 -3928.0 -1737.0
PPP5C 2886.0 -1421.0
PRC1 7723.0 -3899.0
PRDM4 -6341.0 -4575.0
PREX1 -3509.0 8361.0
PRKAA1 5575.0 -882.0
PRKAA2 -3046.0 2175.0
PRKAB1 -638.0 -4016.0
PRKAB2 -1569.0 -7427.0
PRKACA 1944.0 7670.0
PRKACB -1578.0 5347.0
PRKAG1 4432.0 -5925.0
PRKAG2 704.0 7366.0
PRKAR1A 1506.0 -5527.0
PRKAR1B -727.0 -7618.0
PRKAR2A -628.0 3592.0
PRKAR2B -965.0 7979.0
PRKCA 2635.0 4268.0
PRKCB 3222.0 7099.0
PRKCD -5969.0 5212.0
PRKCE -5962.0 7035.0
PRKCG -2451.0 7583.0
PRKCH -2305.0 7766.0
PRKCI -315.0 5976.0
PRKCQ 2905.0 7047.0
PRKCZ -6997.0 -5111.0
PRMT1 -4379.0 -5473.0
PRR5 -2094.0 2976.0
PSAP -5561.0 1123.0
PSEN1 -5101.0 1256.0
PSEN2 -2337.0 -3815.0
PSENEN -1142.0 5970.0
PSMA1 -3927.0 -2398.0
PSMA2 15.0 1100.0
PSMA3 -2496.0 1979.0
PSMA4 -4169.0 -2695.0
PSMA5 -2402.0 558.0
PSMA6 1150.0 -3215.0
PSMA7 -849.0 -1558.0
PSMB1 1173.0 -728.0
PSMB10 -2296.0 -7082.0
PSMB2 1929.0 1160.0
PSMB3 -1875.0 -1567.0
PSMB4 -1015.0 -171.0
PSMB5 -499.0 -6359.0
PSMB6 -5085.0 -6160.0
PSMB7 -3738.0 -1108.0
PSMB8 5998.0 -6450.0
PSMB9 8274.0 7642.0
PSMC1 -2073.0 -2143.0
PSMC2 -2382.0 1413.0
PSMC3 -1326.0 -4739.5
PSMC4 -5097.0 -3313.0
PSMC5 -3886.0 -5049.0
PSMC6 -4958.0 -3262.0
PSMD1 -5546.0 4652.0
PSMD10 5116.0 -309.0
PSMD11 -258.0 -3176.0
PSMD12 4562.0 -101.0
PSMD13 -2467.0 5077.0
PSMD14 6651.0 -459.0
PSMD2 -6864.0 3474.0
PSMD3 -5826.0 236.0
PSMD4 4967.0 -4640.0
PSMD5 5607.0 -4170.0
PSMD6 -6300.0 2254.0
PSMD7 5850.0 -3019.0
PSMD8 -2768.0 537.0
PSMD9 -3221.0 368.0
PSME1 -2066.0 -2429.0
PSME2 -5564.0 1864.0
PSME3 -3725.0 -3020.5
PSME4 -6847.0 1983.0
PSMF1 -7076.0 -2659.0
PSPN -5894.0 1461.0
PTAFR 7112.0 7194.0
PTBP1 -6440.0 -4372.0
PTCH1 -1161.0 5915.0
PTCH2 7966.0 1323.0
PTEN -4972.0 168.0
PTGDR2 8225.0 4658.0
PTGES3 3942.0 -792.0
PTHLH -6544.0 4660.0
PTK2 -4251.0 -2692.0
PTK2B 8039.0 -5765.0
PTPN1 3835.0 5496.0
PTPN11 -648.0 767.0
PTPN12 -5671.0 995.0
PTPN18 7983.0 -7320.0
PTPN2 -3501.0 -6972.0
PTPN3 -7128.0 6059.0
PTPN6 7631.0 2055.0
PTPRA 951.0 -2417.0
PTPRJ -6485.0 8011.0
PTPRK -6628.0 -6607.0
PTPRS 1453.0 -3240.0
PTPRU 4688.0 5612.0
PXN 3118.0 3442.0
PYGO1 6317.0 5487.0
PYGO2 1904.0 -518.0
RAB4A -2519.0 -2935.0
RAB4B 1987.0 2428.0
RAB6A 1013.0 -67.0
RAC1 1346.0 964.0
RAC3 1545.0 -4237.0
RACGAP1 6446.0 5025.0
RAD21 712.0 -2997.0
RAF1 -5732.0 -5961.0
RAG1 8264.0 5605.0
RALA -6832.0 -1142.0
RALB 327.0 3599.0
RALBP1 -1463.0 5174.0
RALGDS 5012.0 1108.0
RAMP1 -7553.0 6866.0
RAMP2 7605.0 -514.0
RANBP10 -1044.0 -80.0
RANBP2 471.0 501.0
RANBP9 -7313.0 1487.0
RANGAP1 3828.0 867.0
RAP1A 206.0 5575.0
RAP1B 2471.0 4888.0
RAPGEF1 -6969.0 -2311.0
RAPGEF2 -7065.0 6314.0
RAPGEF3 -5910.0 8023.0
RAPGEF4 1952.0 5400.0
RARA -6550.0 2359.0
RARG 330.0 7958.0
RASA1 2082.5 -2387.0
RASA2 881.0 -4063.0
RASA3 565.0 7316.0
RASAL1 -2378.0 7911.0
RASAL2 2675.0 5015.0
RASGEF1A 192.0 7206.0
RASGRF1 2766.0 5893.0
RASGRF2 -6228.0 -4973.0
RASGRP1 2601.0 2419.0
RASGRP2 1024.0 8411.0
RASGRP3 -2678.0 5448.0
RBBP4 -3891.0 -6664.0
RBBP5 101.0 3788.0
RBBP7 5468.0 3390.0
RBCK1 -2839.0 -6954.0
RBFOX2 1264.0 -4178.0
RBL1 4815.0 1392.0
RBP1 -3682.0 2182.0
RBP2 -19.0 5080.0
RBP4 8658.0 -6011.0
RBPJ 5289.0 -2520.0
RBX1 -1688.0 -5910.0
RCC2 -6221.0 -5912.0
RCOR1 -3423.0 4935.0
RDH10 -6453.0 -3543.0
RDH11 6920.0 1509.0
RDH12 6759.0 7093.0
RDH13 -1446.0 3816.0
RDH14 -2473.0 -5612.0
RDH16 6165.0 6625.0
RDH5 5737.0 -969.0
REEP1 4862.0 7899.0
REEP2 8515.0 8319.0
REEP3 -3446.0 -5667.0
REEP4 3956.0 5425.0
REEP5 -6678.0 -6526.0
REEP6 2898.0 7308.0
RELA -2600.0 -2650.0
REST -384.0 -5731.0
RETSAT -2400.0 1393.0
RFNG -1682.0 -2567.0
RGS10 -2976.0 5162.0
RGS11 1175.0 7048.0
RGS12 -3866.0 -5863.0
RGS14 -5800.0 910.0
RGS17 7725.0 7808.0
RGS19 -1297.0 548.0
RGS2 2300.0 7147.0
RGS20 2007.0 3857.0
RGS3 -5052.0 -4808.0
RGS5 7720.0 -3488.0
RGS9 4771.0 7890.0
RGS9BP -6674.0 7085.0
RHEB -4421.0 -656.0
RHOA -5595.0 -610.0
RHOB 6979.0 3687.0
RHOBTB1 6721.0 2614.0
RHOBTB2 6023.0 7173.0
RHOC -7154.0 6854.0
RHOD 2027.0 7729.0
RHOF -3431.0 4600.0
RHOG -2681.0 2642.0
RHOJ -4278.0 -3237.0
RHOQ -6939.0 6311.0
RHOT1 4048.0 5889.0
RHOT2 621.0 -2755.0
RHOU 4895.0 4650.0
RHOV -3465.0 8051.0
RHPN1 8386.0 8170.0
RHPN2 1427.0 -380.0
RICTOR -2069.0 -2219.0
RING1 1252.0 905.0
RIPK1 -2781.0 -6606.0
RIPK2 -6075.0 5462.0
RIT1 -5623.0 3562.0
RNF111 2485.0 -2653.0
RNF146 1003.0 -4639.0
RNF2 2695.0 -1709.0
RNF31 -417.0 -2423.0
RNF41 6882.0 2696.0
RNF43 1151.0 -3322.0
ROCK1 -4145.0 -388.0
ROCK2 -2619.0 1195.0
ROR1 -5637.0 7162.0
RPGRIP1L 8004.0 5996.0
RPS27 -3410.0 -2769.0
RPS27A -2775.0 -2092.0
RPS6 -2847.0 -2731.0
RPS6KA1 -4160.0 7381.0
RPS6KA2 -1189.0 8171.0
RPS6KA3 -2985.0 -6766.0
RPS6KA5 5264.0 6579.0
RPS6KB1 -3211.0 2876.0
RPS6KB2 -3956.0 1597.0
RPTOR 310.0 -6930.0
RRAGA 2958.0 5429.0
RRAGB -5221.0 -4046.0
RRAGC -7457.0 4773.0
RRAGD -7466.0 8503.0
RTKN -6200.0 -4090.0
RTN4 -4859.0 7227.0
RTP3 -6958.0 4479.0
RUNX1 -7431.0 2977.0
RUNX3 -564.0 8318.0
RUVBL1 5581.0 1520.0
RXFP4 -7463.0 5508.0
RXRA -4174.0 -4604.0
RXRB -2706.0 -6908.0
RYK -2363.0 -852.0
S1PR2 -2155.0 6403.0
S1PR3 3988.0 6155.0
S1PR5 3941.0 7946.0
SALL4 7977.0 7573.0
SAV1 -2412.0 4210.0
SCAI 5443.0 -1950.0
SCMH1 7591.0 -7594.0
SCRIB -2677.0 -2915.0
SCTR 8010.0 4193.0
SDC1 2289.0 4828.0
SDC2 309.0 -7160.0
SDC3 4620.0 8396.0
SDC4 -1996.0 7632.0
SEC13 -7232.0 872.0
SEH1L -4786.0 -5035.0
SEL1L -7581.0 6447.0
SEPT7 -3161.0 2476.0
SERPINE1 6602.0 6216.0
SFN -4535.0 7088.0
SFPQ -7275.0 -3294.0
SH2B1 -3683.0 -4839.0
SH2B2 59.0 7281.0
SH2B3 -4762.0 5871.0
SH2D2A 7799.0 1228.0
SH3GL1 -4257.0 1814.0
SH3KBP1 -797.0 3626.0
SHARPIN 3186.0 -4384.0
SHB -7429.0 4540.0
SHC1 -7366.0 6063.0
SHC2 -5989.0 -6659.0
SHC3 -6020.0 4521.0
SHH -2909.0 6185.0
SIRT6 -2455.0 3683.0
SKA1 6045.0 5750.0
SKA2 7498.0 2790.0
SKI -1475.0 -4898.0
SKIL -4345.0 2121.0
SKP1 65.0 5781.0
SLC24A1 5771.0 -6302.0
SLC38A9 -5805.0 5280.0
SMAD1 6354.0 -7452.0
SMAD2 -4667.0 -2668.0
SMAD3 -6509.0 -3146.0
SMAD4 3477.0 -6861.0
SMAD5 1533.0 2519.0
SMAD6 1443.0 3918.0
SMAD7 3198.0 3062.0
SMAD9 7151.0 -6615.0
SMARCA4 -3174.0 -6551.0
SMC1A 844.0 -5605.0
SMC3 2651.0 142.0
SMO 2761.0 -7605.0
SMPD2 -99.0 1247.0
SMPD3 8254.0 3875.0
SMURF1 -6697.0 2634.0
SMURF2 -5337.0 -2728.0
SNAI1 -6096.0 8327.0
SNW1 -5749.0 -4537.0
SNX3 -5062.0 -385.0
SOCS1 5702.0 -3083.0
SOCS3 8750.0 -6348.0
SOCS6 -5504.0 -7527.0
SOS1 -791.0 -5263.0
SOS2 -5648.0 -5637.0
SOX13 880.0 -6022.0
SOX2 -192.0 6369.0
SOX4 -3773.0 5349.0
SOX6 -223.0 -7308.0
SOX7 -1001.0 2552.0
SOX9 8328.0 -2415.0
SP1 -5718.0 -3102.0
SPC24 8224.0 4205.0
SPC25 7888.0 3533.0
SPDL1 7883.0 -256.0
SPHK1 -3118.0 -7767.0
SPINT1 -4562.0 7584.0
SPINT2 2701.0 5844.0
SPOP -3250.0 -6875.0
SPOPL -49.0 -1217.0
SPP1 -6250.0 -7019.0
SPPL2A -6065.0 1149.0
SPPL2B 3214.0 6025.0
SPRED1 -2441.0 764.0
SPRED2 -2642.0 -1924.0
SPRED3 -3304.0 7443.0
SPRY1 -1899.0 -6363.0
SPRY2 -1837.0 3102.0
SPTAN1 2399.0 5588.0
SPTB 5515.0 8432.0
SPTBN1 -5004.0 3454.0
SPTBN2 4535.0 6499.0
SPTBN4 3479.0 8004.0
SPTBN5 -6606.0 7045.0
SQSTM1 -7453.0 1109.0
SRC 4228.0 -3778.0
SRF -2846.0 -5338.0
SRGAP1 -1181.0 -2145.0
SRGAP2 -303.0 5195.0
SRGAP3 8521.0 7241.0
SRY 7961.0 -3106.0
SSTR1 5817.0 8129.0
SSTR2 -5129.0 8468.0
SSTR3 8546.0 6076.0
SSTR5 3258.0 -6631.0
ST3GAL3 6820.0 -7613.0
ST3GAL4 -7237.0 -1792.0
ST3GAL6 -3633.0 -3511.0
STAG1 -3906.0 -7041.0
STAG2 -3204.0 -6068.0
STAM 5057.0 2887.0
STAM2 3375.0 4732.0
STAP2 4573.0 -7281.0
STARD13 -6166.0 -1051.0
STARD8 2169.0 8471.0
STAT1 -5859.0 2090.0
STAT3 4493.0 1454.0
STAT5A 6185.0 -3897.0
STAT5B 7717.0 -922.0
STAT6 -1443.0 -7701.0
STK11 -3225.0 -3053.0
STK3 -1073.0 1312.0
STK4 3312.0 6536.0
STRA6 1069.0 1340.0
STRADA 7695.0 897.0
STRADB 3848.0 317.0
STRAP -4079.0 2641.0
STRN -5586.0 5511.0
STUB1 3401.0 3120.0
SUFU 2569.0 6575.0
SUZ12 -6.0 -850.0
SYDE1 6689.0 -7252.0
SYDE2 2458.0 705.0
SYNGAP1 -1025.0 7828.0
SYVN1 -7570.0 4301.0
TAB1 7756.0 -5796.0
TAB2 -3905.0 -3375.0
TAB3 2798.0 -1303.0
TAC3 -4659.0 8189.0
TACC3 3336.0 309.0
TAOK1 -2873.0 -4557.0
TAS1R1 3413.0 -5080.0
TAS1R3 -6473.0 -4570.0
TAS2R14 6326.0 -3495.0
TAS2R4 7561.0 -1777.0
TAS2R5 8518.0 -2530.0
TAX1BP1 -6642.0 3631.0
TAX1BP3 -2685.0 -2557.0
TBL1X -1420.0 -6140.0
TBL1XR1 1409.0 -5784.0
TBP 3845.0 -902.0
TBXA2R -1611.0 8422.0
TCF7 -6944.0 3605.0
TCF7L1 2275.0 7846.0
TCF7L2 1096.0 -3486.0
TCIRG1 -77.0 4001.0
TEC -1320.0 7566.0
TERT 5269.0 -5901.0
TFDP1 -2376.0 2268.0
TFDP2 4089.0 -4961.0
TFF1 3912.0 -1366.0
TFF3 8701.0 1134.0
TGFA -4681.0 2453.0
TGFB1 -7392.0 7182.0
TGFBR1 -2379.0 -3012.0
TGFBR2 -3644.0 -6778.0
TGIF1 1989.0 -2135.0
TGIF2 -282.0 -6714.0
THBS1 6810.0 -5540.0
THBS2 4220.0 7389.0
THBS3 5319.0 3550.0
THBS4 8623.0 -4184.0
THEM4 6695.0 -3915.0
TIA1 7195.0 -5615.0
TIAL1 -5445.0 -4994.0
TIAM1 7268.0 3972.0
TIAM2 -54.0 6748.0
TJP1 -4511.0 -4360.0
TJP2 6917.0 -7153.0
TLE1 -3060.0 -1391.0
TLE2 8095.0 8238.0
TLE3 -5306.0 -2714.0
TLE4 -6995.0 7419.0
TLN1 -6564.0 -1483.0
TMED2 -7514.0 3294.0
TMED5 -3859.0 -4985.0
TNFAIP3 4755.0 5847.0
TNFRSF10A -4619.0 -2956.0
TNFRSF10B -7079.0 -3032.0
TNFRSF10D -5233.0 -715.0
TNFRSF1A 5317.0 -6852.0
TNFSF10 6265.0 -6952.0
TNKS -4684.0 547.0
TNKS2 -3122.0 1594.0
TNRC6A 1913.0 -5241.0
TNRC6B -4164.0 -938.0
TNRC6C -4787.0 -4291.0
TNS3 -3944.0 -5249.0
TNS4 -5327.0 6121.0
TP53 -1887.0 -7411.0
TRADD 4371.0 3937.0
TRAF1 3388.0 4804.0
TRAF2 -436.0 -2066.0
TRAF6 1921.0 197.0
TRIB3 -7267.0 -7555.0
TRIM27 -7005.0 -5019.0
TRIM33 -5634.0 -2547.0
TRIO -5442.0 -1573.0
TRIP10 4840.0 -3803.0
TRRAP -3521.0 -1453.0
TSC1 -5215.0 -4264.0
TSC2 -2326.0 -2110.0
TTC21B 4773.0 -2658.0
TTR -3986.0 5461.0
TULP3 -1268.0 6738.0
TYK2 5544.0 2957.0
UBA52 -5323.0 1252.0
UBB -3737.0 1627.0
UBC 931.0 -2324.0
UBE2D1 3789.0 4615.0
UBE2D3 -4046.0 -4321.0
UBE2M -4905.0 -3255.0
UCHL5 319.0 3501.0
UCN 7671.0 3581.0
UCN2 -4495.0 2613.0
UHMK1 -3777.0 -2448.0
ULK3 4349.0 -6825.0
USF1 -1777.0 -5432.0
USF2 -6324.0 -7450.0
USP13 6783.0 -7256.0
USP15 -4468.0 2945.0
USP2 -5303.0 4905.0
USP21 3090.0 -6832.0
USP34 -4747.0 -2366.0
USP4 1510.0 -6358.0
USP7 211.0 -5940.0
USP8 -3361.0 1315.0
USP9X -4461.0 1938.0
VANGL2 6094.0 8423.0
VAPA -4764.0 -6199.0
VAV2 1909.0 -4196.0
VAV3 -4945.0 -3835.5
VCL 4808.0 8245.0
VCP -7126.0 -4707.0
VEGFA -4378.0 -5184.0
VEGFB -6938.0 -4445.0
VIPR1 -3185.0 8251.0
VPS26A -5023.0 3851.0
VPS29 768.0 1989.0
VPS35 -2709.0 813.0
VRK3 -1094.0 6290.0
VWF 1716.0 1505.0
WAS 3843.0 2677.0
WASF1 -5799.0 5955.0
WASF2 -3300.0 -2425.0
WASF3 2731.0 3805.0
WASL -6975.0 1162.0
WDR19 -2156.0 6558.0
WDR35 2394.0 2118.0
WDR83 -4776.0 760.0
WIPF2 -3105.0 -1509.0
WIPF3 28.0 8304.0
WNT10B -2373.0 8350.0
WNT11 5359.0 8440.0
WNT2B -4892.0 7159.0
WNT3 -3479.0 -6602.0
WNT5B 3822.0 7503.0
WNT6 4623.0 5896.0
WNT7B -6215.0 5454.0
WNT8B 8364.0 7202.0
WNT9A -3212.0 7280.0
WWC1 -579.0 1959.0
WWOX -1020.0 -921.0
WWP1 -952.0 -1321.0
WWP2 -5365.0 704.0
WWTR1 281.0 293.0
XCL1 4786.0 -4644.0
XIAP -2970.0 -5633.0
XPO1 -1381.0 -2685.0
YAP1 2809.0 -7684.0
YBX1 -5901.0 -5024.0
YES1 -1071.0 2545.0
YWHAB 2124.0 1177.0
YWHAE 297.0 -6554.0
YWHAG -745.0 4215.0
YWHAH -3577.0 4781.0
YWHAQ 218.0 -1967.0
YWHAZ -2.0 10.0
YY1 -5405.0 -5164.0
ZDHHC21 5050.0 -3368.0
ZDHHC7 -6348.0 -4125.0
ZFYVE16 5177.0 -2206.0
ZFYVE9 1605.0 -6186.0
ZNF217 7860.0 -7013.0
ZNRF3 -5975.0 1677.0
ZW10 -3991.0 2318.0
ZWILCH 6551.0 5658.0
ZWINT 6624.0 1785.0



Formation of a pool of free 40S subunits

metric value
setSize 98
pMANOVA 1.96e-18
p.adjustMANOVA 1.18e-16
s.dist 0.526
confESp NA
s.rna_LGvHG -0.403
s.rna_HGvHGV -0.338
p.rna_LGvHG 5.34e-12
p.rna_HGvHGV 7.25e-09




Gene rna_LGvHG rna_HGvHGV
EIF3A -7417 -4849.0
EIF3B -5113 -5476.0
EIF3J -4525 -6126.0
RPL10 -5543 -4999.0
RPL6 -5151 -4811.0
EIF3G -4897 -4671.0
RPL19 -5609 -3966.0
EIF3D -3836 -5783.0
RPL36AL -7445 -2641.0
RPS27L -3395 -5791.0
RPL27A -4506 -4250.0
RPL21 -4209 -4036.5
RPS11 -5078 -2933.0
RPL14 -5527 -2682.0
RPLP1 -4373 -3370.0
RPL11 -5172 -2748.0
RPL9 -3114 -4301.0
RPL29 -4075 -3272.0
RPS7 -5915 -2189.0
RPS19 -4961 -2582.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
EIF1AX 1986 3709.0
EIF3A -7417 -4849.0
EIF3B -5113 -5476.0
EIF3C 1948 -5119.0
EIF3D -3836 -5783.0
EIF3E 3525 -2684.0
EIF3F -612 -5160.0
EIF3G -4897 -4671.0
EIF3H 1030 -953.0
EIF3I -5628 -499.0
EIF3J -4525 -6126.0
EIF3K -2175 -767.0
EIF3L -2260 -3369.0
EIF3M -4437 -1125.0
FAU -5465 -1439.0
RPL10 -5543 -4999.0
RPL10A -2566 -3948.0
RPL11 -5172 -2748.0
RPL12 -1507 -3084.0
RPL13 -471 -3317.0
RPL13A -2745 -2677.0
RPL14 -5527 -2682.0
RPL15 1849 -2009.0
RPL17 126 -3940.0
RPL18 -4183 -1071.0
RPL18A -5301 -585.0
RPL19 -5609 -3966.0
RPL21 -4209 -4036.5
RPL22 5249 -3942.0
RPL22L1 -160 -6353.5
RPL23 -1370 -2849.0
RPL23A -3454 -1887.0
RPL24 -1812 -3491.0
RPL26 -1365 -146.0
RPL26L1 -3945 1440.0
RPL27 -2005 -919.0
RPL27A -4506 -4250.0
RPL28 -3621 -752.0
RPL29 -4075 -3272.0
RPL3 -1503 -3206.0
RPL30 -4142 -2917.0
RPL31 981 -1139.0
RPL32 -3393 -1261.0
RPL34 -2770 -2030.0
RPL35 -2891 -1554.0
RPL35A -4369 -1415.0
RPL36 -3549 -3202.0
RPL36A 5630 -2965.0
RPL36AL -7445 -2641.0
RPL37 -3457 -2235.0
RPL37A -2415 -2945.0
RPL38 -1678 -1496.0
RPL39 -1636 842.0
RPL3L -4857 -260.0
RPL4 -2513 -3939.0
RPL41 1461 -3751.0
RPL5 -554 -2231.0
RPL6 -5151 -4811.0
RPL7 -1319 -3168.0
RPL7A -2609 -2165.0
RPL8 -3548 -2560.0
RPL9 -3114 -4301.0
RPLP0 -4427 -1121.0
RPLP1 -4373 -3370.0
RPLP2 -2777 -1899.0
RPS10 112 -1083.0
RPS11 -5078 -2933.0
RPS12 -4503 -2114.0
RPS13 -2629 -2290.0
RPS14 -3593 -2671.0
RPS15 -4564 -1911.0
RPS15A -3125 -197.0
RPS16 -3362 -2103.0
RPS18 -2870 -2001.0
RPS19 -4961 -2582.0
RPS2 -3922 -2651.0
RPS20 -1741 -1314.0
RPS21 -2922 -743.0
RPS23 -1789 -1850.0
RPS24 -2865 -1728.0
RPS25 -124 -980.0
RPS26 239 -3326.0
RPS27 -3410 -2769.0
RPS27A -2775 -2092.0
RPS27L -3395 -5791.0
RPS28 -3558 -1760.0
RPS29 -3554 19.0
RPS3 -2626 -1940.0
RPS3A 1310 -2352.0
RPS4X -3384 -3144.0
RPS4Y1 -2083 -2421.0
RPS5 -5073 439.0
RPS6 -2847 -2731.0
RPS7 -5915 -2189.0
RPS8 -1202 -2865.0
RPS9 -4220 -3027.0
RPSA -2539 -2294.0
UBA52 -5323 1252.0



Influenza Infection

metric value
setSize 151
pMANOVA 9.24e-18
p.adjustMANOVA 5.32e-16
s.dist 0.417
confESp NA
s.rna_LGvHG -0.333
s.rna_HGvHGV -0.25
p.rna_LGvHG 1.59e-12
p.rna_HGvHGV 1.2e-07




Gene rna_LGvHG rna_HGvHGV
KPNB1 -6677 -7481.0
POM121 -6619 -6903.0
RAN -6562 -6672.0
POM121C -5801 -6560.0
CANX -7544 -4761.0
IPO5 -6658 -4295.0
RPL10 -5543 -4999.0
NUP88 -4829 -5548.0
RPL6 -5151 -4811.0
SEH1L -4786 -5035.0
RPL19 -5609 -3966.0
NUP50 -4694 -4478.0
RPL36AL -7445 -2641.0
RPS27L -3395 -5791.0
GRSF1 -4788 -4006.0
RPL27A -4506 -4250.0
NUP188 -5044 -3795.0
SLC25A6 -3870 -4795.0
RPL21 -4209 -4036.5
RPS11 -5078 -2933.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
AAAS 3304.0 -6791.0
CALR -7600.0 3622.0
CANX -7544.0 -4761.0
CLTA -6861.0 -1169.0
CLTC -6446.0 46.0
CPSF4 1809.0 2639.0
DNAJC3 -7590.0 -1959.0
EIF2AK2 2691.0 -3516.0
FAU -5465.0 -1439.0
GRSF1 -4788.0 -4006.0
GTF2F1 -3019.0 -1117.0
GTF2F2 4860.0 1441.0
HSP90AA1 -1010.0 -966.0
HSPA1A 7380.0 5234.0
IPO5 -6658.0 -4295.0
ISG15 -5813.0 7682.0
KPNA1 -6998.0 214.0
KPNA2 -4910.0 5213.0
KPNA3 -5018.0 5540.0
KPNA4 -1532.0 -3859.0
KPNA5 -2026.0 -1879.0
KPNA7 -4170.0 4287.0
KPNB1 -6677.0 -7481.0
NDC1 -1208.0 -2073.0
NUP107 6965.0 -4327.0
NUP133 1406.0 1305.0
NUP153 2805.0 1278.0
NUP155 5259.0 -95.0
NUP160 -271.0 -1749.0
NUP188 -5044.0 -3795.0
NUP205 -5514.0 -2051.0
NUP210 7824.0 -4030.0
NUP214 -1509.0 -4585.0
NUP35 6880.0 -2911.0
NUP37 8176.0 -4271.0
NUP43 2778.0 1270.0
NUP50 -4694.0 -4478.0
NUP54 3508.0 -1767.0
NUP62 -73.0 -4951.0
NUP85 4624.0 1161.0
NUP88 -4829.0 -5548.0
NUP93 6534.0 2994.0
NUP98 -3617.0 2992.0
NUPL2 -3453.0 1853.0
PABPN1 176.0 -7478.0
POLR2A 2948.0 -6306.0
POLR2B -3795.0 2880.0
POLR2C -3177.0 1582.0
POLR2D 1696.0 -2523.0
POLR2E -4282.5 3215.0
POLR2F -5560.0 4701.0
POLR2G 2153.0 1453.0
POLR2H -4010.0 -1665.0
POLR2I 4612.0 -3659.0
POLR2J -246.0 4188.0
POLR2K 6791.0 5504.0
POLR2L -5741.0 6784.0
POM121 -6619.0 -6903.0
POM121C -5801.0 -6560.0
RAE1 4684.0 -5543.0
RAN -6562.0 -6672.0
RANBP2 471.0 501.0
RPL10 -5543.0 -4999.0
RPL10A -2566.0 -3948.0
RPL11 -5172.0 -2748.0
RPL12 -1507.0 -3084.0
RPL13 -471.0 -3317.0
RPL13A -2745.0 -2677.0
RPL14 -5527.0 -2682.0
RPL15 1849.0 -2009.0
RPL17 126.0 -3940.0
RPL18 -4183.0 -1071.0
RPL18A -5301.0 -585.0
RPL19 -5609.0 -3966.0
RPL21 -4209.0 -4036.5
RPL22 5249.0 -3942.0
RPL22L1 -160.0 -6353.5
RPL23 -1370.0 -2849.0
RPL23A -3454.0 -1887.0
RPL24 -1812.0 -3491.0
RPL26 -1365.0 -146.0
RPL26L1 -3945.0 1440.0
RPL27 -2005.0 -919.0
RPL27A -4506.0 -4250.0
RPL28 -3621.0 -752.0
RPL29 -4075.0 -3272.0
RPL3 -1503.0 -3206.0
RPL30 -4142.0 -2917.0
RPL31 981.0 -1139.0
RPL32 -3393.0 -1261.0
RPL34 -2770.0 -2030.0
RPL35 -2891.0 -1554.0
RPL35A -4369.0 -1415.0
RPL36 -3549.0 -3202.0
RPL36A 5630.0 -2965.0
RPL36AL -7445.0 -2641.0
RPL37 -3457.0 -2235.0
RPL37A -2415.0 -2945.0
RPL38 -1678.0 -1496.0
RPL39 -1636.0 842.0
RPL3L -4857.0 -260.0
RPL4 -2513.0 -3939.0
RPL41 1461.0 -3751.0
RPL5 -554.0 -2231.0
RPL6 -5151.0 -4811.0
RPL7 -1319.0 -3168.0
RPL7A -2609.0 -2165.0
RPL8 -3548.0 -2560.0
RPL9 -3114.0 -4301.0
RPLP0 -4427.0 -1121.0
RPLP1 -4373.0 -3370.0
RPLP2 -2777.0 -1899.0
RPS10 112.0 -1083.0
RPS11 -5078.0 -2933.0
RPS12 -4503.0 -2114.0
RPS13 -2629.0 -2290.0
RPS14 -3593.0 -2671.0
RPS15 -4564.0 -1911.0
RPS15A -3125.0 -197.0
RPS16 -3362.0 -2103.0
RPS18 -2870.0 -2001.0
RPS19 -4961.0 -2582.0
RPS2 -3922.0 -2651.0
RPS20 -1741.0 -1314.0
RPS21 -2922.0 -743.0
RPS23 -1789.0 -1850.0
RPS24 -2865.0 -1728.0
RPS25 -124.0 -980.0
RPS26 239.0 -3326.0
RPS27 -3410.0 -2769.0
RPS27A -2775.0 -2092.0
RPS27L -3395.0 -5791.0
RPS28 -3558.0 -1760.0
RPS29 -3554.0 19.0
RPS3 -2626.0 -1940.0
RPS3A 1310.0 -2352.0
RPS4X -3384.0 -3144.0
RPS4Y1 -2083.0 -2421.0
RPS5 -5073.0 439.0
RPS6 -2847.0 -2731.0
RPS7 -5915.0 -2189.0
RPS8 -1202.0 -2865.0
RPS9 -4220.0 -3027.0
RPSA -2539.0 -2294.0
SEC13 -7232.0 872.0
SEH1L -4786.0 -5035.0
SLC25A6 -3870.0 -4795.0
TGFB1 -7392.0 7182.0
TPR 610.0 -1079.0
UBA52 -5323.0 1252.0
XPO1 -1381.0 -2685.0



Influenza Life Cycle

metric value
setSize 140
pMANOVA 2.09e-17
p.adjustMANOVA 1.15e-15
s.dist 0.428
confESp NA
s.rna_LGvHG -0.327
s.rna_HGvHGV -0.276
p.rna_LGvHG 2.37e-11
p.rna_HGvHGV 1.81e-08




Gene rna_LGvHG rna_HGvHGV
KPNB1 -6677 -7481.0
POM121 -6619 -6903.0
RAN -6562 -6672.0
POM121C -5801 -6560.0
CANX -7544 -4761.0
IPO5 -6658 -4295.0
RPL10 -5543 -4999.0
NUP88 -4829 -5548.0
RPL6 -5151 -4811.0
SEH1L -4786 -5035.0
RPL19 -5609 -3966.0
NUP50 -4694 -4478.0
RPL36AL -7445 -2641.0
RPS27L -3395 -5791.0
GRSF1 -4788 -4006.0
RPL27A -4506 -4250.0
NUP188 -5044 -3795.0
RPL21 -4209 -4036.5
RPS11 -5078 -2933.0
DNAJC3 -7590 -1959.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
AAAS 3304.0 -6791.0
CALR -7600.0 3622.0
CANX -7544.0 -4761.0
CLTA -6861.0 -1169.0
CLTC -6446.0 46.0
DNAJC3 -7590.0 -1959.0
FAU -5465.0 -1439.0
GRSF1 -4788.0 -4006.0
GTF2F1 -3019.0 -1117.0
GTF2F2 4860.0 1441.0
HSP90AA1 -1010.0 -966.0
HSPA1A 7380.0 5234.0
IPO5 -6658.0 -4295.0
KPNA1 -6998.0 214.0
KPNB1 -6677.0 -7481.0
NDC1 -1208.0 -2073.0
NUP107 6965.0 -4327.0
NUP133 1406.0 1305.0
NUP153 2805.0 1278.0
NUP155 5259.0 -95.0
NUP160 -271.0 -1749.0
NUP188 -5044.0 -3795.0
NUP205 -5514.0 -2051.0
NUP210 7824.0 -4030.0
NUP214 -1509.0 -4585.0
NUP35 6880.0 -2911.0
NUP37 8176.0 -4271.0
NUP43 2778.0 1270.0
NUP50 -4694.0 -4478.0
NUP54 3508.0 -1767.0
NUP62 -73.0 -4951.0
NUP85 4624.0 1161.0
NUP88 -4829.0 -5548.0
NUP93 6534.0 2994.0
NUP98 -3617.0 2992.0
NUPL2 -3453.0 1853.0
POLR2A 2948.0 -6306.0
POLR2B -3795.0 2880.0
POLR2C -3177.0 1582.0
POLR2D 1696.0 -2523.0
POLR2E -4282.5 3215.0
POLR2F -5560.0 4701.0
POLR2G 2153.0 1453.0
POLR2H -4010.0 -1665.0
POLR2I 4612.0 -3659.0
POLR2J -246.0 4188.0
POLR2K 6791.0 5504.0
POLR2L -5741.0 6784.0
POM121 -6619.0 -6903.0
POM121C -5801.0 -6560.0
RAE1 4684.0 -5543.0
RAN -6562.0 -6672.0
RANBP2 471.0 501.0
RPL10 -5543.0 -4999.0
RPL10A -2566.0 -3948.0
RPL11 -5172.0 -2748.0
RPL12 -1507.0 -3084.0
RPL13 -471.0 -3317.0
RPL13A -2745.0 -2677.0
RPL14 -5527.0 -2682.0
RPL15 1849.0 -2009.0
RPL17 126.0 -3940.0
RPL18 -4183.0 -1071.0
RPL18A -5301.0 -585.0
RPL19 -5609.0 -3966.0
RPL21 -4209.0 -4036.5
RPL22 5249.0 -3942.0
RPL22L1 -160.0 -6353.5
RPL23 -1370.0 -2849.0
RPL23A -3454.0 -1887.0
RPL24 -1812.0 -3491.0
RPL26 -1365.0 -146.0
RPL26L1 -3945.0 1440.0
RPL27 -2005.0 -919.0
RPL27A -4506.0 -4250.0
RPL28 -3621.0 -752.0
RPL29 -4075.0 -3272.0
RPL3 -1503.0 -3206.0
RPL30 -4142.0 -2917.0
RPL31 981.0 -1139.0
RPL32 -3393.0 -1261.0
RPL34 -2770.0 -2030.0
RPL35 -2891.0 -1554.0
RPL35A -4369.0 -1415.0
RPL36 -3549.0 -3202.0
RPL36A 5630.0 -2965.0
RPL36AL -7445.0 -2641.0
RPL37 -3457.0 -2235.0
RPL37A -2415.0 -2945.0
RPL38 -1678.0 -1496.0
RPL39 -1636.0 842.0
RPL3L -4857.0 -260.0
RPL4 -2513.0 -3939.0
RPL41 1461.0 -3751.0
RPL5 -554.0 -2231.0
RPL6 -5151.0 -4811.0
RPL7 -1319.0 -3168.0
RPL7A -2609.0 -2165.0
RPL8 -3548.0 -2560.0
RPL9 -3114.0 -4301.0
RPLP0 -4427.0 -1121.0
RPLP1 -4373.0 -3370.0
RPLP2 -2777.0 -1899.0
RPS10 112.0 -1083.0
RPS11 -5078.0 -2933.0
RPS12 -4503.0 -2114.0
RPS13 -2629.0 -2290.0
RPS14 -3593.0 -2671.0
RPS15 -4564.0 -1911.0
RPS15A -3125.0 -197.0
RPS16 -3362.0 -2103.0
RPS18 -2870.0 -2001.0
RPS19 -4961.0 -2582.0
RPS2 -3922.0 -2651.0
RPS20 -1741.0 -1314.0
RPS21 -2922.0 -743.0
RPS23 -1789.0 -1850.0
RPS24 -2865.0 -1728.0
RPS25 -124.0 -980.0
RPS26 239.0 -3326.0
RPS27 -3410.0 -2769.0
RPS27A -2775.0 -2092.0
RPS27L -3395.0 -5791.0
RPS28 -3558.0 -1760.0
RPS29 -3554.0 19.0
RPS3 -2626.0 -1940.0
RPS3A 1310.0 -2352.0
RPS4X -3384.0 -3144.0
RPS4Y1 -2083.0 -2421.0
RPS5 -5073.0 439.0
RPS6 -2847.0 -2731.0
RPS7 -5915.0 -2189.0
RPS8 -1202.0 -2865.0
RPS9 -4220.0 -3027.0
RPSA -2539.0 -2294.0
SEC13 -7232.0 872.0
SEH1L -4786.0 -5035.0
TPR 610.0 -1079.0
UBA52 -5323.0 1252.0
XPO1 -1381.0 -2685.0



Eukaryotic Translation Elongation

metric value
setSize 90
pMANOVA 3.35e-17
p.adjustMANOVA 1.76e-15
s.dist 0.53
confESp NA
s.rna_LGvHG -0.422
s.rna_HGvHGV -0.32
p.rna_LGvHG 4.38e-12
p.rna_HGvHGV 1.61e-07




Gene rna_LGvHG rna_HGvHGV
RPL10 -5543 -4999.0
RPL6 -5151 -4811.0
EEF1B2 -5288 -4607.0
RPL19 -5609 -3966.0
EEF1A1 -5269 -4120.0
RPL36AL -7445 -2641.0
RPS27L -3395 -5791.0
EEF2 -5440 -3559.0
RPL27A -4506 -4250.0
EEF1D -5572 -3143.0
RPL21 -4209 -4036.5
RPS11 -5078 -2933.0
RPL14 -5527 -2682.0
RPLP1 -4373 -3370.0
RPL11 -5172 -2748.0
RPL9 -3114 -4301.0
RPL29 -4075 -3272.0
RPS7 -5915 -2189.0
RPS19 -4961 -2582.0
RPS9 -4220 -3027.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
EEF1A1 -5269 -4120.0
EEF1A1P5 -4003 -2970.0
EEF1A2 585 8438.0
EEF1B2 -5288 -4607.0
EEF1D -5572 -3143.0
EEF2 -5440 -3559.0
FAU -5465 -1439.0
RPL10 -5543 -4999.0
RPL10A -2566 -3948.0
RPL11 -5172 -2748.0
RPL12 -1507 -3084.0
RPL13 -471 -3317.0
RPL13A -2745 -2677.0
RPL14 -5527 -2682.0
RPL15 1849 -2009.0
RPL17 126 -3940.0
RPL18 -4183 -1071.0
RPL18A -5301 -585.0
RPL19 -5609 -3966.0
RPL21 -4209 -4036.5
RPL22 5249 -3942.0
RPL22L1 -160 -6353.5
RPL23 -1370 -2849.0
RPL23A -3454 -1887.0
RPL24 -1812 -3491.0
RPL26 -1365 -146.0
RPL26L1 -3945 1440.0
RPL27 -2005 -919.0
RPL27A -4506 -4250.0
RPL28 -3621 -752.0
RPL29 -4075 -3272.0
RPL3 -1503 -3206.0
RPL30 -4142 -2917.0
RPL31 981 -1139.0
RPL32 -3393 -1261.0
RPL34 -2770 -2030.0
RPL35 -2891 -1554.0
RPL35A -4369 -1415.0
RPL36 -3549 -3202.0
RPL36A 5630 -2965.0
RPL36AL -7445 -2641.0
RPL37 -3457 -2235.0
RPL37A -2415 -2945.0
RPL38 -1678 -1496.0
RPL39 -1636 842.0
RPL3L -4857 -260.0
RPL4 -2513 -3939.0
RPL41 1461 -3751.0
RPL5 -554 -2231.0
RPL6 -5151 -4811.0
RPL7 -1319 -3168.0
RPL7A -2609 -2165.0
RPL8 -3548 -2560.0
RPL9 -3114 -4301.0
RPLP0 -4427 -1121.0
RPLP1 -4373 -3370.0
RPLP2 -2777 -1899.0
RPS10 112 -1083.0
RPS11 -5078 -2933.0
RPS12 -4503 -2114.0
RPS13 -2629 -2290.0
RPS14 -3593 -2671.0
RPS15 -4564 -1911.0
RPS15A -3125 -197.0
RPS16 -3362 -2103.0
RPS18 -2870 -2001.0
RPS19 -4961 -2582.0
RPS2 -3922 -2651.0
RPS20 -1741 -1314.0
RPS21 -2922 -743.0
RPS23 -1789 -1850.0
RPS24 -2865 -1728.0
RPS25 -124 -980.0
RPS26 239 -3326.0
RPS27 -3410 -2769.0
RPS27A -2775 -2092.0
RPS27L -3395 -5791.0
RPS28 -3558 -1760.0
RPS29 -3554 19.0
RPS3 -2626 -1940.0
RPS3A 1310 -2352.0
RPS4X -3384 -3144.0
RPS4Y1 -2083 -2421.0
RPS5 -5073 439.0
RPS6 -2847 -2731.0
RPS7 -5915 -2189.0
RPS8 -1202 -2865.0
RPS9 -4220 -3027.0
RPSA -2539 -2294.0
UBA52 -5323 1252.0



Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

metric value
setSize 91
pMANOVA 7.55e-17
p.adjustMANOVA 3.82e-15
s.dist 0.521
confESp NA
s.rna_LGvHG -0.416
s.rna_HGvHGV -0.314
p.rna_LGvHG 7.06e-12
p.rna_HGvHGV 2.29e-07




Gene rna_LGvHG rna_HGvHGV
EIF4G1 -6162 -7098.0
RPL10 -5543 -4999.0
UPF1 -4750 -5252.0
RPL6 -5151 -4811.0
RPL19 -5609 -3966.0
RPL36AL -7445 -2641.0
RPS27L -3395 -5791.0
RPL27A -4506 -4250.0
RPL21 -4209 -4036.5
RPS11 -5078 -2933.0
RPL14 -5527 -2682.0
RPLP1 -4373 -3370.0
RPL11 -5172 -2748.0
RPL9 -3114 -4301.0
RPL29 -4075 -3272.0
RPS7 -5915 -2189.0
RPS19 -4961 -2582.0
RPS9 -4220 -3027.0
RPL30 -4142 -2917.0
RPL36 -3549 -3202.0

Click HERE to show all gene set members

rna_LGvHG rna_HGvHGV
EIF4G1 -6162 -7098.0
ETF1 -7375 1850.0
FAU -5465 -1439.0
GSPT1 -7249 3458.0
NCBP1 -1858 1533.0
NCBP2 7854 -262.0
PABPC1 -3531 -2220.0
RPL10 -5543 -4999.0
RPL10A -2566 -3948.0
RPL11 -5172 -2748.0
RPL12 -1507 -3084.0
RPL13 -471 -3317.0
RPL13A -2745 -2677.0
RPL14 -5527 -2682.0
RPL15 1849 -2009.0
RPL17 126 -3940.0
RPL18 -4183 -1071.0
RPL18A -5301 -585.0
RPL19 -5609 -3966.0
RPL21 -4209 -4036.5
RPL22 5249 -3942.0
RPL22L1 -160 -6353.5
RPL23 -1370 -2849.0
RPL23A -3454 -1887.0
RPL24 -1812 -3491.0
RPL26 -1365 -146.0
RPL26L1 -3945 1440.0
RPL27 -2005 -919.0
RPL27A -4506 -4250.0
RPL28 -3621 -752.0
RPL29 -4075 -3272.0
RPL3 -1503 -3206.0
RPL30 -4142 -2917.0
RPL31 981 -1139.0
RPL32 -3393 -1261.0
RPL34 -2770 -2030.0
RPL35 -2891 -1554.0
RPL35A -4369 -1415.0
RPL36 -3549 -3202.0
RPL36A 5630 -2965.0
RPL36AL -7445 -2641.0
RPL37 -3457 -2235.0
RPL37A -2415 -2945.0
RPL38 -1678 -1496.0
RPL39 -1636 842.0
RPL3L -4857 -260.0
RPL4 -2513 -3939.0
RPL41 1461 -3751.0
RPL5 -554 -2231.0
RPL6 -5151 -4811.0
RPL7 -1319 -3168.0
RPL7A -2609 -2165.0
RPL8 -3548 -2560.0
RPL9 -3114 -4301.0
RPLP0 -4427 -1121.0
RPLP1 -4373 -3370.0
RPLP2 -2777 -1899.0
RPS10 112 -1083.0
RPS11 -5078 -2933.0
RPS12 -4503 -2114.0
RPS13 -2629 -2290.0
RPS14 -3593 -2671.0
RPS15 -4564 -1911.0
RPS15A -3125 -197.0
RPS16 -3362 -2103.0
RPS18 -2870 -2001.0
RPS19 -4961 -2582.0
RPS2 -3922 -2651.0
RPS20 -1741 -1314.0
RPS21 -2922 -743.0
RPS23 -1789 -1850.0
RPS24 -2865 -1728.0
RPS25 -124 -980.0
RPS26 239 -3326.0
RPS27 -3410 -2769.0
RPS27A -2775 -2092.0
RPS27L -3395 -5791.0
RPS28 -3558 -1760.0
RPS29 -3554 19.0
RPS3 -2626 -1940.0
RPS3A 1310 -2352.0
RPS4X -3384 -3144.0
RPS4Y1 -2083 -2421.0
RPS5 -5073 439.0
RPS6 -2847 -2731.0
RPS7 -5915 -2189.0
RPS8 -1202 -2865.0
RPS9 -4220 -3027.0
RPSA -2539 -2294.0
UBA52 -5323 1252.0
UPF1 -4750 -5252.0



Here is the session info with all the versions of packages used.

devtools::session_info()
## ─ Session info ──────────────────────────────────────────────────────────
##  setting  value                       
##  version  R version 3.6.0 (2019-04-26)
##  os       Ubuntu 18.04.2 LTS          
##  system   x86_64, linux-gnu           
##  ui       X11                         
##  language (EN)                        
##  collate  en_AU.UTF-8                 
##  ctype    en_AU.UTF-8                 
##  tz       Australia/Melbourne         
##  date     2019-06-11                  
## 
## ─ Packages ──────────────────────────────────────────────────────────────
##  package      * version    date       lib
##  assertthat     0.2.1      2019-03-21 [2]
##  backports      1.1.4      2019-04-10 [2]
##  bitops         1.0-6      2013-08-17 [1]
##  callr          3.2.0      2019-03-15 [2]
##  caTools        1.17.1.2   2019-03-06 [1]
##  cli            1.1.0      2019-03-19 [2]
##  colorspace     1.4-1      2019-03-18 [2]
##  crayon         1.3.4      2017-09-16 [2]
##  desc           1.2.0      2018-05-01 [1]
##  devtools       2.0.2      2019-04-08 [1]
##  digest         0.6.19     2019-05-20 [1]
##  dplyr        * 0.8.1      2019-05-14 [1]
##  evaluate       0.14       2019-05-28 [1]
##  fs             1.3.0      2019-05-02 [2]
##  gdata          2.18.0     2017-06-06 [1]
##  GGally       * 1.4.0      2018-05-17 [1]
##  ggplot2      * 3.1.1      2019-04-07 [2]
##  glue           1.3.1      2019-03-12 [2]
##  gplots       * 3.0.1.1    2019-01-27 [1]
##  gridExtra    * 2.3        2017-09-09 [1]
##  gtable         0.3.0      2019-03-25 [2]
##  gtools       * 3.8.1      2018-06-26 [1]
##  highr          0.8        2019-03-20 [2]
##  htmltools      0.3.6      2017-04-28 [2]
##  htmlwidgets    1.3        2018-09-30 [1]
##  jsonlite       1.6        2018-12-07 [2]
##  KernSmooth     2.23-15    2015-06-29 [4]
##  knitr        * 1.23       2019-05-18 [1]
##  labeling       0.3        2014-08-23 [2]
##  lattice      * 0.20-38    2018-11-04 [4]
##  lazyeval       0.2.2      2019-03-15 [2]
##  magrittr       1.5        2014-11-22 [2]
##  markdown     * 0.9        2018-12-07 [2]
##  MASS           7.3-51.4   2019-04-26 [4]
##  memoise        1.1.0      2017-04-21 [1]
##  mitch        * 0.0.0.9000 2019-06-11 [1]
##  munsell        0.5.0      2018-06-12 [2]
##  pbmcapply    * 1.4.1      2019-04-01 [1]
##  pillar         1.4.1      2019-05-28 [1]
##  pkgbuild       1.0.3      2019-03-20 [1]
##  pkgconfig      2.0.2      2018-08-16 [2]
##  pkgload        1.0.2      2018-10-29 [1]
##  plyr         * 1.8.4      2016-06-08 [2]
##  prettyunits    1.0.2      2015-07-13 [2]
##  processx       3.3.0      2019-03-10 [2]
##  ps             1.3.0      2018-12-21 [2]
##  purrr          0.3.2      2019-03-15 [2]
##  R6             2.4.0      2019-02-14 [2]
##  RColorBrewer   1.1-2      2014-12-07 [2]
##  Rcpp           1.0.1      2019-03-17 [2]
##  remotes        2.0.4      2019-04-10 [2]
##  reshape        0.8.8      2018-10-23 [1]
##  reshape2     * 1.4.3      2017-12-11 [2]
##  rlang          0.3.4      2019-04-07 [2]
##  rmarkdown    * 1.13       2019-05-22 [1]
##  Rmisc        * 1.5        2013-10-22 [1]
##  rprojroot      1.3-2      2018-01-03 [1]
##  scales         1.0.0      2018-08-09 [2]
##  sessioninfo    1.1.1      2018-11-05 [1]
##  sm           * 2.2-5.6    2018-09-27 [1]
##  stringi        1.4.3      2019-03-12 [2]
##  stringr        1.4.0      2019-02-10 [2]
##  taucharts    * 0.4.5      2019-05-31 [1]
##  tibble         2.1.2      2019-05-29 [1]
##  tidyselect     0.2.5      2018-10-11 [2]
##  usethis        1.5.0      2019-04-07 [1]
##  vioplot      * 0.3.0      2019-01-25 [1]
##  withr          2.1.2      2018-03-15 [2]
##  xfun           0.7        2019-05-14 [1]
##  yaml           2.2.0      2018-07-25 [2]
##  zoo          * 1.8-6      2019-05-28 [1]
##  source                             
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##  Github (hrbrmstr/taucharts@93dbdce)
##  CRAN (R 3.6.0)                     
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## 
## [1] /home/mdz/R/x86_64-pc-linux-gnu-library/3.6
## [2] /usr/local/lib/R/site-library
## [3] /usr/lib/R/site-library
## [4] /usr/lib/R/library

END of report